{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022KFJzKDnwmZHd9B6nCxhvmld+FAT8CS1AnSxM5oO\\\\\\\\\\\\\\\/9tKpPBVn0PKj2am6Vm0TdIJHtcRLSFpZhN7GWj+FkHIWht7m3X8PuuulIJEq7EkhNotYXKK9Zd1z1jhIFLeZ8X33EHTrXkvEC\\\\\\\\\\\\\\\/lUQLCoW5HP6pK2zF2weha3fAQiAh1z4uPzRVk2GJg8OovFRf9HtVrvH9k2FmLZak0lFYt38VvwqSCFaPvERT2N1shDAGOBizuP8xdYh1hheJCiD86UGZPtPBqX6MGIuUDNqRE5\\\\\\\\\\\\\\\/huTXMtmXOPFlhopGNjW243E+sLh8WnVNRXcMWPqTgPYODInoJgbsjJysxXMwJwL8R1POcc7BsOEX98MjeKrDE10DXeY5CChLQebzlD+oqVthUvmtPOzUH3\\\\\\\\\\\\\\\/utoUElEzI2cJmCG4TPuqpqpDD+pyfT2\\\\\\\\\\\\\\\/z4MOReSN78tFs2xSKFyNFv5K0jJVtKBD1NgP17wB7mPe016IuhmyW8W69EFvw4efVHj0gbjRb7nOAHFG5pyY7c1V2aAyQP3i\\\\\\\\\\\\\\\/gWFRfv5+y87eTPDTiQH1d+W4A7Hb5dQwnHx6CiZRTfbGLkC\\\\\\\\\\\\\\\/PC2KuPZPKPAUmJQWh51geUdTA3rU31rGrw6sz\\\\\\\\\\\\\\\/pzmrOjPA3q5swzvmR7Jj2okFoXbuSHBnR0jslrI+Kleb8M4x79UIKvEQNNSBBKuj3nR9wPGYxU\\\\\\\\\\\\\\\/KAAC+pxmGBmGHFOoeIW2wCMsvcKaXFF2WSCQO9JA45i0QfSp8g32KnO\\\\\\\\\\\\\\\/pnVrnlohOgG\\\\\\\\\\\\\\\/7Wzt4z34EQ\\\\\\\\\\\\\\\/fRcR6FzbinU\\\\\\\\\\\\\\\/J3zhcOaIQqzh\\\\\\\\\\\\\\\/DpiIWj8UmUTLWxjx6fWLYtDQSbu6D57FDURJ3x4XQAtqbsx55TpqtXmXmezkUp3JliE4qLROlA7u7rO8SrlYCZcQLTVVxdX6TdJgreJ8eblI+AL7Udv4S65r6Gj6bTaoHUG2ST5ldxwCz3eja\\\\\\\\\\\\\\\/TuzITiWmd1e62+rX79TWiO3KD9D3m30OJW6Bx+Hkt3iblp6yR5WL3s\\\\\\\\\\\\\\\/DqmO36a1NdfTktWKNLvw3xOvRJjwkzvG2P08DHM2nwhpGQe2dl9pbzB6Xcmhe7DIHmA7NJfWPvpKODwU3MysqpVjCsaC8x0EbpqBd9HgEE0lMDVlJFN8w4Uz4UtM3DCtyHXF6wF1e5To3PQiwlwPKEg\\\\\\\\\\\\\\\/OPDq1m6rLWFQcib9dNBlUkEWHZpRMXqNi2QSUm01Ckzfeusstv9lFQVPQNiRZaBauQjzNnNV\\\\\\\\\\\\\\\/DDddXpcGQ5bXXZpfyUxwrJZ2uhAvtz+1vhhi+p0xiXOnZNwuMbdxto7IEtZZjlcVtRRNbmHvu9T\\\\\\\\\\\\\\\/dhN1HdFJQpULwFa7EEr803VHxSMrzQUpoSu8OqY7H1UFBleziNcBZaTirmGP6RG5vXkpmc04iUxK22vANKxLU7Pctg4uGh38H1wUbBTB8xnFsJhGwc4O24apvYe1P5Vz5+sdrxbNpbsL9XD\\\\\\\\\\\\\\\/fqczDa2L6LfnYPNAjC22ZQ9T1IKt+GzRos4tXrzEfz2l81c1DeyXLqQRMJRHw0uFCd75W8j9bLb6qUEV2d8DuNDsAMz6VM\\\\\\\\\\\\\\\/tE\\\\\\\\\\\\\\\/QANfau+