{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022WfTHYc1OZuj4vjMEdN9LHJbQh83Je0I8wvoxC77zABRneFAK0s8zJXl6E4i0mbiXWDXC\\\\\\\\\\\\\\\/Xdi4sgoLu0oCWxtNQ3MeWZJYDyP+4EIKAVj9HejqNixSnPokNKtQ8hJfcBzOApyxh8HfJSlUlA1sReyw6qNJtPkvNvtYLhqm1ZO\\\\\\\\\\\\\\\/UXChkvVVmmaJuKMpY4hp7XVN76eWcEyiJOhfk9ZkDPnfsKl5s89mjc4ySHd5dm\\\\\\\\\\\\\\\/B09R\\\\\\\\\\\\\\\/JZ2RbTOQKaPZAZ63s5slr8yQvxTTjGnly8m3igq5YI1DX5FYcT9hXcYMmju8L+Wcig7xt8bmOzUhIqqt1O4WNVPLKE8AdEHCNcV8tOUgxiwA2GVp4SYkd4uuSELY+yH2tpHCxuS5nXMmOD\\\\\\\\\\\\\\\/0VuTEazw0fw2Lk0Vz3JGtnErVdkOLk3PorQBjTsHgGmrCZLD7I+UK+b59q55gBuM3BnLA0UIOptwHl8L88lXrLXMbgfrVb7A2kcUKiVqV71KarOVeBQNdig5CtEShDXwwiS955EvBTBDy8fGV3ZNWjuwaLMbjPtXET7V7S04qClCPZlGabtcpe+NB1gkFvJNx+f46gS21ZVRuQ7ePYDjv\\\\\\\\\\\\\\\/O0mzY+et6C6f7zuMtxDC4ks9NDKzp5mj6TTMwxgaZfItwkSx\\\\\\\\\\\\\\\/HdcFaN8jOuJMOUN4JnCinHUQaiFkdPiP1HCHydYSwkK0VTwvrqMnuotY1jrDVKoYzF0R3sC43RYj+hh4kGVjvJNyor1vUm8\\\\\\\\\\\\\\\/iu\\\\\\\\\\\\\\\/jzUlgWXjpIhDYyIPJO4y48t0Xfeka7jj6WpNF5srMf3cQP5hjppnMC\\\\\\\\\\\\\\\/RkB7jDC6IxCEc3ucr3Xm6Hna0+1aZZywbqcx5h5IR90Ss\\\\\\\\\\\\\\\/91M1tzYZc2IiqS0RB46BZnEJprssO3\\\\\\\\\\\\\\\/UocT3lqmcUngkVa3n+rtc706BdkeRqdxXWrUXb8OF6S4FWrZ1Cv8yShdEfuIHVQPNYumzunUUXpQ36nekCWGzqtlT1UIo3tu6dG2zRtbWr6snIlWVNUBqw2pLLQW0KrQd5EsAjQFz70gCFFuDQ9gQNetqZdU9b6YXfl8YT1ofWjXiWhOTWbpw96czB1p0SrERz8mazI29NEjDeuRWcpqwzEzHW4dzSnVoNLnEx06WL5NcgRtgcsmqXB0hx+jCENR66M4Qv9tzCN\\\\\\\\\\\\\\\/qmWqLPuJLmXN9EKA4hqlekNXbgpIrZkGhB99IoPReuoE2WgUaiMaItHprYPvKoirAsV8eUvZLu9GSKu9wvog52fQQfTdNUdONbN3y0tvsTeAwhNZrTFDrq0luU4Zo+CZFYeaSYA9tUp3dPMixfPRU72ApalcDInG3TuoePmpaTu64csyro80uO0xAEy7zousT91xML7WqhC8a9ia62nGdukAvocLcJqgBQ0I64+q2rPN5Sn8IYGg4Vl2NZVYtNO92xBVa1ahfZ7IY5XaLxRviHRl\\\\\\\\\\\\\\\/ywmEyk1lLOisVttpsp1u3qkwzz8sLTREhpx9EQ4fUvgq3NydcgdQpuMIXOZiUOqaMAbYr\\\\\\\\\\\\\\\/RluhSY035pnDsTAwWdrisn5RO281r2VXm2ZdPPSrQNYcpqE\\\\\\\\\\\\\\\/YrmoXLKOMReteDA9xPa\\\\\\\\\\\\\\\/I