{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225VTB7YK0DTD2G2OvFKZBoiyG9xZY9XYQLPfcVWQoovRD8a72W3Wd4O7w5stQxlQotev7\\\\\\\\\\\\\\\/GUn2R0uHOUR\\\\\\\\\\\\\\\/GlbG19aouDksAfcTB7Lm0cC6R2KBec+nmYl\\\\\\\\\\\\\\\/wHdiRv9iUOe528d8VbmHt6yM3v+\\\\\\\\\\\\\\\/KXqX8g8xBF9b9AIaZ03znODRa4a9TBlv6vfuRDD2sX\\\\\\\\\\\\\\\/I5Ez\\\\\\\\\\\\\\\/x1melyVgBDDkNfsrHzX+qxcfivTD+Wt2Cq92xvyEPO0AT81RfDT2U1UTkPLg2GDB+yxJwFXTtAokYdM92AgTDmbtHgSacBKUjp14wcG\\\\\\\\\\\\\\\/7kh5UMxdMDWeKbwCDFFyF8+PKHVhck6QG45NErHjUwyCaB382Ez5ukSgfCKx+7sPoFaKO8gBLvtRlrJIJtdBwVIZs4X8DkascQvNSrmcNAt4CWlxRsgq4sPJXFr3\\\\\\\\\\\\\\\/wEJz7gZOWK5eHBOPgb\\\\\\\\\\\\\\\/knEFzcF44HAfXzFftd6IRErm+Ld\\\\\\\\\\\\\\\/IRFSYqewypM\\\\\\\\\\\\\\\/7cMGnxr+fMzcR1h5cCufKXd7wpXF7pUYMGzYuoq149EFlbG7iQ2rnlDU54+0WncdltooPsiwaVW1DwzjJ2Q0XuXIg7IlKpAVvbAZW1sdPvj6JCxjwVA4qjDEhzyZ\\\\\\\\\\\\\\\/jgJ5DTn9CJlSKIKSa5Kty01GV3KmkLYKeWPyDa9SrztnJ3OeW+Q8MkNsiaFmABRiB3AlyuFASIIoojRswM5kRiNgA7XL90PByts5QhU5enC+T0UV+J34WmBqZh08Xfix34AzTy+ViNcStTVMhID2Akim8eKjOFTZaK5kwzXuy3Nm4K5LM+Xfugqg173DYpqNKSqEyckBqihdplMvksMOIGhKqEwKcTta49F4k5osYP77uFP3VMXAqoMsDz\\\\\\\\\\\\\\\/dUSgtVDKZEKP+FzztjOlcLKkXpecfSwR0Tf1vZFxbR70RQtglwFYW8Tqwv8tnd1MCEwib6MBJABCYhjcE2g4nSVv6yJvFPL0jvRsfa8hDYAheXKcydra6AoODB+VRflcQldY\\\\\\\\\\\\\\\/4drdjtEhGY7xt8G6z\\\\\\\\\\\\\\\/DKDQGRtv5cLxTYM7stnH\\\\\\\\\\\\\\\/5IkcKmB2Coxa5ei7rN4KhYIOtZXyPesCdEmPHQZIPDW7gNVVafVw\\\\\\\\\\\\\\\/j3Idg4X5zAp3xEamcJW4Iu9a3n6S8yoYBpzls2HxJCOOMP7zE3xZNDavBZwwKmHyHs8OAo0viHExP10gLobrsJ4LNRZpCkUye\\\\\\\\\\\\\\\/9Y4ioey6Bz4ynOPumMSNOuGzLiDhTPi+WRkE473e55laR0D7OF75noCqILH6ycrXvPj+TfKwEeHu6nf15Ikw84VFJgbWidFIDM1Oynku8ioi87s3XEDPTzVrgbVsiJM5QzFL2wk\\\\\\\\\\\\\\\/BWeVtMka0zZD9IhT6BzNxNKpqULMZm4jpO6RgScc6PGI6hyT241A28WKgUdyWnoBY4RpQL5UWFGTbJn+NotVgp1obt3KI1AGEwm+AGmNCslaT+FG2AiX0HffSo4vmtCNI7kAV388pDlBy65xxYOjkzbEl2qcxiuvkijU2YrwUuGmBMC98UPpGycUQ\\\\\\\\\\\\\\\/qBFdEmXqTVlqzqxUAi+vfsLyFZz1Xjgkcq8xUqufeFFs5EWSEbPsSTiOk2K77xoGQ4Kxq8\\\\\\\\\\\\\\\/e7MwmHS9POcnwDgb7WNODHzPCyvEHse7PJ\\\\\\\\\\\\\\\/w4VacbawTQBDUIks\\\\\\\\\\\\\\\/KqIPjiKA+XSLTnbyQIPPx52knAFIJYVNZy9XhEDHm+CwMD775ixzD5UfBLGCH4hWuRIeSVEa9ysyg5ifLlkvr\\\\\\\\\\\\\\\/c52eTkP4Ox4FvfWalVLEnvLlqbUyiUNwx5R146Ni0znqKbQp+RS9kOFHNqd6\\\\\\\\\\\\\\\/lsOWp4zPZr4WybM4Xz2\\\\\\\\\\\\\\\/KVqcZqQlcTf+mzD1NJvlpyghxd9nV4i1Ac5tvcAmpT3A6aM3bvoVUjyQE1OeRI65Zf2BP3qcc5ZebkwrWP06Sn6+y8Vjzra9hUZ3TS8bP+7eSI6m+7q6BftFxyZ\\\\\\\\\\\\\\\/MZNCE6lGw62VZXLrk7zIjHH1rcWH9D6PFDTY8sdZ5FU1P+em61OaRfY+5Cf9gWGXoeLyg9osnWNvyftZJUJEvErFwfWAGEQcOubds+B0yNc12nEUxd8NsJMJqGK\\\\\\\\\\\\\\\/sx\\\\\\\\\\\\\\\/vtdR706I+ojMaNWegBipSD1p1H2pj7nGD\\\\\\\\\\\\\\\/nu2Tg0J3f77uH3nv2veoOszhCr2cu7sJf9ubmC7aFDnESyPrriL++aZGcmqs3kqtZTK5gD9xR6TrR9PzYyqlVfLZvPY45ZGBphHweFiAs3OT7iHa7jUxsxD3wZBxbi0ErKeiFqTPY89yjfiVvIQriDXrZLCv1Vt2358KOQ04aHppRIuzbEPhUgfro\\\\\\\\\\\\\\\/BpIwrbgxAIhk6j21lbyLcyZ+RyE69tezUOXVOn78ze7uq6t7usCr5UFFsLNnYgWn21AtbvEpSTjpVZS0djcRxl1E2q5TEisQoK8rG4ikBhBb2dzhyeu1HZtYbQeJZFJIJrAB9C3faa93Pe3k5e18TP1Dklb9Vpk86ZvyC8KrqqbqDV3WYHTx8dlmh6Q34lPWjg7E5MlnLBxSK48al91bpzUwe8cdI5TeeG9V+Oxss4pum0tCUO\\\\\\\\\\\\\\\/o9qrY3mHHA1zreJSId3FVVVZru+Jnedmumskz18HpV8XrqF9aTU0ZQh65g2rBuy4eQNDnD9wgnRj4faPJCQ8PYVQu2CtvsUHQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022V2rtex9cRDui4zQoZz5MNA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227c21f52e6cfb68b87d25d665ec0553fe481e19d0b39a48675f09a4df71e9a5b2\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A494.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A494.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0445\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0445\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0445\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}