{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022H\\\\\\\\\\\\\\\/H2kDIvDRu9xGwtWMuNXRiUuzudfSalwqRY8Pm1ekm\\\\\\\\\\\\\\\/zhRa5UovlzepSylzN9uqW99vzjX\\\\\\\\\\\\\\\/rXEhSMa8E9bLCoNxqB9uobtWf+Ur3tz3m7cyau+RVqc6lxci4N2cEQQQB0mceWotk\\\\\\\\\\\\\\\/FRYkTauvucHjau+ob0xyj5tfYzJE0kQaExeaKjVvSO0RJZVl9ea8DHO3SwswokYj3VCJV4XCmkrc9tFO2XZ0RBTpJasDNw\\\\\\\\\\\\\\\/ifYivdMFjQgdlX1UWEeS95yScggjcmf\\\\\\\\\\\\\\\/UQcAFHzwdjZHYOlDfL2+Np40g0quRAIAdv7RJju57My54+PShunt2Sp8wm6Q\\\\\\\\\\\\\\\/mRbs6PxK0LrSFrz1Z5AxkRaxVkewhCZWfN47z34tRFFn4B6c+xE1EGbhsvoJliTjmsu8AG9tOqzZ6sc2X3wS4j88a+RptsfJvlvkBG54fvoG95RdkiIPNp+HXjjxr3+t05R0u5PbaYXM1iFPwG4V\\\\\\\\\\\\\\\/YQ\\\\\\\\\\\\\\\/tnUn+9RenSUnbVah9Fd+gTUQ6a8b80BqF5aXHS+TXRt\\\\\\\\\\\\\\\/fEzgn3X+xoQFkcLYf1\\\\\\\\\\\\\\\/t+t7WAFkagoY87muh1Ba4jtjRM53Ll9tiEvL0y22G12pO6zKuBpql8pakVz93qOy8W\\\\\\\\\\\\\\\/mNfhl9XrbBXqJv\\\\\\\\\\\\\\\/5r1MTDHvp1BrP1rbKd5wM3YVX9uvOXLVq6RF1zJiggb5gRM0KUdzPq+UoNo0xXx5m84BE2bWflN7kg8SmZ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/EHEWtwsDdJQWyp0DkmKnotCk6d59LY\\\\\\\\\\\\\\\/PxJi54hnCuUn6IiAN0Ds2VUKcXGSQkuFp5bwYeL9hBIJfL3Xk0Wnslx9n4lXk1j+EFwXihSeEEiZXlLuCeGJAnflbe4ZXUiBp+ZDp8Mo3OMT25rIaWYwF697OEnAL2mYFFX2OHhp3Nfq4Bukmd\\\\\\\\\\\\\\\/W6KcgMf3\\\\\\\\\\\\\\\/bX7kylzruZEdBUyUvmHg+KYoDet\\\\\\\\\\\\\\\/VFi4hCIkvLHZpLoi1E1W\\\\\\\\\\\\\\\/d4zmD0eWx6zgyrwVxVENHP1PocsA5pIPgavHRa+8iJuBKctn6Az1pH2krrC4ZH1XTNaMOBaFwnsTn1hys9fe7kp1qKn+DL6wevKc6s77yLqFamW\\\\\\\\\\\\\\\/SbzlGbdpUU8gsQr8LPamRbJVKUD7QeW1U+v6bCU9sXQ6MW+H228wiNw5PDcM\\\\\\\\\\\\\\\/jSNGNJwW4jdOM6APQ\\\\\\\\\\\\\\\/alKL4ABShD2mQ98og2516Kv0TbH1fl5BHVgg+m3Vm1oG5oP+Lha+8tkxq3VVd5o\\\\\\\\\\\\\\\/D4H28LnLusK2JWf3BMVz7GLeEvGl\\\\\\\\\\\\\\\/4s5E9aXb38UROPZD0miWLxsK1YYPg4yIVO\\\\\\\\\\\\\\\/9RYorrYHU\\\\\\\\\\\\\\\/tfTKPdpMCKYhxcIqhZZe+TR2IHyPENYFTvH\\\\\\\\\\\\\\\/JWYbPJre6nzOhutL2eVgsn2iGqqrLvv5wp97Sk2PY0x9JmBOgrYhBrL31k30JFfAOJmQCYX+gtm\\\\\\\\\\\\\\\/CzzXrpLbcPnjUm98uXUd8euCxFa8D7gmUterTlAIIWfEth97\\\\\\\\\\\\\\\/lFnTYmdVzP6EhDQuqZjOFeV4Q6KecyaIkXJaWdncIeGPWUqYD4yn6w4yGf\\\\\\\\\\\\\\\/BPvNZ3CccporfPDCTI7hDUu4bBZ5jpVMYnadzr9\\\\\\\\\\\\\\\/vukdxGB60F16ACqO\\\\\\\\\\\\\\\/FiWBpMVmkkCh2Y1Zl71q0szZzsSGNYIIrkPnsauhaDgXol8NTcPtIbX+Sgp3LilJVGhlel3lJSEkDZ5wKIPIW31mfmKv80XunQUiwwjgzziKN6zJmKnSv3hpsRcTUpIX0f16\\\\\\\\\\\\\\\/HhPcMrOxaXthf\\\\\\\\\\\\\\\/7s9xxwF1BG4MqR+yYsmo9gH6EG5oGiHqdlUsEk3WDbKfVs3iqQjO4cVUgJusoGsC\\\\\\\\\\\\\\\/E0yE38Ww2K9lz5qelmaUX\\\\\\\\\\\\\\\/0aGfbfJcqcEM7CgVTQr6bddgXhEQOEg1i+WyvXEKkL+5hZb0QScpG+k5w+wA0v7bacglgUzSsogNYSIE\\\\\\\\\\\\\\\/56MVK4LiCTeWT\\\\\\\\\\\\\\\/Epgo5Sxk43gtU22VtpeNCDfdfra8PLkjcxkowXhPbn+eijhPLfxNAtaBEviKrDaLOSErtohEG88kgBmCsPyyYcXJ5WObSt+Hp+uebXotVsxTEM35BgWKBqjlfKTpOLVn1lfepK+4H4bgzeUevN5si+\\\\\\\\\\\\\\\/x\\\\\\\\\\\\\\\/JAdQiZMOBughg7snmzsie1rM+Tm4NOUk6Kpg5MNCx6vzgWwkkCBoARh447AqX+Uvj2s\\\\\\\\\\\\\\\/rOzaGcGOz2aJbB2238+\\\\\\\\\\\\\\\/0ab+foBm8Cz2hbOFF9y9z0vxDyQkCJa+MoX7nD5ZNvdc5pdS0CCqy1T6kSqpf0UpYaOI50+te61znu7xMx5ee9WWaDE0siX8S30HVvLM1RcCydGmBwmwxfn2SWWm7LwkfVoxFJjVUvh7vr6e3jW2EsMoA3kfTf7V8ZUSjZDAEadkYLo8e05CGecz42UeEcizRQrO999k1syBE6zwwpkZxXPwc9ql14kjlYpfrbBuqcvDKLzC\\\\\\\\\\\\\\\/R9Wv6CnDOWlshEpVCy4CTS2WIv4ibxhwT8JiDahJ83PZTrjNgJ6V6nIc\\\\\\\\\\\\\\\/b1utrP704+kcY1eJg24VV8d0OO+9tpHvoOFxyC1tFnb53Tl1LTJza\\\\\\\\\\\\\\\/kWpzMWODG82rXNq0qmMtRcbCuME6ouvRq2fJs\\\\\\\\\\\\\\\/evRxgP\\\\\\\\\\\\\\\/POrEpxjAU+tvg5cG1QdFsZabF63Aa0aQMWIsWQzdIuFjPBqv\\\\\\\\\\\\\\\/qoFfFj3wRDz8gaxt9XRw+A2nOrh7QSkJGZSpbI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XtiMSwsjvu+39FMDDgBmqg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222d431aeab1f36e61f4c27e3e0fda319a52c4f48077871f0cf54d5037112e509c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P425.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P425.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P425\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P425\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P425\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P425\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}