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class=\u0022em-addr\u0022\u003EStephen_Hodi{at}dfci.harvard.edu\u003C\/span\u003E\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article abstract-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003EAbstract\u003C\/h2\u003E\u003Cdiv id=\u0022sec-1\u0022 class=\u0022subsection\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003E\u003Cstrong\u003EBackground\u003C\/strong\u003E Investigate the tumor diameter and density changes in advanced melanoma patients treated with ipilimumab plus bevacizumab, compare response rates based on different response criteria, and study association between these measures and survival.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-2\u0022 class=\u0022subsection\u0022\u003E\u003Cp id=\u0022p-3\u0022\u003E\u003Cstrong\u003EMethods\u003C\/strong\u003E Twenty-one advanced melanoma patients with 59 measurable lesions treated in a phase 1 trial of ipilimumab plus bevacizumab were retrospectively studied. Tumor diameter and density were measured on baseline and first follow-up CT. Responses were assigned using RECIST, MASS and Choi criteria. Diameter and density measures and responses by these criteria were studied for the association with survival.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-3\u0022 class=\u0022subsection\u0022\u003E\u003Cp id=\u0022p-4\u0022\u003E\u003Cstrong\u003EResults\u003C\/strong\u003E Twenty-three (39%) lesions and 7 (33%) patients met the Choi density criteria for response (\u0026acirc;\u0026#137;\u0026yen;15% density decrease) at the first follow-up. The response rates were 14% (3\/21, 95% CI: 3-36%) by RECIST and MASS, and 52% (11\/21, 95% CI: 30-74%) by Choi criteria, when both size and density criteria were used. Larger baseline tumor diameter was significantly associated with shorter progression-free survival (PFS) and overall survival (OS) (log-rank p = 0.001 and 0.003; respectively). Diameter or density changes, or responses by RECIST, MASS or Choi criteria at the first follow-up, were not associated with PFS or OS.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-4\u0022 class=\u0022subsection\u0022\u003E\u003Cp id=\u0022p-5\u0022\u003E\u003Cstrong\u003EConclusion\u003C\/strong\u003E Tumor density decrease meeting Choi criteria was noted in one-third of advanced melanoma patients at the first follow-up scan during ipilimumab plus bevacizumab therapy. While larger baseline tumor diameter was strongly associated with shorter survival, changes of diameter or density, or responses by three criteria did not predict survival. The role of density changes in evaluating response during ipilimumab and bevacizumab therapy for advanced melanoma remains to be further established.\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EMelanoma\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EImmunotherapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EAnti-angiogenic therapy\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ETumor response\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDensity\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERECIST\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section glossary\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022glossary-1\u0022\u003EAbbreviations:\u003Cdl id=\u0022def-list-1\u0022\u003E\u003Cdl id=\u0022def-list-2\u0022\u003E\u003Cdt id=\u0022def-item-1\u0022\u003EOS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EOverall survival\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-2\u0022\u003EPD-1\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EProgram death-1\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-3\u0022\u003EVEGF\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EVascular endothelial growth factor\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-4\u0022\u003ERECIST\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EResponse evaluation criteria in solid tumors\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-5\u0022\u003EWHO\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EWorld Health Organization\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-6\u0022\u003EirRC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EImmune-related response criteria\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-7\u0022\u003ECT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EComputed tomography\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-8\u0022\u003EHU\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EHounsfield unit\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-9\u0022\u003ERCC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ERenal cell carcinomas\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-10\u0022\u003EMASS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EMorphology, attenuation, size, and structure\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-11\u0022\u003EPFS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EProgression-free survival\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-12\u0022\u003ELDH\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ELactate dehydrogenase\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-13\u0022\u003EMDCT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EMulti-row detector CT\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-14\u0022\u003EPACS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EPicture Archiving Communication System\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-15\u0022\u003ECI\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EConfidence intervals\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-16\u0022\u003EHR\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EHazard ratios\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-17\u0022\u003ECCC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EConcordance correlation coefficient\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-18\u0022\u003EGT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EGreater than\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-19\u0022\u003ELE\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ELess than or equal to\u003C\/dd\u003E\u003C\/dl\u003E\u003C\/dl\u003E\u003C\/li\u003E\u003C\/div\u003E\u003Cdiv class=\u0022license\u0022 id=\u0022license-1\u0022\u003E\u003Cp id=\u0022p-1\u0022\u003EThis article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (\u003Ca href=\u0022http:\/\/creativecommons.org\/licenses\/by\/4.0\u0022 rel=\u0022license\u0022\u003Ehttp:\/\/creativecommons.org\/licenses\/by\/4.0\u003C\/a\u003E), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. 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You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022content-block-markup\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/melanoma\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-melanoma\u0022 rel=\u0022nofollow\u0022\u003EMelanoma\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/immunotherapy\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-immunotherapy\u0022 rel=\u0022nofollow\u0022\u003EImmunotherapy\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/anti-angiogenic-therapy\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-anti-angiogenic-therapy\u0022 rel=\u0022nofollow\u0022\u003EAnti-angiogenic therapy\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/tumor-response\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-tumor-response\u0022 rel=\u0022nofollow\u0022\u003ETumor response\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/density\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-density\u0022 rel=\u0022nofollow\u0022\u003EDensity\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003E\u003Ca href=\u0022\/keyword\/recist\u0022 class=\u0022hw-term hw-article-keyword hw-article-keyword-recist\u0022 rel=\u0022nofollow\u0022\u003ERECIST\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-5\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EBackground\u003C\/h2\u003E\u003Cp id=\u0022p-6\u0022\u003ERecent advances in the understanding of the mechanisms of tumor immunomodulation and the clinical application of immunotherapeutic agents have brought a new era of cancer immunotherapy [\u003Ca id=\u0022xref-ref-1-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-1\u0022\u003E1\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-2-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-2\u0022\u003E2\u003C\/a\u003E]. Clinical benefit of immunotherapeutic agents is best demonstrated in metastatic melanoma, in which ipilimumab, an anti-CTLA-4 antibody, has shown significant improvement in overall survival (OS) [\u003Ca id=\u0022xref-ref-3-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E]. Ipilimumab has shown clinical activity in other solid tumors such as lung cancer and prostate cancer [\u003Ca id=\u0022xref-ref-4-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-4\u0022\u003E4\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-6-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-6\u0022\u003E6\u003C\/a\u003E]. Newer agents, including anti-PD-1 (programmed cell death protein 1) antibodies and anti-PD-L1 (programmed cell death protein ligand-1) antibodies, have also shown marked activity against melanoma and other advanced cancers [\u003Ca id=\u0022xref-ref-7-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-7\u0022\u003E7\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-10-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-10\u0022\u003E10\u003C\/a\u003E], further expanding the role of cancer immunotherapy.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EIn efforts to further enhance the efficacy of these agents that block immune checkpoint, predictive markers of response to immunotherapy are being actively investigated. The immunosuppressive microenvironment of the tumor may restrict the anti-tumor activity of cancer treatment, which may be further enhanced by the abnormal tumor vasculature [\u003Ca id=\u0022xref-ref-11-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-11\u0022\u003E11\u003C\/a\u003E]. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that regulates angiogenesis and at the same time increases proliferation, migration, and metastasis of melanoma. VEGF is also known to inhibit dendritic cell maturation and T-cell responses [\u003Ca id=\u0022xref-ref-12-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-12\u0022\u003E12\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-13-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-13\u0022\u003E13\u003C\/a\u003E], thus suppressing antitumor immune responses. Serum level of VEGF-A prior to treatment was shown to be associated with clinical response and OS in advanced melanoma patients treated with ipilimumab which confirmed a generalizable mechanism to immunotherapy resistance via angiogenic cytokines including VEGF [\u003Ca id=\u0022xref-ref-14-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-14\u0022\u003E14\u003C\/a\u003E]. There was no correlation between changes in VEGF levels following treatment and clinical outcome [\u003Ca id=\u0022xref-ref-14-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-14\u0022\u003E14\u003C\/a\u003E]. The finding led to the phase 1 study of the combination therapy of ipilimumab and bevacizumab (anti-angiogenic agent which inhibits VEGF-A). The trial demonstrated a disease-control rate (defined as the proportion of patients with best response of complete response, partial response, or stable disease at any time while on study) of 67.4%. The median survival of this phase 1 study was 25.1 months, which was longer compared to 10.1 months in advanced melanoma patients treated with ipilimumab alone in a prior phase 3 study [\u003Ca id=\u0022xref-ref-3-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E], providing a basis for further pursuit of the combination of immunotherapy and anti-angiogenic therapy [\u003Ca id=\u0022xref-ref-15-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-15\u0022\u003E15\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003ETumors treated with immunotherapeutic agents are known to demonstrate unique response patterns on imaging, because these agents exert anti-cancer activity by blocking intrinsic immune inhibition by cancer and causing T cell infiltration of the tumors [\u003Ca id=\u0022xref-ref-1-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-1\u0022\u003E1\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-3-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-3\u0022\u003E3\u003C\/a\u003E]. These immune-related response patterns may not be captured by conventional tumor response criteria, such as RECIST and WHO criteria [\u003Ca id=\u0022xref-ref-16-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-16\u0022\u003E16\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-17-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-17\u0022\u003E17\u003C\/a\u003E]. Immune-related response criteria (irRC) have been proposed to better describe treatment results of immunotherapy, and the efforts have been made to further optimize the methods for immune-related response assessment [\u003Ca id=\u0022xref-ref-18-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-18\u0022\u003E18\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-19-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-19\u0022\u003E19\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003ETumors treated with anti-angiogenic therapy may benefit from incorporation of tumor density change on computed tomography (CT) measured in Hounsfield Unit (HU), as a marker for devascularization and necrosis in response to therapy [\u003Ca id=\u0022xref-ref-20-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-22-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E]. Furthermore, diameter changes smaller than the conventional threshold may represent response in these patients. Choi criteria defined response as \u0026acirc;\u0026#137;\u0026yen;10% diameter decrease or \u0026acirc;\u0026#137;\u0026yen;15% decrease in density in patients with gastrointestinal stromal tumors treated with imatinib, which correlate with disease-specific survival [\u003Ca id=\u0022xref-ref-20-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-22-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E]. In 40 GIST patients treated with imatinib, 32 patients met the Choi response criteria of either a more than 10% decrease in maximum diameter or a more than 15% decrease in tumor density at 2 months after treatment, and these 32 patients had significantly longer time to tumor progression compared to the remaining 8 patients without Choi response [\u003Ca id=\u0022xref-ref-22-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E]. Choi criteria have been used in renal cell carcinomas (RCC) and hepatomas treated with sunitinib that blocks multiple receptor tyrosine kinases including VEGF receptors [\u003Ca id=\u0022xref-ref-23-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-23\u0022\u003E23\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-24-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-24\u0022\u003E24\u003C\/a\u003E]. Among 26 advanced HCC patients, 17 patients (65.4%) were responders by Choi criteria and had a significantly longer TTP (7.5 months) compared with nonresponders (4.8 months; HR = 0.33, P = 0.0182).\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EIn RCC treated with anti-angiogenic therapy, another modified criteria called MASS (morphology, attenuation, size, and structure) criteria has been proposed, and define response as \u0026acirc;\u0026#137;\u0026yen;20% diameter decrease, or \u0026acirc;\u0026#137;\u0026yen;40HU density decrease, or marked central necrosis in predominantly solid enhancing lesion(s) [\u003Ca id=\u0022xref-ref-16-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-16\u0022\u003E16\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-25-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-25\u0022\u003E25\u003C\/a\u003E]. MASS criteria were recently studied in metastatic melanoma treated with bevacizumab with or without interferon, and shown to strongly predict progression-free survival (PFS) and OS [\u003Ca id=\u0022xref-ref-26-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E]. Given these prior observations and the recent promising phase 1 trial results, it is worthwhile to study tumor diameter and density changes, in addition to conventional tumor diameter changes, during the combined therapy of ipilimumab and bevacizumab in capturing tumor response and predicting outcome.\u003C\/p\u003E\u003Cp id=\u0022p-11\u0022\u003EThe purpose of the study is to investigate the tumor diameter and density changes on CT in advanced melanoma patients treated with ipilimumab plus bevacizumab, compare response rates at the first follow-up based on different response criteria incorporating tumor diameters and density, and study association between these measures and survival.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-6\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EResults and discussion\u003C\/h2\u003E\u003Cp id=\u0022p-12\u0022\u003EA total of 59 measurable lesions in 21 patients (median and mean number of lesions per patient: 2 and 2.8, respectively; range: 1-8) were included. Table \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003E1\u003C\/a\u003E summarizes demographics and disease characteristics of the 21 patients. There were 15 lung lesions, 14 peritoneal or retroperitoneal lesions, 11 liver, 9 subcutaneous, 5 nodes and 5 adrenal lesions.