{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u002224vrMUQpg2ui2ewfb\\\\\\\\\\\\\\\/mAJbdPnKxU9e702dvs9eK6iAXBOUvuJGZx4FBORbcdDYlzJf+XUxzi5yy0bEua\\\\\\\\\\\\\\\/FErcF4D2TYrNucwisB98r2JuSljsy29iMGlV7z68PW+Cf4cO7hfocDlw9oA9rdo+aYSvoMsl3XZtWT2ZjhWp9JMa25ue2DZPr4uDRjDyXuIqlEQgP71jkSQTgA5DxyOA+Knfp5XgSHOotZt+x\\\\\\\\\\\\\\\/TLPmDDfSpSSmr\\\\\\\\\\\\\\\/02sWpsidGAJ7eTOPSRHvN2HyYTmAp6n3ePgk8I+pQBb8MIbkWAgJeqwAq5scdYL1\\\\\\\\\\\\\\\/+zIVgNGwfk0msnH1AFQgXKHk1yQKpJ0Ih7rYIJI8vFKQmt9hmr7Xh1fhAnM6Ipf\\\\\\\\\\\\\\\/thrbO76ZefkSdNQXjDkPo+T4O1dDvuSm5jHYGjAsO97dkUGEUGLcPv5rUrEH9cX\\\\\\\\\\\\\\\/TrhT0+odJL60OpgXcxlT5yXeCVF\\\\\\\\\\\\\\\/dgiTX0NPUJBCklUT5JIpWd\\\\\\\\\\\\\\\/d1jYVtXnIEdsVgU0lN5RBjzVWkBJlvA1D4Jfy+n9fQUvggK+9DVaAdfZuE5SlcwCvi7kEgRtp5B6PYt8IvcqSlWNMekQUh\\\\\\\\\\\\\\\/96iiKMHx1lfSEgpRsNXF1jR0jYo5baUuAw9Y\\\\\\\\\\\\\\\/7v99MkvUX+EtJgYqB7su\\\\\\\\\\\\\\\/YMgZFqpmsegZbug60Vr8NEOAXt6PyjhBWSzIgmdVwHBIgV4b5HnXWw74OyKdEV57nDcO8DPK5aO0GbXaOH\\\\\\\\\\\\\\\/hg\\\\\\\\\\\\\\\/AqmargrGTgTJsYd+UMLnG3l2xwvBALg7qVstKhHKedvSHQwTR1hU8U4rOszSR+cyK\\\\\\\\\\\\\\\/UXs71m7PHG07XsIqijIKwSL7VGMXGYZetbga8emZc5dZulqllOtIGL0xErvrEs8tLpADb1TfbZW1jwryONbXAdm\\\\\\\\\\\\\\\/AyoBZklPmqo1xGSSJeo5bdZBT3OJalOO5b2D3Cub52YkPHSLKhHcz4ayvuIbqnPFsGg2la4y4T+FSpUm9sp9bG+6qzs+OaF5HA27WnTkKQ5voOUEUf1OIQP3iYmNdi7+Uwxn2g6L+Y1MbAzzcfAXTzwvKp5zcJXLL1MdQ00FYiFpXhkI4vKcF2yaAAAYNWyAKbCr4vpbvehdmnK3QnbFTNfxPqqa28+HYIjQGOWks\\\\\\\\\\\\\\\/BxXPzCOU\\\\\\\\\\\\\\\/aVLsSC\\\\\\\\\\\\\\\/IVYhqQRWE12XRD1S9LAdzD\\\\\\\\\\\\\\\/qz\\\\\\\\\\\\\\\/7tzWBVUesz8nxZEQ+kcfuB2lwVJvDjg20RuHZ7n5vfzeEv7c7bUabD9Sb0xECl4JmYJyTy8QAp\\\\\\\\\\\\\\\/TchT8iQc4I9jmfMOOxZfJWF+puPJXR3pVrKGDCaaX0lvT11P95HlpeHro9dYyedRfFWFRpyWNLlOdG2jmCukh7RNpmGIQrg95gL4mhmHmpr\\\\\\\\\\\\\\\/c+IV8zfVpEfzi6tftfV\\\\\\\\\\\\\\\/z+7qZWAi821Q68roHpEtIkjbR\\\\\\\\\\\\\\\/J2PfkMXJan6XXijNhPnMjdmBogOI6Q1QazPdTSdeBOyjnQ3jCQVim0jvuWBSQ1BvrRkwk4PpD2vpe2G0qbFMIXsKh68JWKnsCsmTCxLt316B6hh9nnVSDrxwr