{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022JC7OhNCiCfi8ExTS+DwoA4TzOej3h\\\\\\\\\\\\\\\/K0DQd3uE1NprP\\\\\\\\\\\\\\\/Bar+YixZA8ROzAq0TEu7BFHxaY7CCbaJywrWypIt+YBwlkogOqJ0DPjMLWMHRe8xhuAeqWOWJpoV01ycoWh8PyKSs5wFbIvklvIJtvYzSDVWWxzwZhBwZgvdKZ\\\\\\\\\\\\\\\/iJtxZz5py9z1wuHbpACLwaHdDVq51stltHKhpLsVGD+l2UOsW5Z4EDGil\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/sc5H6F3aFp8InzvWZIkYhjyIcF\\\\\\\\\\\\\\\/jPkJm5wQsX9eFIGS4\\\\\\\\\\\\\\\/0iniJXDzcXaXG5Xajl++asKVgG\\\\\\\\\\\\\\\/BEyOKFRm+PQQJgZjkXcJE09X4w1K67kcUmp8AzzwBqoKSBcQzjvfSCf04wvk1svuqZgCRYr3FqeVQjdCBzCiKdFDo+4piVyGVmC0ALqReJZp5PpUb5zOHNNest2FeLzytaXkacDm0Pxa6VmWWQTwWNIpYaIXMklwJnuQ6CLe0HpWh+VKWe8AMbWUColkvSeurUXDrxzUrJ2LQhgrsh9qQWXh940hRfXH7x0E0H0sJH1Dp1shv07PNerNZg\\\\\\\\\\\\\\\/SXuhj4R4uKZuShVkoulUz3uJ+\\\\\\\\\\\\\\\/TRVZUdfmmPmOAJmp\\\\\\\\\\\\\\\/SaIWUDxkxRNwF\\\\\\\\\\\\\\\/Qq4pKKC696EnypVeuwOTn4+vPq2efUszC+f95E5yb+IceCcK0NEtisXhcNd2LUWvgGq8IHpRehKri6xxqNoxc7IoPeuBRwpw377Z9rgpSGZYqcvi8nVInxLL8pHn3lVAo7LhWUcUJCmQ4VtWJCmNhN6lEEgJs+ELiXZKZSnnw9lVzqeSaDKlrbN\\\\\\\\\\\\\\\/I6\\\\\\\\\\\\\\\/N\\\\\\\\\\\\\\\/ih2\\\\\\\\\\\\\\\/09yTl6q+Lc+CnESfeDfHEeXcz7ADB5n8JXvQvdtX6O+efDvPJInrlIr0Z9Bxl\\\\\\\\\\\\\\\/BiW4Lnfjlhqa5zQX2SJeJ6TWXsEy3bJLFueIRSI8IwL5\\\\\\\\\\\\\\\/jacya2Tl2Q15PZgUilZXB4E1Q3q0Se2Hw5Es0kPp54euFz54DUQoweHPUD+ws1uPn1w2S\\\\\\\\\\\\\\\/fPwPqalR26SZgOeYG6nxYtHihjwG9pBX9ZVOWoUJ+e9KTVF0n73XwGKcg278g4DrKu1i26+3tTCT3hmnibrow35+\\\\\\\\\\\\\\\/p5zE7KPoUTRMFnKelhTbczDeQHYAhr0tykfHfB8TNcji7EeiDPzEWq34DeNZG2vGKuNMJybrRYsyIQrBdcKY8gP4H\\\\\\\\\\\\\\\/TbewymtvCW3j6VhYEb2gbVy7hk6pUDOPZK1cuub+70nrbybZzj027hFpixaGyM9M9jwIlLBn5Ofach11eN3O4MrAgFYKp0AfGtCrmhfWFby2bcenPtwSl338orAvS070viBBJ8SYIKUkY62M1hTFDjl2yntNjcwzVzmbjcbGntxvlxReD8C5f5AMzFhosANX6wc2W1PphwjFRyrADmeWYwC5kInjOpHke2kN+tPo2z1f9RnO7edy8TPNocwUcOs8+NNnUE20C7yMwBxzJaQ970p6ibu+5LZfh+sDYKJnkThKeam8gJLjNMcbeA4ZMtwTFi8xVBnV8AO8mVflf3haYVrM7vw+Qe8Q1ng13yY90nM3z7uXkIwDw86jnxHXn6xAMpChbYrVVAUgPR3gN5MB6Pd1f1afVjKmakcQ5AfC9Z1yzt5fbXhmNj8+2UG23jIPS0u8KteIsaipTvsPQruNuqx5A3YonXBJb0av0NDI9\\\\\\\\\\\\\\\/29cvfer73N5nGkDs7SBfzdPVzcFlDVJGeCoufNHNKSfvotUeY7Q9jiMXOkUNrZV+A3UYOX3\\\\\\\\\\\\\\\/Q5dNd38cqN5aG6EVfuIDeydxe+pzqi6knNzPY0N2QsNMCcYvQs9hv9Re5SSCLlnPtEyZ1co4QZ6A8EEwLZzcPmgG7tFXBq80+cnMwt07PYpiBsGcS+yItRwyv9z7lxg9VbUHJN0ZUoCeMbvhZAwiD+TrVJHEysfyy5VfJdWZPi2W66uu45PLiDfNN8hEbMyUbda39Jmz6YuuvHjBOaazPzO6GadxzAmifSvnIucFmmXjQCckKCkwCSpvXE2vZqr\\\\\\\\\\\\\\\/GQLNIvP5O5nPtvf3T\\\\\\\\\\\\\\\/llwyBU2X+90tbL4ygWj9zSZwdGaDwx6Of1CCb8yz8oKyxwiL3EPmjQJ535H\\\\\\\\\\\\\\\/bwcRhHVIeIVv0nd\\\\\\\\\\\\\\\/nX4Nkk6XRQEQb2GQh5fLxDDedmsOGWw12jgexie8RIxeNPvA\\\\\\\\\\\\\\\/C9ZxgCTr5ikEwG6zDFaMzZbcqCnrAs6EI42KwkcPTdVOiOAy\\\\\\\\\\\\\\\/w2PXQHiyw99H5CPkmrnZngjO9Y4vMaT4qyHSUT6y7SFtwO5MtAXzHbS2UL7qS2HmvUw2GZwRlCvNSvxEp+LhiomuYhSUhKNjktB+p5azOAq\\\\\\\\\\\\\\\/KPWW8KK+rhh2AFRDBhErgEgAc\\\\\\\\\\\\\\\/rp0dPqhZcjSWAJKIi+4r1px6uzWItZ7MBc7Tpqac61EeHFRnd7CRnPwgl0nBnBu0bJ6BP12bSKu2o2KiXX8itlegdaD5j8FZGU8CJ5UzOFMNhpM7idbWVvNy0z7AWC14ovPwdf14AoVj3NKS9t14IwWmWUiVaURMPgO0yeM5jIadBDnhvKgrG3L6K5C7RU+E\\\\\\\\\\\\\\\/u4oK56mTVl1dx7r20iPTKGrhrCfB1jrQbXxcx1hMK7RAXuqWpPn84Yl\\\\\\\\\\\\\\\/G66AO4YuqQixjoXSmM9gdl15rJX770tDWhoZNmNKlg3S2JldmrPDUVs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022RoqnMO2uLNEssHbH8d42kw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220a55db741d3071c03b43f4642ec097ea28acdc2395c579c0fb9a885a9ad77ad8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/12\\\/e008067.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/12\\\/e008067.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-008067\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-008067\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-008067\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}