{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QBJ\\\\\\\\\\\\\\\/9yKG9iuazsKHI4pSnPdvcUr2ZyWbghYcFXYtU+CZJYDI6cWMRARyZIIcT9BzouiyDUQaVGc6l30KhzRMhlp2+C2aYEwwmdWkL7TIUUaRPDf3bBuM\\\\\\\\\\\\\\\/Lch\\\\\\\\\\\\\\\/jkkE1wgDRtOhWOlbseaHNtNn4b5or20PE\\\\\\\\\\\\\\\/sxGXIZ4jeIM6KQPdvZ4M7pjBgiUCXo9TMBqrtFPVHQxq3hRip8N\\\\\\\\\\\\\\\/zKfIz7ipCnZ6xFPUXFB1lzqn5oHglWPcmbTWzX8se4J+feujJkZ8NAanw84C1w8VnQ9Are3wZPOqZktkD1MikKLjLA84wQabtBSSfBZfPG0EJmrzGZC592AQsuH75JTI2fSpJuY8xQSuoI1Kk7D2t3T1UrgnnDILeuF2WuXXr2GbbBOdgoKYyXes1EcqNXfvaXY90Kdo7NjwbwrfMpQLCJIy+G71Iw6NTwwFTAYssR8407rEWw1t\\\\\\\\\\\\\\\/gnMBVPXuRz06+nzNHWIIRL076lDVmSTLF05P66Zd2iyszaItPF4mEQdn4DEZfTNGgc4PRfK3RJggwtoUyDZXaTgI0C7w7x\\\\\\\\\\\\\\\/5od2n52bCgazPAFVGKf7jbVJuUDqVgih+1yUgjcZT2yfVMEwh\\\\\\\\\\\\\\\/OXlI7uJi4ibBg13MN\\\\\\\\\\\\\\\/Z\\\\\\\\\\\\\\\/tDl6wUbT76xFCLTNPFUUpzdDt7pR\\\\\\\\\\\\\\\/NOLPE1HNJOcVD\\\\\\\\\\\\\\\/p9h1vLSy80sqgYA9levxgOkfLlNKiQFHmDapfaIJTkwW0JgvZQV9t2Q\\\\\\\\\\\\\\\/BqVXjVcLFc69yl9dD\\\\\\\\\\\\\\\/l+Sa2Mei4fKHtulmmlGk8EZvHnOZ7hb+42A24lNSBtODh5dsxA75R1q1nwcA7Twi+j90KVf5bUAVUnuGxRJsIsSW+n6738zlOwKrLl2eHeo3edgrcC8Q4BoyErS5mCH+W4oMVB\\\\\\\\\\\\\\\/BQlVLRza9IIKaatI+hDOb9uxFzpzotjWJaD+Q113t19LmhK8h7aX2aE9Pm6KCGJrAF0F8gT2YapjB97cGyPjK7A6KaT27GqGf9TA3zA3\\\\\\\\\\\\\\\/r81+mQaxC6WnMG8ILV5asL3sfLVYHDdmII82wQokeDPVrCsE1QjEDhp+KuyBYGWrqpaEKZUtl1GqoTFMRbg7gOtrr8oV5tCRabur35\\\\\\\\\\\\\\\/kTi7cWrFGCh6H+6IfjKVLVT2HXhfDogH\\\\\\\\\\\\\\\/5mItHjKVCdJ\\\\\\\\\\\\\\\/RsVvoabRgQ92AHHGyYmV65w\\\\\\\\\\\\\\\/Zz0zfKpRVgZD1xSkD47FWmNhgTg\\\\\\\\\\\\\\\/jxOaKyEHLK3E711aicyDhw+I8RcB7xK1vYbK+wZ0HGCETFWV3XhDLfDbAQwllxsJO9jAAFYct1IX8hLA5u6ulO9sgOjw0d9rrf7ROKVPEOgEpPgmDPZubfb\\\\\\\\\\\\\\\/pzCS3o0xPTGVleBGYvJrUVkhYXdZMgddOrAthNApmyhDaDzQ\\\\\\\\\\\\\\\/Q5czF4sxQ2nlAdp1m353RXDddm4fZRwBsM8H+NdllY8h579d4xndnNeCE9zhdF9mV0Xq0Nc0I53GzrCTRzfC9+mpWG2jS6YUbvYttH4bSzKPDxuSinfF6At\\\\\\\\\\\\\\\/nDHkDoEPVVGd\\\\\\\\\\\\\\\/hPC9snBcQPhuhMuzsJJnUV62rywdsal9mJfdOShteJf\\\\\\\\\\\\\\\/wB8CLGWige4XWdENY26f01+L91X9nZMgXovUeL\\\\\\\\\\\\\\\/dq2hbvXMG\\\\\\\\\\\\\\\/AmcsqCK7mCzAi0ZmBKRO7hPaKe6Qk8IskyCVK6p\\\\\\\\\\\\\\\/9e9vck3uW2YsZ4lkj\\\\\\\\\\\\\\\/00dO33c6x9rQW2sC7AdwWREtuUvkj9TlBv3tnoK7X+jOyV9orv6ZP2s7Zv2coksIeeNs+EMuwtGhUzASdwEskW0pEvj5KWfIoYY6hln7Rk6xqpx3ak8LQemAjA4dsenn0g06Ic+1qHpt5je9Jx5gIBSRySihA0l41MfVla9rEPdT70NdJZptSnfDC++TzWgO+CbHGIHvunnWtdiOPebSMmrq5Mvx1L2Opz9M5FVdQUaTs1lCrZ+rrsS69EDdXtJKa31VqZPcr43fiJiHXCNTVsOsk15giU\\\\\\\\\\\\\\\/CrPM31Uw\\\\\\\\\\\\\\\/cQLs4N5aRqEL8X9\\\\\\\\\\\\\\\/ZltfLtktoJsVeph\\\\\\\\\\\\\\\/Y47FT0fx1IS0MnzgdN1l80WlnELFsOwOrnMHoYlTQeiV6VBln0DIfzsHTHPmeSrSNbRVgsXiB+4AUgqh02ZkRGJQtMf5ArhGAAcmBQdNboJXG4UpjkcdHcwBRFwFSvos2HnMrmnEG2WNS3PgHk6dK9n0cnjfHYej1fLSFWpceAanHXEuXp7p+sI2fQbhXUHc9MVztmRjon5kxG23PIporrcxG1CoCrz7zR2D1LSEsHpr3nt8QTz0hXBZTWXfiSQQm64hfCVmoLL2+WIsr+cclkzq42a9skiu9fxAqdfRwtHlVio3HRX6UqzoMRn5zQe8Yw2jurlmsyBh9\\\\\\\\\\\\\\\/yYBN1kMqTcOfiSaOB5Om62hfbtP7npZi7qVVBc4DfUG7J+bj0hEBM+uwO1RfPH1R315\\\\\\\\\\\\\\\/zPM8zNeM4o3Ew6gP\\\\\\\\\\\\\\\/a7oW0+zV1zzbdNjD90RlEd9dfpusuZJVoJUbD4coYpUFHy1QZzTU3l1Aofm6RdGmezzZMVefqt1N9nrSUAbjjJBJR+SvwWbhhWDHMXCF8Xoa3wsNCLS16hg3zS1mDW6eqCh3ReM\\\\\\\\\\\\\\\/Wd39LTj6kAE1oZE+WXylzANQzTjU+ssi0kezG\\\\\\\\\\\\\\\/1EDa+RtC32F+vW1hg6\\\\\\\\\\\\\\\/YC0QMsSqR7kXcnJeUBiDImyPLL5dqPA\\\\\\\\\\\\\\\/UkhM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wDfSS82nZ9oDuRdkXnn8QA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227df206a7bb9ebb2056b90f8a316984a148f5a4154cbe05ceec08f101c9641a2a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P274.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P274.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P274\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P274\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P274\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P274\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}