{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aogq1EgRDQaNo5Ji5CXl5wsE0lHJ854F6xK0\\\\\\\\\\\\\\\/EVvDzsles54UH9OEg7rrFJL5rH5ZBD+5w+6Q78xQqqIzIO7M+z8lZvUnQjrJbKlxa3\\\\\\\\\\\\\\\/jK5bpaoUMHcB9Clgzt64Pz7N914mRQscpW0vhlFSsgrIJEWcV1aFZ5BC2IgG\\\\\\\\\\\\\\\/TvHXiiN2k\\\\\\\\\\\\\\\/JfVld65mOn7nKPXeEixe4bUzQl+szZFwKPjuGa+lHAvsHX+EKqLV6gZmIhgsqQU33xT2K4GwfhfnHW82+4jckN29JIHwAO2CZnVSnY5ZanOoc9oARlxI9VQ5hXiJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Xw36JZJ+2YVwTVUasC2tS7YVFZN+JW5Ivp2RMdApDQMxyYUBSLZ\\\\\\\\\\\\\\\/2DBiFFpQXLXnWTCRVP9fXbMJtivbsqTP7g+VyC20rKEtMMvVStyQLNBKgQfX6RJkAYr0\\\\\\\\\\\\\\\/eggtu+07zWWzdskijnO0zqbyLY6d\\\\\\\\\\\\\\\/dRFl5RqJ3Kj99GaLVGJexhROUr+H74hP8hKscfiuQFy4SaSWzP4v\\\\\\\\\\\\\\\/YqaNvmbxll7Bn95UzyTxgxPVlZs9bJ\\\\\\\\\\\\\\\/ShdQTYlJCZQa9tOxp67C0X+ZAKnZwZQmbeYcSBaBKy6Od2UvH7\\\\\\\\\\\\\\\/f6A7ZT+yJQZe573mWW4CzsyMNnIy0ixG98dNQvxGiAKvLWEOIGJ2aSuPACmU2ibglem7ix6LE1KTcvJRPKRufdyFaOsQO3bMNvo9zItDqdQJhq\\\\\\\\\\\\\\\/2gE7krOgO\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/W\\\\\\\\\\\\\\\/EBrFncIt48aKeeoVQNsMH5XW9El+Kaf7KjnOaCzYJjv8MwWU081ggf+PX5NRaicUukY76TsLFyLByeeqM\\\\\\\\\\\\\\\/UT1Ohqmw1AoO5tNmiysg1d4PmK1oErtCtOfcCtxFcXqasZ8HTFqZGZA2h9pc4HFg8Z\\\\\\\\\\\\\\\/KZz4i0iL3nY5+pccc6UEf71O4QARytMVFhhGAz6pxHYlCkBkvzKKAQLqnyf+935yLyyefizHJkIUlZGliKU1yf\\\\\\\\\\\\\\\/jRNSys2QHZiG492v7k67vGTplwiY4VCjbYX9wZ6rXzBbQPNWZBoCg2s7hSnpLB0V1nlWSiXuZnREH3ddw3KgnvA5iuPwQv0nnHCncvAJqG2d8eqxREJDeWrElF\\\\\\\\\\\\\\\/YiRAJBFvO6mVF0yq4PttcV9FtrLSlYFhsD5\\\\\\\\\\\\\\\/VxtADT0GdGx\\\\\\\\\\\\\\\/Q73TZMkVgOacRcYDw7b+juqsmBEplbGTwVlBfoqcmATZXMb2\\\\\\\\\\\\\\\/j76\\\\\\\\\\\\\\\/mDkV9MO+637IlZ1HM1aab\\\\\\\\\\\\\\\/5bKNTi41NuQojvaLg0RmDR8ZVUtcTGxp++yTYr1Io+jsSumQV1sRLvS\\\\\\\\\\\\\\\/13ISkM8fQjmHeeUv5DkNyvfsQQ29bcmRM6QQtRa+uMj+TT56rsVqsIUcExdEptK+ryUh9PTlb9sZDIL8q2AurK\\\\\\\\\\\\\\\/wb2gv095BqBwL+6XUBjUtDCf0zvE7jDcf+3xkvSxSLq7VArtpesjdIshI7GbWY88pZ+Aei3f5UJrFjpG2QIO7BfRAfoZVrVETDLtdBzTbQ\\\\\\\\\\\\\\\/Ajy1+O7DE\\\\\\\\