{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iQCyFtzVG1HfueAtksubConGGH3JWJ3EewtTzshQmmc4Z2u8YIoSWXEhL0g1YbXHcooaVzmCxaftfjUXx3LnHETAl6SSyjJWAwNcLHtHmlnBhjZnhBGPKYJjrJg1Gl1ZP8LvponJNNaEtHQ9nNdHWXH16h38DMeWhbORzuji09P905i0nBI1\\\\\\\\\\\\\\\/XGWPy3L\\\\\\\\\\\\\\\/rqJjM8QmyIWBc1nKCleJy+x63m3MOaBcCSBmSfYWOtqnrZIeyIvhDZt2GdWByR4dM\\\\\\\\\\\\\\\/ZFAQihI7kN8mE2Z22U2VkqjPb0GrOUnCC\\\\\\\\\\\\\\\/MvKMKlXOxRvnoUdSL7UJTnCym9gTmIHR\\\\\\\\\\\\\\\/L4SeEGayqsm+gmv5IISzEIQoNQEnjrrYtb5O0GM9zYvPcb3Gn35jnbSigq0G7Tt7BEdOZ4JgctJ7KflbcmChEJec5hYVARdOLN9X7EdevH47RA2OgI\\\\\\\\\\\\\\\/6fRlFBQkbOEcx\\\\\\\\\\\\\\\/eU9kSs73lTDcrRak9b7j6TKQ7oeptnRPUHCnJLgTzmGSdJbaMNcrfnCdTeyD6\\\\\\\\\\\\\\\/KSwq0x8jkcLfrsWwRvQQYOI0tiUSVeyvmgNU9YUAmC40iRw6a0kiBQG8y1PX1iwqIVcmGgTN6PgbV+u8IKa27aGcNH8bGJyWu8tzxchHiHPG60EUFoVR2QOpkd5j5W0ZHK\\\\\\\\\\\\\\\/y8ia6gfs9IfmlbIRU+DWjPLG85qrRvGeDu7a46NEmIWGTIjOKFY3wqIYMq7\\\\\\\\\\\\\\\/DliU14dgf+cenShz8zuvA\\\\\\\\\\\\\\\/f1AIF3B7lS+07uZhxjPM\\\\\\\\\\\\\\\/cAVRwAOwArJtLoMqDKxizHxG\\\\\\\\\\\\\\\/RmXIc+iiraP2dxsz9m6eHRKaz4WVOvkKxmco64qXBYUmuzlcWFzg3XU1kp\\\\\\\\\\\\\\\/MxslBWYDKKtI37prHkTDllfsn2w8o6h+FKaHA5TpXZ1A966nV6dNKs4hSZhzQ+87IK+jxJ6pfLCYxdX+UIbapPgQmhxJEXBVFYZcA\\\\\\\\\\\\\\\/cFjHEhHSFA0mY7YVLTtJIo+FR52sEjDIIjIV1LyMrV5dcta80gn0vk0GANVQOxlSvMc5CGb41qGlUDY2GHLazBw\\\\\\\\\\\\\\\/st57w7IiAhma9dVWuwLqCPyrTe4AKd\\\\\\\\\\\\\\\/h2mjb3km34kaOYbX8LpFu1B1SzznOVzjkTP55W6AjuzrbV02cI0LsMY+fA2xyOOV9RJGsiMK+PFXKxm1E15Ua32sHroTyRfO03EPsfKinHn6PzNwYz+kQ3Z6PncvgUkp3uHvdze+lyznbLvu7PUl0J1tTqEaSqg1cB3eXLcrrecP7kNJFfUM+5MQXRsOxZuiVJ1lk61kIgwdkmj5SKXn8NPTV7\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/fI0U0VRyX7n3so8TxaW4+Wp5dcyHq5BcKR5veVeTwQRNZFbtnT5Mkv7+5aJ0vURKkYf9N7wiQSdZ4wMmfu0SeVhO24IQ2b7YuFm6Qn2xCg8Q3IpvEj9He4aMw16bgoBif7W1y7aIGDXo5y0tS0QPoRCazKYkzcSphD\\\\\\\\\\\\\\\/VMO7MmWDsOmTEaZFNRDYEWxgHz+cZSdlct5dbCQEeKL23nYo1PKMflOOOz