{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022cxXg1JFbXkfXiFpDzAS3umqgxw8FQ3wSx8mPdOXwctLVMxwPwD\\\\\\\\\\\\\\\/owpjFPZlfofiH1avZ8ywGGllU15aoozjlbx8kx0DvJsLZVjDyGLG0IHWLDFtD8URkGuKILXme12E4VdfKM0q2knQ\\\\\\\\\\\\\\\/It\\\\\\\\\\\\\\\/Yzmmfl0Tt4KmAak1cXNqGEyHx3yUXLfCKEYvBi+kAhhx47rpAXQA0oQ\\\\\\\\\\\\\\\/Z8vTAKJM2iT739QqZTt4pSxsdQYvgz7Twf62gxetmJ8gP5BH4RXyEW7WhN3yUMSCYX0xNCL8kizsKPPYxlA43QDfF4eupZYmhL50Ur1bGyaKZNUlMDqPDhQC7bvzPzuJT6LxWlSKdeg4zere649Sn2Ep\\\\\\\\\\\\\\\/V5W3H\\\\\\\\\\\\\\\/ekThPbc51mUQJR4J5iUPZD5cpawKTxgKIovCjC1Hb5QMjXxwv4EpYXuiq\\\\\\\\\\\\\\\/K2NnYQCiQ5SF24MaqcJho2msKePRZ1AqSZEytyybbvz6uavTCaTWjqfShMjhEi\\\\\\\\\\\\\\\/XJqbrl7qrjdDlCLh1a4U0lVeWj+fgyF0\\\\\\\\\\\\\\\/Ha4794\\\\\\\\\\\\\\\/3FRNv0183qSLg\\\\\\\\\\\\\\\/Vy4RqLT6j296lQYUE3xJD5E5PimPcYKeXe8SJ0gR5BKWvG\\\\\\\\\\\\\\\/AsU74+51VbMtYgpHIIYz7hH4sE82N8Rq9uaPuDVXftLIOLB6F0eS\\\\\\\\\\\\\\\/LnjcgxqBNpagWMECf1xnoMDCYnCI9UF6x9zu69sEJ7IA2aFMHFZEcSUaACHqH8yfKMAfVrIMBndF0I7E0affDMRQYA6xKuVKZjCPZO2wtnKsluFwFLV5its1CZth\\\\\\\\\\\\\\\/UYwCN96\\\\\\\\\\\\\\\/rwfI3Iu2vDSQ3VRuupHQG1dA0Yns6dRgSM6b\\\\\\\\\\\\\\\/3SmmVgyPOq5r428QccLEKDjdRgZJy83MzIaHg6Ia3Pc9Qh9Abo4VKKli6WdJ+AYuXr87zM9q9jATey3+b+kuTg\\\\\\\\\\\\\\\/VAIrEp\\\\\\\\\\\\\\\/x6SIff+DsVvu9pYZmFbkMop3HB4xWPS2Z7VsOqFVC9+sxOtF37yXpRbo0T4Jicz3YJaltGaG3bhsUnri2TXuqVIWr\\\\\\\\\\\\\\\/3f8Nzk0hODKqXnFHr+lwGKOj3ssLG8PA\\\\\\\\\\\\\\\/FzvA1oVEChB0hgKU0APUlXQkcIDP07iAi8pARyqMI+nEkx875GJihkGRIUn3tDBrYkmYt2Vk3cF3MCBAr96ALSfU947NvPJyUemVdPZG7VLdETQKChRO5q+4qHXpCW8vExMfTQ2o4MF8g7sxkWaRHcbtsktwGsapi85NbqokcLHnXCtRalnxH7LHAnPZ6wHJ17+vDQNOCs\\\\\\\\\\\\\\\/SDCO4IUa\\\\\\\\\\\\\\\/jay+KGumc0r50NAo+mnlATnHSlT4jD1tTWO2XDD2wm\\\\\\\\\\\\\\\/q7zjVXKGeEWV\\\\\\\\\\\\\\\/5FLP6KrIgfeWvo5g4zfrp3fLHUFTUN1AKqldiUeB5GkMV3ElNzCkcMQr6Wcnlt2qVdS0xrXVb25FBcKdMyQ93VM8W5zOUqgMYVNflajIMeMbtXuv5XsquDc1ThVkxwjbTg2DED+kGARS8CACqnQRd4EjZTTnGleq3nTyEnxdW2GYwLO9wxpxqo\\\\\\\\\\\\\\\/OaYIyIDi\\\\\\\\\\\\\\\/PorH4T1ePdZDr1tBwc2no0iMDdcRdyjZnGr\\\\\\\\