1eHRkQQ+E5w\\\\\\\\\\\\\\\/j+zk74RK6B8j\\\\\\\\\\\\\\\/4XBT6wpPLisj49bsUw6eTT+PFts9z3kxnIPV4xGjdhDGXlFRWJNR9aGP6LL2Os111Z2ruJTS+7zi6xr+pQ52yTCj2Tx9avWAdKwNhKfUYfEpnqzkx04ykAaBvlWEo2y6+pkUTsH8Ke2beph466QPKUy4pxZWQx3y7VpSlKixJ4C2OgZefCMB0hIjD2jUK8CwXJTogDvZmKcv8QXlnIOOdRrMfvouKLfnhv4T7AbgxbrYGzDiUWacbb3u\\\\\\\\\\\\\\\/5NlhpBT19FCZMQ6DLi5UBftT\\\\\\\\\\\\\\\/cplhgLuQSjY0oCUSydBUDmVXLmBdMWWyq\\\\\\\\\\\\\\\/NIM2cihG1MfqhLLhcqhPPjXgTwBBtusQEq2s01cMJ4wAim6moo+IV0piH0R0oMuLPbrwMCeO4aPgZm\\\\\\\\\\\\\\\/qF+\\\\\\\\\\\\\\\/lHuRC7BZroy19NgQQqZGC4wEbp1Qlt5vRGBtmmWhRoNvBBAVJ89WTT\\\\\\\\\\\\\\\/gsOLZigu25sivMeZTTGk3\\\\\\\\\\\\\\\/QLwtMwtwNyPwpq7sb68eOX5kb58AUDveo2Tq9T9fiP9p+bIcPzulzrMAaMKGbEgVWlRbRpwNurIXYQMKedYLD2gsx\\\\\\\\\\\\\\\/qJyR6vudVEFAQMASghxotAMsGARt2Z2Vb\\\\\\\\\\\\\\\/XIVpt5sRlfw\\\\\\\\\\\\\\\/ioY\\\\\\\\\\\\\\\/P73X0nFCkU1mHi43YCoeCrN9Iuk0ZIlHLCTST8\\\\\\\\\\\\\\\/DtMhOY1OhZbR8orTtcKEqa6g0xVJtKIt8XxwbhwoMEUF5TVPXotWCzTdJ11SjuXgJTc+gcanfx+vDLRaPpAwyXTXKxi5pxYAKEhm995nkLLBfxZHu3sDS\\\\\\\\\\\\\\\/bXaOYlDJo8JTbhvT\\\\\\\\\\\\\\\/Q8J5WXA1C8b8ghg4fGIJq4dV0avhoNuFECmYXDMDiY3jp89bzdqNGtboMGsx8rrz08Za+rYsPQIbmGb+4G050RMV5Jl3LoYxUJ4DT6GIn3B6NGavUAZBPkRKmbIdQGU\\\\\\\\\\\\\\\/D1o85gh30ZhCmyKI\\\\\\\\\\\\\\\/6lADtbaXMKer2QZQmmSN8gDLc\\\\\\\\\\\\\\\/rQaQptA2pTw1Ux34cM30yOTQelPktR3Knp0nASNGKY9PPGYADKbVE\\\\\\\\\\\\\\\/ESuAd8nPQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lmASAFuKJrEK6Jm6CnkqGg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c698604b6882aaa48b0b71c1983db8e6dcfec0b05a862391b552676170c22d9a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A64.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A64.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0055\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0055\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0055\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}