{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DQje8W+V8J1Yj0co90MqdpIeqGsGuSE113L6vNKPd8+es4p8oEmxusPIXLpqt\\\\\\\\\\\\\\\/2\\\\\\\\\\\\\\\/zxnt9Or2\\\\\\\\\\\\\\\/9I5NvTPIky\\\\\\\\\\\\\\\/5XcJZn66U+INuqx6y98Y+TTs6VPkNHB1fNQOUMHbFtiCktDZRkSsoimypRbzrxU2p4BrtgB+qMDB5fcg3ySaTCcHl35z2J8+nPBZYYM12phPHgju0C01pYIZ5AF+VNBYTzn1M5q40Btv2\\\\\\\\\\\\\\\/1OhHKo\\\\\\\\\\\\\\\/u5muXnTfta1iikA+ZDHPTujlsH1gre5nDzH68dr0vwSf6riF20wAK9G3A3JotbKIqN0+achq2d0Uv3TIXnBOts81hyhWJj8f9EQCkExzsRC29GeN9XMPv1Ef57Ire9r43yVu6tRr1tNQEbFVAVR9lXbeKhayPTjuVPs\\\\\\\\\\\\\\\/PprDOkwygZN6yWEbqdKgXqdKUE\\\\\\\\\\\\\\\/cyoCqNj5Bw\\\\\\\\\\\\\\\/D\\\\\\\\\\\\\\\/vkhrmR1MC0OPJMhvMn7nlVOmX1QOQ8macP8GPhOwxQv7iGJnr6Rtk0Csyw8LboVQfZvV\\\\\\\\\\\\\\\/lge7vW\\\\\\\\\\\\\\\/FMXEDomNyqKDFDD63QY3T0Y0FiV+CpvwYpUGy5\\\\\\\\\\\\\\\/orZ7O8YIgU2g7s6uzOX+iLf2NVMCPs\\\\\\\\\\\\\\\/3QUfQ18+c2rmGcZ0m6I\\\\\\\\\\\\\\\/rLSBYi40OwmSLFHS\\\\\\\\\\\\\\\/9hdh8BryEqXXtekk\\\\\\\\\\\\\\\/nmMhQuPEm4a3QEp0CjBH59TqUD4tcqEE2PE+WhYc\\\\\\\\\\\\\\\/KHWr5yh3gP6jxESOdZV8ZvpYJ8vYcX+XOb1f\\\\\\\\\\\\\\\/2QdBL5nIKVJTTlub+3IV5ZTkoxI9TwXJB4kP1h1J4VpAdGi2LV96WGMwgFCj4nhsPVU8yQFrfjb6sAemPb4h+bv1ojJ4bEas3nA19x+XL227hEKNqJ807DOY5Zw584n9d\\\\\\\\\\\\\\\/FeBU3jKZIGQEashPuWFAo5fytVjtMC147th4oQwNhTim9mT1o4D9+6EfIMO24PR5e6TkGpR4sjc1A+oiraqsaIfcury53hz+tHmnCJydhOZNbtdOja7PR1IVhOTkwI5j4JFgdYbovKWcmWV4\\\\\\\\\\\\\\\/aH\\\\\\\\\\\\\\\/bEZIXdkG70jP57+UnoK4fTkS9HJ+RlU1ujv0X04kaqrY8nq6iokZD4pTkzUCRuo+iKfkMx6rklnWExghQhAlermbKgpWMeMrkleaJUMp3T\\\\\\\\\\\\\\\/yn+0HtKuEcW0xD0ExoQYfPCw27Im5NeOyD1Wx19s1nzaoLR3SbV37Ix4hgy85JMhWR+1oejg5\\\\\\\\\\\\\\\/kZ6hEDAiSwnSkZ6gUKcPOmgpjz\\\\\\\\\\\\\\\/ilS3os54KtwR58iYCo7j9TABCEgN89thC2kqhoqLLuk5arqBm96TmZ5+ma03nVd3UzYM4azaSH117J1NBjSZIsxrsXu1jppP7+TXCstWGu8K2k4vQAIahjVkvZNiQA7uDcxT1gn\\\\\\\\\\\\\\\/YyLJ7v56AZW6e+frdsVdtnqwRbs1c8swFUkOHVvwPEPpei3jYLzj+8MiGLZG5gTmyC2foI+NVuv7fx+wqH2cZ1CphGb9qJIRyiUSbEkBp9kd\\\\\\\\\\\\\\\/8vp3w6SxyZVrpzErSxuvNvy24gKiOl3PvNlLelGmQPByaLyjjMIg78vxs2+hsRAULCcC4OCSkxqGGWdBGN3rnWow7Z8M5JpC4Q3\\\\\\\\\\\\\\\/UQt8chrrtrhsxGnqDaosBEvQL4V0BVGmbO8ZzB79MWVzzgXvJ\\\\\\\\\\\\\\\/Aw8uqbABH7AeFlh7E7Mm7BHljdMwG2v8UsOCqyPSMBf78K2hSWIHWXQzEor+93drKUlyjGBhF1K7DR88+eLrojT8QG1FUiB+t8iZoVGg9pW9AUX\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/WCwwsLM0ruvNzvK95QIMyWsR6AWFUyHKvriRuqwCebN0MJyMAeZVonhEswYdgrhe8I43CUBxtaqCR28\\\\\\\\\\\\\\\/rSvn3kBEzBg75rG3bV1A6SDE3AW+J\\\\\\\\\\\\\\\/p7GIeUCnsfGqnEjPkj6ByO6MLr2V7U+DdS4roojIHWDggUQ6a9dOEYoea759NzQ5ffcQLb+KovCVH7ZnKOTHRFry4I2tf4hMvHPnBBaHHSl+kldLe2A8e2BiGKznjtqKvWy3ssr\\\\\\\\\\\\\\\/8sHXukI4AEj\\\\\\\\\\\\\\\/5UaB8j491poleaqVGiEdLV2H1yMNQiFnUh\\\\\\\\\\\\\\\/y8rFb+HbrqMWiCx71d1LaPZq1MycLxYrURZf0CE1\\\\\\\\\\\\\\\/tPz2RpvSNcKlv2TP1oviCW4YsRRlTusX77vC5ygunMcwGu\\\\\\\\\\\\\\\/yFEkNSid5VLet0qvLA5QW0g0P53wPNGGdLGZFng4xqhGp+QKW0j\\\\\\\\\\\\\\\/SibTYA45oJ3sGhkveW3lAfaUHnPhexyE7F5G+2Ieb7DecAizH9imoFIlVrPvRiIBsHnUgVS9v6tGIIgNmx+RUHWyeP1MSa\\\\\\\\\\\\\\\/j+3KEo\\\\\\\\\\\\\\\/CL936x3rqcTfS1w6sJLH6Y57qCr9e2mJwMMwlK73BIstGXaqVyQFiGpYS7wyCUCDipBUhB+DGHEPMGlzoYEY4O+8QtYP7PXQfdkJpjyEuRcMxDWgaVHEkckNVzRAs5iTw5ay+mQmHgAp81hPVCU0JASLPw2oFzjZZEqaJe4tNFBsua1QQnV5+b6qmClYcvzecx5QnC2E+xMME3+ys5eps1nfAQFe3HPCqVgl9BbS6ngWLQh6OZP8S6iCMjDCKqCWqU81OTF+knrrkRwAgg0fHlbMs041+3DbGZfOHXwNlNrX8wJGA4RceuP6EZ3zRIzdj2TS0Y1x4\\\\\\\\\\\\\\\/OKX9Suq4pY3+bz3Ygn9DH3cKp6\\\\\\\\\\\\\\\/o=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022+tfMfgsAbzgf3obbvK2ffg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221489f2734d877149e5fe039c8cebb510649482816e3e2f1c805fdb987d3887ad\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1015.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1015.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0912\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0912\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0912\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}