1GYx2Xwe6qPsaMMuFWJ7jMFK\\\\\\\\\\\\\\\/BpQZl4+zKsJVxnTxkEsS\\\\\\\\\\\\\\\/AkGLU7j4jzBGjf8gHXgWg1hOD7ur6+fAAdN4GDLEl3fcrxpwWCNMsacNGZBuiHnXTv52e5UoQNk\\\\\\\\\\\\\\\/VABV09A5FNzFxOhvBMzcKE9n2+RAAeSpT5KInwp27oQhWudN9ECvrTUrdW5GIK0sp3ys7EbPcmYZNS3nx0HBhaOWaVfR8OUvGEBj2vOjw2Hj94sYI5uMMyhdbBOE\\\\\\\\\\\\\\\/wuNRzMoCORok0GlthwnJ68jLQ5IE4iqi+f2j\\\\\\\\\\\\\\\/yQR4r7XxTHQpPut30xtdnI5h7J9TX2J+sMsMAVrg+tM2rjNRRGoPzx4jDZEugvLuDWYfqq3omq8jqGdV+Pb6V35av84TlJKyJ\\\\\\\\\\\\\\\/E6F6don7cAl1RYL1ozCHLDEkZPuyHzE\\\\\\\\\\\\\\\/23xnUYUBqzfDAybttAuuGXA4C6Sal1mkorJZ4J5cr2RJ8k8Oh1ugvtpneZg2g8dD4J\\\\\\\\\\\\\\\/WPFHD7GVKOmCg1hiqpwW5Uyizx3FpnIE46S0UNARrTO0LC4TKV5xbjWPcN6oDbnokN4FpdEL3oQdYTBpmJXZ+HIi4jkxscCiH+rEOaHze3+bziDzRX4I1u7EBv3MiMZfGNi+CNcA348nbgUBIyUsdIiFp4UtpLXxHnhgi4dHlaIVkpKQBjPYIIVlF7jpHBGAN\\\\\\\\\\\\\\\/y7cgiLKhCtm+cheinKDF8zkqmA7NpDnqO+Hmgj6mwFhG2CNxjsBzmBBNSNnWzXoDm9Zls\\\\\\\\\\\\\\\/xyCqTsK5VyrPEhtYv\\\\\\\\\\\\\\\/XTgI9a7soWcVdGwgViVCIc6jOultuVmZmLQyWxkA\\\\\\\\\\\\\\\/pd1hJARGrQYmo0CKOYv\\\\\\\\\\\\\\\/ERcwTjK8pQeLp6bEKZFBGZ9AirSaACs3kZPS9+E92dsWNs7Zd5P12m0sR4RFH55RgefmvqbG5G1Uf7IvDWAq6MELA++iNYYM8z5OAklRQZSGUGhw+ByoxifIVRdQA2uEy+tYGjzGl4\\\\\\\\\\\\\\\/8lJXvKQe5I6USFhqJPjCUQexSvV6IFb\\\\\\\\\\\\\\\/+s0ozHBO\\\\\\\\\\\\\\\/WzlqvjUMztYAYnPnDqaee0P7pfRsjIn1E8jkFQcXxQaTFA+G0SVHB383vw2\\\\\\\\\\\\\\\/i2hNLFW+f4vCpsWO70duCkyD7imzUkK7UFk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022tsfiy7Uo8\\\\\\\\\\\\\\\/w+BrggzoY4vg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022184a0369e2e279cc5001957b645a2447d1b411f629b8eddb62dd54a1445db4e3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/12\\\/e007905.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/12\\\/e007905.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007905\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007905\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007905\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}