{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022k\\\\\\\\\\\\\\\/8qJkMidrpQge0yPHA4cEcWK7Gair768V6MzWF5T5mmiq8wf4PRgoOZ5yrGBrlD8qLgkuPlZLIbr1d7BBIUIvKrPatzh7j88syWHVt4dwVDsHDTuU1hrg+o1DUbjkRHB72ayQc7VKCUHHfDtP6os49EjVeinFSdySmplPvDKRN+2R8auMiM9lliBxQ0T9s670+IpKs93hJDyGQ+wbpWl4QdX2uu9vVn2sgEWW63wbxUa9ljCfiP9Bv7GCyDd3u+HhYuzkcQBhQ0RBlLXxV9sWJz+lnx7GT0xNDGTifsjwsRcZsZC7JIdp25vdKLb7vibxeATcay0gmc98aK5oIQWf7VbtXhVdL8Wr13bkN+liV+8u2XFEtOpGJYuVVAj\\\\\\\\\\\\\\\/+1JQAOpbt3wbixR+gFcWi88Ph306ex2izKje4vBXlAC3CkVn\\\\\\\\\\\\\\\/XGnTM7NE+u6GhCPYDuXBE+QLEU4N6qMJhQPLG8Al9H0crc3lnMyGIO+a+7QApiThA1YmNsTPo7YRp\\\\\\\\\\\\\\\/VqRPabtdUQEJxavdbFwjS75BU+kSI8+p7v4nn3Mv8l6fhvvT4fCeA3IqfCyy8J36pURzceZqo06foFTUWeD8xGPc15l0TklApczUnRTg78SCT82RPU37g9mrJ1AlxsANGrKB89B9U4JRWcPHPSSE6k6pLoqw8waHE2qXuTvi7ayko0OAHznHYsJQMLw8nznvto40QWXetSgXlKqFUO6SVbltfBZbONMCsMajXL1CuKnHycfuSXX0X7LSJCcxp\\\\\\\\\\\\\\\/wTmoaIDXl3Le9yTpyMJetIkyhNtC0oKDp4bmjPlF9TSxa1evDCcBBScxqbOzyG1bdxxSAf6kaUB367qurDus6AMYJeFyBxTN\\\\\\\\\\\\\\\/EQAMOKZsFhJUSgDVjN\\\\\\\\\\\\\\\/tRyUBfgrBYhrY446+qOv0IAI7ENjj6XjEazk2a42o6Ish1w3Ot+2200V\\\\\\\\\\\\\\\/ysN748t9lIIoxL3PjAMW4L8i45b9YreCDHWnvFS6i5P96tmc7vb7Ais3U7I7uI1jm6OsTlvqVLB54Zn43edosWX3DfLw8XZQFHlUwBX6jtA6FUM\\\\\\\\\\\\\\\/MxuMdxCSf8fCTaZoht6HFllss8001UcCglmdo07Dp5B8Q+OkBPXlpBWYA07p1UKGC2FUTQXwZ9An+TvtTshPySvoTdp1RDrvoSODY\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/9HLXyUq7Gm5rp0ixJs7e6bdZsmnaQUGezs0asbRoh6H+QOCClTxTqLE\\\\\\\\\\\\\\\/6q3unvBpv53rlJpDtW\\\\\\\\\\\\\\\/f6EhtBb1xnR6gbEeoV+lQLNGPCWqBe+GmW4jMhC9K6eTkt0KKxWa9o2BmlpjzRBmuE70UoUJ9TGW+275ouCGodGxWfgd1S4EX4ew9\\\\\\\\\\\\\\\/qL7uIDddYxu+jpGKbyCv+2uDtA\\\\\\\\\\\\\\\/oJDx9zFuRUL\\\\\\\\\\\\\\\/xhK9OoDcIejTNKYQdCHIfhI6L6IvlNzYwf+kZSMI9\\\\\\\\\\\\\\\/3uhBZ5Po6TUYqichGPUKQx\\\\\\\\\\\\\\\/Ze\\\\\\\\\\\\\\\/Hd7o+kT07YDF\\\\\\\\\\\\\\\/rJ9DJ94eF+WRJfZ2nmU7eWag0WPu6MEV3j\\\\\\\\\\\\\\\/0xxE8so898fiWLisWv3oslr6Bqzc3slvO8h2aw1wSixuMG\\\\\\\\\\\\\\\/NsTHZSC48lhTziNeUSS28AIYSYSeFMoyjgdYZjznWTc2wQns17xhFD2O\\\\\\\\\\\\\\\/C+SgGhLDrpcESt9++iydRHfmlbYdukJKk25YDxNFsksMD7OZnjl6W\\\\\\\\\\\\\\\/4yXQYfINQEmAo9y3vEwflYj+VIPY1aciuF\\\\\\\\\\\\\\\/h8D93g6KtKd1WJS44gWEJtAqchdb8BvCq2mWSOpwL+QgrHwOjWNxXau\\\\\\\\\\\\\\\/M6QPVLwx+7nol24uyEHXzgkOUxFeR61xPvu83xgAoUmLG6FmOBCOf\\\\\\\\\\\\\\\/lG2emSx2wDrzNCt6YjmkNCJx57pS6Vr8SOVlMEVkzIimP\\\\\\\\\\\\\\\/OcITPMqFzGrayyyunSBIOtt9IZc2FAAq7SYxSKE7+unJCmPcWlhbF94Xs03OawZzZTP7iiuz0CBURhGbwaPRe4NMZ\\\\\\\\\\\\\\\/BnUiejYvQegObu46NT7lCxqFwWtPLPO1E91w3aegiHAyt8JNQtyZgSxZPvtyvCJ75AkcmCVA3PegbNVinaOxi\\\\\\\\\\\\\\\/nqL0D21CmKoUbr5DZeT4BdiU6OF9hcSAr6PVuI2TV4FXGZwjd2iFU0w2bBk7WC1OWwzcsennAP4nC581RVjDW1UAwCMkFjeoYMIV8CDQLWYYfoli7f4A1e\\\\\\\\\\\\\\\/hC78SWeYeEk0D9+PIGNe6F44lttWo\\\\\\\\\\\\\\\/YF\\\\\\\\\\\\\\\/IbQsazTNL75OtP48kYjJ\\\\\\\\\\\\\\\/MIdLL7iLhyCTZ7knkZq1KBCPLO1yWIjj4aXTKCylzLZxSI93ZvsRIQjkGw0FR8R84ZvP8l\\\\\\\\\\\\\\\/HF0uhSmhGBT+hueobYnCq2\\\\\\\\\\\\\\\/4ZQeyCS8xWfAHsizQWQS6EtbucVKW1TnqmkZvdw+98mliakoZAAToKC920NygzWVCNQfuJAfy0WbvR9Y43LdHJQDIOUs3wTULSE\\\\\\\\\\\\\\\/GgY8yjLHA\\\\\\\\\\\\\\\/wqxxoO5XmGMCxKRffskYztANO4blKOp5EWqT\\\\\\\\\\\\\\\/hMTzio0VFIUTMiq4\\\\\\\\\\\\\\\/mqjiL6gU9GxDtgxwMo\\\\\\\\\\\\\\\/Kz5ImwrmF1gJxw7sxJfq+3CNTFcuXA150ahPWoD8TeLiOQWpG\\\\\\\\\\\\\\\/corTCqnuvfHGdTRWSuvD8XXhDifNGOWF5B+M96ehVKFjqZB5BAC4wubZIuRKStD0z9e+l7\\\\\\\\\\\\\\\/JUNH7vHvsNHJZ4rBjHqrcdY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022f42dwDDnR4gP4h9NhiOXtg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022669a1a4ae3a9bdcd34746fff378c13529456a9991de9a6a1a6ce237a8bc14f53\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/1\\\/30.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/1\\\/30.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-014-0030-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-014-0030-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-014-0030-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}