{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sU7+XRImxX2kZkCdD7xdBDnQAGFSS10AEhNVF7Rq658+DZlEh3qenowTFwBToaDnDAFTOkx+47gPjH97m3OrBKJMQcZBiwOdNoEPJxshqUP54NAmcqKiVPXphvvAcFlvO3eYu0TPSEp61b2gAUopAfbOBEVCxEG1M1ConEpgjbrdRuNIg7eq5X4t3HPrKD2LV8938mFrIQRrF0ExQGq5yLwGZ1ijc8Pqk+7o0rSzLNSDMIQhRjiBeqWXXVN6a08ESu4\\\\\\\\\\\\\\\/XaBaG0FQCsbSBuO8AatQ5iyAPotKX+xWFviA1zj42iep4eN6dfQ5TIhVLWJqzZMK1Mlqet9akfLVFZ\\\\\\\\\\\\\\\/ayqosL74RsqcWdabNx8LmrkpFfIZnziqsGe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/VFlmdkaOfaRzfZaFrCdcdoiPL2moWgfsG5qYKRacekVRKWip0FHN64XvIU7FkaftwZGoknjNuVVZXrB52XM6HbpD0VMBEi0d5\\\\\\\\\\\\\\\/KS50hj7W4zPTple5uRCkuLVPMKNbIeC+4VWwzbARXJzN\\\\\\\\\\\\\\\/OR\\\\\\\\\\\\\\\/peH9b63zQJt\\\\\\\\\\\\\\\/ZIGse0\\\\\\\\\\\\\\\/aJMLLmc+b290fLWizo7d066gHC7DQASjPdjbIuCf1WwHDQ\\\\\\\\\\\\\\\/l5WM3FPU5o3n0EfBg8\\\\\\\\\\\\\\\/yo5nGFhf4FlNhEXfNIbl2S1lKeL7Op\\\\\\\\\\\\\\\/Gi0WyPEFeOLsFOJdKmIm2H7Yh4rAUbvZwxrm5BfkbPsD3lbcwjrvMIRM96C8wyBUj4d6El3038ppFJVJIpe92Sa8WDp4C8gBd7wDaW8AKZB6qpICh2zOXmu+TXHVg2Lc1bm078yGCFLhMqMStUYEdODGN+85Bv7Pcj6t7UgjNaZoYGmdFmFkqAKBRwaiTBbG47FGI2TRGeHi7hz4s2Jj5x079Lg+Lt4PXpRbg\\\\\\\\\\\\\\\/oGHRSKgBk89uRrpYK56DXh1IrUT2xEA6KExY+Hkw2Uvv\\\\\\\\\\\\\\\/6lmyhF29KEZKsqxPDFloKooWJcONpN+RDS4KRP9EtQDqx1dWoEB5uqavKgubGoGiz4w54scfdtE\\\\\\\\\\\\\\\/evkDmR7FiIo476pcyOw4YgdJsKAj0meg7MPZHf3O7S+FQ5+nMkw3GHBGDh+T+nZylBF+zfJ2MGIdbqAVslc6\\\\\\\\\\\\\\\/BIGFoKYfEo8avbu\\\\\\\\\\\\\\\/mBGNrKEc5r+ka\\\\\\\\\\\\\\\/UE4VUuLntQMP6vrI1F1XbdbZ6G9S29yYp4DDhw2yDo8O5PmuJLqhoILpGr8CrKR9gjlb8VXxcn8J7xajuAtc13xOumVx3nusGdmy8vMw+XZqq1fHDATYD1Epd3r0i4lu5+b3SXrdpI5Pj74I2vqqWfF6BqbP4Q694\\\\\\\\\\\\\\\/7mJPJvwdID0EsFNSKjew8D6+t0Hu4y9rbG8g0+ToA7nrjec2FiSrG4VWrFP4YzIWtZH8lpn\\\\\\\\\\\\\\\/Y+TeosVhTcP+6pyvD\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/vh6N\\\\\\\\\\\\\\\/ftHv2rD7\\\\\\\\\\\\\\\/OB2CAJdUrIlf899okVV5zN8qTpD30dJALNrGe3+Zs74sKkQsEuqghFy5BeyRXNFwa2WL18mDbB2tIu7MNlRHzayFco977V49qeOyb3nh5BwIojfo82CORMbwH4TmIXTbLhkdPrm7jxTf8b5Hse\\