{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Dt\\\\\\\\\\\\\\\/PEf6lsXA+SeEU61fe5ppj2ouG8S2HU908WPpcHLyuCZ30dBi4\\\\\\\\\\\\\\\/g39zylP1WygOwBW+7i2NTgGulR8uUM9Ow4EZP2TCsOMoKdalIvCHuSQ87q7bq5vCa3O6NjWoAoNUcTnNTcarPrHqusfw5e9FnTZx8Sv2mpxTnLe4L1sle6uguO9L2Fnici2yv90W73F9RV2Ofyw7AodBeYLO8wl+pZ7c+qYGvNUNqywBO\\\\\\\\\\\\\\\/QktBwgd02d4Su6IFQjxpNWx5tT6CBKC02kHZuXhTJpphC0bA1u7StjV9BurJzfdHkryKI5mBqTX\\\\\\\\\\\\\\\/kEbp3T2VxZP5WHlZmk5YsV9zYJ\\\\\\\\\\\\\\\/O+hk2yannHldpWZo0kzQD8HCGwL9L+vmetn8Ogx7kDJMa6RL\\\\\\\\\\\\\\\/tKAyhaYnR26kBMZzQyUtJmonOcaRIQ0Nw4IaVjqiBqM+\\\\\\\\\\\\\\\/EHUjY2XnOzNEK837VwyfOoq4nu6VjO1WR\\\\\\\\\\\\\\\/AyxcpE4kIxArr7GRTPPpxAbvCcIj6E09uJKGWc60HDHJ9M+iHeRDg7QoX1sCYgZFDXlvChtYQ4xpOimDib\\\\\\\\\\\\\\\/yqjGojkTn3oMEHJC0OcdDTiGmVpMolo5xH3EHOB55bH9rGHxUHF2MIjzjYZTmOAnzJpoCr0CWV5N3rQA7ZNkprJmhiCgNTDs7MqqdDU06zMj2Vr3Ggxb+7ObZ\\\\\\\\\\\\\\\/Y1pH8TuosodFSQOzcA3MSDldfCVxK6GHYkzWlfH7Re4l11t+ZkwbaD+oYMM9DpB+LkYWk0XNag+uHvPtrLUF4cjaPPXmUfI0XIj+7RHYf75ML22xiYRkivZeao7KaSTEcR96GbF+yB6Zxjc4cKv2toKdDy2Y55NrMh2m87GNgPiVhQQNGeK1b1M4pdT+eKodeDfnUKRvHDw8zFsXQcOxfAc9yb\\\\\\\\\\\\\\\/7V0Agzgr6oqNp92271dj6PEMMZWkfmba5EAzDF\\\\\\\\\\\\\\\/vZfXHVQdjzu0BYIIdg0czbA5go6bQJQ9KNBBc5GX3\\\\\\\\\\\\\\\/C7aVbTwGSBEIUE9Kh2FQ1EVeSOAzUpHZG1GaNCreecCGFzNMV2x9ZuKfA73AJbuwDcAjNrbe1F\\\\\\\\\\\\\\\/H7rPV5GdxJ1pvecYnFBJqS62Q0loZcu6pekte7wR1O6ZA\\\\\\\\\\\\\\\/Kjf73lWhgABI+0A25NiGXLLtqoxj3IhGtmTxaRRjR3nvXMy1r6zg5uYfimu3gO24nF6xh+6esoNsT8cuL+Due6qvZbcj5lYYBubh6Dr5cNCmDi\\\\\\\\\\\\\\\/hNH3wWwqEsb8hoFAxENj94ZEGLy9KxAFNifXXKYUFOii4cw94UiVFLwQuAd8W3O0IIGVLVxkURRlK91hW\\\\\\\\\\\\\\\/h5d59RnsG9TOqw6pjnP9twCkqlKgIWxilO3ovYhz4plnWEncIPczA0fl5JmhRrrMWw5rQ9I8R71BEOokqnuqYANQw8gHewL2HR3zn2npbR3lfgRS45jpuu+9hHVUDlgN39TXLXreDec88n0PBvoiARBbjybb3REnulJz\\\\\\\\\\\\\\\/WQUSuyud4uJnQ4Q0TzqBdwEW1KKV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/q2SHivGa+28LShztiqLyLxb+WOkUtAA2oinFmITOYIlu+Ds5umzD3pxONTdxEJMBApMTKqE9UHqDPvA0Dkf0cJhr4wPw7bXf37svDXmm5qDguK\\\\\\\\\\\\\\\/CdzpfFghFEYhqgqXTdEWvznqFk9L6VAZemPSCKTLE3\\\\\\\\\\\\\\\/VjwX0wExTaUvZYsNJfxdIXDHSfjsCbjO+of1cxs3Ks4oJDLDgsbE\\\\\\\\\\\\\\\/LyKcIys4xjDHg7KTGC0iJEsPa3AmdKxn4I15iabw+rRr5x7n4e\\\\\\\\\\\\\\\/nmGhDsrP+6AmYDbzJj9eQ6SWeHE2RtbmVUZ+oqpj\\\\\\\\\\\\\\\/JVqXPpGqd5FBK6G2ddNBv4isCybL34v4orcAHeQWWoE+CtjD7hS\\\\\\\\\\\\\\\/ApyBB8NIjBzsmDnzT6R\\\\\\\\\\\\\\\/oTj6FXCjb4ZZQUKNZOpVtm1d97oEDxcCUGk17zynpNvR5T8kugN2ZyZyc4CONEDyp6kjgNgLRapT8hkyAS9JF0gng+cWjGPZpTVqIppmXEjsPaZBFt\\\\\\\\\\\\\\\/HtfNilHkGdXa85vntk\\\\\\\\\\\\\\\/RP6KuVLQboheLq75WEvSPvMy5SMcYWbrFXShDJxQF+yv27FgX3\\\\\\\\\\\\\\\/re5RSWVYqBBuLr0PLJa6zy6O1vOw7TlHy2656SW+5vgPRUmZqbmulhu6QXbUP3xz0OF\\\\\\\\\\\\\\\/Xja04J4XG1kNLIVdxiAEguGwROs0fiZ2ZSInw9QV8cMmCtIhe2WJ3mNitT8qrYAYAJnZMN7n\\\\\\\\\\\\\\\/5rr4EczqdIpXj1T6xX8qdv9MA\\\\\\\\\\\\\\\/MW2cyvltTi5T5l63DsrpJK1LP0RDRfcKq4WDnqUFGbIaGYmrUT8NUoF1UVXL8si43TRoqwH4X3UqLbKD3cI\\\\\\\\\\\\\\\/cNzu1zy\\\\\\\\\\\\\\\/f2sg+HIt9ylnkPSloM2PZVZ56VCHW83NwQIQkln1gNrjKZ9hvFC1ETs3Fgp7JIVkLgpc6cz2HEwsM+p+0gm\\\\\\\\\\\\\\\/4NsVBjdxw1r6yQAAYbxRTZQC5vV+rqgeiXHTOVC7kU94Mcc3hOTa5iIgIXvxRLwuu7RGLx8AHPvzQpKSCCAkaC9hpNjQ36bLijGU3\\\\\\\\\\\\\\\/pbppTZg4O6dC3jcnOMr\\\\\\\\\\\\\\\/PSRSgccDwdFROPtbjVMLfTFtBMaV5yJxFMEtQbZm8RHTgnoTSI30tD2yo3tbRhYNZkYmbCpCzghLPiSvGzIHOQjHptqmNXPglSQjJcplm8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022drf6MPv+VlJRAmyuPadtNw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bb2c762b751c4edc46539bef2404480f05f0decc754883aa81b0a35f16fc9015\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A405.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A405.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0356\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0356\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0356\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}