{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022VSAlC2Tg6ih59KoLVL3E79jp795vwTpCZawZfstJJdRmGfmJu5yClHjGaR2sLI68UXc0of3Dohc76yAxp3H+5QkKoFQrxy8Eg4jtXZeBmk25R1FuNCTA\\\\\\\\\\\\\\\/dXSRq9M2rbE0stcURGk+MEUoJhpPFwvH4N8T\\\\\\\\\\\\\\\/64N4pSXUj7QUsU8hntbo+j+6Plljy9fyyPrRtQxhfgtabUDNb+dc7XgYxZuJYjzfgfnBEWgeLlDurBznQNVY2uYHf7MFyif2tIbv3fntKc8UTem9i5hBQO4H3rx4BID1ua7O0evBve9kt4mMfxT6hHJ+YvD2v9KJoiQTXTq0aYzuWqmSReuSkLWTZtTGcn+6MyEUpvrsX36EJNjp8M0SFVIISZNGmdtTQshsN2iHTTlytR2zRom563f5j47MMEVO2YFxAVZujeOLf5r5HPp9GmhEk1u+kvbYhNVBQmy+NIw+Oa1E829OlUfI1B5AoKyu8MCPNFboS9NJkkmM\\\\\\\\\\\\\\\/FOaBnqSKXDk4dotG68iFXf+SEjhmdTG+yP9z1Hb8KZUv52pyaxmBnKcsJK8mF2KOGtE5BP2yzdOoEzikd9Uhi7yB0zxbcxIvZU1b\\\\\\\\\\\\\\\/avDq0Z+e2OX08HxYmgfBZYsUF2bWkxiVVoPZdqOyBIsxHNgybtXinufQqkyRo0QIQdDLkgnEpy9MU2HTJ+lDq8XnTs8l+wb2vsNm\\\\\\\\\\\\\\\/5FF05wH1BeZbPyRItp5QtXBBrfBEXnmWnUz5Odud\\\\\\\\\\\\\\\/K4j\\\\\\\\\\\\\\\/j9Q7vUIakj3c+SRX2V+xUwtlaHbsvj6QbBP4Yfq+zc7OL5fsbZM9htODWF47z0WGQbIb0xYKfi7jY02oDfG42tNFQaksSXpcyDx9LwDHbB5Hb9RS3DnN+TlKFlYMVS3vB\\\\\\\\\\\\\\\/C5hScYnPq1zFk7d68KKFs3iRskz6c3OS2Y2606WW1AZJ2Mz3RfaOuCz52y3bKn2yjkS62xtVnBpTrl7v\\\\\\\\\\\\\\\/d4VogvyFvrx8J89TV0SDR7NyQx5WUFFxXhPzc3UizEElcT2RskcvDmRTz7GaIRd9ztwL7xLlFWDffXmcVsPnauDaHVqRnFoaklP4\\\\\\\\\\\\\\\/xT1XJPXnz91t2uKtB\\\\\\\\\\\\\\\/h57tW+kKrCKYf\\\\\\\\\\\\\\\/dgCzihUNDWd8k6b2ExFbSm67Cl6eEDHkYp\\\\\\\\\\\\\\\/hdoiCEqDxeFu8Qflu4b2A\\\\\\\\\\\\\\\/VU3yEknNMoabZlEuymZudsath6vuxGrKKkF6RItF54ZkUzcOIYJwyU3eQtszsrmRLRxd+HafeGxdpzwUqj7kY7vP7Ds25Pj0zc4WwE4wUF8ucSGWH8DpgU+b5m1EJ\\\\\\\\\\\\\\\/rPUtbVKUBodM6V8e86stH6oGnGkCv1PPIXbehFlVKO1okzSXQN294p4rHhMV6Mu2uUMD5+wFeD3fUNSlbGVkj5aPUYcyCpqLxPcOt2jgR8UeBXqZrB1ZLcbgRucJWNua9UJSmBMZX9gwur9pRkVlXMRSdCU1whZcv\\\\\\\\\\\\\\\/e7P0mWlYpeQJk5Ik8MmTKh2N5gV+k\\\\\\\\\\\\\\\/Gn\\\\\\\\\\\\\\\/tQmOeiHOtwvE2N5Gx\\\\\\\\\\\\\\\/LRgGupUA3FtodVpfsNnrffTxLRgqV\\\\\\\\\\\\\\\/j10dO\\\\\\\\\\\\\\\/CapB5Vwnymz6YBOPQOsXXSpTPh+2YyQmrHTrFlKcaMdfRY+j\\\\\\\\\\\\\\\/RmVCsnASzBeVPEAthYFq4+wra0QIaMVsIGC+yRVRYxCN9jx+uRgYdZ\\\\\\\\\\\\\\\/rdX0KMiSJnBEGiNioYGOIPWxezaDnwtNPgd6tx+2137T6R8vlOleICuRWnhiO+JgfW4QhU5U30YWYOfhJ847sMoQNXmi8xTNUyplJodiy73WM+L+tBwo82Qfo7apZzCY5+kBPo1jyMXTU9uPcQ7jq+qmfNNbx0e5QrVfqglfZb5JmRoxGpF931pqiMfQ22tnqZYuPlf+p8PAKUGFTJaC9wIjyB1Qfr1AllKoDd8xkuEiBdz8SG9p+gxWsRczw7ME\\\\\\\\\\\\\\\/GF3H9btx3mupDHykEIIDv36akHABGpBaGOD+gO\\\\\\\\\\\\\\\/vHG\\\\\\\\\\\\\\\/WsNWfGTg91l8ZdS40Jlo+pbu59gV\\\\\\\\\\\\\\\/LBZBOfZ58oRj7u2aFvyRfYtaRmO7gdo4daZhK8APVXN42dQ5l+ENra02fH8K+s6KqSdvSyhidgA2rJJITX1FJu9d77MW+JQvMKkOikzdz\\\\\\\\\\\\\\\/txnYZkehCGcHkdCxSJPMKQrKxuAx2Roi4Y0SvR5PTpgJDRgHjimS3iXLQrEiTJSlhZH3VSsawqGWayG0eSV+GlTTD7dikcB8OTIF5v1OywemMWr8QX6UAj8dULQpKX1\\\\\\\\\\\\\\\/Cuk+UwagpDKVXTcZ+4UB3UStwJCuCcWUi4n\\\\\\\\\\\\\\\/D7PZP5amVpyFU9OVLfl+mQubj2RHrmAbkpamdWazNncobP71PEclAZ\\\\\\\\\\\\\\\/4ufEn5d5S2wjzTBP0HyUrfBG4ccvTw2WLaW4Sr0UspGLtbgpCZhreUmoRNX7vANVrS2I\\\\\\\\\\\\\\\/AnfHcj\\\\\\\\\\\\\\\/A6c6jylJeH+flN1nd3NYz+rQ8XkvmGuXDpHfLhl8CeStaTnziRf\\\\\\\\\\\\\\\/3cXnu\\\\\\\\\\\\\\\/fRiLgbLTdZpKOTfKXdvNjnaqkd\\\\\\\\\\\\\\\/9zSNPRJ\\\\\\\\\\\\\\\/5A\\\\\\\\\\\\\\\/F9EAtNPu1pRhApFrM3ZWBi485cWz0i6X8JvT07SVe+Iw\\\\\\\\\\\\\\\/wjxINT+QW+7w3R+RGtCpdAmIJMvQv0LEWzsPKjSudFaffkbSrjKwMW0EAV\\\\\\\\\\\\\\\/ahm0leywB8VpXyWhtJDbLkJIrJs6JIncKpcdJ1L46m9XswywJkuKFwo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DO6Tm0P\\\\\\\\\\\\\\\/4u2TyuosbYcqEQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225049811a77da9bf4817e7f9b7455a679f597cae74732c88dcf9de6a1fe52a729\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1269.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1269.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1153\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1153\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1153\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}