{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZOO4Hso7UBB1uR6UZc3xI0PfLTMpQChmV5A3ouXZf5OlJba6WGf+Y5PmBXzjCUbyMK\\\\\\\\\\\\\\\/LSqRnwss5tAByBBaZZMfYkY5Ex3HoDX2v8EYwEfTWkxC0mi9cxwwx8LBFVzZJFfcQycH3rluCjYEep0wEzA8MDjamVsF+QIU\\\\\\\\\\\\\\\/3DTNd5kQn5mYCgCM24kQqLQvNQ0bMLuPO9KJif5V4mfFr1wpxFLJ4cI8oBMN81TjttvjAK+TPd5cUHgUY8oMQ1w5EkR6di\\\\\\\\\\\\\\\/NdKg2f8Fa2L+S6mOAje00+2+jU\\\\\\\\\\\\\\\/3t73rMw9fmxL91uNENeuVuczZ2933tZzpCTXqBk+HLrAwfiUT1\\\\\\\\\\\\\\\/GEopkq3eubXZ7NDTeoRJxAFtRhmN94dupxH+rTzdK16gBioy+5Kui4t8U2OhIUc5FlfyvE87qCsPlWG8Ym0fHEGF9vKwPkB7DGOt6k9XUkTkihK1AESjWP9oI8Ow2hIX3abL0gyWEGGOsgFwOclZe3iag5O8HymSMu5bmNS\\\\\\\\\\\\\\\/il8EQxORWEYgtYp8ngMsiuA8iO9z2WJHIuT2jxniC0f\\\\\\\\\\\\\\\/s7MRz0Gg57Qn3VZXWzJGKoagbIId1iRMz4LcAAPslSBOk307xCoxLi5prnidNYbv8ZiiW4lkOC47Atu61wGu5eqcAiuaWI1BdF9u9p3Jvjn6VPcmqYuWVJ0KGU27uuUp00aN4ZNlKTR8wr49aIkj87doLtECvgk7ze6jBN+Y0x\\\\\\\\\\\\\\\/v78jl0HqtS+7Phw9jEv2o+ylEpnJ6xy3\\\\\\\\\\\\\\\/bo2rnLDARUWH7SKjzndzRAjyrLWbSNCj7wP+TGie5nANRYqNdwTxepzn6td+9Gj6HQPsAFCsXDa73wcPPW6k3i6aCjEIfnuw6CN51fE3fHY4gt0niNeueMotko60Sj\\\\\\\\\\\\\\\/ZLB815BovmQ0xoNmBIlbbKnWSnAczWC5\\\\\\\\\\\\\\\/rolKS\\\\\\\\\\\\\\\/0ytYrsneZEghR6kWdy6VDZN\\\\\\\\\\\\\\\/2DUbAbPLrbw2IyUuunINyqGVj5KFeoQY0L1+sSx4Wpxrn9FN\\\\\\\\\\\\\\\/PN6lFar86AKWgZwjNq4qDeOJORpRIOSPFlAmjyL4EkrxCRl\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/4Bv9redNlQJc4IjN\\\\\\\\\\\\\\\/1Ku5r7uEsGT3hdYdbqmY5chYoHRdheY81eW6e8sd9NRmREztkITAZ8dVurzfHcySoTW6vo\\\\\\\\\\\\\\\/UZ8UWCFg+e9lllAhr4U5g7Su37Qye92Z2OuaxI2KI7JntWSmR+ByBeb5UjJ8XEWAFy\\\\\\\\\\\\\\\/TykMgh8+tJcNj3sC4EeOo0I41SsrjvJq+vD1YSh1RIDu8FCtM69TtzVfb7tMeFrOO7R8wJEUYKf+jnWbM0u9YAZivHDR\\\\\\\\\\\\\\\/06RksQoiuoBkvRVrmlx0R1r1yIGQUXJ0uYvV7e2T9llSQZtZdHvgXGLnROq0bI+UVC1ZqmonD4yIVhXcpljzJJ3FaLKs93mlUoRkzq7jetEtK\\\\\\\\\\\\\\\/G8vHX57SGeGG3apaKiPwKTSpfbpmu23cfg5oCoitHnS90iRv77ZlqILuws10Kd\\\\\\\\\\\\\\\/i2dd472XabQbGnXbguB2ZGIx2A1rGnbCu7m\\\\\\\\\\\\\\\/HJsaNem7+bPc2RCJBciud8cP7PtBss5s5CJnFuPVrxt499Wl4lk1XjzJrZ7qsKOWFjy1QN6B9z0TZP36lUyVtHwGRSQZ6xZiIkPNop\\\\\\\\\\\\\\\/8ybcG1z8FFQIGa2QxaF8prZwPjP52xAXUycD4DZUv5In0045YL5ibQpWnUbEIB5UGUsy7\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/x8o3hpsjax5VBDEaa9XpkYRpegUxBYsdBf\\\\\\\\\\\\\\\/9bBGi2XXWTB+x8gT\\\\\\\\\\\\\\\/3nMfVVYTn7mV5tmNBC3p8fJUEaADWaxtn+LKNm0ifb2luj62TzkQVejVknIcqOZ8639k\\\\\\\\\\\\\\\/AUrSGHOWm\\\\\\\\\\\\\\\/HPwDsX+tN40s5VM9Wj6NE6MLRhWtYYvHP1yL82FAKWQab6NKJmJ2NyiOeFBahehDjeR7ydcabgktlCMrDroOJf6fIFKeR9gElREeI0aznSyoZs80DF4AOJcf9BjhJXkbOzeGONjVRCx9n7CWSvKCI26QQSUFKMXYw74DnLuiBjMqwm1dm24JFwFP+yF0lldY5BJ2hXp6In9YabC9qYZ1AWiMbs5VY3gr8lJvT2yzXlM91zqct5RYT7YwPiNfoO\\\\\\\\\\\\\\\/uRDqxWY9mwf6jKNaQNPRSfltcHp7jFRr+Qt5uTOHTug7etEIZVa4uLU0ZBw2mGPrjz0LlgzXtHQNDhq7M38x4QT4TFj+\\\\\\\\\\\\\\\/g01wgTitJNFWc2ARFJA7bJF4epiFI+DacjYDh7jmXTOj2+9BzLtcDLzFFuhbb7UguesiDTSlv\\\\\\\\\\\\\\\/j\\\\\\\\\\\\\\\/pDQnBEMfhmaAQbgZU2FNwq2d2Vud2Q4Us+lb7OuLwlLWfWBX8mOlVMR5pdZIllZKi1I1VpDzPQlBdE5lrNpl0f1eFI3V8lB6Mr4mpByyTsKeAUKWXLeaLocYgk9NDuvtLJGcg8zlMtehHtVAO\\\\\\\\\\\\\\\/JqPZhNhezvvjaeq55lN2L4i+EO+TFV3x3h9LQuLSwzmr0QfFrSD8cdzTBpTU3mNJpRPCSR6\\\\\\\\\\\\\\\/4YOxFjKlOJoOcXdHVVME3V5H6xre+l7ZyffvNJiJxP2HCXiWIqdlC2GKMwmfZfodYMRE6CLZD5ONFaHH8wPp7QR72d7\\\\\\\\\\\\\\\/LUUPydkXMR4j5WNhugIdfWKvL58akML3ZkFn970pFE5xYWH+hXs08QQ+fn7e2w\\\\\\\\\\\\\\\/o=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hONKEOvF5GQQ6NAfqEdPpA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225bd5a15fafc9db655f9872f289b45394c6d813549b98d6b60e4922dd497083ff\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1296.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1296.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1176\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1176\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1176\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}