{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ji4qRClKdGS3VBWKjEl6nPiI\\\\\\\\\\\\\\\/FA+\\\\\\\\\\\\\\\/QCyTZKDNeTok816rJvVqcnftAfppBmWjKkiY5ft0winqo694om64mo+asOv0khlxI5D\\\\\\\\\\\\\\\/7CCJ7hcp3MQAGWRTxRNyDzNYm0D+O8oV3I7QqSVJePcn42QXhVb+mzcGkiyWOZGEj1qodZYTMyLZ6nfmdd8ZRxZotN+3YbMjSK4pgOjsqV8UJWiG0LPzIdjNC36aGJL1OER4V9AjnZFkp47mC7KbcPpeqOSuu9sACzzrmksnvILjoC9VB9FK7F1kgGS3amG4lZA+w1pNOqNdX8nRs13AT9747i75Xv3T3dvMMfF9\\\\\\\\\\\\\\\/6zMmiChmjg\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WxWVq432ehM6uaSwkDfei6Ax+VAusSYoVIf9G0jjBa9ITaLkvFgMeUriFSZ\\\\\\\\\\\\\\\/0aDnpHRL8+obR8a89GXxXIEGz2nQymWWTUgdqAhsNVoWW6w1zaU8wF+QoAmCYjWrcyHLJMpXFG21LGdbafyKWu8NkfLxzqAnG1Bcu7l2ey2c4q65ytFwZ6Gvi61WLzkZZL3\\\\\\\\\\\\\\\/6dsSVrPKg+JhNHYUCzmjmYgljMfP6fNd6cpY+v1XiIabWyiFDHYK57jkXnlXVVgSH3TVvA3gorTRq5CPYYHOBWvjdAgXM2shTlgll6TC7vLiPy04UbGTgENiVBrfbZ7E4ft3OyfQUPRXUJeEgYWcw8tu3dxPrs5rVE4PPWuGqyfzZx6FZzr3kWXJfFt7Brg7MMRZibbhk64bVVAup7RVaoQxw1wIH0gW2bTsXhtQ6YJcEa\\\\\\\\\\\\\\\/pEGoMJUF2wbAHOPFphjEjgfDUxOaEfbl1ou9MMTHXya\\\\\\\\\\\\\\\/UMQb3QaNHdxEonufsTNtHutnuRWKkAQj6UimJe05vz+rq2WOZxPW3wpjB3R9RKFCIUAzxf4G445rZpCXTi9uNPKh\\\\\\\\\\\\\\\/qLIeJtr4cVigRbW8aqkZvN+AJ7mQnz4JInULuPGSyrf2uRp7jC7AtrSRbsxfAe9daOTAQTxpeNf2AwUgZeApoR5GGUMU0BwLNVmNKL29B\\\\\\\\\\\\\\\/sYviS7xy8W4I2fdsTJic25MOoqn20UVD72XBgPeUp9zZmINjXbX9B535f8bGDAgAXYEGDUCJl45oT2ofhhQTjsV3Dyq3mCJNMkZ5qNLF30XF1tODZ+DNr7ACDUDJCn8H6WXXcnrIqC5XEHys+\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/HAc8SIqXuqVbFuhNLBZOGj+fboL1JoG4pa8asij+BWOyld9He+eqvsxCHD1tqnP2fhZkVROJJx3ZBzNisc8MFLvs1025zXUwQ3ZrMyDLjPyBXMGIY\\\\\\\\\\\\\\\/ZKRRVC10KAFCfIq9FFUWYPAkJoRbR8jZVRbiacLUI6BEXBeuB4NePdVBx8tf3Ixa6s3PfJa86zKZHKQzN7IYWOzdpoIWhq6hcKtVrj8+VjHrtWPQneg3jVTnH3\\\\\\\\\\\\\\\/DqvrAW69mHI7fvbjtFwB2hCQZq01T1BV4gabObtZS\\\\\\\\\\\\\\\/X9bGqWmoz\\\\\\\\\\\\\\\/UITbdg1rUY9SciyF6MFAE6oJHWM6xJ8avK8kfIDuJEXMSjHTvKZcMsXZqH1x8L7rmoPIhDy1pj1cvhicchjUCIDCQkD9MpuKGv\\\\\\\\\\\\\\\/y2YDHZUP1IASZLHi9iEkbqtls4NIDDp5LQKjAUIif\\\\\\\\\\\\\\\/TuN69novPjxLQJ4guNx9FW528peiNYUEQmk3qHlj8LCOJD88SyldqA5rK2tBmfO4j4oRl\\\\\\\\\\\\\\\/4RmUN6sDFKV2ljnEMbviwjRSWufJE7LVfxny70Y9+v+OjisKxLMObg03+vfH9dHrQ2VxlI+mFRiaueET0n\\\\\\\\\\\\\\\/A1maGOv\\\\\\\\\\\\\\\/utTVxfRudAznOcQYTMRNbiLldYQ7nHO9ryD2gZ8XQR+IFi1QmUoioASqNl0Zawxp8dWbUDUBHU4jRLEwreCw9AameQPzqxO9VykWLa1IPTq5\\\\\\\\\\\\\\\/js6+UrNVRpnwIvcqwExfjTWnm1YNPrJYlL2nyaQwK2EHlkLuHJjUQeRGgNtQLsH9edpsJYNdyRkG7wTumAjeRpbmUYsh9CJh7y9DnxpTl\\\\\\\\\\\\\\\/GpO9Utj1fW7M+FVoNTWSZOkM3MVvUzOkd7ICincM5veyZi9qNXbf2GePSl4FAZMLPHmCS4zpOYuVybacrdrTWAyNnYiRm9shHuqB\\\\\\\\\\\\\\\/GTHY0O5+XjG\\\\\\\\\\\\\\\/9IuGNv1PhlwYexLKENP2QlJfin98V3YbsbAna2Q5MzXhnAOG\\\\\\\\\\\\\\\/N4\\\\\\\\\\\\\\\/IW7WtBgw5Lxo2ITShhm+IWUqKzlT2DOy4sr9ZaxbAQA5C7ucD4Ly7vo7qBUMJopPKP8s4qruux8GmRZ+YoOjdOvn12l6RQWRK54oMfGRRdfHuxWqrriXHcpt5OLkcfGxKxU+SAHMY6YM2iNQEbcE2DJYx8ukNe0v6TAvxv\\\\\\\\\\\\\\\/BB7TJQloBVkwUIKL+s4dZE5TuGLjkM1S3xsqzvOyZt0RPJKNr65m0osBGlhwr3\\\\\\\\\\\\\\\/wz\\\\\\\\\\\\\\\/cwAlXcaCR79I7pFRuc1PePm\\\\\\\\\\\\\\\/lT2yw9r1l8KtejAEiE+gvCIuXpJi6hs3dirqz3ohewUKqduoLHtTVTSOgp9itmQw6xqQ4XVwLennZ2UCrvEQ11RSBJv8Eozf8sc0l51NWlCPPYgymvNJsvvEmr7BVjw\\\\\\\\\\\\\\\/XIjYfI3kE7dR6ZeatA\\\\\\\\\\\\\\\/FW+67HG0zvD8Wdj9berLgzQgp65OttyBTEJ3vhkQ810zFUDM8dU\\\\\\\\\\\\\\\/K3c87S8+ckSSRRlwU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hP8pAZ4ixqhoIA0BxwURrA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228fc410031728a4a1f093e337365deb2e8b97233ecdd715e37551934f8c0e4efc\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1666.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1666.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1502\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1502\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1502\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}