{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229ofniqOK8DnbK7mfPV88oxsVaugWmlKXFmo6JJxGwotJ0Rk4UQs5ejO\\\\\\\\\\\\\\\/x1X+sDg1VTFYSxkfRSnYdz74UDE+Hc4JQ6CsUlXl\\\\\\\\\\\\\\\/lw0AADGetHNVysO0Gu0OSb3DMGDLupaxakx8n\\\\\\\\\\\\\\\/wFiOpkItA57fQdAu68i9a\\\\\\\\\\\\\\\/0JBA3OBXkTuozetrP6FhY3qJxDowbSYejh9wGEcsgTV2KmD1Nd+6nHb5fmDnLm6GN+RCLD5mP9S7g3fNI5emCNKHwF9Har6g7XXMesPNBdtMS2z3sae8CYLr8tjU6HPOM1gyV6CMNAmfOh2naAA+oF7wgBnc7YW4H0es5cm2qce3UFq2tum2t2twF8Orw7en9vv3eoLrOG9wkmgJTxWLrKTopT3iEHBHER+upndjvQYd4JxPpIJxsm8FME0CzomFwyaaqiphpzmEL\\\\\\\\\\\\\\\/uZpgCfhfQGC0lFGxgl0leIx+QsMyngPBRejZryI+00UwDC+1TObnchi2618Ytcl+O9Hwxl60yuxDnSi7m0KBpu6zumjJDTkVkfbwkdAQtWvX0BCnVuLIDDYXcEslmzzwEunjtSz54spFfyIYzchSpgrs89P\\\\\\\\\\\\\\\/2cQ5EnNnKCwoyn05HTxNjRolcWSTZy7t8LHvUfkD\\\\\\\\\\\\\\\/70ywe7p1aW8LUV\\\\\\\\\\\\\\\/JoGhxIaXgD5pQogS3mBcIyM57eCtrCQfAXEJMhhj69qLSf+OyGLJ9FbKPWXMSUc0Uvunoio7VPzAFGX+8Y2+Potp2HA0A1GBxZU81Wa3O0pRG\\\\\\\\\\\\\\\/bJej18GxIval5Q7N4hQB6FVNxHs4F4kBF7O3appnVXwppomxgXZAe9nphLXD4fm\\\\\\\\\\\\\\\/l2HwbVh3AOq+XX5CxBY2fO1cxv9yrs4XeqtzVuyQoqvC8NJ3TRqbH576Tzt9J5s1E8L93lQaemyl+E9jZXKdCSstPBaBJErGIyDzJLaqK6uyoE+FaOHGXVX8hjhQiA\\\\\\\\\\\\\\\/68h4SFyhFsM8fCkQKm4xPw8G+XRGRmrsnXgVRrvV80AqAo1\\\\\\\\\\\\\\\/ajQ85T9pfQQurFrflthvf3XaNRZbXyM0nD8JKjIeOyAmiILbqZKrY9YnvDKNhu2+NjxUXmUYXOSiAdNkGA05pI6IzPYSKTeRzeUM6QVd3gYTR116wXKzTUp5PSu6pCE33SjSTukagEcjzI+eVCVvbzg02a5vccPPLSTb4Ig0O\\\\\\\\\\\\\\\/UrZos4eSrKqnf1Tv8qgp7ASAn8GtO0JKqEv8kII327j8+hIkmZzPm5wJwyDzh4wUdWZpFqzuoEQCaUND+Y50tu6z9sDBSsdX3Tz49iAZHIkJqVQYFVpRe6ZxIgqdxtw2oty4hpbsqiPKvy+f8OWDJEW0qjC344430NJ\\\\\\\\\\\\\\\/O9qnpaJrJEytV2fFreoMpVvpDNx333okO2Hb2+3eaCJwQ0Dqjb\\\\\\\\\\\\\\\/E49H6zLxCDCNGRWUiisk6HjNG36iIeHf\\\\\\\\\\\\\\\/uEYWuyXFuQREZin4SFYPBCE7xiNn1Iw1ab0zRADt0jQfiwUi5W8zKPBn+ivS9eox0+RzCtvVKv+2uxg9jNb5FQFxyOJgDIpktajNo5AOZ7FXn4SGhTd5XDXJGhPxte\\\\\\\\\\\\\\\/BVUWsDX+HdRdO9F6a8+7y\\\\\\\\\\\\\\\/0g8Hpe5y0qBSbStUnicNO8+qc5lDO7r74SV4gHVP81mun0K7eSDoDom0kHXDsN5tvP2v6zVG8qUQpHfEz+hhuDbYuQRF6mt9I7eAHDYS7JcXrNi+tIQkO1pA1KM4Z6c2wKpwm1Vlo5LyEBoR\\\\\\\\\\\\\\\/VI4yA84q9mP0r\\\\\\\\\\\\\\\/ccmtWerkc09M7PAJs\\\\\\\\\\\\\\\/lYa+ztNiX0RUexGaG6+UjvDjzj+IPN\\\\\\\\\\\\\\\/k6s+O2mbHYHPBLuhiHyH0t+Qp0+QrNvL8+74k+g7n6yEnHjt+rmWJvCGPk2RVxTMsV9shdsKVCgyF8MgVYNjY\\\\\\\\\\\\\\\/jGlkmpTucIEBS4BGXlIq0Q1hNavNyvLqpiMqvfkiTU8WgHxk7xF1oHLh70xr4HZRMReTjoJYn2FTXI7uQRDOXrEU1sEUo03vVslrbcWpjC25HzUWZJPkexDNNNOoJPp20wUqtmIpYyz3sF7pTfrJURFPiVdP2cecN4+0lGL8FaL\\\\\\\\\\\\\\\/kB8Wl2os4612Pl7dAk3s8JpqE06SO2XN0DedB6A9k73i+w0NIsMnY8Ri9MhcduotCn0CiOpot+ApFIApy9y5FyDalhnB\\\\\\\\\\\\\\\/216lDLMSBBBeA187avrAZcUGt6lgdEQTrLzYBrUcbvmYWpcV0b28N\\\\\\\\\\\\\\\/KcgPi9QiJa+OAhu+kzFgiiuNUviKABfse4CTVWp8HOeIBKkA68V+yOMjVuoubP39va6Dapdiq2hgp3QiSgk78MUH6gnXc6rLyPVD4UJ26BEiHvSDxhBzSJsAdOsi\\\\\\\\\\\\\\\/9V5Y8Ngpn42eQ5yTbiR33AgCFBW32kxR9QCSanGaJSVKeNYG9XkkBBsVcWYiNBBTJQpZWRR04WdQlL1lVzZ3bSQdWdZPwNbx2GDN4AbgP6Lo+hzBnpl1FM4tw5Gvd4LCNRnpJCp8VVB\\\\\\\\\\\\\\\/z7Y+P1159Mqtv+7C29JY\\\\\\\\\\\\\\\/Wswml+qSZJSq+tzkw8VeS7DDmpoEk6Xk\\\\\\\\\\\\\\\/Uhd7eT+rEmlBQd9Be7ShpTIe3DWp5CAq7bRXC0KhuF\\\\\\\\\\\\\\\/Vb7dvQVGVYu2Zs\\\\\\\\\\\\\\\/+RzKhMAYZ7bcwUHxpWhOMjaxDRj0ixFeCMe\\\\\\\\\\\\\\\/JOyBM\\\\\\\\\\\\\\\/dkOr4KPVWaD+QkJE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UoSiEmEVtiaLbuGrPTkl3Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225091af740019e4ca3209a576f5940eb45fd21a69132ff57f2da68c6aec1e8849\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/1\\\/24.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/1\\\/24.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-24\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-24\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-24\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}