5Nrs8Ds9cYT0H\\\\\\\\\\\\\\\/CBNGqAd0yl5dKeuJPe33Wz2To7JFNAcWx8acG\\\\\\\\\\\\\\\/6T8yJ2YVDjdtGQQbvBna5KOKfC7+X3H9+ZkQbrUE+uSB4lL30r\\\\\\\\\\\\\\\/z53lZ+wYqcDWHcE5BQyfW8YL+OJf9KbyrtWSXSotqnOZ9RUKVA9T7gxFqLLwtouc7+3xAce6Uhtowj+0cASiW2cP9+OZd4CH3Wno9l2LkrO0rcQG\\\\\\\\\\\\\\\/uPVHWRI\\\\\\\\\\\\\\\/NvShBUTHkwxcoj7Cx1I21aaE\\\\\\\\\\\\\\\/J5IQfyDjrnQw0ml1zTysGI1PmZ7zRyX8gNxNQvXDf4ZXeQ6RNjZBdkreZYUZh6Pk5IOtdB96TnFiakZoRCz4R1RxfEmWlVijUWeGLMhBQEmrNngeEuPKS7R82AwOUWizU+lcQ3jkv0yy95x3NH+SWP5SkdGlmaEZKM7U3f4VtKkUBof2yAi5hXovyyLwngU9C5nOayi+BKjJCpWfHy8Zc56DYLcH4354rSpu86Nji7jTHimnYyUP5wdqalbv+qmQ4wZ4tFxue1GB8DI2xLc4hU87XZ95kg8X2X+lZXtrdhw590Ou8d\\\\\\\\\\\\\\\/Vgyvez6ZtJdkJmYLHs0WPGERNg7laFXMwUzYSf06BFqS91\\\\\\\\\\\\\\\/VFlZ+e6Tc1x+t3Zr+j7zBshCSEqkb9MSs94qPvYPQb0CiMEkwK9R\\\\\\\\\\\\\\\/cxzMPkhSWk35zvnH81O3Y7KGZiZotIcED3WFTa6oVm8o0emL6dXDBOVaPFxEnIvD+KVXIVW4+pdWfh+ArbUDXBjJ0uqJOM\\\\\\\\\\\\\\\/vpgiad23DLe1kQQaPy4Mj5o3sJgBaf5tppCkEX55SSGs3wJxASn+wvPUDucQ4AjBCc9QTt4NWlqzs4cGnuq3KJIJtzyljwftwh3zW+kvBsr3DFkZbKuNFfNvxYSuPY\\\\\\\\\\\\\\\/qt\\\\\\\\\\\\\\\/ur0q455qDQn6K+oytk8Uw6Rxj8LGWqPlpvIIXahlnpexeoX1UuYCfTNzyiR452uqLwGGmMwDhEBaSjWeD++Vo\\\\\\\\\\\\\\\/6uybG6vQ+5XbDswbQ8FlQ2qPm8tox\\\\\\\\\\\\\\\/UjClbNBVMR0+GtrIzIxO20Un1hN+g5mIeMFqzDlyfnNrvr\\\\\\\\\\\\\\\/yzRcAvZUUWbxCj1REOh9LTQFHcV3VURgtxaR2swWEYT4wHsIoZ6EuLv3o5VZa5whM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GEEzK6KtjyRc08PLuU2f+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223c7e82603ff772a228514060cfe5dff0e91ffb2a16fee3c449958c8056b82abd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A431.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A431.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0382\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0382\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0382\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}