\\\\\\\/O82mt5sd8ZjJFySUvgw6kFuhvg1d6LmekWKICpC\\\\\\\\\\\\\\\/sfbowfUcZAW54Z8mHGtkGYb2pBreGKSilORQY3\\\\\\\\\\\\\\\/U+9\\\\\\\\\\\\\\\/3mQU36+FltlKIbPg9O9afArxYgeq+eUABc0Xt+BEOGchbXpZx5xV8GCcDnrcC1j7KBOPHS20z8J9\\\\\\\\\\\\\\\/rjHYN7+96jxpJ4Stpzk3RQjtxUDU12jAoyYJvgccIgg6Dv3vqcly48HvQyqB46SPIPNvNCkXnYqwvMv14eq+\\\\\\\\\\\\\\\/Jn3FNHLP+PU7KWFM6QYcUvCsfPIqjEql2WdaZ34AEuqJcjkf5xuJQYjCrVb4u\\\\\\\\\\\\\\\/jmDp3i6LeSxj4vHzYwRSh7Lt4cLrlnQiZeE7DjTaHQ71Un85EQ\\\\\\\\\\\\\\\/KUCPBkrdPci8kxNFVf+\\\\\\\\\\\\\\\/kZIUUtAU07IRrM4jRrBzmPA7EMqSy8INFteTWzbUVJrxzrY3dLAaI2wE1BD\\\\\\\\\\\\\\\/1ZmcwIG84zJDQKh9bDGhDQFrDdNZAy13CdCieJxInsM2xgRMh8mAZkV3HhVVwjaB9lwH1oBKvfvoaTCEekpihoqgBfen\\\\\\\\\\\\\\\/gjtBANFiQsd0V7Guhs2YR4cljS+qqrk7AI7IN3E3dQtGwiM10RiCOC0ksZDq1NcNGvrCgao067PR8UT9C6UjeQCzO9edEf004d12mXkAhtRLBCwjV1irL0Z1R+rxWxJPqABlJJtHSN9T1rYVSz0uA2Mo1Erl8wuaYXkEFC5ImrZuSgNz8oz3Yqp4JQTdClHsZHUkiM5q3MaWocaYHDoYdfnOy34N+PfVbYDu4m+LRIM9Z48aj1d7fhgWzEo\\\\\\\\\\\\\\\/+6y97PHE+udum5tTF1SBA968weDsYAljFiycQWOzUuamQMd\\\\\\\\\\\\\\\/XPF1EVltJ6gKS5lG47OdRmaxrkizn6wCiB1OiL7EjUEACCG0Bxt7wvyU+TYMzDnqj10r2ewNKlCPTHmPH1KXaq2o5aXiSF39lToyTCHgD0YVhQrc+faL8YLJx+TMjgazPGmUcuGO\\\\\\\\\\\\\\\/9mT1eVvYbRdPg6yBhf1XLFi3pa73g1+a8\\\\\\\\\\\\\\\/y9Ts\\\\\\\\\\\\\\\/DioCUli1URgsqjs5ikFxUtC7suMPOSo+JoE5SrLaisnK0ku3RppO1M8mdEa8C6KlHDQgVd0Ly8sBN9xxpihQO8jLbl9r90z9kXGGDu8UOJJVpLAOp6yAbCTJNF7gz6dpRgmQlJJrFLEysOc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022C3soOQz1oA5eJWNh2h31gQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224705ff56690867ce1110eb323c2571f45f8dc2a8a38e88ae9d2053cbeb42d070\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P67.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P67.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P67\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P67\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P67\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P67\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}