{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_1JirQ7tm_dyc9OUCKvnjR4PnELi_PnQFPwQyzJRjKVM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_TXiI7Aif-havz6TpDoMe-RyLR-BfEhYUG-5U241ixVs.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\nif(typeof window.MathJax === \u0022undefined\u0022) window.MathJax = { menuSettings: { zoom: \u0022Click\u0022 } };\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022UqKdSrBSChZDqxcMoShMXEl+sq1L0ONs6iI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ZOmCfhaetlGT\\\\\\\\\\\\\\\/u5d2vWzlGYV+Lz2McFIeTA1rZ9F5whqkCX99lVScU+JxYO1vmrh7JjfhJ4b1ZIEeIjofp9q09r4oJneZA9ySQn\\\\\\\\\\\\\\\/rF2eAUbTw8ZuzCC+GOglzAHo9tJPVGaiRZxAo+l3DbDxKcNprE15CFmMnKkmm2t2E+HawFdhPt8X2uda9ZNG0v8tYXsMhdExGDD2g5BFySbn1NeOfGrnXC00no6UqYyffUH5vT\\\\\\\\\\\\\\\/FxXg\\\\\\\\\\\\\\\/V3Q1woWsckCFpbo6P2ftV7MyD6Wqi4LMHItO9Yb\\\\\\\\\\\\\\\/q5D5VjPMhSG4+XPsZtjWulM9ee8A6dNj5Jt0aRxu2lVaw2BIIdLJlw2\\\\\\\\\\\\\\\/X8Zipgb5y2JTpgmL\\\\\\\\\\\\\\\/8CRYAGcZGgcu38Trz7Hnj2q43h8Rl6LdqpIxoH6ixVFsvvxJVcZtDwFyvCUyEtvqgkJh3YWUFr5sNiEFpD3aqnMw5dZmoP6RtJNnWA515PmxwrCF0UWBAhif9+gD1jwvfcLzol3+dRTfzP373B6QDPR\\\\\\\\\\\\\\\/jRF0Jejm9chFRElidnbnQjtGeg2NbFP8OCKJyC7I8ogtkGM5oC\\\\\\\\\\\\\\\/nu3uIGhBjo+rSFfDsjAo9rbgmOM1rZRwtSsFLstdOy9VST66Rep3SstajsGtPwTLgyfrtYPhgMlypxdsKAClRxjBUfrodNP8DZFKzyeXlz9ZFjY4QzOtj+5212qHLMDOU8ioNdr7v2DQNo8sO4ZLMnG55QES42fn2QdrBrWw4goeDiCh1IoZlJCnitsM2PwbNhfi2oWSTjJ7O1SahVOSiEuO9Xdanej5sP9kG4V1DpgZk0NqfMJhxqZ1EaIeYYwKBAz\\\\\\\\\\\\\\\/5itEQRtM04fagc0z7qSiIhb5SEH4A0CL7pxTb9Nw9SoNhLYiileIJRwgz6GeEiHUns8XgK87X7kSChvO33qAJE9rFYfTEneFD2Np4EWpV7zeRBYTwEPjvQunn1m4WjHWCO3EKkO3apAlVzxbo+IayET1TGEN0tK1ECWXZ3op3pDTxv9TVo+iBIMatRdOH6x4YFZE\\\\\\\\\\\\\\\/FeRYS3fc\\\\\\\\\\\\\\\/9IUfNkUVfx8FhJG6xawiXrZ7V4T776JyuwhY2j9FVoZo0S7rNKWGW2y92HYsJgq2j8cVoGwz37wYi+S6SBqKYc3RH3hzZMnybRcCpGXKxxR0xBO6lmjsC8uoD2PV\\\\\\\\\\\\\\\/Gt3\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/YZiv7\\\\\\\\\\\\\\\/lawwrbWe9z1g2xmLFrYzGdNjMpzpBdCoAXyq9b3BGLaazFDg72Po0tkCjCFj9szV2jZQj+VoM8f0LYI4rCuTlZFpYjUXIEaO2eI8NUI9BN0SBE2V4l2M7nnS6fdNtY3pL+XUa6vQGaZYFnZWW9Hf+lqfJ5K\\\\\\\\\\\\\\\/whGuHEhse13Tsfba5ULyUExIcgUYxYeA3fmXPOgSLi8L5yIOqRw1vgfPpqiq3jlxUWf9MDy0PTaWmSwlzxk7kNnKHxtsaeF12O2nYVdItDMj9xb7THVQFHe\\\\\\\\\\\\\\\/Ku5uq74SQfm3hhUd7PgetKCvM8gP7rJYRxWc\\\\\\\\\\\\\\\/P2c522v38LC5xWeNCbjW\\\\\\\\\\\\\\\/f54mBujENMSGkaeooFKMkldeG8Ua3+HGvQRPqjufUpTH5Vci0KErzLVjdxHQ+1i4PFBMbbzlgQEAV7yxaHppe4JWD1coek4w2o\\\\\\\\\\\\\\\/1hwSxTu5RI2AsxoFoiz0JYbD0D80J6A\\\\\\\\\\\\\\\/HP6V2jE9yPAVrLdZZaN4QPt4xFlUm666dxeHNA+E4Ai2eB8gDsjZ6ADThXmg5LIQlyNYe7F57s1\\\\\\\\\\\\\\\/1B9CcMk09\\\\\\\\\\\\\\\/aJp5pCdkTngByY45qJFQb3MqE3EMQNDHfUIrV3RyIRIDIyEyBrzvN07EshV7zlbqbR0tE03R0k6nI4AXCPDo+S2hehXaxBKiYdHzChnF66zvT0QUzn8IhLcMhKDjytPG\\\\\\\\\\\\\\\/XyGQzEWFjKBtJAPOyfllvs4jqNXK2MNb\\\\\\\\\\\\\\\/VPXlOyojO6ynjBtsAjT5TDOkNR6y4ZjT5VRt0uJwnBzCh6IyIYT8UN9ORuwMyrn4aywfGArumONjQFhilAszUidq2cj7KI4K+5x9elcMFlrrMVv2PvgqInmMM4PJYREXQwrykuzlnXbatnV7Snv133TCPByNf5hsrTzwK9DSKxNdki6NO\\\\\\\\\\\\\\\/Q6kDcZ6uFPBitphuVgILvY4w7xDDrUWzrTRXTqDrQEWxSFkrw+Oz2ilw8T+ADGKYTrGIbvdxPLHuWWSOoGhKdWyNufl1v+C4ZxHRTluV2xfnjx8u1Oq6R7haxyFl9LIBRYDt7SxflRHF9MIWNibHxsgpezmhDerC8g+crdmyT20hceQcoM5dCT1LHJBAVyvvKV0e8sDz73BSLpkT0Ztg8OLyp7qUYNZT5QRFVa2Jw9le\\\\\\\\\\\\\\\/JF1mofVh9Y0Yq8K6F76y3\\\\\\\\\\\\\\\/47hsbCYyi7pJcqSVLzcPL6\\\\\\\\\\\\\\\/TqeY9YAcpBrbolIQP167YGA\\\\\\\\\\\\\\\/OZOA+vbdaFly+sf1FA2xc0D\\\\\\\\\\\\\\\/nIphh2Ve4S1Vr\\\\\\\\\\\\\\\/5NEChtZWwPg9Q1vIVDLcvX5oiH0+49fECwLaK3fP9EmISiq7AkfK9N41ShibDdQND9FKAJrMVKMEcnIg1I\\\\\\\\\\\\\\\/2ki7qENzbWRiudavAfnn3Br1OPxK7o+Jo\\\\\\\\\\\\\\\/1FC+bKfu6\\\\\\\\\\\\\\\/Z5RK8oJ40PtcEnJp+ViZ9iMh8BG3hvWf6KPPDPsT4Tnps=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00222EztPqFaRV4I9AZkWWUJ6A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022321d1eb993a72266fd07364b9abaffc9c6be1d567c3be66f67d16988b1ba0e7a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1116.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A1116.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1116\u0022},{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1116\u0022},{\u0022requested\u0022:\u0022long\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/Suppl_1\\\/A1116\u0022}],\u0022processed\u0022:[\u0022highwire_math\u0022]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00221\u0022:1,\u0022sites\\\/default\\\/modules\\\/jnl_template_bmjj\\\/plugins\\\/highwire_markup_process\\\/js\\\/bmjj_author_affiliates.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/highwire_markup_process\\\/js\\\/highwire_at_symbol.js\u0022:1,\u00220\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__WQiS3ck4zk_oYJMdLhTT-CHpv_wd1TntgyolXxchYqw__H8IDiO0U5hxt6_zxX1yD5dKF2jP5qm4oe8UqdAAcLMU__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022content-block-markup\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1008\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.1008\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.1008\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 class=\u0022highwire-extract-pdf-wrapper\u0022 xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cimg class=\u0022colorbox pdf-extract-img\u0022 data-pdf-extract-path=\u0022http:\/\/www.highwirestage.com\/content\/11\/Suppl_1\/A1116.extract.jpg\u0022 src=\u0022http:\/\/www.highwirestage.com\/content\/11\/Suppl_1\/A1116.extract.jpg\u0022 alt=\u0022PDF extract preview\u0022\u003E\u003Cp\u003E\u003C\/p\u003E\u003Cp\u003EThis is a PDF-only article. The first page of the \u003Ca href=\u0022\/content\/11\/Suppl_1\/A1116.full.pdf\u0022\u003EPDF\u003C\/a\u003E of this article appears above.\u003C\/p\u003E\u003C\/div\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_am8GAfrhW3uXc7HVCmqF3MltMmNunvhyJ6MM_6EffRE.js\u0022\u003E\u003C\/script\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}