\n\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline table-callout-links\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u0022view-inline first\u0022\u003E\u003Ca href=\u0022##\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/6736\/expansion?postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022view-popup last\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/6736\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cp id=\u0022p-13\u0022 class=\u0022first-child\u0022\u003ESummary of patient characteristics and tumor measurements\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-7\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003ELesion-based analysis\u003C\/h3\u003E\u003Cp id=\u0022p-16\u0022\u003EThe median baseline diameter and density for the 59 lesions were 25 mm (range: 10-55) and 44.9 HU (range: 7.2-80.1). The median changes at the first follow-up were 10.7% (range: -64.7 to 102.6) for diameter, and -9.7% (range: -56.6 to 177.2) and -2.7HU (range: -31.0 to 28.3) for CT density. Figure \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003E1\u003C\/a\u003E demonstrates the percent changes of diameter and density in 59 lesions. Table \u003Ca id=\u0022xref-table-wrap-2-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T2\u0022\u003E2\u003C\/a\u003E summarizes the response by diameter and density of these lesions. No lesions met the density criteria by MASS, while 23 (39%) lesions met the Choi density criteria (\u0026acirc;\u0026#137;\u0026yen;15% density decrease). When diameter and density changes were combined, 4 lesions (7%) responded by RECIST, 9 lesions (15%) responded by MASS, and 29 lesions (49%) responded by Choi criteria.\n\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Scatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 59 lesions. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026ge;30% diameter decrease), by the orange dashed line for MASS (\u0026ge;20% diameter decrease), and by the purple dashed lines for Choi (\u0026ge;10% diameter decrease or \u0026ge;15% density decrease) criteria. No lesions met the density response criteria by MASS.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;Scatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 59 lesions. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026ge;30% diameter decrease), by the orange dashed line for MASS (\u0026ge;20% diameter decrease), and by the purple dashed lines for Choi (\u0026ge;10% diameter decrease or \u0026ge;15% density decrease) criteria. No lesions met the density response criteria by MASS.\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 1\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F1.medium.jpg\u0022 width=\u0022567\u0022 height=\u0022578\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 1\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F1.medium.jpg\u0022 width=\u0022567\u0022 height=\u0022578\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6554\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1\u003C\/span\u003E \u003Cp id=\u0022p-17\u0022 class=\u0022first-child\u0022\u003EScatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 59 lesions. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026acirc;\u0026#137;\u0026yen;30% diameter decrease), by the orange dashed line for MASS (\u0026acirc;\u0026#137;\u0026yen;20% diameter decrease), and by the purple dashed lines for Choi (\u0026acirc;\u0026#137;\u0026yen;10% diameter decrease or \u0026acirc;\u0026#137;\u0026yen;15% density decrease) criteria. No lesions met the density response criteria by MASS.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022T2\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline table-callout-links\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u0022view-inline first\u0022\u003E\u003Ca href=\u0022##\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/6761\/expansion?postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022view-popup last\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/6761\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cp id=\u0022p-18\u0022 class=\u0022first-child\u0022\u003EThe number of lesions meeting each response criteria\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-8\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EPatient-based analysis\u003C\/h3\u003E\u003Cp id=\u0022p-19\u0022\u003EThe baseline sum diameter and average density and their changes on the first follow-up scans are summarized in Table \u003Ca id=\u0022xref-table-wrap-1-2\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003E1\u003C\/a\u003E. Figure \u003Ca id=\u0022xref-fig-2-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F2\u0022\u003E2\u003C\/a\u003E demonstrates the percent changes of diameter and density in 21 patients. No patients met the density criteria by MASS, while 7 (33%, [95% CI: 15-57%]) patients met density response criteria by Choi (Table \u003Ca id=\u0022xref-table-wrap-3-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T3\u0022\u003E3\u003C\/a\u003E). When diameter and density changes are combined, 3 patients (14%, [95% CI: 3-36%]) responded by RECIST and MASS, and additional 8 patients responded by Choi criteria, resulting in a total of 11 Choi responders (52%, [95% CI: 30-74%]) (Figure \u003Ca id=\u0022xref-fig-3-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F3\u0022\u003E3\u003C\/a\u003E). None of the patients with response by these criteria developed new lesions at the time of the first follow-up scan. In 2 out of 13 patients with 2 or more lesions, discrepant CT density changes among lesions of the same patient was noted, with some lesions showing \u0026gt;15% density decrease and other lesions showing marked (i.e., \u0026gt;30%) increase in density. Both patients met the response by Choi density criteria when the average density was used to represent the overall change.\n\u003C\/p\u003E\u003Cdiv id=\u0022F2\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F2.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Scatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 21 patients. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026ge;30% diameter decrease), by the orange dashed line for MASS (\u0026ge;20% diameter decrease), and by the purple dashed lines for Choi (\u0026ge;10% diameter decrease or \u0026ge;15% density decrease) criteria. No patients met the density response criteria by MASS.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;Scatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 21 patients. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026ge;30% diameter decrease), by the orange dashed line for MASS (\u0026ge;20% diameter decrease), and by the purple dashed lines for Choi (\u0026ge;10% diameter decrease or \u0026ge;15% density decrease) criteria. No patients met the density response criteria by MASS.\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 2\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F2.medium.jpg\u0022 width=\u0022567\u0022 height=\u0022427\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 2\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F2.medium.jpg\u0022 width=\u0022567\u0022 height=\u0022427\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F2.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 2\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F2.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6609\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 2\u003C\/span\u003E \u003Cp id=\u0022p-20\u0022 class=\u0022first-child\u0022\u003EScatter plot of the percent changes of the tumor diameter and density on the first follow-up CT compared to the baseline CT in 21 patients. The cut-off values for response are indicated by the yellow dashed line for RECIST (\u0026acirc;\u0026#137;\u0026yen;30% diameter decrease), by the orange dashed line for MASS (\u0026acirc;\u0026#137;\u0026yen;20% diameter decrease), and by the purple dashed lines for Choi (\u0026acirc;\u0026#137;\u0026yen;10% diameter decrease or \u0026acirc;\u0026#137;\u0026yen;15% density decrease) criteria. No patients met the density response criteria by MASS.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022T3\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline table-callout-links\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u0022view-inline first\u0022\u003E\u003Ca href=\u0022##\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/6647\/expansion?postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022view-popup last\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/6647\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cp id=\u0022p-21\u0022 class=\u0022first-child\u0022\u003EThe number of patients meeting each response criteria\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022F3\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F3.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022A 61-year-old male with metastatic melanoma. Contrast-enhanced CT scan of the chest at baseline (A) demonstrate a lobulated right lower lobe mass measuring 37 mm and 54.3 HU (A, arrow). The follow-up scan (B) at 11.4 weeks of ipilimumab and bevacizumab therapy demonstrated the lesion measuring 36 mm and 44.4 HU (B, arrow). While the percent decrease of diameter was only 2%, CT density decreased by 18% comparing to baseline, meeting the Choi response criteria.\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;\u0026lt;div xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u0026gt;A 61-year-old male with metastatic melanoma. Contrast-enhanced CT scan of the chest at baseline \u0026lt;strong\u0026gt;(A)\u0026lt;\/strong\u0026gt; demonstrate a lobulated right lower lobe mass measuring 37 mm and 54.3 HU (A, arrow). The follow-up scan \u0026lt;strong\u0026gt;(B)\u0026lt;\/strong\u0026gt; at 11.4 weeks of ipilimumab and bevacizumab therapy demonstrated the lesion measuring 36 mm and 44.4 HU (B, arrow). While the percent decrease of diameter was only 2%, CT density decreased by 18% comparing to baseline, meeting the Choi response criteria.\u0026lt;\/div\u0026gt;\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 3\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F3.medium.jpg\u0022 width=\u0022358\u0022 height=\u0022127\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 3\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F3.medium.jpg\u0022 width=\u0022358\u0022 height=\u0022127\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F3.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 3\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F3.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6882\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 3\u003C\/span\u003E \u003Cp id=\u0022p-22\u0022 class=\u0022first-child\u0022\u003EA 61-year-old male with metastatic melanoma. Contrast-enhanced CT scan of the chest at baseline \u003Cstrong\u003E(A)\u003C\/strong\u003E demonstrate a lobulated right lower lobe mass measuring 37 mm and 54.3 HU (A, arrow). The follow-up scan \u003Cstrong\u003E(B)\u003C\/strong\u003E at 11.4 weeks of ipilimumab and bevacizumab therapy demonstrated the lesion measuring 36 mm and 44.4 HU (B, arrow). While the percent decrease of diameter was only 2%, CT density decreased by 18% comparing to baseline, meeting the Choi response criteria.\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-9\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EAssociation with survival\u003C\/h3\u003E\u003Cp id=\u0022p-23\u0022\u003EAt the time of analysis, 14 patients (67%) had progressed and 6 patients (29%) had died. The median follow-up was 29.7 months.\u003C\/p\u003E\u003Cdiv id=\u0022sec-10\u0022 class=\u0022subsection\u0022\u003E\u003Ch4\u003EBaseline diameter\/density vs. survival\u003C\/h4\u003E\u003Cp id=\u0022p-24\u0022\u003EBaseline diameter was significantly associated with PFS and OS, with larger baseline diameters having poorer outcomes. When patients were dichotomized at the median baseline diameter, which was 38 mm in this cohort, median PFS for patients with baseline diameter \u0026acirc;\u0026#137;\u0026curren;38 mm was 27.5 months compared with 4.1 months for those with diameter \u0026gt;38 mm (HR (high vs. low) 5.3, [95% CI 1.6 to 18], p = 0.007). Each 5 mm increase in baseline diameter increased the hazard of a PFS event by 14% (HR: 1.14, [95% CI 1.05-1.23], p = 0.001) (Figure \u003Ca id=\u0022xref-fig-4-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F4\u0022\u003E4\u003C\/a\u003E). Median OS was not reached for patients with diameter \u0026acirc;\u0026#137;\u0026curren;38 mm vs. 12.6 months for those with diameter \u0026gt;38 mm. No deaths occurred in patients with baseline diameters at or below the median. Each 5 mm increase in baseline diameter increase the hazard of death by 18% (HR = 1.18, [95% CI: 1.06-1.31], p = 0.003) (Figure \u003Ca id=\u0022xref-fig-5-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F5\u0022\u003E5\u003C\/a\u003E).\n\n\u003C\/p\u003E\u003Cdiv id=\u0022F4\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F4.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Progression-free survival in patients dichotomized using the median baseline diameter (38 mm).\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;Progression-free survival in patients dichotomized using the median baseline diameter (38 mm).\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 4\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F4.medium.jpg\u0022 width=\u0022472\u0022 height=\u0022352\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 4\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F4.medium.jpg\u0022 width=\u0022472\u0022 height=\u0022352\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F4.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 4\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F4.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6870\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 4\u003C\/span\u003E \u003Cp id=\u0022p-25\u0022 class=\u0022first-child\u0022\u003EProgression-free survival in patients dichotomized using the median baseline diameter (38 mm).\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022F5\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F5.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Overall survival in patients dichotomized using the median baseline diameter (38 mm).\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;Overall survival in patients dichotomized using the median baseline diameter (38 mm).\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 5\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F5.medium.jpg\u0022 width=\u0022472\u0022 height=\u0022351\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 5\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F5.medium.jpg\u0022 width=\u0022472\u0022 height=\u0022351\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F5.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 5\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F5.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6989\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 5\u003C\/span\u003E \u003Cp id=\u0022p-26\u0022 class=\u0022first-child\u0022\u003EOverall survival in patients dichotomized using the median baseline diameter (38 mm).\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-27\u0022\u003EBaseline density was not associated with PFS (HR (high vs. low) 1.3, [95% CI 0.4 to 3.6], p = 0.68) or with OS (HR (high vs. low) 0.7, 95% CI 0.1 to 4.0, p = 0.71).\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-11\u0022 class=\u0022subsection\u0022\u003E\u003Ch4\u003EDiameter\/density changes on the 1st follow-up and outcome\u003C\/h4\u003E\u003Cp id=\u0022p-28\u0022\u003EAmong the total of 21 patients, 5 patients had progressed at the 1\u003Csup\u003Est\u003C\/sup\u003E follow-up scan while 16 patients had not progressed. These 16 patients were assessed using a conditional landmark analysis at 11 weeks (the median time to the first scan in this group: 11.3 weeks; range: 11-12 weeks). The continuous Cox model, although limited by the small number of patients (N = 16), suggested that the percent increase of tumor diameter on the 1\u003Csup\u003Est\u003C\/sup\u003E follow-up scan result in shorter PFS and OS. Each 5% increase in diameter results in a 13% increase in the hazard of a subsequent PFS event (HR = 1.13, [95% CI: 0.94-1.36], p = 0.18). Each 1% increase in percent change in diameter increased the risk of death 1.5 times (HR = 1.49, [95% CI: 0.8-3.0], p = 0.25). Neither the percent nor absolute change in CT density influenced subsequent PFS (HR for each 5% density increase: 0.997 [95% CI: 0.88-1.14], p = 0.96; HR for each 1 HU density increase: 0.999 [95% CI: 0.94-1.06], p = 0.98) or OS (HR for each 5% density increase:1.08 [95% CI: 0.82-1.44], p = 0.57; HR for each 1 HU density increase: 1.05 [95% CI: 0.91-1.22], p = 0.51).\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-12\u0022 class=\u0022subsection\u0022\u003E\u003Ch4\u003EResponse by RECIST, MASS and Choi criteria vs survival\u003C\/h4\u003E\u003Cp id=\u0022p-29\u0022\u003ERECIST and MASS criteria yielded the same 3 responders and were summarized together. No significant PFS or OS differences were observed between RECIST\/MASS responders vs. non-responders (p = 0.45, 0.46, respectively). There was no significant PFS or OS difference between Choi responders vs. non-responders (p = 0.90, 0.94, respectively).\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-13\u0022 class=\u0022subsection\u0022\u003E\u003Ch4\u003EMeasurement variability\u003C\/h4\u003E\u003Cp id=\u0022p-30\u0022\u003EThe intra-observer agreement was high for both diameter and density measurements, with CCC of 0.9865 and 0.9967, respectively. The 95% limits of agreement were (-22.5, 15.5%) for the sum diameter, and were (-5.8, 6.5%) and (-2.3, 2.7HU) for the average density (Table \u003Ca id=\u0022xref-table-wrap-3-2\u0022 class=\u0022xref-table\u0022 href=\u0022#T3\u0022\u003E3\u003C\/a\u003E, Figure \u003Ca id=\u0022xref-fig-6-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F6\u0022\u003E6\u003C\/a\u003EA-B). The inter-observer agreement was high for both diameter and density measurements, with CCC of 0.9774 and 0.9934, respectively. The 95% limits of agreement were (-27.1, 26.7%) for the sum diameter, and were (-12.0, 8.3%) and (-4.1, 2.8HU) for the average density (Table \u003Ca id=\u0022xref-table-wrap-4-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T4\u0022\u003E4\u003C\/a\u003E, Figure \u003Ca id=\u0022xref-fig-6-2\u0022 class=\u0022xref-fig\u0022 href=\u0022#F6\u0022\u003E6\u003C\/a\u003EC-D).