{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022GNskguCwn2j7VdMV6ev+Bs3tQ5mOUE5yhyuaFN6AkOrM0PUtBs16findpJSIb9cd\\\\\\\\\\\\\\\/XPqMdBt8kZl\\\\\\\\\\\\\\\/Gm8FcbbrReIBlm+m7N3KqBWDAyFQH2q3VzgJvQDEv2jNvF7CU+jWe2f1BfrgXSk4wc\\\\\\\\\\\\\\\/FbD4XolMOh7oh2WSQLtKoEvPMhYYT8sSTsUlys54lX68zbwlqwsYlfgdw08uUDUD968L8tkWTD4MnV3PU8AZtxkxL2rof3fa7ohlrSUVEeEpiUfu\\\\\\\\\\\\\\\/3Sw6TqsxmKRWlkLEysxeRS9dYtvLi663rw7\\\\\\\\\\\\\\\/dxXDt0Uj8aJcUkWfq+Qok6zxBtZDvb1vIAfE1JZmePGueDG7\\\\\\\\\\\\\\\/2RA7amfaTsspZJbyhClM1eh6ln9a\\\\\\\\\\\\\\\/FNgadZ5I0jsVCFNCq9\\\\\\\\\\\\\\\/qOA0OIccucD7Du6UVoQhVib+vWnIwo84S9lp8vXvcZYYRTVX7vuDc7dXue\\\\\\\\\\\\\\\/Jo7v1fn+DQG0EsojlVksXW2HmQ8I7ETnfs7DxuupNAG\\\\\\\\\\\\\\\/4rpvAewjOEaaKHk8fhPmAZeI1dxYjouYhTspxKY83TDARUNwJb2VXag0tR7gqFtu3PFTCc3Kxspj7xZ6W1vQT1HpuwDyX+1vKC0oDKHyQoEdcGU48CJwKEKRdyT6yY2jBTrtYUatMC0KFoQTCYH3C3wez6YPACDAe3c62+gaSmk0mIBNkgBs9cjFrpRIeuDZ4Cb2DBp2LglI0cySeuQUYnUOV\\\\\\\\\\\\\\\/qw\\\\\\\\\\\\\\\/Ysigvb0p8QHAd0zOm7k3tSedV7ScBBI\\\\\\\\\\\\\\\/c6hli\\\\\\\\\\\\\\\/7dbM94e0tQ25AWLVB2I5gP8EkfepcKQgsDbual1FcIdqe2wykkxqTGVlxp8JWWI\\\\\\\\\\\\\\\/1rWoGl4H5cbo3MlICdmZZyaSktdeG\\\\\\\\\\\\\\\/nRfkiia5JKsI1lSBY+PbGR\\\\\\\\\\\\\\\/1GrCEu8kD9baYZBE4ATwxWT\\\\\\\\\\\\\\\/pprh1Vd5TijzyJQvzkkg5WKCwJkuuBs0rgnv1U4PpC6xwfeTkgbWwaygulODXYzIN7ZUXQlYQ1pKkyYurrp2cmyHK+baCE0zr6noj2jGEmd80gzl98jZNJ2PKtIx7KkuSH1kugJozDA67eyIiSxCkcKcyPgolwRcPUcg6zULpJMvxyYl6Dbvz7RgMn9nQEwA46hQUr8kmeSrdBVo\\\\\\\\\\\\\\\/asED4pIuQkB9yNY543gSuQQTCwrtqUJ+2b10Kx8xFrfXLfCsOn8o3Uu7MVznhzuo\\\\\\\\\\\\\\\/VqYBIEnszn8\\\\\\\\\\\\\\\/8wn9\\\\\\\\\\\\\\\/xIz70Eev7Bppu9\\\\\\\\\\\\\\\/Bn9cuIaRDME1oWKczSJ6EunFDpavdpKOz+LMGQ9GEiYh3sxUe1ZRNJMOnbNNZ3Lc0ioYyecrlbp7fRwBzUSXSKwJPe2YZdMuUXFOBiYyaZaJmeq+HBDx0pJL7Ju9Yl0Kjly5YyTtmzx5EH71nb9Y1nReznB740fujyYgo29y6Onhbc9uEmYfznrM1VvbWh5+DEh4vvJeSj0Ag3vSwKcmlIN1qQK\\\\\\\\\\\\\\\/E97Rg2GMCXako4K7eZ5WbVVBKdLwISQdMsiJ1\\\\\\\\\\\\\\\/mTiyceN6NS5