{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CToEyT2yh5m31eNykpdnH9Jo3CfXE485fgIu9s9zm8aVxE09AFAvq3OfLHFbDR05kDc63iFRRafiI3OD8pXXR+7\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/nGz5jaygUXtRJlfxfeevyHncsgJVSOIRxqofvtTA59VmHG1DyYs9mWOC+ZkUrQL13seDk0K\\\\\\\\\\\\\\\/Cv5hf2dN8FTqxq1oaUPhFi2pVej7ER15yMm1E8u76j4Uwl1T3qKRA192lumfzVuPLX70Y72mlo0Ek5OwNOnr1y9zHtUBIHMLizEvvn52lzfVnpRxbwJRDqkictzoRHS+\\\\\\\\\\\\\\\/82JRTlM5KGC7vxQTMaewjIO5kNon02IGJJRuXydOV4avGE9isxgByFqtfyv1ooqkYL6LTxC82H\\\\\\\\\\\\\\\/I9rEIYUQ3kFAg349G71CnO3HXQQ4V4itbPtQygn7PZpHtxTAnvopfFN5WfhJWkY374Q7PSxTZTHN\\\\\\\\\\\\\\\/wD3GWq+oap8setVj8qa2hnwPhaeZEfp0tru+7twWITeo1GhY7KraT0gCS96iIUhW8G9n1gtaN1WRF+9uQcRMYpGITY9kzJ9FUljJFxbnt86ki695MmpQ\\\\\\\\\\\\\\\/jE13v2Jr8P1MGfF8g8RTi6Qgu86PJX9lHcXjGO4wAIAE6jzn9dHWkM\\\\\\\\\\\\\\\/M47EfBpFsWqQ6CgTLcS28CDcNc7hoepRtxg4xOGn+uFYmRom\\\\\\\\\\\\\\\/12CMBQWjcE81O+UnELmJMgx2u2zyTiL9Irc+mPgEjFIyFctmYrgHDGAv1e+jjTWcAHVDc4GAPU9VZDAqZnrHci3HeTGR02yksLlyGGPPN2A98Su+u85SbKr8TEFnFm3ZeXulVs2BTVhOhySI8ur7QIY3t\\\\\\\\\\\\\\\/bNy2HrViIJfCXg92AuAXX3cfkxEB5lTxOhnHZfUd7ov\\\\\\\\\\\\\\\/vWl\\\\\\\\\\\\\\\/813Q5HKGANmtTzjodBgMEvduWijCSrQI68fMhS5EA0AASIBAaLKki8dIzeV\\\\\\\\\\\\\\\/wffs05uQh5LAYOM2nxBAdiQMBjKx3zoWXExa8GbBUiy5EgGJ\\\\\\\\\\\\\\\/kmQDh9ATWCteMoq3Icmw\\\\\\\\\\\\\\\/BxQ4r4tmtUz7+edC9OpgbOguaiOdxHRQW1DWyB5IRkaMat0mas6mv\\\\\\\\\\\\\\\/jJPrybrsIe0hzM85aGy6jKyezLJtwTqOQnOp9dln8gNhRpxhbBN800x0cdPiD+d\\\\\\\\\\\\\\\/AvH+UdeFFuHzSmLyPrWZJhkH1wTMH0Pk2GMmr9\\\\\\\\\\\\\\\/BRGtrYZYkC4eWoJ+mvI75Akk36sb6nAb2NngImroxvj2hFcKSs9HZI4nDJxJ24jvab+OUpM1127rqfRY1OlrvOvgxMnlH2XgFt+PfYfePwk47yRPbXb7qoAsU3H6E3WE3+lhJT4bHGJm6riRvX1rPmi\\\\\\\\\\\\\\\/HEo0JXRSvVL4DRGqNGT00oOVo3ol3yWZHoMz8KvphoMSnROm9QlgvDhgFw1LHbts+J0GZXEgOD50HRAmsiKYO6ybs2nj8O2oVka5TvFl1f1w+gVGt+OoJbvi0S0Z1CLsEBefWPehIBASI3zNAg69LQEMTP8dIzGcPxjCth4sv0OCaXoy82qVFI47ZOvHfHLmi3WMwWzd6Rn7q71gqn\\\\\\\\\\