\n\u003C\/p\u003E\u003Cdiv id=\u0022F6\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F6.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Intra- and inter-observer variability of diameter and density measurements. Bland-Altman plots demonstrate the variability of density and diameter measurements (A, B for intra-observer, C, D for inter-observer, respectively). The relative difference (%) in two independent measurements for each patient is plotted against the first measurement by Radiologist 1. The straight lines represent the mean relative difference (%), and the dotted lines represent the upper and lower 95% limits of agreement (%).\u0022 class=\u0022highwire-fragment fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-236191646\u0022 data-figure-caption=\u0027\u0026lt;div class=\u0022highwire-markup\u0022\u0026gt;\u0026lt;div xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u0026gt;Intra- and inter-observer variability of diameter and density measurements. Bland-Altman plots demonstrate the variability of density and diameter measurements (\u0026lt;strong\u0026gt;A\u0026lt;\/strong\u0026gt;, \u0026lt;strong\u0026gt;B\u0026lt;\/strong\u0026gt; for intra-observer, \u0026lt;strong\u0026gt;C\u0026lt;\/strong\u0026gt;, \u0026lt;strong\u0026gt;D\u0026lt;\/strong\u0026gt; for inter-observer, respectively). The relative difference (%) in two independent measurements for each patient is plotted against the first measurement by Radiologist 1. The straight lines represent the mean relative difference (%), and the dotted lines represent the upper and lower 95% limits of agreement (%).\u0026lt;\/div\u0026gt;\u0026lt;\/div\u0026gt;\u0027 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022hw-responsive-img\u0022\u003E\u003Cimg class=\u0022highwire-fragment fragment-image lazyload\u0022 alt=\u0022Figure 6\u0022 src=\u0022data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\u0022 data-src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F6.medium.jpg\u0022 width=\u0022778\u0022 height=\u0022583\u0022\u003E\u003Cnoscript\u003E\u003Cimg class=\u0022highwire-fragment fragment-image\u0022 alt=\u0022Figure 6\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F6.medium.jpg\u0022 width=\u0022778\u0022 height=\u0022583\u0022\u003E\u003C\/noscript\u003E\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u0022download-fig first\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F6.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 6\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022new-tab\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/F6.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022download-ppt last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/6844\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 6\u003C\/span\u003E \u003Cp id=\u0022p-31\u0022 class=\u0022first-child\u0022\u003EIntra- and inter-observer variability of diameter and density measurements. Bland-Altman plots demonstrate the variability of density and diameter measurements (\u003Cstrong\u003EA\u003C\/strong\u003E, \u003Cstrong\u003EB\u003C\/strong\u003E for intra-observer, \u003Cstrong\u003EC\u003C\/strong\u003E, \u003Cstrong\u003ED\u003C\/strong\u003E for inter-observer, respectively). The relative difference (%) in two independent measurements for each patient is plotted against the first measurement by Radiologist 1. The straight lines represent the mean relative difference (%), and the dotted lines represent the upper and lower 95% limits of agreement (%).\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022T4\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline table-callout-links\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u0022view-inline first\u0022\u003E\u003Ca href=\u0022##\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/7007\/expansion?postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022view-popup last\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/7007\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cp id=\u0022p-32\u0022 class=\u0022first-child\u0022\u003EIntra- and inter-observer variability of measurements in 21 patients\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section discussion\u0022 id=\u0022sec-14\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EDiscussion\u003C\/h2\u003E\u003Cp id=\u0022p-33\u0022\u003EThe present study demonstrated that \u0026acirc;\u0026#137;\u0026yen;15% tumor density decrease by Choi criteria was noted in one third of the advanced melanoma patients treated with ipilimumab plus bevacizumab combination therapy at their first follow-up CT. Larger baseline diameter was strongly associated with shorter PFS and OS, however, diameter and density changes or responses by RECIST, MASS, or Choi criteria at the first follow-up were not associated with survival. While density decrease is a relatively common phenomenon in advanced melanoma treated with ipilimumab plus bevacizumab, further studies are needed to define its role in assessing anti-cancer activity and therapeutic benefit of the agents and to identify objective imaging marker that can predict outcome during the combined immunotherapy and anti-angiogenic therapy.\u003C\/p\u003E\u003Cp id=\u0022p-34\u0022\u003EThe degree of diameter and density changes in our cohort were similar to the previous report by Gray et al. in their study of metastatic melanoma patients treated with bevacizumab with or without interferon, which reported the average of 2% diameter change and -7% density change [\u003Ca id=\u0022xref-ref-26-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E]. No lesions or patients in our study met the density response criteria by MASS, indicating that such a marked decrease in density is a rare phenomenon among melanoma patients receiving ipilimumab plus bevacizumab. Our observation is similar with the report by Gary et al., which had only 1 out of 118 lesions showing marked central necrosis [\u003Ca id=\u0022xref-ref-26-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E]. Density decrease \u0026acirc;\u0026#137;\u0026yen;40HU were more frequent in their cohort (6\/118 lesions (5%) and 6\/44 patients (14%)), which could be due to the different therapeutic regimen in the prior report where the majority (39\/44, 89%) of the patients received interferon in addition to bevacizumab [\u003Ca id=\u0022xref-ref-26-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-35\u0022\u003EWhen three different criteria for response were used for 59 lesions, the lesion-based response rate was 7% (4\/59) by RECIST, 15% (9\/59) by MASS, and 49% (29\/59) by Choi criteria. For the patient-based analysis, the response rate was 14% (3\/21) by RECIST and MASS, and 52% (11\/21) by Choi (4 patients responding by diameter decrease, 5 patients by density decrease and 2 patients meeting both diameter and density criteria). The increase in response rate by applying the Choi density criteria indicates that CT density decrease may be a sequela of the anti-cancer activity of ipilimumab and bevacizumab therapy. Similar increase of response rate was noted in the prior study, in which response rates at the first follow-up CT were 7% (3\/44) for RECIST, 14% (6\/44) for MASS, and 34% (15\/44) for Choi criteria [\u003Ca id=\u0022xref-ref-26-5\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-36\u0022\u003EHeterogeneous changes of CT density within same patient were noted in 15% (2\/13) among the patients with more than 1 lesion, while overall assessment using the average density met Choi density response criteria in both patients. Tumoral heterogeneity is an important issue in assessing response to targeted therapy [\u003Ca id=\u0022xref-ref-27-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-27\u0022\u003E27\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-28-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-28\u0022\u003E28\u003C\/a\u003E], and the quantitative imaging approach to address this issue remain to be established. The current standard approach including the one used in the present study relies on a certain number of representative lesions to demonstrate systemic tumor burden changes, which is associated with inherent limitations. Further studies are needed to assess the frequency and impact of heterogeneous density changes during therapy.\u003C\/p\u003E\u003Cp id=\u0022p-37\u0022\u003EWhile different definitions of response can give rise to different rates of response, these modified definitions of response need to be validated by studying association with outcome. The alternate definitions are of great clinical significance if they can differentiate responders with survival benefit more accurately than the conventional definitions. In our study, baseline diameter was the only significant predictor of PFS and OS; other measures including baseline density and diameter\/density changes at the first follow-up were not significantly associated with survival. Univariate Cox models suggested that the percent increase of tumor diameter on the 1\u003Csup\u003Est\u003C\/sup\u003E follow-up scan may result in shorter PFS and OS; however, these results need to be viewed cautiously given the small number of patients and events. None of the three response criteria (RECIST, MASS and Choi criteria) differentiated patients with longer survival at the first follow-up scan, indicating the need to further studies to identify objective markers that can predict survival at the early course of therapy to guide therapeutic decisions. Given the unique mechanism of anti-cancer activity of ipilimumab, the density changes in the present cohort may be at least in part due to infiltration of tumor by immune cells. Future investigations may also focus on the biological background of the density changes, as well as the comparison of tumor density among cohorts receiving ipilimumab alone, bevacizumab alone and the combination.\u003C\/p\u003E\u003Cp id=\u0022p-38\u0022\u003ETumor density changes have been extensively studied in the context of anti-angiogenic therapy to improve strategy for tumor response evaluation [\u003Ca id=\u0022xref-ref-20-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-21-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-21\u0022\u003E21\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-23-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-23\u0022\u003E23\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-25-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-25\u0022\u003E25\u003C\/a\u003E]. Recently, immune-related responses have been investigated based on tumor size changes [\u003Ca id=\u0022xref-ref-17-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-17\u0022\u003E17\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-19-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-19\u0022\u003E19\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-29-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-29\u0022\u003E29\u003C\/a\u003E]. The present study represents the first attempt to further optimize the existing tumor response criteria specifically for combined therapy using anti-angiogenic agents and immunomodulating agents, which will be more frequently used in treatment of advanced cancer in the near future.\u003C\/p\u003E\u003Cp id=\u0022p-39\u0022\u003EGary et al. reported that MASS response at the first follow-up strongly predicted PFS and OS [\u003Ca id=\u0022xref-ref-26-6\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E]. The different results between 2 studies may be due to the different regimen. Our study also had only 3 MASS responders. High baseline serum lactate dehydrogenase (LDH) level was also associated with survival in their study [\u003Ca id=\u0022xref-ref-26-7\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E]. In our cohort, stratification according to elevated baseline LDH was not possible since there were only 2 patients with elevated levels. The association between baseline measures and survival was not mentioned in the prior study [\u003Ca id=\u0022xref-ref-26-8\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-26\u0022\u003E26\u003C\/a\u003E].\u003C\/p\u003E\u003Cp id=\u0022p-40\u0022\u003EOur study demonstrated high intra- and inter-observer agreement for both diameter and density measurements. Based on the 95% limits of agreement, 15% density decrease was beyond the intra- and inter-observer measurement variability in our cohort. However, 10% diameter decrease was within the 95% limits of intra- and inter-observer agreement, alerting the possibility of misclassification by measurement error when applying Choi criteria [\u003Ca id=\u0022xref-ref-30-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-30\u0022\u003E30\u003C\/a\u003E]. Intra-observer variability was narrower than inter-observer variability for both diameter and density, indicating the measurements by same reader on baseline and follow-up scans help to decrease misclassification. Given nearly two thirds of Choi responders (7\/11, 64%) responded by density criteria regardless of the diameter changes, it may worthwhile to see if adding the density criteria to the conventional RECIST diameter criteria (\u0026acirc;\u0026#137;\u0026yen;30% decrease) may better identify patients with therapeutic benefit while avoiding misclassification.\u003C\/p\u003E\u003Cp id=\u0022p-41\u0022\u003EThe limitations of the present study include retrospective design and a small number of patients treated at a single institution. Due to the design of the phase 1 trial, the doses of ipilimumab and bevacizumab varied among the patients in the small cohort. The study reports the initial observations of tumor diameter and density changes during ipilimumab and bevacizumab therapy, which needs to be studied further in larger cohorts. The study also focused on the tumor changes at the first follow-up study; the role of serial measurements of diameter and density in defining progression and treatment failure remain to be investigated. The serial CT density measurements may also help to identify cases with delayed response to immunotherapy. In addition, the serial measurements will provide an opportunity to assess the impact of immune-related response assessment incorporating new lesions into the measurements in comparison with the conventional RECIST based approach in the assessment of CT tumor density.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section conclusions\u0022 id=\u0022sec-15\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EConclusions\u003C\/h2\u003E\u003Cp id=\u0022p-42\u0022\u003EIn conclusion, tumor density decrease meeting Choi criteria (\u0026acirc;\u0026#137;\u0026yen;15 % decrease) was relatively common during ipilimumab plus bevacizumab combination therapy for advanced melanoma, noted in one-third of the patients. Larger baseline tumor diameter was strongly associated with shorter survival; however, diameter and density changes at the first follow-up or responses by RECIST, MASS or Choi criteria were not associated with survival in these patients. The role of density changes in evaluating anti-cancer activity and therapeutic benefit of these agents remain to be further studied in a larger cohort.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section methods\u0022 id=\u0022sec-16\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EMethods\u003C\/h2\u003E\u003Cdiv id=\u0022sec-17\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EPatients\u003C\/h3\u003E\u003Cp id=\u0022p-43\u0022\u003EThe study included 21 advanced melanoma patients (14 males, 7 females; median age: 53 years, age range: 25-68) treated in a phase 1 trial of ipilimumab plus bevacizumab at the Dana-Farber Cancer Institute [\u003Ca id=\u0022xref-ref-15-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-15\u0022\u003E15\u003C\/a\u003E]. All patients had baseline CT and at least one follow-up CT using iodinated intravenous contrast agents, and had at least one measurable lesion (\u0026acirc;\u0026#137;\u0026yen;10 mm longest diameters for non-nodal lesions, \u0026acirc;\u0026#137;\u0026yen;15 mm in short axis for lymph nodes [\u003Ca id=\u0022xref-ref-31-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-31\u0022\u003E31\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-32-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-32\u0022\u003E32\u003C\/a\u003E]). Patients were treated with ipilimumab with four doses at 3-week intervals and then every 12 weeks, and bevacizumab every 3 weeks [\u003Ca id=\u0022xref-ref-15-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-15\u0022\u003E15\u003C\/a\u003E]. The protocol was approved by the Institutional Review Board of the Dana-Farber Cancer Institute, and all patients provided written informed consent. The clinical trial results including survival and adverse events of the entire multicenter cohort have been previously reported [\u003Ca id=\u0022xref-ref-15-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-15\u0022\u003E15\u003C\/a\u003E].\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-18\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003ECT tumor measurements\u003C\/h3\u003E\u003Cp id=\u0022p-44\u0022\u003EThe standard clinical protocol for body CT at the Dana-Farber Cancer Institute used a 64-row MDCT scanner (Aquilion 64; Toshiba America Medical Systems, CA). Patients are scanned in the supine position from the cranial to caudal direction from the clavicles to the pubic symphysis at end-inspiration. During the study, 100 mL of iopromid (Ultravist 300, 300 mg iodine\/mL; Bayer HealthCare Pharmaceuticals Inc. Wayne, NJ) is injected intravenously at a rate of 3 mL\/sec, with a scan delay of 30 seconds for chest and 70 seconds for abdomen (portal venous phase). Axial images (5 mm thickness) were reconstructed and transferred to a Picture Archiving Communication System (PACS) workstation (Centricity, General Electric, Milwaukee,WI).