w\\\\\\\\\\\\\\\/H+7H3k7\\\\\\\\\\\\\\\/7S2YkubnzC8KlmqpxOSxnSzqjMFui2c0jA9zEMGBn7+wBGiCG0TQs7wAlmpX8hLfU0jTpkPBlEmOgWrptMNhAtpvw\\\\\\\\\\\\\\\/jiZ2SsIWl8nfom3k7s1om8PDs3LHFpQvQ4Z3\\\\\\\\\\\\\\\/+hd\\\\\\\\\\\\\\\/b1BYK1DpwU1O9zGuGHcU30JePcnufKjBIugbXPIqT4n+DXAYC3ATDAQVwchuvbByYmUCSX8CT5i3TMtihlHkvgzzLU3ZKkWLFuOJI8958W7UcNu8L\\\\\\\\\\\\\\\/1lYX2A8qs7wetg0JSbEYdsQvMhaSRAEqt3wfxZ0Xy6edrlNTtHw75GifAO9e6Pku+pkRcelNhhKtY3tPdB07sMl19LOqEU6vMPJTIGdyOsO8nGIVbtCbn3FGQ9ZDZ55yX\\\\\\\\\\\\\\\/zs9LgXxWGzAaQgXiziKAugE+IGspu1WWuUcInDgX\\\\\\\\\\\\\\\/O7SOZPkJphbYeE92LmMNGISW3XPQQTmyF13w7PGjC2CyFlFkidblzN9lDRToL1jPUkVaz4ilQYjQUQjzIOmpD6fmJdZoy3kv4O6W7oPppyfX1FeClk60qu\\\\\\\\\\\\\\\/uJ\\\\\\\\\\\\\\\/ydKh+Vaq63CdsPKwvugEBD64B7bYyk7LfdkAondLc\\\\\\\\\\\\\\\/a08yxsYUYw2pUgaxZOknwwNw9NhQZIP6rCINlItpBldDFxcyYOS76xOX6tbzXTjF3tr8VirJdLGKVCKT2mwjT7KR8+LTRC7sYthrzZRNvwnEEVqdGnFF3cnEBx2bJhYl246Qx5qQtBy7XhUlxVdFqBx1k7Kz3gyrJly6zLtsfiEsooUYENfNbFkuQdOuWo\\\\\\\\\\\\\\\/RX4+85C0Bqa83U5vLsZZzAP2BkZKRL2m4livobHpUqz5TbuEBL+uvP6yfwXVQwVTdG8SjADZMHD1Es7mkLVzxwwm1uwFQYtlhsuqr7Im6HOH3VIkauIY7T+vpWL1toh4JRaJcBT2CglPNQFGu+oLsDiGNRZhLgQSE1IEOom\\\\\\\\\\\\\\\/mX0McB7dCj+dGdc1mx1H64WLdLrYAVEmUe6fR5\\\\\\\\\\\\\\\/FfmMGZ5Y4QjVeoPF+6dqDfN6vDnMD3pWPspcY9\\\\\\\\\\\\\\\/8fpgAYCwj1BwI58MlwIRmbX7IpJ8fb7zSECuP7l6VvMIH58+9N0VZkzmR67NOeiWwQyErAzV8PVW6ve2fI9MKc4POQ4jv1YLBEHs3VQhn0VQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022rJ0vZYhnBjVE0wnXO8owWA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b701f255b648f378d39aed1a1286143386bf4d596bed94fd134d6b353b3f82ac\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1476.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1476.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1325\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1325\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1325\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}