{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221oX9+GopKP7UK7ASu\\\\\\\\\\\\\\\/xNzzYBojyUFFx7rypvvYmlI2j8ZbGl3oPn96ACLENuSXa8b1dNuhEpYs1E2fdYJkzXOjWcSIiKw47fjke48pEFvO6G29P\\\\\\\\\\\\\\\/GQvUvwfbKzACMgTJwX978tFgQoxBs22+OKmG4B9sNn\\\\\\\\\\\\\\\/IrRCgKkFFOu69cg2CkaoIUS0Tx7h8xBvPBQHxqc6XgzNUDGOHqe+i1pcZFlw8uYGPSCjfH4YKQKgNPhDrruzBZHJnzSRenAlhMATI21egpn1uh6IDpMByc94ejjQUGgYcf2ERJixjLSAC1lquhny9zGoKnCCbjpbsfztGTWZr1p76MIw89RE2Fcdo2S752dZCd0EdoFz8v9ZYQLkufx2rbWUP5+bGoVvod\\\\\\\\\\\\\\\/suZp4tl9U2dblkvkwuI1Trf84xMwvQYwzU5Jp81fZtykOJq0pC7o1\\\\\\\\\\\\\\\/W4B8rfYkICn5W+ayOQtNkzt\\\\\\\\\\\\\\\/U+MggR\\\\\\\\\\\\\\\/vEBb3V3ruda6AfTuxIJCiIVhuYBO014XYv7RnLi7yY8IuPBcvyndNumexg8QFNRKHP41hE5NxSP+kUaFHtf9SjGxZ0Znw3xh1GhDruynHngctU5I5yU0QO50PGtG+pvi3B1tRIHtsI\\\\\\\\\\\\\\\/Zwo43R7o6HGii8g8JaMeGbqqHB6kkJVIL\\\\\\\\\\\\\\\/1XpmIWclyAL0F1X0++7CrwTw0bS7L5NWVWGFSkbNoKEGqh\\\\\\\\\\\\\\\/B2y5FSxRyJrZw6iJnxzqH2nBmEuStFqFLHEqAx6tJqJfIZniwd137aG34XdwOMc9Ipdh+R4Nm\\\\\\\\\\\\\\\/zMRtoZm+1g+WqlgRjoK1T\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/cIa9Xk9la3mZDN7BEi\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/RSXlGwdaTuatWwdA8FT7faEhbuS3vzvotGRsKhc1faFoddqbzut6+aDx\\\\\\\\\\\\\\\/6hVJuJgC\\\\\\\\\\\\\\\/MOqo\\\\\\\\\\\\\\\/wsSfVSO9vZtoU+rFqG92zItjEHdtf+bAHYQsGxt5dM2OKv1BNw\\\\\\\\\\\\\\\/Mq6V0ssksr9h18z132vh3Z68Ka1Pr5CU27yp4X+BVhzfnVvF5i9SVJ4l0XM0HIOoadb1WTKulPxXar+194NuI26lvTq9pdDRBX4p61Ttr2cH3HV6cTpZEJwhBEze\\\\\\\\\\\\\\\/aARizscAh71cfHdb0EbWch97wLDzaXLQPT\\\\\\\\\\\\\\\/KV167LPKcnCCaO0fzeDPXAvj15IrKtAO4SCqAbJWUBEv+Lc\\\\\\\\\\\\\\\/R3mXApdOS3ECcUuxSNAhXoCi39tT\\\\\\\\\\\\\\\/7xNnwrfSNYXNh3htNLfCen\\\\\\\\\\\\\\\/RoUxoVSDjFUpqhIjELuAUuS0s\\\\\\\\\\\\\\\/WaL5onWGTHVZgtQvNI3RYN+UY95Tb+p71tBhcW9OjIVS8qYOqE6r2+MjQzLBuwN9yAnVsbSsre+hIZ0rb\\\\\\\\\\\\\\\/SSaMXHzUnQrtZvwARVHMNDsYCqne5zDSULxTPkTgYkmM6AzhPO2GPGJcnmDsg74ev6y\\\\\\\\\\\\\\\/Oc141GmBt5DpcStJYA3zM1YLEcDTlA9qMeUeEf+25ykdAMttm54XAuUylFsvavW8cGdM0yszf0p7RB+kxQ33eXNhsIRQZXYhs1A8XfosX5YOP2uw+ps8S\\\\\\\\\\\\\\\/XU7WdVOZT6SmKlLLq\\\\\\\\\\\\\\\/uNsMIVsouRK53nWQ20tlXCjnzSqRdtNV9z7MW3RYuq1gAgZcJyEL7qVVfzUdUVCAnmp9byXwB5v9m5Ka\\\\\\\\\\\\\\\/g0hrOMjFnqpDFCASCvTh9XjMP6WLIjAp19zjt0xWAGeaBlazT4Z+g9wQesu1HLWn0QGd1kTiPT6JGO2\\\\\\\\\\\\\\\/A246L0vFL797tc1VyUAvniJMbvEdsbL83n+aQn4pOe0GC61U04WLxsaP5snnEXDUhW6W+qgeBhgD7sYhe00dUCQmZn9shazmcBJZ1uyg2d9J3RiAZx9Bvb9IF3KRe8\\\\\\\\\\\\\\\/5FRyqE2apkZiIS4Rb8gYQQeJ8n9syUbrHs+DnAHwwOPl6dXAiZJZs\\\\\\\\\\\\\\\/0V5yDGUzEQYCbN+YBark9ySENGQBz0NWOGypI3jEMg2Np\\\\\\\\\\\\\\\/s7OnztvoM\\\\\\\\\\\\\\\/lOaJ606IjetA4ruWuvWhpA7g16KdZAWDeIIECWGHPzG9mgURfIaIu+wzs37O5FNAbEdKtq1IvnDXOAz4tzoV13ZClT4gY+kPmRD6Jg+d0mu\\\\\\\\\\\\\\\/LtrB9JXoJJE+49jXJoT2PNe8ajCZhlqI7dmdRo9A2x5wOhDQZnj\\\\\\\\\\\\\\\/0z6tNNmq9GVDLIiy0d+1J62N4oh++BUbKkE49uPmstNG1Yqf27izjuC00XsQ+01fVAsjNx8GbSJcHWI0j3Arm5lY3MTZU2JPYRNtjW4b8+l6zymxLT7zycVR\\\\\\\\\\\\\\\/TeroCNQDF3oD73F5cnF41HEn9oppmvWvW7du3gfa3EfEoOH\\\\\\\\\\\\\\\/FarqmAcNJke3ChMT1eZ6In6S7tUDM6XafBomzXFEE0vB664dYAzUvc10ubMLYC7JzD\\\\\\\\\\\\\\\/7Yfj7ZI\\\\\\\\\\\\\\\/bbVZDtyWhVfxAbo08iFeIyTqmLS0LdMjv0kVsLG1sEqH74zOBrQdyCCmzCpwxuQoINn\\\\\\\\\\\\\\\/5BzyV2Ct0ZkTM7M9JBL3EevAlEUZmnMXz35eZKyq9Jj0ArUrWFds2I+yfBMyYnS8dqPnFXnsOu++YpO4bHuw8X5Sxhxt6ltbPM6RaywSYtI2IbXDCXpY3+xvBL3mvwXmYcA3c9pAkmUuNhYU+1pFobqopMlItQUdVRJVzGCoWuguxK02+iFVV9gQUOeRS0f+\\\\\\\\\\\\\\\/h\\\\\\\\\\\\\\\/dJxhI1uLeaFXWsw4B\\\\\\\\\\\\\\\/vNgnJgCdU29w1o+0Gm\\\\\\\\\\\\\\\/Pc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221hdsWetCTWVNpsKcKn6n8A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002259c29d27ef9a79a22c8fce85b3106debaca63c62a437ebb127ea296512cf0ec7\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/1\\\/20.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/1\\\/20.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-20\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-20\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-20\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}