\u003C\/p\u003E\u003Cp id=\u0022p-45\u0022\u003EBaseline CT scans prior to initiation of therapy (median time between baseline scan and initiation of therapy: 1.0 week; range: 0.3-3.0 weeks) were retrospectively reviewed by a board-certified radiologist with expertise in oncologic imaging (M.N.). All measurable lesions in each patient were selected, regardless of the number of lesions in total or per organ, in order to evaluate heterogeneity among lesions within the same patient [\u003Ca id=\u0022xref-ref-28-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-28\u0022\u003E28\u003C\/a\u003E]. The exception included 2 patients with innumerable (\u0026gt;20) lesions in one organ (lung in one patient and liver in other), in whom the largest 5 lesions within the organ (lung\/liver) were selected, in addition to all the measurable lesions in other organs.\u003C\/p\u003E\u003Cp id=\u0022p-46\u0022\u003EThe diameters (mm; the longest diameters for non-nodal lesions and short axis for nodes) and density (HU) were measured for all lesions on contrast-enhanced CT images on baseline scans and on the first follow-up scans (median time to the first follow-up scan: 11.3 weeks). Diameters were measured using a caliper-type measurement tool on PACS workstation [\u003Ca id=\u0022xref-ref-33-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-33\u0022\u003E33\u003C\/a\u003E]. The CT attenuation was measured using an oval region of interest covering the maximum area of each lesion excluding the surrounding structures [\u003Ca id=\u0022xref-ref-34-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-34\u0022\u003E34\u003C\/a\u003E]. Three lesions (2 lung and 1 subcutaneous lesions) demonstrated \u0026lt;0 HU at baseline due to partial volume effects, which were ineligible for the study and excluded.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-19\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EDiameter and density changes on follow-up\u003C\/h3\u003E\u003Cp id=\u0022p-47\u0022\u003EThe percent changes of diameter and CT density were calculated on the follow-up scan in reference to the baseline [\u003Ca id=\u0022xref-ref-35-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-35\u0022\u003E35\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-36-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-36\u0022\u003E36\u003C\/a\u003E]. For CT density, the absolute change (HU) was also calculated. For lesion-based analysis, the diameter and density measurements of each lesion were used. For patient-based analysis, the sum of the diameters and the average of CT density were used to represent baseline and follow-up measurements [\u003Ca id=\u0022xref-ref-20-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-22-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-36-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-36\u0022\u003E36\u003C\/a\u003E]; for those who had \u0026gt;5 lesions in total and \u0026gt;2 lesions per organ, up to 5 largest lesions in total and up to 2 largest lesions per organ were chosen according to RECIST1.1, based on the baseline measurements.\u003C\/p\u003E\u003Cp id=\u0022p-48\u0022\u003EResponse was assigned for each lesion and each patient, based on RECIST (\u0026acirc;\u0026#137;\u0026yen;30% decrease in diameter) [\u003Ca id=\u0022xref-ref-31-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-31\u0022\u003E31\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-32-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-32\u0022\u003E32\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-37-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-37\u0022\u003E37\u003C\/a\u003E], MASS (\u0026acirc;\u0026#137;\u0026yen;20% decrease in diameter or \u0026acirc;\u0026#137;\u0026yen;40HU decrease in density or marked central necrosis) [\u003Ca id=\u0022xref-ref-25-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-25\u0022\u003E25\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-38-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-38\u0022\u003E38\u003C\/a\u003E] and Choi criteria (\u0026acirc;\u0026#137;\u0026yen;10% decrease in diameter or \u0026acirc;\u0026#137;\u0026yen;15% decrease in density) [\u003Ca id=\u0022xref-ref-20-5\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-20\u0022\u003E20\u003C\/a\u003E]-[\u003Ca id=\u0022xref-ref-22-5\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-22\u0022\u003E22\u003C\/a\u003E] (Table \u003Ca id=\u0022xref-table-wrap-5-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T5\u0022\u003E5\u003C\/a\u003E).\n\u003C\/p\u003E\u003Cdiv id=\u0022T5\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline table-callout-links\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u0022view-inline first\u0022\u003E\u003Ca href=\u0022##\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/6664\/expansion?postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\n\u003Cli class=\u0022view-popup last\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/6664\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_tables%2Chighwire_reclass%2Chighwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\n\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cp id=\u0022p-49\u0022 class=\u0022first-child\u0022\u003ESummary of tumor response assessment and definitions for RECIST, Choi and MASS criteria\u003C\/p\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-20\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EMeasurement variability\u003C\/h3\u003E\u003Cp id=\u0022p-53\u0022\u003ETo assess measurement variability, two board-certified radiologists (Radiologist 1: M.N. and Radiologist 2: N.H.R.) independently measured the diameter and density of all lesions on baseline scans, without access to other radiologist\u0026acirc;\u0026#128;\u0026#153;s measurements, as described previously [\u003Ca id=\u0022xref-ref-18-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-18\u0022\u003E18\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-19-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-19\u0022\u003E19\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-36-3\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-36\u0022\u003E36\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-39-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-39\u0022\u003E39\u003C\/a\u003E]. Radiologist 1 performed measurements twice with one week interval, without access to the prior measurements.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv id=\u0022sec-21\u0022 class=\u0022subsection\u0022\u003E\u003Ch3\u003EStatistical analysis\u003C\/h3\u003E\u003Cp id=\u0022p-54\u0022\u003EDescriptive methods were used to summarize patient demographic and disease characteristics. Measurements on a continuous scale were summarized using mean, median, standard deviation, and range. Categorical characteristics were summarized using percentages and 95% exact binomial confidence intervals. The distributions of progression-free survival (PFS) and overall survival (OS) were assessed using the product-limit method of Kaplan-Meier, with 95% confidence intervals (CI) estimated using log [-log (outcome)] methodology. To investigate the association between baseline diameter\/density and outcome, PFS and OS were compared between 2 groups dichotomized at the median baseline diameter (38 mm) or density (43.2 HU). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals; p-values are based on the Wald chi-squared statistic. In addition, univariate Cox proportional hazard models were used to estimate the effects on outcome of 5 mm increments in baseline diameter or 5 HU increments in baseline density. Eleven-week conditional landmark analyses were used to evaluate differences in outcome according to response or changes in diameter or density.\u003C\/p\u003E\u003Cp id=\u0022p-55\u0022\u003EAll p-values were two-sided, with statistical significance defined as P \u0026lt;0.05. There were no corrections for multiple comparisons.\u003C\/p\u003E\u003Cp id=\u0022p-56\u0022\u003EIntra- and inter-observer variability were assessed using concordance correlation coefficients (CCCs), mean relative difference and 95% limits of agreement. CCCs are products of a measure of precision and a measure of accuracy where CCC value 1 indicates perfect agreement and -1 indicates perfect reversed agreement [\u003Ca id=\u0022xref-ref-40-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-40\u0022\u003E40\u003C\/a\u003E]. The mean relative difference (%) between the two measurements is defined as 100*[M\u003Csub\u003E1\u003C\/sub\u003E-M\u003Csub\u003E2\u003C\/sub\u003E]\/M\u003Csub\u003E1\u003C\/sub\u003E (M\u003Csub\u003E1\u003C\/sub\u003E = measurement 1, M\u003Csub\u003E2\u003C\/sub\u003E = measurement 2). Bland-Altman plots were used to visually demonstrate the variability between the two measurements [\u003Ca id=\u0022xref-ref-36-4\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-36\u0022\u003E36\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-39-2\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-39\u0022\u003E39\u003C\/a\u003E],[\u003Ca id=\u0022xref-ref-41-1\u0022 class=\u0022xref-bibr\u0022 href=\u0022#ref-41\u0022\u003E41\u003C\/a\u003E]. Two measurements of Radiologist 1 were used to assess intra-observer variability. The first measurement of Radiologist 1 and the measurement by Radiologist 2 were used to evaluate inter-observer variability.\u003C\/p\u003E\u003Cp id=\u0022p-57\u0022\u003EBoth survival and measurement variability were assessed according to patient-based analyses, using the sum diameters and the average density for each patient.\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-22\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EAuthors\u0026acirc;\u0026#128;\u0026#153; contributions\u003C\/h2\u003E\u003Cp id=\u0022p-58\u0022\u003EMN: Conception and study design, data acquisition and review of the images and measurements, statistical analysis and interpretation of data, drafting and revising the manuscript. NHR: Conception and study design, data acquisition and review of the images and measurements, interpretation of data, drafting and revising the manuscript. GH: Data acquisition, statistical analysis and interpretation of data, drafting and revising the manuscript. FSH: Conception and study design, data acquisition, interpretation of data, drafting and revising the manuscript. All authors read and approved the final manuscript.\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section ack\u0022 id=\u0022ack-1\u0022\u003E\u003Ch2\u003EAcknowledgments\u003C\/h2\u003E\u003Cp id=\u0022p-59\u0022\u003EThe investigator, MN, was supported by 1K23CA157631 (NCI).\u003C\/p\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section app\u0022 id=\u0022app-1\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EAuthors\u0026acirc;\u0026#128;\u0026#153; original submitted files for images\u003C\/h2\u003E\u003Cp id=\u0022p-64\u0022\u003EBelow are the links to the authors\u0026acirc;\u0026#128;\u0026#153; original submitted files for images.\u003C\/p\u003E\u003Cdiv id=\u0022DC1\u0022 class=\u0022supplementary-material local-data\u0022\u003E\u003Cspan class=\u0022inline-linked-media-wrapper\u0022\u003E\u003Cspan id=\u0022DC1\u0022 class=\u0022inline-linked-media\u0022\u003E\u003Ca 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id=\u0022DC3\u0022 class=\u0022supplementary-material local-data\u0022\u003E\u003Cspan class=\u0022inline-linked-media-wrapper\u0022\u003E\u003Cspan id=\u0022DC3\u0022 class=\u0022inline-linked-media\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/DC3\/embed\/media-3.gif?download=true\u0022 class=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022icon-download-alt\u0022\u003E\u003C\/span\u003E[40425_2014_40_MOESM3_ESM.gif]\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n\u003Cdiv id=\u0022DC4\u0022 class=\u0022supplementary-material local-data\u0022\u003E\u003Cspan class=\u0022inline-linked-media-wrapper\u0022\u003E\u003Cspan id=\u0022DC4\u0022 class=\u0022inline-linked-media\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/DC4\/embed\/media-4.gif?download=true\u0022 class=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022icon-download-alt\u0022\u003E\u003C\/span\u003E[40425_2014_40_MOESM4_ESM.gif]\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n\u003Cdiv id=\u0022DC5\u0022 class=\u0022supplementary-material local-data\u0022\u003E\u003Cspan class=\u0022inline-linked-media-wrapper\u0022\u003E\u003Cspan id=\u0022DC5\u0022 class=\u0022inline-linked-media\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/DC5\/embed\/media-5.gif?download=true\u0022 class=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022icon-download-alt\u0022\u003E\u003C\/span\u003E[40425_2014_40_MOESM5_ESM.gif]\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n\u003Cdiv id=\u0022DC6\u0022 class=\u0022supplementary-material local-data\u0022\u003E\u003Cspan class=\u0022inline-linked-media-wrapper\u0022\u003E\u003Cspan id=\u0022DC6\u0022 class=\u0022inline-linked-media\u0022\u003E\u003Ca href=\u0022http:\/\/www.highwirestage.com\/content\/jitc\/2\/1\/40\/DC6\/embed\/media-6.gif?download=true\u0022 class=\u0022\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cspan class=\u0022icon-download-alt\u0022\u003E\u003C\/span\u003E[40425_2014_40_MOESM6_ESM.gif]\u003C\/a\u003E\u003C\/span\u003E\u003C\/span\u003E\u003C\/div\u003E\n\u003C\/div\u003E\u003Cdiv class=\u0022section glossary\u0022\u003E\u003Cdl id=\u0022def-list-1\u0022\u003E\u003Cdl id=\u0022def-list-2\u0022\u003E\u003Cdt id=\u0022def-item-1\u0022\u003EOS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EOverall survival\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-2\u0022\u003EPD-1\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EProgram death-1\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-3\u0022\u003EVEGF\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EVascular endothelial growth factor\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-4\u0022\u003ERECIST\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EResponse evaluation criteria in solid tumors\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-5\u0022\u003EWHO\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EWorld Health Organization\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-6\u0022\u003EirRC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EImmune-related response criteria\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-7\u0022\u003ECT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EComputed tomography\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-8\u0022\u003EHU\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EHounsfield unit\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-9\u0022\u003ERCC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ERenal cell carcinomas\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-10\u0022\u003EMASS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EMorphology, attenuation, size, and structure\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-11\u0022\u003EPFS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EProgression-free survival\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-12\u0022\u003ELDH\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ELactate dehydrogenase\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-13\u0022\u003EMDCT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EMulti-row detector CT\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-14\u0022\u003EPACS\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EPicture Archiving Communication System\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-15\u0022\u003ECI\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EConfidence intervals\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-16\u0022\u003EHR\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EHazard ratios\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-17\u0022\u003ECCC\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EConcordance correlation coefficient\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-18\u0022\u003EGT\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003EGreater than\u003Cspan class=\u0022def-item-dd-sep\u0022\u003E\u003C\/span\u003E\u003C\/dd\u003E\u003Cdt id=\u0022def-item-19\u0022\u003ELE\u003Cspan class=\u0022def-item-dt-sep\u0022\u003E\u003C\/span\u003E\u003C\/dt\u003E\u003Cdd\u003ELess than or equal to\u003C\/dd\u003E\u003C\/dl\u003E\u003C\/dl\u003E\u003C\/div\u003E\u003Cdiv class=\u0022section ref-list\u0022 id=\u0022ref-list-1\u0022\u003E\u003Ch2 class=\u0022\u0022\u003EReferences\u003C\/h2\u003E\u003Col class=\u0022cit-list ref-use-labels\u0022\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E1.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-1-1\u0022 title=\u0022View reference 1. in text\u0022 id=\u0022ref-1\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.1\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMihm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESoiffer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHaluska\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EButler\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESeiden\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMV\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDavis\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHenry-Spires\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMacRae\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWillman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPadera\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJaklitsch\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShankar\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKorman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAllison\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDranoff\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EBiologic activity of cytotoxic t lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EProc Natl Acad Sci U S A\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2003\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E100\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E4712\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E4717\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1073\/pnas.0830997100\u0022\u003Edoi:10.1073\/pnas.0830997100\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E153621\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DProc%2BNatl%2BAcad%2BSci%2BU%2BS%2BA%26rft.volume%253D100%26rft.spage%253D4712%26rft_id%253Dinfo%253Apmid%252F12682289%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=12682289\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E2.