{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QKrNSvRSDkUJmKUD5Zc2oNwiDOITy++aNyNDOKejREs8lHsJDS2\\\\\\\\\\\\\\\/lEwz+oWxKB4\\\\\\\\\\\\\\\/I34wlH2xwJ806hoT4zB1mre7\\\\\\\\\\\\\\\/4XNcVG4msq\\\\\\\\\\\\\\\/dxAAvDNdj0ZnZat3r4c\\\\\\\\\\\\\\\/V3g+AV8Jr77loi6UrjM44tTH8B3yEOmn8ShudSvkIvdfNa6P2QDgLpEEFdjdYCqnQBsV9uSQzoMmTUrZG\\\\\\\\\\\\\\\/QJofMqcvEfFc6axN5EQ3XLW9GAuZFEhl5W\\\\\\\\\\\\\\\/oev9xDq4b\\\\\\\\\\\\\\\/yj6SJd1omfofH+VbLEqNUqwVq6iIyiVWbpWwNJRY5bJkfx8Mvc9\\\\\\\\\\\\\\\/o++loLLMKC4Q8wEA1Wvxe3qL99RvgMLWgciaPruPtsqMiH6hNuNakmkCPdN4dbFVqrXRyajIr2iffvvM32AQvuO\\\\\\\\\\\\\\\/ttlOQ1P0mc9pEkWw3c1uIFMvlDg78Uff2FHZXxPSkW9ID8c2UNiRUF\\\\\\\\\\\\\\\/zY6N4aiDUbMKdWPeHIwRsEPg+qKF5MKKAJvI73AgyUjBNfKF8fDT4f6zuXmLkwd2vI9f4f6hj3mL\\\\\\\\\\\\\\\/jv6MrHXT8QIF8ReW2yJj5kZKyRu\\\\\\\\\\\\\\\/g+C5ueLW7nAs8PH\\\\\\\\\\\\\\\/n5nA5LzUohyRqSLP4AJ6IxpFZ3X9VG7CIqXqNtE+Mrr8G5usgvJFIPM2Yb8IiKj6vYrDX1m00AGLrWKulk8mbevSJAwE3zZJvVVnrDJ0Rl\\\\\\\\\\\\\\\/sbKOfGAcmZJ160S\\\\\\\\\\\\\\\/79Rj+K3fvJvqXx5I19VT1q5hPSW9DE6SuMsUB1lD3J9uimS8Mwl2sKfpv6R5irUAq8Oam+Turz26iBZc\\\\\\\\\\\\\\\/Xmh1vRrjky2CXhI1gJGN8G8MKxGlpQGn\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OF2j+j4j59S+Ks1KT2gcgGgy4QnMFGIdRMihmw9RBFjHnZEh+CztTIDgsaVkI+SOfUZonTxBKO4ZUJ3Y+7gdHzTPLC8SOMd\\\\\\\\\\\\\\\/36Itpg2aj4JChBVFhtY3WNVlKztNhImrIBrBkfNqmTe28pJtLNrBDjRmLDspoWS4bCMiN8SjJe0x6ZCuL1vf1uQclioiu7lgf\\\\\\\\\\\\\\\/Qhkkb++T5b5+BbHeoUPX\\\\\\\\\\\\\\\/F0h++DbvJJFgKj2coHtSzEHAgmudqKKFg\\\\\\\\\\\\\\\/bHYJ55eX4BeNxfWgJaOleePyY0Px3CU6WS2\\\\\\\\\\\\\\\/Qgv\\\\\\\\\\\\\\\/yh4+fcLqvtkl0GvexXxXbNLMJLjs0pZoYUN7qnK9kkdZNJRHgXFUNC5jzkF2lFoD3jKjhZceiFKknSpmirK84s9ZQSNdcYp0YFCO123y7DLcvvNgaOyKjReXoI4eywGAbBJNDHxfmRWq1gltIigjOPbadhmNJAqLww8P0tFHJ\\\\\\\\\\\\\\\/4wfcj4MRUb6VBEUAoggQHY2flBTaZzhTIRfJggnViOEP+CTMhX3YchPFEFarwYOUs5rneq\\\\\\\\\\\\\\\/UuMxHmkBRVmeo3S9v+oE5AYBP6eQPMUS8hSxI12KsbtT2HTrw26cHMK7\\\\\\\\\\\\\\\/FoBzq37oQ0B6XDYCxzCT6HxzOFnanhcQxHkmgofDVfC12n\\\\\\\\\\\\\\\/uj1923unQAXQe9h7p\\\\\\\\\\\\\\\/LTfAnJvC0MbZfmhqvq4ymCpQsYwMDZBgLnw8onpM5at+5MZscAnQKu9BXDKSlqJbEcUrJ1byD+lylo8EzlbsciO2Ajb14\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UFWE8q6KnNh9j5QCkD6x2pytgx2greRRWM8B0hopfaMG8zx0SYcgAQFwBVlW0WORiNS7p23U1SJyhfYJfY61fWgdG1OXJZBm4YX71fNKmNp9x1GuG+PE7dZUjQLg\\\\\\\\\\\\\\\/WSy5GBA+oSQ+VdR7QnwFr\\\\\\\\\\\\\\\/MWIztQjKrspu\\\\\\\\\\\\\\\/de9esTh8vkP0aDH3fq5Itdh41C492zwG62RaeJn+woXs3nR0pa0B\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/F2WEaJSA4nbCKVcwLVZG9yE9g+4wky5akMAUm1twfiRhW32hMHFNG9zBqtSR2w\\\\\\\\\\\\\\\/jDpDsHDprbE8COxKi3NQMorqYANok6bvjHedz5m\\\\\\\\\\\\\\\/0QtWYao7OF3mlraXeaehkKWfp09M6BuY1SkRi61hg57iIbl1fmInTvx4tI7CshpN3HHTRnKWaMIYQVP0q1GFM9aINfw7KZphzQSc1uzq5erwQ4uPv9ksPL7ZHZgvPQAEiw5KKdCpxWIir6uX7NkKQer3W1aUq\\\\\\\\\\\\\\\/YLpk8B0AV4aal6w9wVIpB5ipF6J3ywb2tzSb2HBNRT6mv1B47uVC\\\\\\\\\\\\\\\/1w6xCc8twD\\\\\\\\\\\\\\\/4P1aiiVVgRcLTid\\\\\\\\\\\\\\\/QiSHhevQsFyztp4yV4gvcOpqGbCpJtN+IeNgFLcEyTBUQg+m6mJHJzEFqMHwSk5NggD5aBZik2sdWzI9GFi8lEuXl72d31ipBBduw0gja8akAcmU5oBuiWuVRtYovSZHu5zxiO7P6gdPgYS71U\\\\\\\\\\\\\\\/4EYFRk5E3OhNc\\\\\\\\\\\\\\\/pF+LBvAUk9jB1FYjd1iJTWJpjCqioEhDAGvIVkAylVJgLUTe3d2JhTbqfe3WMtpKElNNWXBNOY5AxRUQZNUOxWKTTqQqrX5USTisRTwy+60JfG6NWrE\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/jIkl9HDMu89eugj16Gh3+sjd4g+B1TiQkXbaHvvUhJ79N2zVEvSwKFF6\\\\\\\\\\\\\\\/iKxVrDaSIb3Wr72IYLfGSq5UgmGFS\\\\\\\\\\\\\\\/hBXfsfdisvjsIKIaLNdQWtANvnSZP8l9x7\\\\\\\\\\\\\\\/OaW\\\\\\\\\\\\\\\/GwAG7+sg3cmUWFAABHRYMSkTmUuE+txVIvhKO10vN2Y+CAkDEEJ89wjuw8qqKzvaCgLqoH1cyztjwfzFFdWADAx2Vtv2BKV4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022NTITyLLb9nfmM9flZRpxyQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002285a3ddd881ef3da3eb89c6adbdd60e0be0c80eb968e87d806014d241edc5758b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A642.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/A642.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0563\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0563\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0563\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}