{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Gv\\\\\\\\\\\\\\\/XWsU94ZLtTGSUPa9kuP2iOMnzbzFq0tF0jIe0hadw0X5E5pzIhTMS7G98ZGW26HzlBfuN7f2ix47XkSoWyD\\\\\\\\\\\\\\\/fiqO9BA5Rjzp5407LSPCllPLHtAYcfQge2nrZRHUmiXsV4UlonaGuP6IpHnPUKh53f2tYrD0hGHDsgcEnQrdi2AlKyQZL4fv1A53bAYDUVpo69bOYJBwcnebsfAMquGLqXnkSMf2rMmyWyCOOOhxd2Jj6dmymTp5qXae9I3L66BgvVWUjECeWMSNk7n5ac8pih+JlpugU+pnyzqgi+pZFTG+36d2yN42c8Roz7Yp8yWuNYL1W2xq9aMjP2Iwk6N4zfuKXesuEgncK0cUOCPByTfChj5XxKe6nx87\\\\\\\\\\\\\\\/vBOrCJ6jf7Dk1UYkqJdNLOI3Op+ydyy0OWZ2odBxOz4FgW6gGIV+nhsXyEJHLZDp0oE+7RQ1lLd4hYuRDyjzJ+dBtVgVs0QkDSE+dIDBX0Mo7pOsoxi6Dy++Hvpg6i+8BWo5VYRqnnt\\\\\\\\\\\\\\\/KDSKJcecG9pRuXe5cDQRepbRXFw7vVHhj\\\\\\\\\\\\\\\/Wm+aYTaiCt1SP3SBaH32hymb3OwCpx\\\\\\\\\\\\\\\/b2ORDPPbOAxppF4lbhQxLWUFu7s0rIzF0xbbkWIAYaWngKUPSM1ZU9tdgAnC\\\\\\\\\\\\\\\/W7rc93Ghz5zDscAXrtwDjC2TT30X6ErNuLRAILosYRjRP5TwEMsyAFZgUkYv33TgoAxvg6obml0j87gHldD7HZG5FCqw0Q0+hODWu49zM3UHnwEZ4JTd5t0ZDKQqRqzm6hfbFBl65wUKExDz9J\\\\\\\\\\\\\\\/seXVS453afn8pTmRimE89Xb7Yej67JKVsn3pA\\\\\\\\\\\\\\\/HMTLF2MNP\\\\\\\\\\\\\\\/0gjcuN3o72Oupf+1Kykm02wSPsovN3Ot0kfD0EZ2g5221j7GKnwltuLZj5nhHwylsYCScXTUu0JgjHrqZlkKoUEb3jFcKQ5OLfKrra8ROKPYemVX4Uq41rsYJ7r7HGeX9hH5Ox9LPGUp1akvsps+O4cQfjQXJJT75T42bKg6mGuXGIBQq68Bi4c8nCvuqHxbC3\\\\\\\\\\\\\\\/dPLByqc\\\\\\\\\\\\\\\/JaF52QfMXk1gNVERVUgF2qkPVdVmDFfbmN8oAaQ7hdawpzkLGaedG9jAw2cTvpxh43632bG5U6njjFgyc7GXKLq7R1yVByGlkKhgwJjOW+6Z8FWrJ3gv0NM4bFu9G6Uy21ekCRyBkZFizITy8ABqYLIsuWAg3tv9J8Ow15L0KCA07mTxGoXltFe90w3Ou97FTGuJpFZstTPFkm\\\\\\\\\\\\\\\/Z55bvncVLx8gS5tAmV8Rj+YxIanHB5ayTpgm7NeI3r2MQnxYhq00iloWNfJ1o635Fz\\\\\\\\\\\\\\\/3Qs28iiCNuw2w2qMBlgDcMw074yffSaOl6+dFuK9DgFoTdRdnMgD\\\\\\\\\\\\\\\/cJCpGgxMHV5v0Va2Isy2E8FOQhTJxYQ496vfgcLj6bqp5rQwMnuj8wB\\\\\\\\\\\\\\\/k10CDTGIhWBdSGpgeERvGmZZBHLCeKArxtEwZa23dGraG\\\\\\\\\\\\\\\/he3Dj8qY8MXagEwq9wJnCVvy8zv+3yLo7+ta\\\\\\\\\\\\\\\/AHZ69qm3MO8Leoe\\\\\\\\\\\\\\\/oi7JqFD2cKXUf\\\\\\\\\\\\\\\/182nRyNnT55oqwz0EsRQRStFsmNZ+gHsb\\\\\\\\\\\\\\\/FZ4qA