{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224fUIZkxD+RlPL+AUiUdQYmgQqd1ukH4atdpScTW+7Smy\\\\\\\\\\\\\\\/Iv6sDJhSG30lVxIUMD8NPDMVrJeucAoUfZ8FHj12dDMWUVddLBJA\\\\\\\\\\\\\\\/Md+d44UOKe9VdrbiBhOGNIrgBypnrog07T\\\\\\\\\\\\\\\/UKhCtNCL+Bsr3Mu6JOW\\\\\\\\\\\\\\\/mvq+C6b1XDvpZUxkFS\\\\\\\\\\\\\\\/pnljlnSiXfXJiJk3u7O6rdPqeMYhaquxJVRkZCsM8C6SX63ZQP579H\\\\\\\\\\\\\\\/Wt9ksjc1JKyZpx+bmnG5+n3hA0giE92FP1ObMOiEYxe5wavy3TfCv5AdGC16aZB4E89U6hC+gq2\\\\\\\\\\\\\\\/vcUSdHGMCgRasJk1f3oayzItx0sNAcoVxdln5uDSEpeqGiFqViKSmXjfE2DDAiMUW50oUhXT7eXfCNYDtAOgIIOuOlRO1oC73B9aZ8MuECP1xltYzMPuDD9tJXw5PO\\\\\\\\\\\\\\\/VzASlMktRXfA5ce6VTwnzbhxO6Hf1sZ+23nA6vRcWewv2fqsW5Iv3O27IE7qYeH0tPuuBQWJhWAokQqJg+fP7LiRx\\\\\\\\\\\\\\\/AwQjnmuqc6aGXGeX+Wemqc9xXBr440Sf0rdLrg9BLyofmk0gvyIDRYyqhH+kfp9quMMnTsNK2+KKgoO6OWKCG\\\\\\\\\\\\\\\/ekaSn2uygdUPvUk2dCllaOx8uxh2I6wyUFPDYBzRTEbvsPl3oumJQeZoMYrMlJyVHXDEFmZa9WAJKleAqhnqqVTabThQoTEWQw\\\\\\\\\\\\\\\/3MfdraG\\\\\\\\\\\\\\\/tQuVk7\\\\\\\\\\\\\\\/sJJzfbgSVQZSODjC3HuZiAL4zFlNAKl4zycNwReHTI6s7rkPzEsoDbWUH1elU0kcyLEHeVHc6pGdeHxYPRUVH0B1nbJ7AvNSyJtlK2zLIuV9LxrAzqKDDuloSe9+oM02RT1vxkhCqqfKPQE756p591TzT3z5UdUxWengtR5JZ6DCaDxI5Q2qMksdIjplBHB1byFfNsXcTxVTad8EvN3ZNmRALzylwHG9kFreVTRFBId\\\\\\\\\\\\\\\/s5M6pahqTSxttswFKoFqAWssXvN21wcILfsXzYIOHdxo7td7pMltOuZXIR\\\\\\\\\\\\\\\/HmygRRUabi6H8iNeJ2En2cHVxSDAhpKMDjxPyGQh\\\\\\\\\\\\\\\/OmmwaIFED9VCFZzj7qegglM5ubUS0pZ0sPmkPoqNinIJ39QNB4eBc9nATBBa5sJqv0grQciLtAxi4mUAIh\\\\\\\\\\\\\\\/30fGtgpnQ8Al7nAL3NXbAXzwjvB1nWKw7Xw3LTSll7woEysbmTvX4kL\\\\\\\\\\\\\\\/j62hJLxQkgYgv5afb0pSfY3iTfZQcB5peLX+ngvimT96Nx46n7x1s6+5yjlOI7YJTxnv88FMjUo+YplwMd093jjQc0ssfEfgo4DtgWwiaQxOGHe0YFUBvESWLgyDsuWDn\\\\\\\\\\\\\\\/W6J\\\\\\\\\\\\\\\/4conRR3wFPxiODO98D1HiaDDv+9gwLFrtH\\\\\\\\\\\\\\\/tW\\\\\\\\\\\\\\\/214zBT6Epkyw++Dg\\\\\\\\\\\\\\\/rJYDrdrpL34cB1\\\\\\\\\\\\\\\/eLovZDeerApOrJraGHNM6OoBUrTnxb1rJ0aMNjD+RefokqrWIEpGCtjgBSPwwYqgLrWOwH1YQcjSUGU45zdFevrxJG6grTXA3hm978mSlV62JY0xdwmRyXMZlkRkCykIuVlJBeu2REGgK7Ly90FIwQXxFomHHu0y5gyMXknPkGFeKtlxg1pm91wQuVYicReNvveEJR0W9PY1BLUti4tN9yRsC5yi15AY6OfcS6+SNWwy0aFsMfQANQbDByyZYhcsg+7VsTHYKF4KYXER6jX4Bfpl6Pmv02NvHB98RLCjCpcTJGuXG1yrfVJLrIqSwoOIILhT028xEUflsffPuuo\\\\\\\\\\\\\\\/nn7amgt12Ub1hGniNA3TT2n7g9NlFk7mgWsY4dJf4mWqECuskHkJhMZP\\\\\\\\\\\\\\\/xtDF7aMmNQcYU9ueu1AeRt8FsV5fg9hAIDbr8QNVcmrXWMrKlrgpafXwXRwWokyZsyJw1wm33ahddqlQ8\\\\\\\\\\\\\\\/M3yOEf9yK1d0g7nwPkAECfD0wf39\\\\\\\\\\\\\\\/d9HfB2GftLN5rJ6QyEP67eUPQvP1rm1h4vd26Fa4SIP9NjG6kfbatB3+klquNvg4mcn7Bc5ULqB6WU8CfMheHSzr\\\\\\\\\\\\\\\/HIEAcrV+Sq5n+Zy7NG6GDx\\\\\\\\\\\\\\\/4rWu2KHNrTKZLuWaJL1qeFmgloOVTGXfVQ8hHY76NYhCrnkDTaoKZDdc5ZICK0ucJEBUp7ChaVvzk\\\\\\\\\\\\\\\/6uRkjbZMZv3rJoN1Rt40DkubYeUoCTCfTyoih\\\\\\\\\\\\\\\/Vh7wiiJAu3v3kPySYYu2zhk0W4n+L\\\\\\\\\\\\\\\/Ae1ghj9+hv55buCcpisioKPyNjJXTPlad5XmQ199E\\\\\\\\\\\\\\\/svlMPz2EjqT6OsR+8m7J8b2DSATR+3oULwHWFk6KolaFV35vlhnwgk\\\\\\\\\\\\\\\/2PbBzX7tgs588QIY\\\\\\\\\\\\\\\/4A4blRGGOl2ZkA6jmzAuYuggS9SVZVlp5cwIBxK4aD5D5HulXs4ZgWkrwacIrka69gT8RrSCRMYi9+S7KKSxzrwGvzS111RHoKsnc5O6PNjIlpT\\\\\\\\\\\\\\\/gsgYEU1G2UiJ6ePBYzYpkZcOx5zjoCt0wsr9l1Du1VaRSVc8jvBkCC5JtYUbq1k\\\\\\\\\\\\\\\/KHLYIb0agX5hXZnY3brhoS1cDIgBlH\\\\\\\\\\\\\\\/daXXz\\\\\\\\\\\\\\\/zwKwXyWNPjZCHLSPhPZb6ZyK9WvXyO7lq\\\\\\\\\\\\\\\/erGeW70yvEAh8MD\\\\\\\\\\\\\\\/khcm0ChRta5GWto6SNr2Hr68yC\\\\\\\\\\\\\\\/ldeNfaap0gwmS\\\\\\\\\\\\\\\/NSF4o6XPhxeE66+Z9ii0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223BYx0BUkNzFRkWZZMntcAA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227a1778291a8b7443e38e5b2a47c1d563eafd20aeb6b0f97299f2db56b811d301\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/1\\\/11.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/1\\\/11.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-11\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-11\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-11\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}