{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00228zgaddla0MqdBjoZrAVV\\\\\\\\\\\\\\\/wYWSOumzs30WT+7Tor7N+OHPYBUjnxBestVTPtFDYvY+t0ts8j8PjJLyfbdnxwiBpyS7A2t\\\\\\\\\\\\\\\/n0LVFJddCfltS8vuH38DMX8D7J1wi6gFj\\\\\\\\\\\\\\\/Lcc+XgAE45ASny7cqSS7kmannuuVEKlS9GfJj2tK+E25IkRfvXiT3zjsEVq00Zxm4mPdYrwSPexnMflgTJDKogkDO0SAIXmBEnEQU0CYADQkO3araHYJhQLm9deRk0QyH6PiQMEdfiNa8IZIbmxzSkBuCi\\\\\\\\\\\\\\\/1U0qHcB1JD6fymAKL21BrXOwG3ZJxKs\\\\\\\\\\\\\\\/tXv8Ywc58NqpuhtzaSJLlVGaK3tKVoL3ukCTrVp2TTKUE+8pyqJrm90iE23hxM25n\\\\\\\\\\\\\\\/FApTpxq0hGYbUA5BVr8YHY8JGEITD3bCz+Ox\\\\\\\\\\\\\\\/5oqNJ1ajm2F0dBrs+\\\\\\\\\\\\\\\/VxAqSZgfBVc6h1tGocGIwK90W2FQvr+L9EcG41H1iYDaMB8cMMfhj\\\\\\\\\\\\\\\/FZgHv+ytg4IGTPE5z1YYI63Q16WddiARhMu8xU5qtby7WOkRZsQ3bkddlftaJjMEljfJfvbqGSi+v\\\\\\\\\\\\\\\/6MvHHN1H2GFMbW1qMmjmAPT0B1DIAQPr\\\\\\\\\\\\\\\/FSD6yNl6aIjdrYyMaZMYLwUk9PoF635JxEnhSrHe8PfjWUc\\\\\\\\\\\\\\\/mAp133\\\\\\\\\\\\\\\/3Rvkp0OEI6f5DyL3Q7t6BR45Y63zdU65xZdKs49J9NQhg5y1EoetgJQPfU28jyIbKOh382kZTuhtJgpl36+NI7Uupqu5cJkr6j4oUcGNmlnHEyKF6ommWXOPRr1+GuK2dALfwrf7MttzjoC0\\\\\\\\\\\\\\\/21xd6XszY9zYFDg5LBIRC9tQGHJi3V5GZ\\\\\\\\\\\\\\\/ekI4WcVp1kwZcVhEPM8pSsbV7PcGJQM1MmzL78+c75zbVE9u0dNJeloEAHLP1yTdWaAs+E3VI1TdIYpdwopPOoVIWmSoPNEHSkRmH8K4kVzXK1wHRp\\\\\\\\\\\\\\\/VWZsodfWo13H6D4lpCBcaPbXTGOuJQ64nvSCYptBe2o92weBVxpnC3hMSyTUlresj\\\\\\\\\\\\\\\/LpYIU+VfSHyCf6wDmzyvxGOJOSZJjtp5hrmWPT0MCFjSmN2IAk9I7lLhzvUsiMKO8nimVm3XbiLnnsLDDEdNqjAkuHMPb6toLIFg0RGhgWAQx1c2NMyAD+ubZ7jl4MZjhTeMu4ujeSx3E9KYazSX\\\\\\\\\\\\\\\/MIWWXw2XH3sSslTuCETweuUwil3iTjdCB63kU6pw\\\\\\\\\\\\\\\/fXg6A5gMYGT5DlADcGnNjg0iLFHy62wQRaY8SmVtenyg3cAVXhqwToCpoLb9Iw+R9hUPt3u+icOyMXhpunxRu8v\\\\\\\\\\\\\\\/lNukgFxngDZm4Fsh0cgO\\\\\\\\\\\\\\\/bRkO81h01ooxSHqmfe2c\\\\\\\\\\\\\\\/sLCHbRQJG2YAZuYp9OtepZ+EYsmujJOfcmgcXiDJMj+8SOdKKUbtuSz8pU9epAs\\\\\\\\\\\\\\\/+wqWP0nBHy6eQl1VriRl2pp+I320lEmXHN4BWw55KulxAQbC6YkGRVWidOKxrsbK2XGDJcaNbWtlZ5\\\\\\\\\\\\\\\/cnXdrPdqagDRTibh2ZcOOrDSWZuHlxa69XyAbMvLShkoxECQX2y5PUQGwsiwwUq\\\\\\\\\\\\\\\/nRFyAonl8kuTvDXwLa07hvhqfwMnnIS9PTPeVGFXNz8SrLCNUr+tFFD3Aq1IA7wSsF96RwSeyNphIJ27OXuwH0WpdjonPNWtSYNLK5TlVr7qsuwerXJWawLSL7O4UP9xmgZlTCqV+lRpJRDUTgKbF+JRRNeiWL4FfEwYkQdK8of7FKk05z8ywAIXH9e+wYDjUjbMTfNOTNIj6YAgTTI0G3LYB6DwMOAowc4lnGXi5bn+EBtwn05g35hQUNe1VBGA32s6S0wtIw+IWRB6MKk0jlKBvl5tSbHUy0DQI9RC5sYMlGsGUZQKnOCG\\\\\\\\\\\\\\\/7b3Dg5VxpMXdNEdb\\\\\\\\\\\\\\\/oIb7C5aS0tHxmpoOhjdayyS1gH4svR21B+HilY434v41\\\\\\\\\\\\\\\/97s1KwF55AxNgx+M1wixEZodicsYxN9pXuNMZu3iLkdsPaJQbXT+D6HnxUbM9RdhTC3T3C\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ENl5gz9YzhI+Htp7fZMNUbTpGrY\\\\\\\\\\\\\\\/rMPd2MBL6kpgftOr4GNrQpI\\\\\\\\\\\\\\\/31Ko+yvEVlhFbwUAwBmCbXV8\\\\\\\\\\\\\\\/vu+kS8nS37XCYJ63ugo9Butw+K8fT+2uRp1jfPXGiD7uOZhyCeGfIjCqNEOACUWBtZGb+k4Bi9L+cQtSeI5KUA04ZoP5ceo6SAtUvb073dKYpvlkZerMPjz2TURKDE3ZfZcFzsyJZmu15EUHsablf50e46RjRq3UO08cOvWk+7iCxfZXZRRcaT75nNkJaDp1y3wPejSdUXm5Hrtt8JOLdIreFEA2f1SdA4z1TUBaogwNdOL2yb6YLovmsR3nrfE9WPb3ks2iYPXFGxf\\\\\\\\\\\\\\\/Yh96mHqN58nu2HFRsgZ3esQZuLPHLD2damyqnsv2S9KoWAzMrz\\\\\\\\\\\\\\\/fnwG7sbQDIi+PcSxDTS\\\\\\\\\\\\\\\/zZ1iK6Oh0UvPpQPI0lAF6jIaX2CDgUptOBWVAvBShn+JRTBJ7zQdGSeGKhn7DArai2x8gFTiSMjAnmnU3Sv7C7\\\\\\\\\\\\\\\/zdXAoMIE6\\\\\\\\\\\\\\\/OE6L5lMOG1izsB67rzp\\\\\\\\\\\\\\\/TD59Vs+ZtR2P0xPYhJHvnz4+qyFdwFD\\\\\\\\\\\\\\\/mAZFEtWcPt64AsboUAOLb1wakjq7XeYK9YyaHC3RGeo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022o3jlMUntH0F9ZlfddqO2Jw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c8a26b488081a2e6bedd47952716d3d02b40a32dbe1df280d87bc66462c4a36d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1149.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1149.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1042\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1042\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1042\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}