\\\\\/xnBo1FKz9zDamK0ZkKrhdwDn6NBGpBpWvzfePEwkHL\\\\\\\\\\\\\\\/dXRgORxB1w7V9Ny93nxdiPKA6tp+n0+UImA9EC4grZ1p1xSCq037\\\\\\\\\\\\\\\/Y49\\\\\\\\\\\\\\\/mfZx75Kg+WuC4lp50O\\\\\\\\\\\\\\\/xpD4WlxRYQUbAstIRwEapwL9q7XhIRUf+Aw+yJDE2zyP3VCqafWfQ2+7WMuxG9TgvalID5WTEl0MJQCwsHjR3\\\\\\\\\\\\\\\/B5tiGckSE\\\\\\\\\\\\\\\/bupDKv0i3Qa5B0sd8y7LuLDkI5b1ZqVNIwpSwcGFNrEkJoq0tMC7N7jaoSaxxmon7r1y+woOcxSpWLhyS6nI6wP8kTH2N1SUpGt13JBuqIMRWWSakzVB2mNOtLuGQSoOfvTkhscUN\\\\\\\\\\\\\\\/sG2gR3tvSKD9MZ1nccdDijFmTHw\\\\\\\\\\\\\\\/WW5VHNZ6cW1khyLeg5zktYT2Xq0BGVQOEpH0gce3zZLIFnsrEY\\\\\\\\\\\\\\\/9Rg05gdPJd9pv+jftlKzHe56QdmVVFx1VXkEAevJJoNEt\\\\\\\\\\\\\\\/Cvnf9eYJYcpO3KAlKBWvDTvzOuvS72YAOwP8Vkewr8FSEiQ60f59ZekFG0P36XRmpptR6YXxK0jq4mdx1XBElL7h7wv3Q6W0Ti43P4zC0Y49ETs0fU4CuE4kLeVm\\\\\\\\\\\\\\\/AKDSl1bOvvVzqnrOaQKxxqqGhzG9SmMkCFz9htBuGLWHn0ZO2\\\\\\\\\\\\\\\/F0HtBShuTMnrdwmWKjUvcr6mnT+s9OQxKmOirdDguUNvBvd9kJgZQJVfuP1h\\\\\\\\\\\\\\\/sud6+AHVKJr0k1MTuHoZUs1IY3vmVBYq2rtLiRbSITgElCNq4NU7IDAKW553zGR34G3GQy7ZcMXGisJ\\\\\\\\\\\\\\\/24eIGe8LJqEqiCxjEDIWoUjgjc1MrER2EMYxm4oHkTgpMzf0Tit0Yb6LTA\\\\\\\\\\\\\\\/cRDLkoQ36VebQQ5z77MltD\\\\\\\\\\\\\\\/oBOQITCm5G0di6Z+mK4PxvwggpLXJKVE8iRl08n1P2GR399+hBKCcP+Vzmjy8rinCxeIq7LrObzG8s2fUS0oOQwc96r7D8hqKWZPQkQy+2nEm2zdnKHGt3\\\\\\\\\\\\\\\/4TRrkqFq2T79ZarJBfA+Alq2WjYjt+7RAYg7s+JI6G71VUqKh1bWm0BQWID12MyuDOuPbiTePq6I7+AgQUaRxC77jv7U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022TzRZ2EvuK7LoGNSLYh8bbA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e21b5bfc84937c79c5a6f29c7ff84ba2e7557b8ec87c8fd78babfcdec16c6d91\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A93.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A93.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0083\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0083\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0083\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}