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-2-1\u0022 title=\u0022View reference 2. in text\u0022 id=\u0022ref-2\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.2\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EOble\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDrappatz\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVelazquez\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamakrishna\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDay\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKruse\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMac Rae\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHoos\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMihm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ECtla-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the cns\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ENat Clin Pract Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2008\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E5\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E557\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E561\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1038\/ncponc1183\u0022\u003Edoi:10.1038\/ncponc1183\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DNat%2BClin%2BPract%2BOncol%26rft.volume%253D5%26rft.spage%253D557%26rft_id%253Dinfo%253Apmid%252F18665147%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=18665147\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E3.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-3-1\u0022 title=\u0022View reference 3. in text\u0022 id=\u0022ref-3\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.3\u0022 data-doi=\u002210.1056\/NEJMoa1003466\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EO\u0026acirc;\u0026#128;\u0026#153;Day\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcDermott\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWeber\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESosman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHaanen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGonzalez\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERobert\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESchadendorf\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHassel\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJC\u003C\/span\u003E\n\u003C\/span\u003E, 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\u003Cspan class=\u0022cit-name-given-names\u0022\u003ECH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELebbe\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPeschel\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EQuirt\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EClark\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWolchok\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWeber\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYellin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENichol\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHoos\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EUrba\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWJ\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EImproved survival with ipilimumab in patients with metastatic melanoma\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EN Engl J Med\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E363\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E711\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E723\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1056\/NEJMoa1003466\u0022\u003Edoi:10.1056\/NEJMoa1003466\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3549297\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D363%26rft.spage%253D711%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1003466%26rft_id%253Dinfo%253Apmid%252F20525992%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1056\/NEJMoa1003466\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20525992\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=000280996600005\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E4.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-4-1\u0022 title=\u0022View reference 4. in text\u0022 id=\u0022ref-4\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.4\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELynch\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBondarenko\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELuft\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESerwatowski\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBarlesi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChacko\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESebastian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENeal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECuillerot\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EReck\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EIpilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage iiib\/iv non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase ii study\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2012\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E30\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2046\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E2054\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1200\/JCO.2011.38.4032\u0022\u003Edoi:10.1200\/JCO.2011.38.4032\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BClin%2BOncol%26rft.volume%253D30%26rft.spage%253D2046%26rft_id%253Dinfo%253Apmid%252F22547592%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=22547592\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E5.\u003C\/span\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal no-rev-xref\u0022 id=\u0022cit-2.1.40.5\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EReck\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBondarenko\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELuft\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESerwatowski\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBarlesi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChacko\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESebastian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECuillerot\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELynch\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETJ\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EIpilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAnn Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E24\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E75\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E83\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1093\/annonc\/mds213\u0022\u003Edoi:10.1093\/annonc\/mds213\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAnn%2BOncol%26rft.volume%253D24%26rft.spage%253D75%26rft_id%253Dinfo%253Apmid%252F22858559%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=22858559\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E6.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-6-1\u0022 title=\u0022View reference 6. in text\u0022 id=\u0022ref-6\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.6\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKwon\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDrake\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EScher\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFizazi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBossi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003Evan den Eertwegh\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKrainer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHouede\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESantos\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMahammedi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENg\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMaio\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFranke\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESundar\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAgarwal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBergman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECiuleanu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKorbenfeld\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESengelov\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHansen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELogothetis\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBeer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcHenry\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGagnier\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELiu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGerritsen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWR\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EIpilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (ca184-043): a multicentre, randomised, double-blind, phase 3 trial\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ELancet Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E15\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E700\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E712\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/S1470-2045(14)70189-5\u0022\u003Edoi:10.1016\/S1470-2045(14)70189-5\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4418935\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DLancet%2BOncol%26rft.volume%253D15%26rft.spage%253D700%26rft_id%253Dinfo%253Apmid%252F24831977%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24831977\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E7.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-7-1\u0022 title=\u0022View reference 7. in text\u0022 id=\u0022ref-7\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.7\u0022 data-doi=\u002210.1056\/NEJMoa1200690\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETopalian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBrahmer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGettinger\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESmith\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcDermott\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPowderly\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarvajal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESosman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAtkins\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELeming\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESpigel\u003C\/span\u003E\n \u003Cspan 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class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESharfman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAnders\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETaube\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcMiller\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EXu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKorman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJure-Kunkel\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAgrawal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcDonald\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKollia\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGupta\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWigginton\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESznol\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESafety, activity, and immune correlates of anti-pd-1 antibody in cancer\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EN Engl J Med\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2012\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E366\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2443\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E2454\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1056\/NEJMoa1200690\u0022\u003Edoi:10.1056\/NEJMoa1200690\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3544539\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D366%26rft.spage%253D2443%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1200690%26rft_id%253Dinfo%253Apmid%252F22658127%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1056\/NEJMoa1200690\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=22658127\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E8.\u003C\/span\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal no-rev-xref\u0022 id=\u0022cit-2.1.40.8\u0022 data-doi=\u002210.1056\/NEJMoa1302369\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWolchok\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKluger\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECallahan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPostow\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERizvi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELesokhin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESegal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAriyan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGordon\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EReed\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBurke\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECaldwell\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKronenberg\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAgunwamba\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBU\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZhang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EX\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELowy\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EInzunza\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFeely\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHorak\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHong\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EQ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKorman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWigginton\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGupta\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESznol\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ENivolumab plus ipilimumab in advanced melanoma\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EN Engl J Med\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E369\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E122\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E133\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1056\/NEJMoa1302369\u0022\u003Edoi:10.1056\/NEJMoa1302369\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D369%26rft.spage%253D122%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1302369%26rft_id%253Dinfo%253Apmid%252F23724867%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1056\/NEJMoa1302369\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23724867\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E9.\u003C\/span\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal no-rev-xref\u0022 id=\u0022cit-2.1.40.9\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETopalian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESznol\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcDermott\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKluger\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarvajal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESharfman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBrahmer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELawrence\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAtkins\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPowderly\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELeming\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELipson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPuzanov\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESmith\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETaube\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWigginton\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKollia\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGupta\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPardoll\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESosman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESurvival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E32\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1020\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1030\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1200\/JCO.2013.53.0105\u0022\u003Edoi:10.1200\/JCO.2013.53.0105\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BClin%2BOncol%26rft.volume%253D32%26rft.spage%253D1020%26rft_id%253Dinfo%253Apmid%252F24590637%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24590637\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E10.