{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/uuKmocRdoocIB+Hz59HMkzyl4ucv7Txqrn6bTKfN7ArndQRGRxloIxnNDDw\\\\\\\\\\\\\\\/Va0e6cwVEgCJh49Whdy0wwoffKBbX5jtRU3KAqvwJtEDfYsU00fQCL+YKn8NEXI9olTuUvH\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/SmHXdGeGCAmee0VUk2ZuqGrZB7R3ToU2dNrUoFqg2uBNbvnIfDx02iubcjXRepFXJ4XDTwUMrgxTgLt49w\\\\\\\\\\\\\\\/Dz9aWcN7JvA0sD6PRB4sfQ0MKTdjCm2y\\\\\\\\\\\\\\\/gdfVaGgZL691WU9nd84UtTyRFsePRCQOWlK6QLSmxmR1FOL8OuYQpZjPwOAoE4zU80eCQjoo+Ba5ejAyJS2JMZCpJ\\\\\\\\\\\\\\\/G8TMDLw0+b+LBvlG+o9++bSVj6A0DVfEMjZGSPdEMHrMlaF2UPBGhE0KVRo6ogGJwxispdaLSvxJRnWVMFXOrh6CXAh4iOTjEK76qYnk3vh0V+IigFQfklk6lSRfEH4Vmb0Q93tlPjd27WE4cIuwuWsdFjoaasPlfPyaFbXuBjIwDrRiwS\\\\\\\\\\\\\\\/G0tXBbpv\\\\\\\\\\\\\\\/j9A+6lmR3YV3wr7PgSqPo5GjY6uSdex4WgtfpSNSht6P8LZCNX2ZpRurxw6ndp3we8CqGehurd1kGQPvXgUG\\\\\\\\\\\\\\\/KJ\\\\\\\\\\\\\\\/UPOymitGcFbHhkcFcYDbIamjgVzmtN6DghzLYNy+GmFRYW0nVa3LM3jHEDWaTNtex2HDZlRkWUkpw\\\\\\\\\\\\\\\/17IIYGDBCS1GTwYWn6xwfQ9uVj3jCowmF+lQfhSm1RaKBld5w2sNk1C0XArBchSBOcxD\\\\\\\\\\\\\\\/BJhRiVBUyn0c7WaxF+L\\\\\\\\\\\\\\\/AJL\\\\\\\\\\\\\\\/GJ7lizZ9Od+faBQRB0k2Q1fznNZvELZ+x1FewkmXH8MW5fR+6m+YvhOTl8M27yY71uVUsDcEC01WEOaH2GlJ4EaA1gbxMEXQmeiFqsl51+cd0yesDVQMO8bSNaso4MdEcjhasFJ5H6NVmMFliunKCRscEqm9z+OaN5QUaGxslbXtA+3RY1yDKfNY6Wr6lIxvnWel1AIHLyxemsu\\\\\\\\\\\\\\\/WkdARknGA3QduwTZWvG3gqs9JG5Ifq4I4Iv7i4qPZhQ76hvhD2q8Y4ZWE+8B5nfhj8+kAp4oh1TvNV81APj1eXMZkjA4ZyysXBMQR7k\\\\\\\\\\\\\\\/a+RHLlbUl39nE1rquY0QB+iJ+CyiwzNr7bIp\\\\\\\\\\\\\\\/svz7\\\\\\\\\\\\\\\/IjT92nGb6mJPG9S2tNyY5srohwZHAxPxkqaojc1qpT+KSNvu3eMjZvZcaqI1BZfEC+OVLu1R4T95fjPJ5Yl9qxz6iy\\\\\\\\\\\\\\\/kcBvctM1386TgHu\\\\\\\\\\\\\\\/YqYYKihFzifXduZAYfV2VGFxT59WI0wZlbI3I2dkJaymiNrkJIK30o7rpEuw7W+Zax0Nlx+RseeYBn8H1n82Xp3I+NhWY1xrevlg3107kvqRI+Grl5SOo7fRXBvTGLFturTDnbiZ3RPcLyrALuCSVUDWwCFaTP1cPk51kMUHjnCIYmCY9L2+NhS2Rr47UIAb5DJ13kUrIKz+MZ4+43m2G68kvj8AfMyEchMb5aVSBb6JAujeiVoQoI+acXMgIlnKj4GQeQmki2dyNrSX\\\\\\\\\\\\\\\/npGBL+Hfum95tqcXpJDGVJ3TMn6eAmkKn9lAxLMASrzIMUz3933Z9CKC8C3OdD99zAbIw1k30\\\\\\\\\\\\\\\/sE2ydy2i\\\\\\\\\\\\\\\/RT+8rgql3LJVhavbe2asytNQaXxW0Ylyo1gxNtp9i85sQQrDjPWdCj4KEtFt4tIosQtUgeGLmp+1cSFZAbh05Qmbo4tyfqtktWXAUrClUXpLtzyff1DX68U6TwXr7qCtGgJKYsBiwaTVjFXkWIOq3sWELHmt1Oxkf8K29nLBzYbSkK7D1y7zCYcg6K4HQ5V1LIeGDSA4X8c9jTi0ZWD2xeMPPV7xR59hEDaUdbZVl+HIQrfM33V1C1GV5it5DL\\\\\\\\\\\\\\\/6thCzeiAGs30BZDeOqseScZ3hkbrnWjk\\\\\\\\\\\\\\\/sVLOgIkvtMH5M7Wdf+ogEg0RJzFYA7mvIkmi2vAwOn6iA0Lg\\\\\\\\\\\\\\\/NVDNmGKs3tWSMyrNcM3RDni25rnQFgLWBTtknCSmox\\\\\\\\\\\\\\\/IrNN0KU5dngoNj2M49J1lHz+zF65RmF6NSgxTw6UqalnvVSkxQcwNCMdp5dEm8\\\\\\\\\\\\\\\/mCYKYUO4o+qQZqxYW2xwGBVML80Z4dTuuxQQGATaZ1ovl3IVMCfWEqTNTW\\\\\\\\\\\\\\\/jRtSs4gmHSCiP5VtdQyVtdIXM49qRac7FggIhclvbyszmSPiVEpi+GDCmXNKhr19kHCtxTcpFJsgQ3d1428nG4vh0ZkqOvQQf5zp2oCxWvhG5JDkgel7f2nngu9pdtQRbhSBd6waweXfsDOTEBDxm2jWeX7VM0W\\\\\\\\\\\\\\\/DMjzrBgOQOtV5g25c0b9l007ZB02yFVgbKmI7sMTSNpww5Xz9GTJpgVaxrmzxeaLUtuGbEihoI\\\\\\\\\\\\\\\/szCZsoPUE021MPIxpBYM1OkjoxeamUgp98+QhziQrORNR8NXeOgFODIz4FN2ptBZRNCTcey6Vkc+8gDb38HOYIDs2mzjyWtUI70zLklpdzkmT3NaJReTnpY3l7m9yozUZz6p7MlLhk9zKtK0C2\\\\\\\\\\\\\\\/Kpem7Rwcro\\\\\\\\\\\\\\\/D0pjLv+heqYWKpEJbWeriOZ0RAVGlrrkuY\\\\\\\\\\\\\\\/h6AUrs49vQkELz90GoH\\\\\\\\\\\\\\\/XD5jkIaaYe8mwhbDvWET1lTJPDG+8+8R8xpVsovSBjfdyDFg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022U8JSNHcEZVSzGPCzNraf9Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b778f0631cb6f51455829104e3ea2137055a8f296ceb6497a74faac385f2e173\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P105.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P105.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P105\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P105\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P105\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P105\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}