\\\\\\\\\\\\\\\/cXOyPsz2Qs67dGeUkKX\\\\\\\\\\\\\\\/4e5reckJjAaxM2OaP6NkN0Ixz+iAgt+c41EBCDnvSwp7FjTUfOCYW7\\\\\\\\\\\\\\\/ACvA7kh5SBhqNp3E6EsG51HZlyhBLxMt+KvlBML23r4toJ+vq\\\\\\\\\\\\\\\/3V6E8YSlYtlpvbWBLGi2rmzKCOR1YWl9wYMQmP6MEDr4XzaMPGsm6GJfYAAczFpTEYpcUXULAZKgKAMNRAzL0uHFu704FoZ9A3Qf5gzpsGyLrU2BG0oNop4Aehjm0HOQP0ndy9jHSE1DOkT6KFIjbO8ulaZkqWnpyUNhov4tZHwKIIjKa4qR78z2pMs1QTI2YmZ89OKJ5UKb8jmKObTUoWhvlt\\\\\\\\\\\\\\\/i9KMbXULHTer3GmlSGQRXIEq0ww1Mj74oZExJh4jVpDaMGbWOxTFuqXBUTCNoDW3pDWFUzWF84dM2hqqyH9CQ0IPXHTyHnLKCQyZ682WyMjSN1SGaCO+ScOO3wB\\\\\\\\\\\\\\\/VlzhJW4ocWCeoW7lq8oJc4mzClAofY4bUxp3kkBpS6TawX\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/eKbtGMgJugMcw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/TWIx1GyMnmr0G6bA0Kj5Isyy\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/QIhBIVAUnnGK7DSiwxQblJjfrayU\\\\\\\\\\\\\\\/yWJDpLAAhdmnMOl2lgJA\\\\\\\\\\\\\\\/hD6Br5dxSlyrtbgUsUBX8p0UTJDmIh6aQ5B8FAvP7V9qY17AS07p55JhQt3RELW9AgmBUdkyDW2I8HuDrbtyE+m1JBN09GpsaRHqVSQGxrwO4VtnXr9LkNP828Dq0lY3Rauuyxy8zRHlKcTysjcgyC9SHl3e6QnwjXFdu36UtMjtPp9DHKrbTP\\\\\\\\\\\\\\\/7S+OczIQu+4vZbr8TPUMTUv8WFj5ho+1Jahhe66+QrnPx+ne9ePt\\\\\\\\\\\\\\\/U6ebBH6xHEDzkLHdFptnAXdQMbwuq4gCYWq6f6S+p+toggksHpTfdVCsxQmj0JQz4FDSQtIUItq2zcO\\\\\\\\\\\\\\\/qnEEcOuYJy275Hs4oSCRtf9ufuw5cJ9pYtTcxpe2iF91QEVlcFd3bVO2sjW2pv2eA5CP4qo877CFfhBcIwJla+adtWw7h1HF78=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022rrsV04\\\\\\\\\\\\\\\/CJxfObbbhkXZEtw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223f99d176f8d8167a61f97af2434027024fd79dd78e3119c0bbdeaceed6359ef7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P9.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P9.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P9\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P9\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P9\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P9\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}