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-10-1\u0022 title=\u0022View reference 10. in text\u0022 id=\u0022ref-10\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.10\u0022 data-doi=\u002210.1056\/NEJMoa1200694\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBrahmer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETykodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChow\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELQ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHwu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETopalian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHwu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDrake\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ECG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECamacho\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKauh\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EOdunsi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPitot\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHamid\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EO\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBhatia\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMartins\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EEaton\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESalay\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAlaparthy\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGrosso\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKorman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EParker\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAgrawal\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGoldberg\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPardoll\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGupta\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWigginton\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ESafety and activity of anti-pd-l1 antibody in patients with advanced cancer\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EN Engl J Med\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2012\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E366\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2455\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E2465\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1056\/NEJMoa1200694\u0022\u003Edoi:10.1056\/NEJMoa1200694\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3563263\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D366%26rft.spage%253D2455%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1200694%26rft_id%253Dinfo%253Apmid%252F22658128%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1056\/NEJMoa1200694\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=22658128\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E11.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-11-1\u0022 title=\u0022View reference 11. in text\u0022 id=\u0022ref-11\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.11\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHuang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EY\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYuan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERighi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKamoun\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAncukiewicz\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENezivar\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESantosuosso\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMartin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMartin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVianello\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELeblanc\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMunn\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHuang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDuda\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFukumura\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJain\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPoznansky\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMC\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EVascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EProc Natl Acad Sci U S A\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2012\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E109\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E17561\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E17566\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1073\/pnas.1215397109\u0022\u003Edoi:10.1073\/pnas.1215397109\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3491458\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DProc%2BNatl%2BAcad%2BSci%2BU%2BS%2BA%26rft.volume%253D109%26rft.spage%253D17561%26rft_id%253Dinfo%253Apmid%252F23045683%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23045683\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E12.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-12-1\u0022 title=\u0022View reference 12. in text\u0022 id=\u0022ref-12\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.12\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EOyama\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIshida\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENadaf\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKerr\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarbone\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGabrilovich\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDI\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EVascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa b activation in hemopoietic progenitor cells\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Immunol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E1998\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E160\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1224\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1232\u003C\/span\u003E. \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BImmunol%26rft.volume%253D160%26rft.spage%253D1224%26rft_id%253Dinfo%253Apmid%252F9570538%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=9570538\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E13.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-13-1\u0022 title=\u0022View reference 13. in text\u0022 id=\u0022ref-13\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.13\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDikov\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EOhm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERay\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETchekneva\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBurlison\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMoghanaki\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENadaf\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarbone\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDP\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EDifferential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Immunol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2005\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E174\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E215\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E222\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.4049\/jimmunol.174.1.215\u0022\u003Edoi:10.4049\/jimmunol.174.1.215\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BImmunol%26rft.volume%253D174%26rft.spage%253D215%26rft_id%253Dinfo%253Apmid%252F15611243%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=15611243\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E14.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-14-1\u0022 title=\u0022View reference 14. in text\u0022 id=\u0022ref-14\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.14\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYuan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZhou\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDong\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EZ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETandon\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKuk\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPanageas\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWong\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EX\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENaidoo\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPage\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWolchok\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPretreatment serum vegf is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ECancer Immunol Res\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E2\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E127\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E132\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1158\/2326-6066.CIR-13-0163\u0022\u003Edoi:10.1158\/2326-6066.CIR-13-0163\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DCancer%2BImmunol%2BRes%26rft.volume%253D2%26rft.spage%253D127%26rft_id%253Dinfo%253Apmid%252F24778276%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24778276\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E15.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-15-1\u0022 title=\u0022View reference 15. in text\u0022 id=\u0022ref-15\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.15\u0022 data-doi=\u002210.1158\/2326-6066.CIR-14-0053\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELawrence\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELezcano\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EX\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZhou\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESasada\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZeng\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGiobbie-Hurder\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAtkins\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIbrahim\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFriedlander\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFlaherty\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMurphy\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERodig\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVelazquez\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMihm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMC\u003C\/span\u003E\n  \u003Cspan class=\u0022cit-name-suffix\u0022\u003EJr\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERussell\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDiPiro\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYap\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVan den Abbeele\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGargano\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcDermott\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EBevacizumab plus ipilimumab in patients with metastatic melanoma\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ECancer Immunol Res\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E2\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E632\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E642\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1158\/2326-6066.CIR-14-0053\u0022\u003Edoi:10.1158\/2326-6066.CIR-14-0053\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4306338\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DCancer%2BImmunol%2BRes%26rft.volume%253D2%26rft.spage%253D632%26rft_id%253Dinfo%253Adoi%252F10.1158%252F2326-6066.CIR-14-0053%26rft_id%253Dinfo%253Apmid%252F24838938%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1158\/2326-6066.CIR-14-0053\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24838938\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E16.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-16-1\u0022 title=\u0022View reference 16. in text\u0022 id=\u0022ref-16\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.16\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJagannathan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKrajewski\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EO\u0026acirc;\u0026#128;\u0026#153;Regan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShapiro\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EPersonalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of recist\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2012\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E198\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E737\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E745\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.11.7483\u0022\u003Edoi:10.2214\/AJR.11.7483\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3369700\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D198%26rft.spage%253D737%26rft_id%253Dinfo%253Apmid%252F22451534%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=22451534\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E17.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-17-1\u0022 title=\u0022View reference 17. in text\u0022 id=\u0022ref-17\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.17\u0022 data-doi=\u002210.1158\/1078-0432.CCR-09-1624\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWolchok\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHoos\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EO\u0026acirc;\u0026#128;\u0026#153;Day\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWeber\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHamid\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EO\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELebbe\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMaio\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBinder\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBohnsack\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EO\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENichol\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHumphrey\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EGuidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClin Cancer Res\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E15\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E7412\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E7420\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1158\/1078-0432.CCR-09-1624\u0022\u003Edoi:10.1158\/1078-0432.CCR-09-1624\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DClin%2BCancer%2BRes%26rft.volume%253D15%26rft.spage%253D7412%26rft_id%253Dinfo%253Adoi%252F10.1158%252F1078-0432.CCR-09-1624%26rft_id%253Dinfo%253Apmid%252F19934295%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1158\/1078-0432.CCR-09-1624\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19934295\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E18.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-18-1\u0022 title=\u0022View reference 18. in text\u0022 id=\u0022ref-18\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.18\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGargano\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESuda\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EOptimizing immune-related tumor response assessment: does reducing the number of lesions impact response assessment in melanoma patients treated with ipilimumab?\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Immunother Cancer\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E2\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E17\u003C\/span\u003E\n\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1186\/2051-1426-2-17\u0022\u003Edoi:10.1186\/2051-1426-2-17\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4077549\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BImmunother%2BCancer%26rft.volume%253D2%26rft.spage%253D17%26rft_id%253Dinfo%253Apmid%252F24991412%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24991412\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E19.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-19-1\u0022 title=\u0022View reference 19. in text\u0022 id=\u0022ref-19\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.19\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGiobbie-Hurder\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGargano\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESuda\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHodi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EDeveloping a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClin Cancer Res\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E19\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E3936\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E3943\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1158\/1078-0432.CCR-13-0895\u0022\u003Edoi:10.1158\/1078-0432.CCR-13-0895\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3740724\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DClin%2BCancer%2BRes%26rft.volume%253D19%26rft.spage%253D3936%26rft_id%253Dinfo%253Apmid%252F23743568%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23743568\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E20.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-20-1\u0022 title=\u0022View reference 20. in text\u0022 id=\u0022ref-20\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.20\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBenjamin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChoi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMacapinlac\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBurgess\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPatel\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPodoloff\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECharnsangavej\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EWe should desist using recist, at least in gist\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E25\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1760\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1764\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1200\/JCO.2006.07.3411\u0022\u003Edoi:10.1200\/JCO.2006.07.3411\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BClin%2BOncol%26rft.volume%253D25%26rft.spage%253D1760%26rft_id%253Dinfo%253Apmid%252F17470866%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=17470866\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E21.