{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022GkGQuO3VTTRl8oEWshI2NK+ZmFsdiM9iQWSVSCYk7tJ8e6htaclwr3OBIvNVM7NQ+HnvqwFEark3hsuFXdycu\\\\\\\\\\\\\\\/4jOg+o1d\\\\\\\\\\\\\\\/uTYvN7QviH4UGBfsBvVW0dLs5rurX42phIM6UAsV76qOUElynJC+uLiFhd6rBLxcFmJ9QCzXRkElD6uGeFA1iw59qHzBJAqrKjpumbHsKeBOZiXxrnj5XVIecdZlVYMBiG8NPrbOfhOsEtb+tAH8NHE7vt3PVilg3WQ5OQ4rt7MU7n5F3WqhI5MNv04qxPgD\\\\\\\\\\\\\\\/cneAA+nWt01x+yYZ0wETVBwssX3NvAvSmb6\\\\\\\\\\\\\\\/TD+zd7CYPyJA1WUNp7WBsDUXkQSYTgUTZ7T8rZZzEI5UBiAztRQQCjgjtEQ079T8ZYd60liC8c4MDYnDcihvT5jOwTQJAoeChtOpUYY3Lwi1OvYko5MClrcTTNv7bA\\\\\\\\\\\\\\\/1ZFCPdv\\\\\\\\\\\\\\\/WcAMIFFII8PZ3DCxcYbM+Nq55a9pb1Eo4avOzi59xhN\\\\\\\\\\\\\\\/EYGLI7BIoIm+yOt0tFdIbqHd2m36uKyY1dQ9wXQdrQk3kQs717iac5\\\\\\\\\\\\\\\/+p5x5G2yUvSQOmhKcSom4ofP1GER00OvxVma40P5uYIcdwoCCIPxwS\\\\\\\\\\\\\\\/gVjc4cdng8CImFbGG6p8Rg2nVV2XMtBySxokXVbkko68psxFbBVpYe3EzVdazM7YndGh4A\\\\\\\\\\\\\\\/qoBDAgJ6nbz21rO0vHJ7\\\\\\\\\\\\\\\/aasGX31lWToLxJTVKlMsgVL47R2K3SCPiH5uz15lgxEQ5LQGBmjn7ckoSYYCNXDHedEhhXZZpt8v9THvze5mNgquVgED9c7lU4LVoKprh+Jax1bVXHaI9qt3PAwJ8spx49R37dLYaLunOV1LJ2DDHjV7oTG0ntptl+UFvpGwR9jZ9bEAYuLk45Vt6poItPQoY4\\\\\\\\\\\\\\\/vEBIG8xYyCfn6KgStt3C+74xu32E5zTu2ad2VLmbOyZkZsearhucQhs9lYXEmbojrzEsWRIrjGyRO9Zc4vvxTP\\\\\\\\\\\\\\\/BMuJDLHf8WZzmTB+LnyQE2pbTllfKHqz0QwNpdqM1ZidKPKNol+VSM0NiIZKfVRj2F\\\\\\\\\\\\\\\/COHvCBl8SAIl+e35PzLyEefdUHj3KZEnHhClCjropF9jwqzSu1Mhisvax5XmnrFC\\\\\\\\\\\\\\\/cCRq3YorkuRH09DBQaVJ+0xyysjSJEHC46ICMsfVOeutc6Q7JQYnzgmd70825xiag9U9sxE9iXkliShqHfsFNnNnxH8i4Ld4UfCUuBifhyPqp7HMRBLhmoGVVGGgd78viy47z3TC6I+TZP0rcS0jIh62wonIRUkVcJ85\\\\\\\\\\\\\\\/cbhElPv9+SNgEelpQGAJ89YGhW36K9GVUIKODVxTk6Drb1EM+lZ1nIdaAL7Xvt2u\\\\\\\\\\\\\\\/QfqiY4Mw68OEaTkv3q1DUL\\\\\\\\\\\\\\\/HUecGom7zWvx6LSF7c1sf4lmRAYPsKQjQK4ek4mRscSHVRN05A3yuKjDCQ37+0wVHeDFbsLUrsG+1t0tp0KYmKKwqszkyh9AUHbtnaWcaord+Pb0gyWaiSfhjHr37Wgxaj+sm02hUTo+XF8uAZgQTBAWw324+Hnw1t4fTz1I75Ga2H9Ux363XD6tTo893jbWdZ+klEssDtSiM\\\\\\\\\\\\\\\/IuWCMG\\\\\\\\\\\\\\\/EcurVL8iZhohJqyilrbBF2O6OHDPVTZCSFaV5\\\\\\\\\\\\\\\/H9Tg0ZNFJ5RkdEwTCRd8pWaFh8AwCGEXLdSHwuUSVV9X23k2zCCAxyxHpTB808drSG8yaxS\\\\\\\\\\\\\\\/dqt5J\\\\\\\\\\\\\\\/sXbXoxh43VVsG52RoyNV8tIXtnYqZkANhwVQ3tLvOlJxWTjHbm\\\\\\\\\\\\\\\/aeTy3iAwAP23y0n24+KdnC0P3FsN8vAnN9U3gqUsJ\\\\\\\\\\\\\\\/kDObi6dWu\\\\\\\\\\\\\\\/VtHa5Fw3YRdRXAxmnH9p6zKNATPXF1iVkyCfoRoSQjRx7+2anYSMm\\\\\\\\\\\\\\\/tugZmhE4lxCqX9v9e7E2WAFjJ6ixQFiIUVdlkAQPrxGe7VoNGA8xKF3sdoSm7zeZ70OfGSUbIePew9hABjZnhacP5gvcNzbKLOTKWBWjf\\\\\\\\\\\\\\\/QZarJT4MtChjkNgqUW6XDr7vXwaA1e\\\\\\\\\\\\\\\/ZJMHYMiGbYC\\\\\\\\\\\\\\\/zXjiOV5e9bKZk8ThONhLGX+iw+4efRhZZFI\\\\\\\\\\\\\\\/zX2N1ncXRmkwehDJyfEdiYh3iMtGC1YDQ1+sxOSbROzPrnWcm2LU4t8mAgErAnvhdsJlPQg0c6RxlSvDo4Z4JxuRlzCeWPB+yp1HxpxMGAGK7JZPiLrcGV+A8f214S6B7NMFN7VASJcDwTW+T2ceAE3Q6B9CbOUfPrLgaDu3N6h8lqQBb9qAMq57WycP\\\\\\\\\\\\\\\/KNFgnJEKMMUvinvibJ9LuU36peyrASD6g+SAoBGd8n99t1bRF\\\\\\\\\\\\\\\/IXx7KQzZZq06Du8QY2Di4fL3n9H5ZeUZmitiZO+naNBl0crn+1kuAQopEpuOq7KvatPZ16rqX9tcJmr\\\\\\\\\\\\\\\/yyQ437rHAkYyB47IlMonTFMMdkUZgrKdEVVyNZVANZC5YFRCOed5pDfsYEy4xZGBeokkVsyz5wZZ77EBUEkMDPuNjwnyOzkTBhfxspP+kHuS3xHF1gnlJXCe8ah+XoE0rmLiRG+x3FtQGxnRI90hVsvJnftWfdOtE5RNgYeyh+vLpFiZw0xOFzQ87TFL6kfp153dLDEJUGqJsdE4fXh2gGUGwa1EpeJ9rqJvgXYK8SBPy9FSM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229fgX6v7Nxjbmws\\\\\\\\\\\\\\\/YzeUejA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002247a741dae1d386355496f7c9629d5fb709b212cc71b9835d6acf4f2ce06ce853\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P327.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P327.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P327\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P327\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P327\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P327\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}