{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022UC2pxhqN4H+s++w79J4Mi7Rb5Glk36PzJa2kpsjoOYPFyQ4d7DPQNJLHdc+I16Q5pj\\\\\\\\\\\\\\\/0i\\\\\\\\\\\\\\\/lDWmA1yrA1Z6i445BuCTIFUVZErw5RCdbdwcNIJdjD+Mzl59MaMM1ZS8hUD5LYfbAah3P6Ge+GnEXBoriEXp41QlwFdMiCQXHCttlU6tH+PR+Lcd9dZwF4fYaO3AnEG6GAUVej1VEpAOUI+j3TryCIz+2DX7YamOVBxEZ3fBNGfc\\\\\\\\\\\\\\\/1sis9x488TOoajuIBFGHUsJama6mMp8H9Q9tMD4oor8T6fR3cSKPKWuvyiddaw9QqSp0Ae\\\\\\\\\\\\\\\/Kbu4VoqNG9AdDWlIqJOO8bnzL\\\\\\\\\\\\\\\/Fi97IZvmmerAFrymPdJwzPdzQi7Yw3fnM6nOOCfHaK7BRTGIVwB1+G8hbfF3oHrOBpS8zL3FvkJjl82pa7fQfBFMV32oeZYYlX6V\\\\\\\\\\\\\\\/pOl+WxGjCFa1zvpvXmWxJK3+oFiVAAjnK611rhltRqPq+k6cLTmvDsqAyLVarZm4Si0+ieLEMe4qicAevpiqSYte\\\\\\\\\\\\\\\/wUw2E\\\\\\\\\\\\\\\/8roYg0H6Rt+8b\\\\\\\\\\\\\\\/UDFZieESQUc2zS1RPczN8OO38gxU0c8f12ZaZMVqCYwG+HkAxuKy\\\\\\\\\\\\\\\/APQspQqXrOR8wW\\\\\\\\\\\\\\\/iW3uaSrMXitfeiHLZXu0naJo4AoOcfvP9QfevLs8YKnM\\\\\\\\\\\\\\\/7UzU7Nm\\\\\\\\\\\\\\\/MaCgX+yb3S8WEjnt55GkcEpBshXOXUDLkkNWVC8aM91vCyalTiAKY5nik+9vrlb0CYy5ChffhZGSyk5ffC+m2ku40Db3iv61aNi6BT7cWcoMlTvps8UEh1AMP\\\\\\\\\\\\\\\/5dxAIm5pz18hyugMES2avDE3O1fMBA4Qhr2\\\\\\\\\\\\\\\/GCJ4JTeASsEIkFGlgHO0OJy9sXJ9PUp56vPuOEQAoC65UBjT4do0DmifEUh\\\\\\\\\\\\\\\/Oggchgk2fBMXlTvJP1Ddd58ArIrLHzb9ozAQoitBdFJnDq7ElGyw9q\\\\\\\\\\\\\\\/HCjvIrGQXlPevdvWZ4sYt\\\\\\\\\\\\\\\/hkCLsddHoOuA35WWsnS98ovlIU0YaEAJqxb2P+b316EIiTO56gtWwQj\\\\\\\\\\\\\\\/549bvNtJ2\\\\\\\\\\\\\\\/YtyGcSv8FNum7tsNCdz9dKWS\\\\\\\\\\\\\\\/xB08SwJ7ubjjporBl1NcpVZnR+JGbSwGchGnGYSD41nDD2njLFZRIXolrzNSA1Yb3TO13VBDyxq\\\\\\\\\\\\\\\/rkLdHWOlMT90yz2QmtspW+NL1Gm+Za9uHl9gJAXr\\\\\\\\\\\\\\\/KTyfMmmWy9EJyBrvSlsEG6GO3phCnyOQ+n9LQnl9rUZGrUo1k9HJfBwCgoBS9YLydHQiie1O3VRuSQJGFS1MheCGvlVLXyZNXmYDLuQ7yuQnaVDeyExwxvdT5iHPZoiP+9fcvFgVxZO40KqnUcNwbQgdRcRoGKPUIub9gnFCGmrnBrIdEAJjXoxc8Wa\\\\\\\\\\\\\\\/FoI4ADIkqR8vMQ62\\\\\\\\\\\\\\\/REoB\\\\\\\\\\\\\\\/SPf7zDdK3J7rDNJ37rfgd6Qr8sXotGmySSayvTy+iBjTaCt037jncEmca0s0wuWYJ\\\\\\\\\\\\\\\/UOuxxrT7LMdprZwTHNOPIpFNWspCNjdvzOzIggLCRq3cQy5bVaa3XwHI9RJBKGu5bjlrEsVMLCg2a04iYdorr2tyNzQKWIZEfoyYHg9tvS+cDpjx20JcuIc9JelX4N42hbWWrVQhXaUn1pqN9hy94y4T3DNLtj4gYcDZ7QfoiwDmFHKUcqoA4pAswp8eK+brQ4cxwNOiZtzmYxLlPOyVNOUre6HyCgm9dGQ\\\\\\\\\\\\\\\/1xe8NLJF5\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/LfeNEDLI5ekAB8gqPuW4jLll0aiz5BYbDCzO1Ra2a+OsLZtM3\\\\\\\\\\\\\\\/aGi7ESoqeZCuRmYIPdsljIdWa74R+x5X6AP+4zBPAf6cUtOkTa8FUq4gNoxJ7Yy9uQGinyuyBCLeDfzn0mCbxiWklycQ3CZ\\\\\\\\\\\\\\\/RSPPen\\\\\\\\\\\\\\\/INFprZIyhpWxNAUc54Tp1pNrR2oD+pd7VD16qLOhVA\\\\\\\\\\\\\\\/LtsGb+0R48GqjK2yL+ZKA0cWq8k\\\\\\\\\\\\\\\/AMCwktyH2jngWoFMUyFCGjtYKlakJvl5e5q82a5AH9iUTZxWx\\\\\\\\\\\\\\\/Ih8jtZxE5lxRXPVDK+gggF7YCprHjtSU2wnSDuxcfgT2fnXaUulJBW96ZZ69sX19g8qQTiJXjl2koqiEHF2as+cqkBbg3n0PbQulR0X6N7IcGkg1Kltvz8g7W2NjntOklQGW0csuiYiJ5zXVKv0Uo4GCD1wA4yN1RLQ5tkP0A7HDCgC\\\\\\\\\\\\\\\/LqAtMXbr6P32Wq14nafUm11x27iIGbwO9jpYvM7layyNJaHV2PWmGsq8TbwLVzwQHzQMTzvEOCSa636Kc3fAjjtfjf4P4HbNbD9cCVN\\\\\\\\\\\\\\\/2CHMMp\\\\\\\\\\\\\\\/ewdCnm8XLUcHaaFw+u+cObCUTrCpzBdVJa+Q6mDhc3bORllFcIVjEI+bb+8PoLB3lKWzqqpM7ZOBzoea+nw\\\\\\\\\\\\\\\/LwaEavTlBDYXMxXxQLzR5nYTHMpxw2sFs95t3nUBz+LMFXgKCTsIrzGsXXWBsL9s68BW9FaNyneRrzPWCmdlPcrcjOrA1G\\\\\\\\\\\\\\\/MxVuUeABYmN5LqMRhhsW\\\\\\\\\\\\\\\/NY76z6pokNpgIfYHUcvMuf0ppS77dya4v2QcqmP7hS8Mc\\\\\\\\\\\\\\\/ds19fybPX4Tq5qavg9TiRuP8bqGggNp5yPKWTgBGz1JdM4D6darszAaWjrWK+p5MjStHhJyNvOKF9tFRbqO4zn9fL6M\\\\\\\\\\\\\\\/z3x\\\\\\\\\\\\\\\/I0UJnLhTdSw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00224toUqYsx9FhAJlk1GNkEiQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022595f5906d3ff8cfab9917db7eeb7afd5684aea9631dcfce13459ef99770ed903\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P11.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P11.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P11\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P11\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P11\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P11\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}