{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mJ0Gvgvn3gZEHlwDpBGUqxmxH84qXlBlMhPrzd+X+jnyTTOQlcaQWUm9yraR4L2xJPhAT6EjoC5PIMw79cVZR7kqwJ0XaLrAAfLCkySLz+p7osjMvgQJGwX7HMZ1zA+LVpoE6lgu1gfa9RZFC4EXUcpk\\\\\\\\\\\\\\\/xIIwUfgwDTRwYCg21vhDPzwV1atPB99sZ12g+buWxmTIujUgQU5\\\\\\\\\\\\\\\/k8DRDsYzdq3cX2bhJFzMiK3nddFBAr76aGN\\\\\\\\\\\\\\\/WLZE7R05Gna5P85PbnC2mbNEKLmdmTFx2dhN04VlnhxPYRH0j7flUA2wyoPHU6qmzni3EhvJ5RhJOdsBzM6dIzgZ+rfAd7nGIzHyoBw0wfo9HzQp8XZmtwP\\\\\\\\\\\\\\\/ffYnflIXwXTiwckIO\\\\\\\\\\\\\\\/nzI3A8P+dD69hrSWlxYwJ7q1hw1x3nCoH6bp4m55t4vX0HK2EO+pHxa2h7VAwhIueC7bW4nt1dVEHW73UkgUyBk4enmt7ov7lm\\\\\\\\\\\\\\\/zib7ij5ohF5luq6vQT0Gc8tVaAPnC\\\\\\\\\\\\\\\/Mn0MAAjOFgRf6I86sZTZ6bmAv3Y5FTt+QzEWw4Oj9Yvy7AV0XwhvxI4xeS0YVamsA\\\\\\\\\\\\\\\/JGVi3QYw9Mu\\\\\\\\\\\\\\\/0qY6+OggsAD2ZoX+19jBDRgnJ4wzKtivZ+t0c+U1WvboknjR2vif2z\\\\\\\\\\\\\\\/YDczeIrOHf2I4jSkcc8BRia\\\\\\\\\\\\\\\/+PayjLkrW6BigXl+yvkGwyZvVspLTbx47lfUL7jlN5pCkC0nEz+UXTr5HR5eYyxW8\\\\\\\\\\\\\\\/Fau+WoICD3sTUp2fOtvEcKL2GiYlaFbLLgDDECZfg\\\\\\\\\\\\\\\/x0erIQyHNeOdmVGHeO3kumQXjWl63TwjTJr0EC0MMHqSfDAfhdR4gvcttKn+gTe\\\\\\\\\\\\\\\/hZnm6G1MytjqeTAi1I+gus7IjX3HqjC4PNAytnyQT7tD5f5zsA8RS46jzikNVfcRleetyzyZBmeOvCLftjL3ZyTSUjJknLfwHvuSijJOehAQLPj1MgpwwrYUJuCJqM7Go0zc4c5zn08YTuskikKYX05wXV\\\\\\\\\\\\\\\/yyKmsWJ3nQsX3pWyUSshl3KNFzcUCXjz0T2N+DciARRVXJ56ahmgkoOHLxR+tqG3Y5TmH23bv\\\\\\\\\\\\\\\/JXC4HSaMK2pCzKqW+NsjJTsWyewRsngzvVzBthsft2kS8GKlWicnceJO5254b9M4rhWGg5n5QmWHd1lIyshtxEaBK4\\\\\\\\\\\\\\\/WFfPfhB3NdRG4btkJGfG7MDdV5BEOy4QwIPEoSm6NB2twhJwdB2IgtnyHiEz2KnjcKMrGloqTDm4kMVf0O79NZX5vkXlgHS9MXLq1UfHRKpGTw+\\\\\\\\\\\\\\\/vTbSeNBdTfR8y7EQqGVHzRVF4Ty4v1f0f\\\\\\\\\\\\\\\/D+RaNA\\\\\\\\\\\\\\\/XuNoo3l+JIoX0nNF2Qbd9hJKxRoLhil\\\\\\\\\\\\\\\/HpC8GFmtnm6um7+q669OGmZ5nZjOr8Ug0IRKRelbkdkjkTW\\\\\\\\\\\\\\\/AXmSdtz1BHMnqtJLAn\\\\\\\\\\\\\\\/vnaW7Iku2b1X6rpJfAKw5Y67BDkyAjcXczu\\\\\\\\\\\\\\\/440zZT9zuQ7bnx4R50G06jD5ekh+H1zjulTREGiYIJ0iCNX6a\\\\\\\\\\\\\\\/KtrA0uzhHGVJaY5fvuVQaizBDQvzd9GpOqtzhyXv6Cl\\\\\\\\\\\\\\\/h91W76m6TT36r5VPjcoYHmIM5tbH4hRRPRcflwtP9lts6JEaQjuC5N8DIyJtQSeft21gm5fAJwWnk3ivB8vxhPfocK+vntdH5GO1yRnPa7CBtaIfqjpOBHSuoQ8PEf6RyXQ09zj4dHXKhH1868tBfFO56fIY\\\\\\\\\\\\\\\/8MVXPhP7qSjbMDNMe0ZrS59BIF+p5V+MXaw7\\\\\\\\\\\\\\\/tCEENH+TNCnP1SiVU0HAtsYQpilqJip390wy9WXMDkhFffVCxg7TiIwe5twX5UbZvhtMWOHrBwIt5wtXPjQShdHGiSk0sZcTZzeh1eJ5O2rn\\\\\\\\\\\\\\\/E5\\\\\\\\\\\\\\\/WdjtAeuzEa3ZJQhwgvniw2q+MziCGjoURmrQi9xwCr+8U8t5qxIKynLMrDubMSrabokRZc2M69cLDfV5rwmrXOH338gocroGYqTQOK4TK0cs8cjsPHE86bnbaHtjtOk+Zep0SjTZmbetarhX8jVcRIPGrHr89YxYZJJ1XKUikehWaA5n0UbJnfK57RF\\\\\\\\\\\\\\\/5LObz69CkMUPBkAVX7B5MWbtzsi+hUP\\\\\\\\\\\\\\\/JO6gWT1jdaAi38Sfe5smF3GqFxfYrg7HlB7xgLg7EmxQIs1tAIOT1EOzXF27JgFDQdZwcjYXPP6broXt3T1zZXcMnM7spkbZOpwqctMKEbgMYTfT3OoDc7tjE+E+hdjk+Im3jF8MmOY6oiAMaxjFzLZkn4K\\\\\\\\\\\\\\\/iced8c659oYYv3fP7yusSWcJwBfn\\\\\\\\\\\\\\\/mCLb1H13DWcXSby2P3jJraAt8RqUbulJ324Nfe10TiI3aQppDyPdDfoXki9WswSlnsWnbbVhSsrX\\\\\\\\\\\\\\\/PgfUqGcvPa+mCHiBlK3bBq4oTLoFoSQTJcR7UMzPBL0GQ\\\\\\\\\\\\\\\/+VoczSjJefXWupH6P3NnuVeDHGxT3kLhFXjFLgvbXBF9NoPdQ6tcZyRVyh+c7TjNQ1ztFtKHpVireR8pVaGxqfS9K6nusUWBcSPwO0PuN+pP0N1ENbjs5ScviMPPKdVFaijknUggVvVWJhvNuCttoe4C5IUmcE9yzjQfC7gWJF2pq5BXyUMOYw+sAkFic0dXK7rq16IoesNcsaZ94yN7o+5xzgz\\\\\\\\\\\\\\\/MZAtSeMcuc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022KPOv+QMXdDUC7PlsmXbI\\\\\\\\\\\\\\\/w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ad6e92fdb2639bb363ff8a71baee58e59447bd408c2cf8fdc485e01303809140\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/12\\\/e007415.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/12\\\/e007415.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007415\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007415\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007415\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}