{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Dx5g6CNw0NBA9MjnPhAn9beQIzEZcvFqBHgrnOLN7C6v5WMX72Gb6P67rvdK+NW\\\\\\\\\\\\\\\/GrMyWn3+vA2K2I1Qma7MmtiIvL0SPjLxSa1xZ1duFGFOdFaniePc52ECf2hxJX94UVr8wxHoVnG+dj25n4LX\\\\\\\\\\\\\\\/ltBSon1xoSKBC0FzQov5ECPC6aCg\\\\\\\\\\\\\\\/WksBZt1o1Qb1+y8uNoA8z+EJR4YUrv0S0fv+ACnCTYPe\\\\\\\\\\\\\\\/cpm81DVM1iQL9124bw7HbgiwtpmJ+dmYShn3CHy9W9HA971Jwoi9fSVGMBZMIOVMaEh35wrNHBZjFbAdQE\\\\\\\\\\\\\\\/3eaaStupZ4eoUvYA4aGJvaMUFGc5k6mkAkNyj\\\\\\\\\\\\\\\/tLpCiikwa3UlackYY\\\\\\\\\\\\\\\/Xim7Ni8rixreRlq8fODHFnGPtdszsue5V\\\\\\\\\\\\\\\/oS3JzJRmr0hSPrqD8lplG\\\\\\\\\\\\\\\/tDFsHf8PbqCaExe4mHFxZHbHKUdCqdeseSWBDs7\\\\\\\\\\\\\\\/XbGO3u2QjIWfmwfoilmBt5OmEdwpQ2mwtQfmC3QNiOS9kmT1ODWQr0md+WUPxZnPquw5qIdQh8kGzYzw9h39P9pjsXxxmyi82\\\\\\\\\\\\\\\/pNUsH4njFZ13kTgbt8oROqGKJYgsVxtlo98y1en5xbbSKy6E6g8eKsnJcFBklLxCaxT0JwejlDl6T11FBtwp94UkcoSl1bDL\\\\\\\\\\\\\\\/+c5FOBXG4TAR00OoSCVOZNwbsdH+bjAgAmjf\\\\\\\\\\\\\\\/XZZaxNlBmln87hALaCd0qOSrQrbEmVpS8SFUcLzjyw\\\\\\\\\\\\\\\/ATW1Aw3otGL9qtPwrDmjA3XnW\\\\\\\\\\\\\\\/ER0P\\\\\\\\\\\\\\\/fKRJBSEMDf07rCXiqvUlEDxi4CaEUQjIXoaEdqx8Jjhm4YIg5cFBrZARC9UTCIL+zpWnoWIuqemJwUitTzbhNeKj4a6wrP0\\\\\\\\\\\\\\\/Fm79bwy6Q6jNL\\\\\\\\\\\\\\\/xyLjArsmsC53VWDfRcQFJBQK9m0e8Yq3Y8lThhNl5ZiN0gbXP4zklGOkvGQSPUrTmmJBzBg8B+NN7IUqpiR3ZKBKJXf5WE2rpki+oke6DdBdUNFx\\\\\\\\\\\\\\\/t3+j2w8hLwuIMWimF+VeBun1wc2Al66LG+iTsFuHft3h8GqWmS8EsPpHfd2dgfrw\\\\\\\\\\\\\\\/HFXk8LfLNDP9EE2eCOadir0Ea58qrkN5gyOxCmAc8be9lvyBeFGc4V4Z3CC5UcZXIyhLdGpgW010wIDuuNnC2\\\\\\\\\\\\\\\/iyy1eFXGO6ORBwKYcvvIW\\\\\\\\\\\\\\\/BobnO7qLg3r4UoUm2O5O18FQZNLCQuXbivitVWfdIIUceQAJqib\\\\\\\\\\\\\\\/Hbz1MfK5LXkMhePa5oM5zZe28DdmCLPGvqKk9dHCLNQ99aan1FM1h8aPvNTssrsjgu32r0FbvDHBm442b7KqBLXusYFSUqswvdaboROFxg5CcD99v4wzH+HmJLcWPqkojHzV1fOlcGYR4v4PW09+IrM7UwpfdCvDjNEAldD4euyoLf48NH0q8g7cwPB765jW0ZLiShZ0MITbCJjCUTyUmSN4XX23MfJDTHO5dxjXNDOeJXBK\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/B30HEMf0jCd5z+HZppUKsnRktRtRAkaSZmF8TzP0op6NHAfFpUfqUmfjqEnOkkLdzd7FHNxEZPq9KPSLfGkrdC0RqmgTFG7lKrdwYbUdB9AnRNVgigR+ldrrMimhsXHKdEsWrueWQTYvKmiprB+UwmaqWn53gXX9twfxaUjmq+DZrC7UJHHVG9S0TfVwSo9MOhQCZoZav+qb8m3\\\\\\\\\\\\\\\/Od54qhld8mfQYvoyZtnZL50U9PeMvWVzsa+2hGbxQoODGulFtzPqpAwM6Styn1XtriH52iuSgHjA823+M\\\\\\\\\\\\\\\/1No2+Gx9rGkGcvGdpWf+m\\\\\\\\\\\\\\\/LC49w4ON6H8VBMPYFX96sp4uOQfKtx9282VlHgBRFp45jUA7+lsDViEJuaqmVXHmzH1pgG8194KDRvylU2ciB6kaVjUqA\\\\\\\\\\\\\\\/ezO+O1JUWsDVOLMfsdDNGXyCR3+DJcF4kxqPM7VErs+5thlzkurYkGeTL5qShU\\\\\\\\\\\\\\\/QfJAZgM0F4BqCFQp0FxLka0iwbaDoqhTvJQRzYoeB2bJyEb6wm8z1lS1dpcTERdIWqOZ1VF7lCOqaNINuLw4LotYn68fKgTFA3Dlge5hwv9j234uUFQ41XS++m47XNEUJClWSePYraIBHo36nhWZeG\\\\\\\\\\\\\\\/3xxCcAxXBU1NC9YSM7zZW7PQWrXmihzD3+CI\\\\\\\\\\\\\\\/V7P7CYsj+nZdRjSniac3T69D5rMlN\\\\\\\\\\\\\\\/HKliKSufI82LtTqTH2wDTBRZd4h+wtHjmnYZRQ\\\\\\\\\\\\\\\/ArCfSO+Pe63GUm5\\\\\\\\\\\\\\\/RYPKXQC21bw958\\\\\\\\\\\\\\\/leAYGKR0Kks6SzGi8LDTjhRW+qYTXHhp98LN4flblG1guagDzo5NLhQf\\\\\\\\\\\\\\\/gdqVUqzZ3TH7tTOWlVJtqtvajnoYJuoCDL7PpNdlXZd2BK6LhTv5t19oxopUi\\\\\\\\\\\\\\\/bDamwD1ytUwB6Bh++GeG+ZII7rOo3flEg\\\\\\\\\\\\\\\/jNo0Y0Wdcjr6iJi2sHJwcKNL9Q42wUwBUdNd1H20MhfujXOr2EmSVN5dwOZZDUYtwq43\\\\\\\\\\\\\\\/R8RT9n7P2kvDyx1Waa8EuNg\\\\\\\\\\\\\\\/Rd+IlHS1S9cPVPuekPq9KYq1Q70EPlQM+\\\\\\\\\\\\\\\/57agYpfOeaMbEo0PK\\\\\\\\\\\\\\\/RrSLLg6i1C8q6f2EP\\\\\\\\\\\\\\\/pndekxXyhSJQeLcyp+M0o+Y8vm2W6knRDyoS3QfPsUpOP9CalEToogqoK6iEdqrr9edq96FtQ5wg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022D8XtQdzVxKlNfzoYLLj3dQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002215f8ac629c5e525250d6fa93519f5cd61b094b3bf6bcdea5f9990149b7690bc3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/1\\\/37.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/1\\\/37.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-014-0037-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-014-0037-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-014-0037-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}