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-21-1\u0022 title=\u0022View reference 21. in text\u0022 id=\u0022ref-21\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.21\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChoi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECharnsangavej\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003Ede Castro\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETamm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBenjamin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohnson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMacapinlac\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPodoloff\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDA\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ECt evaluation of the response of gastrointestinal stromal tumors after imatinib mesylate treatment: a quantitative analysis correlated with fdg pet findings\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2004\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E183\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1619\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1628\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/ajr.183.6.01831619\u0022\u003Edoi:10.2214\/ajr.183.6.01831619\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D183%26rft.spage%253D1619%26rft_id%253Dinfo%253Apmid%252F15547201%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=15547201\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E22.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-22-1\u0022 title=\u0022View reference 22. in text\u0022 id=\u0022ref-22\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.22\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChoi\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECharnsangavej\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFaria\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMacapinlac\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBurgess\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPatel\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EPodoloff\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBenjamin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERS\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ECorrelation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2007\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E25\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1753\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1759\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1200\/JCO.2006.07.3049\u0022\u003Edoi:10.1200\/JCO.2006.07.3049\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BClin%2BOncol%26rft.volume%253D25%26rft.spage%253D1753%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E23.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-23-1\u0022 title=\u0022View reference 23. in text\u0022 id=\u0022ref-23\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.23\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFaivre\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZappa\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVilgrain\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EV\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBoucher\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDouillard\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJY\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELim\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EHY\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKim\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EIm\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EYK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBouattour\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDokmak\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDreyer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESablin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESerrate\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECheng\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELanzalone\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EX\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELechuga\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERaymond\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EChanges in tumor density in patients with advanced hepatocellular carcinoma treated with sunitinib\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EClin Cancer Res\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2011\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E17\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E4504\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E4512\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1158\/1078-0432.CCR-10-1708\u0022\u003Edoi:10.1158\/1078-0432.CCR-10-1708\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DClin%2BCancer%2BRes%26rft.volume%253D17%26rft.spage%253D4504%26rft_id%253Dinfo%253Apmid%252F21531821%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=21531821\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E24.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-24-1\u0022 title=\u0022View reference 24. in text\u0022 id=\u0022ref-24\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.24\u0022 data-doi=\u002210.1038\/sj.bjc.6605567\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003Evan der Veldt\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMeijerink\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003Evan den Eertwegh\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHaanen\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJB\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBoven\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EChoi response criteria for early prediction of clinical outcome in patients with metastatic renal cell cancer treated with sunitinib\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EBr J Cancer\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E102\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E803\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E809\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1038\/sj.bjc.6605567\u0022\u003Edoi:10.1038\/sj.bjc.6605567\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E2833256\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DBr%2BJ%2BCancer%26rft.volume%253D102%26rft.spage%253D803%26rft_id%253Dinfo%253Adoi%252F10.1038%252Fsj.bjc.6605567%26rft_id%253Dinfo%253Apmid%252F20145618%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1038\/sj.bjc.6605567\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20145618\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E25.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-25-1\u0022 title=\u0022View reference 25. in text\u0022 id=\u0022ref-25\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.25\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESmith\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShah\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESN\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERini\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBI\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELieber\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EML\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERemer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EMorphology, attenuation, size, and structure (mass) criteria: assessing response and predicting clinical outcome in metastatic renal cell carcinoma on antiangiogenic targeted therapy\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E194\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1470\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1478\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.09.3456\u0022\u003Edoi:10.2214\/AJR.09.3456\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D194%26rft.spage%253D1470%26rft_id%253Dinfo%253Apmid%252F20489085%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20489085\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E26.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-26-1\u0022 title=\u0022View reference 26. in text\u0022 id=\u0022ref-26\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.26\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGray\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMR\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMartin del Campo\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZhang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EX\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EZhang\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESouza\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EFF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EWE\u003C\/span\u003E\n  \u003Cspan class=\u0022cit-name-suffix\u0022\u003E3rd\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESmith\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EMetastatic melanoma: lactate dehydrogenase levels and ct imaging findings of tumor devascularization allow accurate prediction of survival in patients treated with bevacizumab\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERadiology\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E270\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E425\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E434\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1148\/radiol.13130776\u0022\u003Edoi:10.1148\/radiol.13130776\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3985552\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DRadiology%26rft.volume%253D270%26rft.spage%253D425%26rft_id%253Dinfo%253Apmid%252F24072776%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24072776\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E27.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-27-1\u0022 title=\u0022View reference 27. in text\u0022 id=\u0022ref-27\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.27\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohnson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMcLoud\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETC\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EState of the art: response assessment in lung cancer in the era of genomic medicine\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERadiology\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E271\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E6\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E27\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1148\/radiol.14122524\u0022\u003Edoi:10.1148\/radiol.14122524\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4263630\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DRadiology%26rft.volume%253D271%26rft.spage%253D6%26rft_id%253Dinfo%253Apmid%252F24661292%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24661292\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E28.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-28-1\u0022 title=\u0022View reference 28. in text\u0022 id=\u0022ref-28\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.28\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMenzies\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHaydu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarlino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAzer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECarr\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKefford\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELong\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGV\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EInter- and intra-patient heterogeneity of response and progression to targeted therapy in metastatic melanoma\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EPLoS One\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E9\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003Ee85004\u003C\/span\u003E\n\u003Ca href=\u0022http:\/\/dx.doi.org\/10.1371\/journal.pone.0085004\u0022\u003Edoi:10.1371\/journal.pone.0085004\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3882277\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DPLoS%2BOne%26rft.volume%253D9%26rft.spage%253D85004e%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E29.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-29-1\u0022 title=\u0022View reference 29. in text\u0022 id=\u0022ref-29\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.29\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETirkes\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHollar\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETann\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKohli\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAkisik\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EF\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESandrasegaran\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EK\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EResponse criteria in oncologic imaging: review of traditional and new criteria\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ERadiographics\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E33\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1323\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1341\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1148\/rg.335125214\u0022\u003Edoi:10.1148\/rg.335125214\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DRadiographics%26rft.volume%253D33%26rft.spage%253D1323%26rft_id%253Dinfo%253Apmid%252F24025927%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24025927\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E30.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-30-1\u0022 title=\u0022View reference 30. in text\u0022 id=\u0022ref-30\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.30\u0022 data-doi=\u002210.1200\/JCO.2003.01.144\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EErasmus\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGladish\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EGW\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBroemeling\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESabloff\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETruong\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHerbst\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMunden\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERF\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EInterobserver and intraobserver variability in measurement of non-small-cell carcinoma lung lesions: implications for assessment of tumor response\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Clin Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2003\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E21\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E2574\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E2582\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1200\/JCO.2003.01.144\u0022\u003Edoi:10.1200\/JCO.2003.01.144\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BClin%2BOncol%26rft.volume%253D21%26rft.spage%253D2574%26rft_id%253Dinfo%253Adoi%252F10.1200%252FJCO.2003.01.144%26rft_id%253Dinfo%253Apmid%252F12829678%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1200\/JCO.2003.01.144\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=12829678\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E31.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-31-1\u0022 title=\u0022View reference 31. in text\u0022 id=\u0022ref-31\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.31\u0022 data-doi=\u002210.1016\/j.ejca.2008.10.026\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EEisenhauer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETherasse\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBogaerts\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESchwartz\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESargent\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFord\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDancey\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EArbuck\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGwyther\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EMooney\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERubinstein\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShankar\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDodd\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKaplan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ER\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELacombe\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ED\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVerweij\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ENew response evaluation criteria in solid tumours: revised recist guideline (version 1.1)\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EEur J Cancer\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2009\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E45\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E228\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E247\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.ejca.2008.10.026\u0022\u003Edoi:10.1016\/j.ejca.2008.10.026\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DEur%2BJ%2BCancer%26rft.volume%253D45%26rft.spage%253D228%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.ejca.2008.10.026%26rft_id%253Dinfo%253Apmid%252F19097774%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1016\/j.ejca.2008.10.026\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=19097774\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E32.