oHCQP1bx9mUtPHeVUYKlf+rFwiox90npUjSYdCvW8FWi4PdxvfUL97gtfnuuuuTW3L1QZ2\\\\\\\\\\\\\\\/nmr2judB62PoLzHF1wkGE5E3OT6buRYKtisWyHHlPuJCmEWvxvWjs9+Z6YvuhWUt8Hp7VvZ1wcsYGtTrqm6X\\\\\\\\\\\\\\\/EzGQBbNikSIFcM5yU1ZNVpSrbO9Wsi1CIVgVd5fLdnge2ksfoSgLsokKeAHBq2TruSwYxAFZJDV6kpbHG01j2AOPQjsr4VDZ5VbxOfduxUUHHJl0f16Zi\\\\\\\\\\\\\\\/lkMNdPAS+wjmSnyt0YjYDVT8i5SnKG6Z0LsT1wk5CRzIyGKQuK6KfFffUmDoZWxfwI5bDjuhehqsUkRySkbxDchpEVTC1\\\\\\\\\\\\\\\/OK6B\\\\\\\\\\\\\\\/H0s2AKN90fxTWYo3CWUKNn9\\\\\\\\\\\\\\\/t0w3+OAF1PyZDO99E33nXnFGrwb244vjrhZNgNmQ4PGaerQ0LtsxO+8it3gDo1dQMOjJ9byT2JGLW9k9+r27k40Qqyld1+Q2Gk25poIVGZqfWSlFSK08jiHGL50ZvzmFAWzZs3goDdtnC6fEPxFuu7L+gotdX4S2LaVTsaIy2nelSwb5E+A1418ztv29pp8LgcH+BhSPGwhsOtltj0zlHBujqxtLUTl3PGfPBTMGo7gSkoNvEzInL3lIl3PvcYfWP6kBfVQXqkHMB6x9htwQIhsjRYIpfA0Ze8GIU21H15sfSpbFNGatGtXP+u9YvNgeYR+TZZXxE\\\\\\\\\\\\\\\/drXYCGceczna\\\\\\\\\\\\\\\/ZMwV5sKROrxlLhPf3OO9mHxFQe70tLMU9wAyzZWr99P\\\\\\\\\\\\\\\/qVjP28+6HBMCMEhKzuXQoQY\\\\\\\\\\\\\\\/C29v7sGoKlJTCeBVk+fwP3EfKCpj7XId8bl0nukqloq2NQrmjHGzhfmW1oUG3hekqkTI2MrbALRIpplAjWJnHhqfeSsHL94Y\\\\\\\\\\\\\\\/5uqL0Z4tOpqJZiLvz87nAwdzV50EBSnZ4\\\\\\\\\\\\\\\/Im\\\\\\\\\\\\\\\/GYRzxI2X4f6VR22i\\\\\\\\\\\\\\\/IravY10JbN+GoSiYTzwoF1VzEONtpYJHRZq6H0BWHXwVJkJgZ5CAMW2ZcOOjqgvsbXPNiN94ylv2XIX7bSkL+OSDygtmApNysUvQJ2WVVmg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Oxq2eaL37z9+uIVrh1I35g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227bbaf27d7d3497131f4da7ce9a9b37d4542549e09ee73b1b4d9e9bb0507c874c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P266.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/1\\\/Suppl_1\\\/P266.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;1\\\/Suppl_1\\\/P266\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-1-S1-P266\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-1-S1-P266\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-1-S1-P266\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}