{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LVpUjrN0ZrEhIS+4ki9YZ4zHScuxh6qlzg3we2wX1gkdOQrGjlaE2MxOx\\\\\\\\\\\\\\\/gllfsWmIzsub0Bt6NPRJKg0d5pknGj4jyfOATpOTdd7D0AIeWxAQaD9mwcY\\\\\\\\\\\\\\\/7FLOgr0McgTQC+ezVne\\\\\\\\\\\\\\\/pMmnRrqJDRBfkGnkPPeVDvqnE7CDUa3wx0dCbM7MXlUJlzaZ3IuH6UaxDrbOH83Lx9AVAfpY7F6LeWTeis+TB47mRGUyvwvyR8oIcfaTxoRwcWnDsa8BSx4tH1g13Pwo\\\\\\\\\\\\\\\/1HDGtUmJYTQ2V7E28GgHOAKOAyTGYCNngH1EMskhLNsfHXAApq81fzEFkN+1tTkCMi1xfMnbAKUBxpmGExoaotwQWQkQQl83Y9cPW8J9ZPqWQ5xBfB7\\\\\\\\\\\\\\\/W7fGoTPTR1Q\\\\\\\\\\\\\\\/yXQy4R2EvrLr4QiaQm\\\\\\\\\\\\\\\/kBFDwVxbeF9h1i2ytQEO0o+eXb30rF4eAo0hx5tUTWaLn23JlXxX7xpSL6C98ezIpfF\\\\\\\\\\\\\\\/Dw+oMVNuy0np1ckMneZwQfgm8T5p+JLj2CiZsVOkpFUJfeCVzrtJsC5Wfa36362Ov3uH5i2fn9ohx4CDBjB4dGQWHNJY0Flb93OBMG15sEq9kQpVfLMPD5I826wv08jf8MB23UzZ4xqdFSI9NEq9KsmSnejQXXoQLylH3ygyT4aAvCNxg5ujovEFAlEYQPFaByIh\\\\\\\\\\\\\\\/kCmxQ5f9vMfC8oKzAvSOxxKbln7N1c7XoydL5SNWohZ\\\\\\\\\\\\\\\/tGYEzujq1i5ty4\\\\\\\\\\\\\\\/dH+eojA3ejkDthN0q1mYvR4ZEbVcoMkDpJKxRiu+XhXIIABAGsBycyr1yCv8LOvFNoi1qPYwUcBmrjc4H4rmJL1DJ+VMHPr70XeMjnuzbDp2eGHPV7OiZxFO7woFg\\\\\\\\\\\\\\\/3jNWzlM4SxbczKFZrivJWbGNnhmv5hT1nlKOczM4Z\\\\\\\\\\\\\\\/yNXo53sxHXZM7ozMVfcdhQLoSmlhLoE8M4313vfoP\\\\\\\\\\\\\\\/tyIXQTg3YYUwE6PZerAo1ln+L3zhgVtvkZOvVKRyPseMss8o8xGihkQUDbhL0jBqg58+dFxhtO3efu8ZKzzeW\\\\\\\\\\\\\\\/b7YzCvD1DjRA7o89\\\\\\\\\\\\\\\/CsDlRx+\\\\\\\\\\\\\\\/27u3Lh4eK3490cyOCtt8\\\\\\\\\\\\\\\/Cg7x3WKr1FzmhL5wVQdBSIWmMzLCVLieIk6qcWkE6gd7ch+yeST98Wkl3bdAxOMIZDf6hAL4XbWvLsR5VEhr3Bx1ptJA+bDRgHtoDSSX8rovmTIWgkXMngLp6dCziWCisEszdS9OgWBE5uOyoB4ovU+5x06vgJd+K1J0MvzxnzlSufCz3IqONhUd9zlUlg7t+\\\\\\\\\\\\\\\/uvQOrR9dgTxdeLmEuhrvISOxzzpva0yQZpCSjHJ\\\\\\\\\\\\\\\/tPTeCzq5D9WEkU18LugLQFCZLLjIjUOXhZgAufWd8lK6+jUAJXyG7HTuj79qm3g4nDr0XWiJfeV78PdQR7PTzj2nctsXSEYW\\\\\\\\\\\\\\\/AAtVDJdnlX9P0R14jTGeMLkgdw2VepC6tfc7FJtYaAF\\\\\\\\\\\\\\\/tEdvI+AAIZhQTXm3ufJcgmqb0WAO5BPsUJTJUxNdgpFR558SS\\\\\\\\\\\\\\\/wG3ThDZT8tv0+Kf7p8k\\\\\\\\\\\\\