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-32-1\u0022 title=\u0022View reference 32. in text\u0022 id=\u0022ref-32\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.32\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJagannathan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVan den Abbeele\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ERevised recist guideline version 1.1: What oncologists want to know and what radiologists need to know?\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E195\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E281\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E289\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.09.4110\u0022\u003Edoi:10.2214\/AJR.09.4110\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D195%26rft.spage%253D281%26rft_id%253Dinfo%253Apmid%252F20651182%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20651182\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E33.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-33-1\u0022 title=\u0022View reference 33. in text\u0022 id=\u0022ref-33\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.33\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECardarella\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJackman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERabin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJanne\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohnson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ERecist 1.1 in nsclc patients with egfr mutations treated with egfr tyrosine kinase inhibitors: comparison with recist 1.0\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E201\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003EW64\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003EW71\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.12.9668\u0022\u003Edoi:10.2214\/AJR.12.9668\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3731976\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D201%26rft.spage%253DW64%26rft_id%253Dinfo%253Apmid%252F23789698%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23789698\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E34.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-34-1\u0022 title=\u0022View reference 34. in text\u0022 id=\u0022ref-34\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.34\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAraki\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ET\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESholl\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGerbaudo\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EVH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EImaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E202\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E471\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E478\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.13.11210\u0022\u003Edoi:10.2214\/AJR.13.11210\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4020512\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D202%26rft.spage%253D471%26rft_id%253Dinfo%253Apmid%252F24555583%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24555583\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E35.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-35-1\u0022 title=\u0022View reference 35. in text\u0022 id=\u0022ref-35\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.35\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDahlberg\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESE\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ECardarella\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ES\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJackman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERabin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJanne\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohnson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ETumor volume decrease at 8 weeks is associated with longer survival in egfr-mutant advanced non-small-cell lung cancer patients treated with egfr tki\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Thorac Oncol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2013\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E8\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E1059\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E1068\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1097\/JTO.0b013e318294c909\u0022\u003Edoi:10.1097\/JTO.0b013e318294c909\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3714311\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BThorac%2BOncol%26rft.volume%253D8%26rft.spage%253D1059%26rft_id%253Dinfo%253Apmid%252F23787800%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=23787800\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E36.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-36-1\u0022 title=\u0022View reference 36. in text\u0022 id=\u0022ref-36\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.36\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKrajewski\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EKM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EFranchetti\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EY\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERamaiya\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ENH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVan den Abbeele\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChoueiri\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETK\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EIntraobserver and interobserver variability in computed tomography size and attenuation measurements in patients with renal cell carcinoma receiving antiangiogenic therapy: implications for alternative response criteria\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ECancer\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2014\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E120\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E711\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E721\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1002\/cncr.28493\u0022\u003Edoi:10.1002\/cncr.28493\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E4031652\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DCancer%26rft.volume%253D120%26rft.spage%253D711%26rft_id%253Dinfo%253Apmid%252F24264883%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=24264883\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E37.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-37-1\u0022 title=\u0022View reference 37. in text\u0022 id=\u0022ref-37\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.37\u0022 data-doi=\u002210.1093\/jnci\/92.3.205\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ETherasse\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EP\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EArbuck\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESG\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EEisenhauer\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EEA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EWanders\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EKaplan\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ERS\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ERubinstein\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EL\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVerweij\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVan Glabbeke\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003Evan Oosterom\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EChristian\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EMC\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGwyther\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESG\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ENew guidelines to evaluate the response to treatment in solid tumors. European organization for research and treatment of cancer, National Cancer Institute of the United States, National Cancer Institute of Canada\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EJ Natl Cancer Inst\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2000\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E92\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E205\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E216\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1093\/jnci\/92.3.205\u0022\u003Edoi:10.1093\/jnci\/92.3.205\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DJ%2BNatl%2BCancer%2BInst%26rft.volume%253D92%26rft.spage%253D205%26rft_id%253Dinfo%253Adoi%252F10.1093%252Fjnci%252F92.3.205%26rft_id%253Dinfo%253Apmid%252F10655437%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.1093\/jnci\/92.3.205\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10655437\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E38.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-38-1\u0022 title=\u0022View reference 38. in text\u0022 id=\u0022ref-38\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.38\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ESmith\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELieber\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EML\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EShah\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ESN\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EAssessing tumor response and detecting recurrence in metastatic renal cell carcinoma on targeted therapy: importance of size and attenuation on contrast-enhanced ct\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAJR Am J Roentgenol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2010\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E194\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E157\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E165\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2214\/AJR.09.2941\u0022\u003Edoi:10.2214\/AJR.09.2941\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAJR%2BAm%2BJ%2BRoentgenol%26rft.volume%253D194%26rft.spage%253D157%26rft_id%253Dinfo%253Apmid%252F20028918%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=20028918\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E39.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-39-1\u0022 title=\u0022View reference 39. in text\u0022 id=\u0022ref-39\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.39\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ENishino\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EGuo\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJackman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EDiPiro\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPJ\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EYap\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJT\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHo\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ETK\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EHatabu\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EH\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJanne\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EPA\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EVan den Abbeele\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EAD\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EJohnson\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EBE\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003ECt tumor volume measurement in advanced non-small-cell lung cancer: performance characteristics of an emerging clinical tool\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EAcad Radiol\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E2011\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E18\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E54\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E62\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/j.acra.2010.08.021\u0022\u003Edoi:10.1016\/j.acra.2010.08.021\u003C\/a\u003E\u003Cspan class=\u0022cit-pub-id-sep cit-pub-id-pmcid-sep\u0022\u003E\n\u003C\/span\u003E\u003Cspan class=\u0022cit-pub-id cit-pub-id-pmcid\u0022\u003E\u003Cspan class=\u0022cit-pub-id-scheme-pmcid\u0022\u003Epmcid:\u003C\/span\u003E3129593\u003C\/span\u003E \u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DAcad%2BRadiol%26rft.volume%253D18%26rft.spage%253D54%26rft_id%253Dinfo%253Apmid%252F21036632%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=21036632\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E40.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-40-1\u0022 title=\u0022View reference 40. in text\u0022 id=\u0022ref-40\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.40\u0022 data-doi=\u002210.2307\/2532051\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003ELin\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003ELI\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EA concordance correlation coefficient to evaluate reproducibility\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003EBiometrics\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E1989\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E45\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E255\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E268\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.2307\/2532051\u0022\u003Edoi:10.2307\/2532051\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DBiometrics%26rft.volume%253D45%26rft.spage%253D255%26rft_id%253Dinfo%253Adoi%252F10.2307%252F2532051%26rft_id%253Dinfo%253Apmid%252F2720055%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=10.2307\/2532051\u0026amp;link_type=DOI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref\u0022\u003E\u003Cspan\u003ECrossRef\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=2720055\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=A1989U124500022\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022ref-label\u0022\u003E41.\u003C\/span\u003E\u003Ca class=\u0022rev-xref-ref\u0022 href=\u0022#xref-ref-41-1\u0022 title=\u0022View reference 41. in text\u0022 id=\u0022ref-41\u0022\u003E\u0026acirc;\u0026#134;\u0026micro;\u003C\/a\u003E\u003Cdiv class=\u0022cit ref-cit ref-journal\u0022 id=\u0022cit-2.1.40.41\u0022\u003E\u003Cdiv class=\u0022cit-metadata\u0022\u003E\u003Col class=\u0022cit-auth-list\u0022\u003E\u003Cli\u003E\n\u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EBland\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EJM\u003C\/span\u003E\n\u003C\/span\u003E, \u003C\/li\u003E\u003Cli\u003E\u003Cspan class=\u0022cit-auth\u0022\u003E\n\u003Cspan class=\u0022cit-name-surname\u0022\u003EAltman\u003C\/span\u003E\n \u003Cspan class=\u0022cit-name-given-names\u0022\u003EDG\u003C\/span\u003E\n\u003C\/span\u003E\n\u003C\/li\u003E\u003C\/ol\u003E\u003Ccite\u003E. \u003Cspan class=\u0022cit-article-title\u0022\u003EStatistical methods for assessing agreement between two methods of clinical measurement\u003C\/span\u003E. \u003Cabbr class=\u0022cit-jnl-abbrev\u0022\u003ELancet\u003C\/abbr\u003E. \u003Cspan class=\u0022cit-pub-date\u0022\u003E1986\u003C\/span\u003E;\u003Cspan class=\u0022cit-vol\u0022\u003E1\u003C\/span\u003E:\u003Cspan class=\u0022cit-fpage\u0022\u003E307\u003C\/span\u003E\u0026acirc;\u0026#128;\u0026#147;\u003Cspan class=\u0022cit-lpage\u0022\u003E310\u003C\/span\u003E. \u003Ca href=\u0022http:\/\/dx.doi.org\/10.1016\/S0140-6736(86)90837-8\u0022\u003Edoi:10.1016\/S0140-6736(86)90837-8\u003C\/a\u003E\n\u003C\/cite\u003E\u003C\/div\u003E\u003Cdiv class=\u0022cit-extra\u0022\u003E\u003Ca href=\u0022%7Bopenurl%7D?query=rft.jtitle%253DLancet%26rft.volume%253D1%26rft.spage%253D307%26rft_id%253Dinfo%253Apmid%252F2868172%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-openurl cit-ref-sprinkles-open-url\u0022\u003E\u003Cspan\u003EOpenUrl\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=2868172\u0026amp;link_type=MED\u0026amp;atom=%2Fjitc%2F2%2F1%2F40.atom\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-medline\u0022\u003E\u003Cspan\u003EPubMed\u003C\/span\u003E\u003C\/a\u003E\u003Ca href=\u0022\/lookup\/external-ref?access_num=A1986AYW4000013\u0026amp;link_type=ISI\u0022 class=\u0022cit-ref-sprinkles cit-ref-sprinkles-newisilink cit-ref-sprinkles-webofscience\u0022\u003E\u003Cspan\u003EWeb of Science\u003C\/span\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/li\u003E\u003C\/ol\u003E\u003C\/div\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan class=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup footnotes\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022content-block-markup\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022section fn-group\u0022 id=\u0022fn-group-1\u0022\u003E\u003Ch2\u003EFootnotes\u003C\/h2\u003E\u003Cul\u003E\u003Cli class=\u0022fn-other\u0022 id=\u0022fn-1\u0022\u003E\u003Cp id=\u0022p-60\u0022\u003E\u003Cspan class=\u0022fn-label\u0022\u003ECompeting interest\u003C\/span\u003E Nikhil H. Ramaiya, MD, Anita Giobbie-Hurder, MS: Nothing to disclose.\u003C\/p\u003E\u003Cp id=\u0022p-61\u0022\u003EMizuki Nishino, MD: Dr. Nishino has served as a consultant to Bristol-Myers Squibb.\u003C\/p\u003E\u003Cp id=\u0022p-62\u0022\u003EF. Stephen Hodi, MD: Dr. Hodi has served as a non-paid consultant to Bristol-Myers Squibb and has received clinical trial support from Bristol-Myers Squibb.\u003C\/p\u003E\u003C\/li\u003E\u003Cli class=\u0022fn-other\u0022 id=\u0022fn-2\u0022\u003E\u003Cp id=\u0022p-63\u0022\u003E\u003Cspan class=\u0022fn-label\u0022\u003EElectronic supplementary material\u003C\/span\u003E The online version of this article (doi:10.1186\/s40425-014-0040-2) contains supplementary material, which is available to authorized users.\u003C\/p\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_K8lPbae8GAGrzh3G-Dop8QXQokbWp140TMrwyyDlgcg.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}