{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PmeRrvxW+8mld+hWGV+6MksI6YO9nFUHG5XF6vokcYj4yr7NrJ90VvHBvgUCjMFAJnnlIZqS\\\\\\\\\\\\\\\/DvRySHtXzvJreXPDBG5NDMMi7IwtQE\\\\\\\\\\\\\\\/I4dDxvsAc3QnpGVabTGsZ8IIuFMpX6HBLJhlLSISrurhaordzkZ8g3AqFj5nCPUTqnTdg8zn9Nno6NZ2TREEVjQXIfw2yOWzmTsfaUKOkXtF5wNZRvUX\\\\\\\\\\\\\\\/0tHOdmimGVzAHcA+DoPR58+bfG23DEAzTyeAdnHUIy5CXcW6EuUQUTj5dylTVrFCrQahNmEQuZW09E+HfLO2PcMQCxHRtcvxfmchPpCU\\\\\\\\\\\\\\\/ElGUbV\\\\\\\\\\\\\\\/HZOIWUm1qfWYP4X7NSI2FbljCfqggdDeqAZ8OXFHySrm6z7EuJu4v1471chubN63Ur5dc+bRCY63YB3puDTO7cjj5riUxEDjMEeL0kNtnz9sR0J0JJXnbFF+9l+Nx9fQFuB5vk5AEb+7WHpvw8CRdASYQgKppRsTVR3DOpGEbY2UUa4iPP5ZuDTaZ0DvS2DFkKNYHbeIxEFBZxcd6LsjR9zHsvgPeIn6q2nZPTE\\\\\\\\\\\\\\\/2oJzvbWnqi\\\\\\\\\\\\\\\/4vJlbVk9rFkayP1lbQGIrMQgyXBdyfP9M+jOloxffO1EIAmLFV9XO2aeS7M045XKxA6QF\\\\\\\\\\\\\\\/8OcEG\\\\\\\\\\\\\\\/sxYdGq\\\\\\\\\\\\\\\/wSwHkT\\\\\\\\\\\\\\\/Q9N6DcZ5G7EMF041kGyfA0+i5IrosPD6uraeAoXixQ\\\\\\\\\\\\\\\/LVhbZQxTRvRsnqXcAygIQng1n305YtJPaY5PYssA0q6WNnzzUXxnjRq7x9W0UKetrNVwg2JMauXt0T7YpHC\\\\\\\\\\\\\\\/44wNi9erM\\\\\\\\\\\\\\\/LJ5oaM1r8V8Yavz0kxYM+u4u\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/daqGE3E2Bsl0djy2\\\\\\\\\\\\\\\/dRSfRXusyUT0Jel3JNYTWUQdRYUU4l31rMT751Qf3lGzLy2DZbSmYMP+mk15EE6rt2BXOPj5uu5opkhUt+3+fg8kH8CXvP3hx5uZ6dk8HMLlyyWRynfMPS9BaLnAILPeP2InhItN\\\\\\\\\\\\\\\/Hpo23R9s2cfsekxCkAELFoSlbRdl323XWSmQ9QKzFWb9RW16fRP\\\\\\\\\\\\\\\/yc5LSGXxUdLdMZa8IqJ0HDAiZmhKU\\\\\\\\\\\\\\\/UdwoJ+pgdzVFDBYWdv06AklYR0g6j75NChd\\\\\\\\\\\\\\\/p6+vANgh8LkX6KFv+dQRK94ndKsLeDNeI9u5KXH37erT15CMAzVS\\\\\\\\\\\\\\\/3sh2gEoBjvObAIjZ5QyQdm2hg+X7QhYCirg\\\\\\\\\\\\\\\/SxRozpeEjvN54X3vdttOuhgA5C+DgucKa179ZEfcJbxrc9dSuFhqF5TIORSj8aweQlez6m84eTGwOSov8aCaFGSWWUS0M9rjJ\\\\\\\\\\\\\\\/k1IAxp+xjM++wPHbZeDNOfnmdOAXUw\\\\\\\\\\\\\\\/+C5wAzRSLWoKiuMEX+N4Wknn8B0nB7ApCriA9sPragByELlLV0XqERglYeggkCteXtB\\\\\\\\\\\\\\\/5mWSvAn1ZjVKVGg2GgwH3My09\\\\\\\\\\\\\\\/S1o66mQJs144HGpBShksIEkh\\\\\\\\\\\\\\\/2lSHBgTHbwHxyAaO4GMTkTSYUwmw5RGImthU3tmwQ\\\\\\\\\\\\\\\/rR7endAhyEI8DmdIB5EwpNpkS3wEz7BwcFtVSYNreBHZ5NKMabNfe1DQIMXiMsRO0KgqkZdDRlpPljOhkpekvwXog8kKWN\\\\\\\\\\\\\\\/xmE06mY4sNvvyGhrbnuAo3RMGJLmEOAAmHw5Ds4NCTgLnDAFW+Q\\\\\\\\\\\\\\\/l4QQAhw8T018I2ijah8IFLI3JDr+ntvwc7qTDu7cA\\\\\\\\\\\\\\\/xremeB6QRHe49WlPCZLnojG+0Opq73u7OPWjDZsbAHjd+egbU2\\\\\\\\\\\\\\\/EOkAXnE3bVscKZNFvQVxL2aj1p7tm5GZEgrTloDgvXEscp\\\\\\\\\\\\\\\/o+FCF3VrU60Iv+TK+I5AKqyU0NZzto2iIwAdyCjzdPF1KjcZ875yVREsdopRVWNOPP56iXiqTG4DLvPaO0ktxbaHEQAEA5+\\\\\\\\\\\\\\\/1nbdgV4woOfd3vN3I7QbcXCe9yNPI5Ki5pSDmWUZtLWMiaoVAzLOIdO1ZCDDGi9F5\\\\\\\\\\\\\\\/UJ3X94U5S2nHFKv97QNOwUsfpfk+zmntHPRgY3J7IjQBg+0K7sUzGx1objYkR5Yog81YQslc0nlRhvO6f8vmGWsBHuFRcjB0cwc181Li4AfPnzbFa486z4Nt67aavQvAwJJzky3T7klHW8QQ4eYuKYxvqtzy9y5+xuY19ISTu4YimYGdxTvQtC54Gc28QSrZYZbrhzHcK2apfYtY3DFOPQy9grKqU0j\\\\\\\\\\\\\\\/URjfX3phJKQA\\\\\\\\\\\\\\\/uh3oRulONk92TzJJx0wdNcD1RzZvl68y5wMFttZ5OoE7CJ+dcPgX8r+aXFFsSd23P6h7XH6+uyLCqhZzSTgCvPU1W4HCAYvVC\\\\\\\\\\\\\\\/+E0hZQdQdvf5KfRwj2EMEbvuAoa7GYZgsN1ppBDyJVoinriY3ZCbbo6K9efEBzCogSaij1nHaMAk7U31FXishjQbUutkBIGEe+VnkdOEdugCs1OeVQX9xcx+Pf+Z9zGFXLaOXfLYRRFGpBvlgNgv0ttI1WDUiW6r\\\\\\\\\\\\\\\/lhuvP3zDtoRHMv\\\\\\\\\\\\\\\/txwV8wPpBbTXsebfSjKVIydCOJaFncPxeH7e4j9h0N3RT\\\\\\\\\\\\\\\/v5+ZCereXVk0hkzCDSTP0p78Bz\\\\\\\\\\\\\\\/RKUB0jV4uvWCrxQTS2sfwFTLZdZlZL2zheceC\\\\\\\\\\\\\\\/JAH37elGCJGitHmy+QRdMIKvj+wMA+tJwcyBBAR25IZzrLQ5SEc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00226p30xX8vbnSiJMH8F+rwUg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220400d0afca7f52d3e0ff0ba4a1d8f7366d980cddf0e61000ab68b7311e0958fb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P272.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P272.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P272\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P272\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P272\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P272\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}