\\/9GLI55KC5K1+oeC2X\\\\\\\\\\\\\\\/fbbLBZCnXHqSy8YvNSPhUvWXSRNCxh5SqWUhcSkOrL2hZWOxqnjhVP0OcwY8tgqqwOhfvCXAXLhaidZ4vrHfpopI7xngV49FeHSOfYdJAeAQSEUX7XzdXPjOcTkB00DdP5vp4FUs1TqcELR6wT5YzsN2I5Ev\\\\\\\\\\\\\\\/dFWNFvngudx3HIBPU2BHthGMBCCD8uJqI9ZfQ\\\\\\\\\\\\\\\/tLtKtLOD48HlRvYgmaLV3T34s9VbZnI9kN13Pjyu8eZXSApjTIVNllqPp8bQMFWmRMn4RzGlea9nul7PXfsLE\\\\\\\\\\\\\\\/baZiYkiaI0LdBs+lkDJfkYmniEVpVCxbtvtOtakAfUgwi5lhmX8BGhPwFvT0IO7Uxx75hWV0A\\\\\\\\\\\\\\\/3M9+gcMueePy080s\\\\\\\\\\\\\\\/SUHx92gMy3n7xDDyCc9fzey5P8kcHgDQgCd2qM3HsjGr0rmiVGLCODhBx9BrqZgQW4SMnEnae7i+7tHN7yFVdP0jA10fvtuzI1FXzP2yn6lclxo27zYMpM21c1nGpNtpWVEast\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/cmEXUKMVbcPikE2vIOHtSnaTh9aHDhY2e2sAWoEgS\\\\\\\\\\\\\\\/AHmUgSYuZVRelb6xjTGpnEUrBcnP7xcE+X+bQis\\\\\\\\\\\\\\\/PWQxG4T6lCArIomu83jzYh4BksRzTCo0+5IR6LeR\\\\\\\\\\\\\\\/1ygMbcaaMchJgDOHoLEa5Ho7JqzovttWjUCTcmqO249EF9TTEW8Q1TwkHWmpFRIKxLp0OLGrU145TvRCfY+s+0iWuArNEsNALqScWIbddUeoLv\\\\\\\\\\\\\\\/iBP+3CJgJy20m2wZj5RJGUX+TqwLBBiQHrCxHr0xsh2TvaOyit6CNKN8Xux7h6RXABZ5IYOH0vS1irU+bujOtqDNArkmjBmTilZD3jxprzhaaP\\\\\\\\\\\\\\\/jD2kAqESEJSvwpOgVSKa1IwSDu\\\\\\\\\\\\\\\/NClhfIvJM961yWCi\\\\\\\\\\\\\\\/teItsbbewUph3nXC+ZXdpuo8CJ9usfiOArpnTjYolkMVpFwaQk9xMjX7Eu+vD810YMIc6yb1e9FLl3Io5uld9kmchfjA8X1fJZxpGPWZaeVsS78EjYyRjC4m+lGz62FB4HlIJlSXyElLH+UgEWhPonHTjPEG\\\\\\\\\\\\\\\/OxIUFk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022eYCb3PXOT5Cod38MHAy6ag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229d212b0d3063b0a7ce6a98e88ad8fd4fca9d330d9b4796ccfeaa29d2e9dbb903\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/O4.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/O4.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/O4\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-O4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-O4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-O4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}