\\\\\\\/uwDE8fohpEwuuan5kiiWw+0WsVq3d+yFUeYbB8qt1NJGJ4klecFoksPOSoCG9N6wk1FSZtMP96xV2XrFCLxWo0cAkl4uU48PcZK0kFBx5NT6D+lHZGK38p\\\\\\\\\\\\\\\/QI4tYDAH+v1PZ5h9O22NsVKXSfg7Rdjb2C78+eyuyAYliEFxHnI\\\\\\\\\\\\\\\/N\\\\\\\\\\\\\\\/3cw+3xyORkA2nJIhlVEZj2gA7EAVwxZC0mIfgIUc1EWDBfoc\\\\\\\\\\\\\\\/5FbR23vjp0vFcj8DBxJ5fdJBlVDXF4JAMbqG2OBvyT7LvsilxmBFms\\\\\\\\\\\\\\\/HAyKLaPc1R9Lc42SCR1px+G0lJ9WgGC7mqEhOm8kh3o5QtQOD\\\\\\\\\\\\\\\/VWHOQu3VVh7Tq0EJrVqseVyc7nCxbBC8oTqSK\\\\\\\\\\\\\\\/LqMe0ml4ujk6X32Tkx1kbk6CjumfZmvQKFKQgK7k9nCt1g9\\\\\\\\\\\\\\\/1qO1Ok\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/M1dmeUA+u3JNyOSChilRvVW1W1wIHRzzZ\\\\\\\\\\\\\\\/IFm25+8yXXIPonQarPpKtemwlHJyTwkBzcVJ4RuvcoBbXtv4zbrOlRxXyCcIIoca1O8cWJMzCRiqskuZusuDRiulZ35SZbNw\\\\\\\\\\\\\\\/rUnVr9Tabw8oS9rF7k3my2yj+szYapeQhjAUSpmzKGO\\\\\\\\\\\\\\\/QNDbN3Qo5y02rtXahZWF0dAhPKnKDDk2c0P+B0hjNsB\\\\\\\\\\\\\\\/C9YWkmwjTE7up0qpQMCStKZ8P6UE0CA4Wt812ais6k0Z+ZG1yIoKGw6uVLJUBNHCCivH75414A1\\\\\\\\\\\\\\\/2RlLc\\\\\\\\\\\\\\\/f3BrjNtm+svdfXLxx96YMgXDtDrDWdzttiYZSBvQSsUEpSu5zvDwJwevj1Eh904KEAwOK\\\\\\\\\\\\\\\/qBBjsz5rji1CSZnMG4DWrKGJul\\\\\\\\\\\\\\\/At+Oxf31h8XlVp76oQtptdWIO3tbKEgefV++VM2MYhicwVJTl1kVq3IM895XgJPfK17dvb0aCezjrHztDBH4dQB\\\\\\\\\\\\\\\/M1Ymr5+ywA\\\\\\\\\\\\\\\/nA0akKeTSPFBkycjP49vsYAFXI9JdsZC324azFQCiMhGWSw0nf1wm7zJBmfyBZ0Gc8SoZoewxpwZAnNvVJ2lzwfmgyQ6wnMR+L7NbRLt5pfhi\\\\\\\\\\\\\\\/KviyiP8iQbLj8udiYwg68imux9CvCWJx2yfWJZvEdhXfKO9l5bA3aqdXbIk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cuf+LVElWkSTNWdOXB9a5Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228627f858b7ecdb00eb59a5834c8d1671d7942cb2d9494143efeb754380b2ec56\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A582.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A582.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0516\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0516\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0516\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}