{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_1JirQ7tm_dyc9OUCKvnjR4PnELi_PnQFPwQyzJRjKVM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_TXiI7Aif-havz6TpDoMe-RyLR-BfEhYUG-5U241ixVs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\nif(typeof window.MathJax === \u0022undefined\u0022) window.MathJax = { menuSettings: { zoom: \u0022Click\u0022 } };\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224f6Pva2G24zy8DU6\\\\\\\\\\\\\\\/0kOHrC7l3butSjAxWTzERliZxzO4MicRb2XxdqGAC1YewMh19OSF5QTB8nOYYBf3HDymLVly9vavB9e9OgeR1JqH1X8Ph2p4IXH7mqFDdHSyczojAiZq+fdzx38tHik0eDUTPJfleqVuplt95zhAcDeEZ1rWDo+5vgOOxndZVnDAxCrIUaJMAASioGAxSpg\\\\\\\\\\\\\\\/RNNQmbhJMeQbZSkE2gLfJnrF3+whXRms6WH7Zjs4FBzQBh97f8uQUJykpjVfO2sfWHJygLw5kOVVL4f0xosn3RDx7JMtSKndA8VydmNHcOeFn6HEMofFPz7CMYB0c0m4+BXmTUQnSkPUmgGYU+OXHvtmqox7tY16TuwGI7NqZ9zFzp1cidXifWyCdPQMXfQJ5xU0xRidxGgDm7VapPS5cJqgUDjjs\\\\\\\\\\\\\\\/Upeo5NSANNYeGfFjlz3f6nEWzC8JPy2emRQkNenUwFczTchctGlNpD9Y8GX9eYEL7y0QOoFGqm324gzS+gyBZ8wCMIkjP\\\\\\\\\\\\\\\/mBUHuQt7AA39QRqELxd1lhCVvctuHlIevD9B1w2ZyuQbo8p3hobPW\\\\\\\\\\\\\\\/ZXAKkmIM5Sc31Z74dUmGa61jvEYQJC9t7wKxQMgoCfp97IN97hleb7cg3pLn\\\\\\\\\\\\\\\/0tijBIhRPCnTUcEilk64i4is\\\\\\\\\\\\\\\/XlIjGWOWbLLRAgPH2jO87YnsNO6GhAwx5csXt3CLy2t5yKu48HG4oPAfKNHWplhcvIdP3EsilGkJ1eLwF6TjwD1C0ojtxy8c\\\\\\\\\\\\\\\/ArwZQV23AysjSzPcVHC73S2hAkXXtLPXCgC+MfIf1v1zCm4VEawDVa5WH05hNvnywV\\\\\\\\\\\\\\\/tlo9WZMAbFgHSW+ZnJ9hqz52SFLXPGiHGXCtkvQpiizh9cfC9Vihg6lF2lJgc6XA29p2bAMbNfzSGjDj4i\\\\\\\\\\\\\\\/If26Yke+J+qMY5bEyteSl4PWtWhxoYqHEIrs1SQhGG0+apNj8TPxv3HqeeNepwoYcOPXvhoplAzHd3bfOKpNbPVM\\\\\\\\\\\\\\\/+0\\\\\\\\\\\\\\\/UZf\\\\\\\\\\\\\\\/IgWNXiGk05gWEc+t+5dlRzFz7CVOlBosXrq2qNVSOzscQnkTO5MykafSq4OHCE3E71GbIFU1amPZC9YK1LjKLYcesV6\\\\\\\\\\\\\\\/80f\\\\\\\\\\\\\\\/vRzGKgubHomGWtNNBkkAxRLg\\\\\\\\\\\\\\\/pDjz9F4LC9Ybf4\\\\\\\\\\\\\\\/H6jjzt+bxjVWu3bfzxbGssd8qCLhkMDtizZluOx9VbFO+j9SzcVSZk6J7FTvmsx864bB5OzMBpm9rvZF43BjUNhrk3VvkEPyzbZ1\\\\\\\\\\\\\\\/a9Rf\\\\\\\\\\\\\\\/jhj+0yd9Y8SdbHh9MnpasByQIRU7gM+Aa60\\\\\\\\\\\\\\\/w6GNxpfdRNz4AbFDdqBDRFhbJoSLLWNVUrT2GhUpX4QSwBovS6R1JWB90IdJ9uSdHwBP+ZAbcNxCNr7RwnXx15wfvt8JQNl9IIe3eiCXLnr2FmuAqn61FiaPcYp9GGXhIyR\\\\\\\\\\\\\\\/tYq3teIim4YxHEpLulOKj5MKKjhvvcnOWyLH8BLvBnF9\\\\\\\\\\\\\\\/O9XczdjIc0LC2VPImSv7SJghvmAyh\\\\\\\\\\\\\\\/3bTERCAXEqtQV8jyHQBpB68ZNbz+Ukmv38HCKA9JueEyVSZVjWlovnnShmqQRSWxrbhPMd7C2FOeVSMDFVbqIbplea2kN1xjleIWKQutumYn16pYexWoGBsajBUCc+g6VuuD\\\\\\\\\\\\\\\/U3fjK9Ll\\\\\\\\\\\\\\\/ky0+1MyehiIgOKECSWWOXxOwo\\\\\\\\\\\\\\\/DHKk0MEsCGV1EGzcIQCEFO0EAguXtGlg+5HkRe2hONmenm00jVx37SUTPy\\\\\\\\\\\\\\\/81yYw7y1e9+jYRfBymivH\\\\\\\\\\\\\\\/RMWncqGjztF8RGy7Ne7SbRlTJEK2XWJkmtM6Z64zr+UWkNxtQHLQ9iGQVxSSpje6BNtSyJiBfFI+YZDwgv6mjw0mfwck6gdfCuBybyNc27ngmenxHpmy+WCewK5ZhD+S8f5aFMIBM+de7zGaPx4vdYvIsbyoU96BpgTrF2DnYy1cxlPx3p3jBApyyIQOtsitFaf7nDxZGab\\\\\\\\\\\\\\\/HPt0T2CL9BKpsW6ddZPBqXfmSKpPz1+tRKqIHN2hAJS07oAmweSuynfbyDkZCcX+1Ka9SIE7UeB3TZbU52NRaHQXmaNBpj65vg1sDaBdDIjL7UzmXLBiMVIkEyNgK9QoBjWmG5oQsyw9KLwLS0aKkVkZQCb2taO6AaJtyhYjYgQ3EMF1ot3icNrJpRI4rQ9SNZ2nPe7ZwktmHT1OhQO2a14Rnz3o1jJ09yLi3VijmiLXk0U6c6ZWkAEuhnv1kGBzs1LX\\\\\\\\\\\\\\\/Qvu0jIrY31wMPISRLJ3faIFtM9tG20W806XuNrQTKTmCLr6hKbQ4DWTtKXIkZ0gApLEOAWkWU+7S4ClBpvGJ73fX+Um4AZUA+FJ2PWD+bor+nF7bLQOTURoA0+xSCbWreF1wv+eLnKInfMh2MwjC6j+8VhTLXPMJm1aXxP3wNYG1dP+rhJg2ubh+63MHuWlwFkUz3DV3pTqo0zqAg5zeaA9uceXrphtxBfyW23RwSrKHWjFwafA4\\\\\\\\\\\\\\\/9xTCHyCn8FBSEKYPnuXPsS9loBw3AOfv8YhBsWD3aipfSkOqeWAldW+ec6MCuJyivhLvtWqwJE1b2VbzsEk6exzRmsXEoCQ1ptYp1MB8EhLv4\\\\\\\\\\\\\\\/3Ell55hehjfd5QzyIOk52d8KCxWxxur6o29hc21SI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220V5TxZ0V56o4Bw+ERo2gmg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002285feb0c27aadde934b7072f0bff5c37bfcb6ee23d1913aa8fa9249689d0d27c0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1003.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1003.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1003\u0022},{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1003\u0022},{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1003\u0022}],\u0022processed\u0022:[\u0022highwire_math\u0022]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00221\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/highwire_markup_process\\\/js\\\/bmjj_author_affiliates.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_at_symbol.js\u0022:1,\u00220\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__WQiS3ck4zk_oYJMdLhTT-CHpv_wd1TntgyolXxchYqw__H8IDiO0U5hxt6_zxX1yD5dKF2jP5qm4oe8UqdAAcLMU__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022content-block-markup\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0901\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0901\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0901\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022highwire-extract-pdf-wrapper\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cimg class=\u0022colorbox pdf-extract-img\u0022 data-pdf-extract-path=\u0022http:\/\/www.highwirestage.com\/content\/11\/Suppl_1\/A1003.extract.jpg\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/11\/Suppl_1\/A1003.extract.jpg\u0022 alt=\u0022PDF extract preview\u0022\u003E\u003Cp\u003E\u003C\/p\u003E\u003Cp\u003EThis is a PDF-only article. The first page of the \u003Ca href=\u0022\/content\/11\/Suppl_1\/A1003.full.pdf\u0022\u003EPDF\u003C\/a\u003E of this article appears above.\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_am8GAfrhW3uXc7HVCmqF3MltMmNunvhyJ6MM_6EffRE.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}