\\\\\\\\\\\\\/yS9HvUA5ksW2oJirMLiI5s5is3hYC\\\\\\\\\\\\\\\/N5zYHVtdOhiipBmfZUU3P0\\\\\\\\\\\\\\\/OcwJEhftXD7da8f\\\\\\\\\\\\\\\/HDAJI99xWHLoYNWzpx6NDdvhdDWbazRFVw9tTiSwdNnLaYO2DfWeIlRGKMLRvDyiZ3ew\\\\\\\\\\\\\\\/9mPUQMj6jnkG3TOPzjvsscOW0ZmOBwUV+8Z6ZxNM8KM0FYKfwX6Xt7jGNP\\\\\\\\\\\\\\\/mgunKZTLS60zSzEwSOAkvF+J7HOHsq1qPUK5yH70mSj5clJFoJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/oo3Ra7rBRxPiB8EFNO8L\\\\\\\\\\\\\\\/OGVz6lEV1QcVGbZHbjBZ9Tk6qgYo8dEhbJl+X4lSaQQYUpGqPhGUc+cPQJ9R2gLUn85uxEhf7Ty54N3ZWZmYzc6rLu62sQER7FwnNqaPMBib4N6o6t5fdCL5FMBk3FkZWCNy4ub6z7wq8RrJYG6p4sKbBZjW5RaPmR8GZAHkiZUZXIHqiRH6RUCweBeXivaEzCpEUHgHg8842vNceBAQyDgbk3C+zKuKaRqQpxy3C6nfLQbYIZT2QtzWBZKzQmjRnP9tKK7mNHyg900qab1GWNzy+Kmcq9vLnuSL80ixpX+vuEQa+FQHEqW\\\\\\\\\\\\\\\/nsr4ux4rgV24RusiV2hFnvHCyfDnpzmke9HXVR8MSKk06YnW4g+sjAa5SyB1CijBZWPHfMyVRMaiQ4GrpkwTZ4kSyAK\\\\\\\\\\\\\\\/UIQTWAnI\\\\\\\\\\\\\\\/Lpdjn3Xk7opMt9jaZJbZFtYpETW4D4QXzLs9Ol9xs0BVmGyjSPBShdy5ObbBnICZGTYhWZViBUJj7MZBvX1giA6KUa8bG+TYveCaHhwsqqryaSgee3JK\\\\\\\\\\\\\\\/imYDIg3lxwr96LH631bvrfP0DFD7tNiEZ0zZUWpeMgrW38DGsRzrNPYg\\\\\\\\\\\\\\\/A0RlocBnuYmXFx1E9jamhpTfCXcZoVm+1k+8Vd5dmCkGhW91DxVwWwv3or8IocJO2OhZGhGUzjs9z7UF41oye50a77\\\\\\\\\\\\\\\/u9qArdc2xIFbRy5LtQ4VPjN2x9cL5fNwAxDLA\\\\\\\\\\\\\\\/9nhYWfV4CM16qP2qG1LwUjIO7io5utmAQVb61dlno5x72JSiOSGzjG4URK2y7UiIuKw1W5b\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/PfyL+vuKIOtEblMcRGuX0B3xk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QBmUPmk4fY2\\\\\\\\\\\\\\\/Tkhmd9I+tQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223659a4eea94bc8a239d303a887c171990a71533c7659ea52ae5da2426c28c0c4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/12\\\/e007279.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/12\\\/e007279.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007279\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007279\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007279\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}