{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221atG\\\\\\\\\\\\\\\/xMyYrhfcwQmxBj405l\\\\\\\\\\\\\\\/MrolhiDp7DzLmIA6SUF38P9ZlCopCRFvlouIjm3zgW3KM7EZWkOB5PWRBCSdcQG69f\\\\\\\\\\\\\\\/1yNt35WEVENqCuoi0hzEkwh5HdRD5SlI9EDv2WF1oUzJrZx2e0\\\\\\\\\\\\\\\/Au5FKwMYFqzfup3tyjSr+9Z\\\\\\\\\\\\\\\/hdgsJEmn5mfvUZ42F4Lyx\\\\\\\\\\\\\\\/HoAqe\\\\\\\\\\\\\\\/Vo52\\\\\\\\\\\\\\\/B1+pPgtoOvfRI9TlILDIL9gt3TCgYs3l6sdiyGJ\\\\\\\\\\\\\\\/XBMMkBA8mduy6caqwqO5XCBZ+6adx\\\\\\\\\\\\\\\/EqY8B5Hf7NTe1LyU2lIom2xYDby+zIzSpFCywfGLU2gNJj1HlKfh9l1DYO0VVZAgwKWzxuw3cu9uN3EK29S1aLLGSJZMLnPhbmoyVgvxTLr4\\\\\\\\\\\\\\\/IRcv3tIBySuqA\\\\\\\\\\\\\\\/LKhQ7FrNRv4liBn1PUiKfb\\\\\\\\\\\\\\\/asRTkLhJxZCPUSO+uyrQm9Ef0uktfpdEX2SlPaSdCkuiIfm30Fv5tNUkRcA8VTcn5aNVa4Pw\\\\\\\\\\\\\\\/PjoIR0EwzmZD7hAUePe6wKXVQ\\\\\\\\\\\\\\\/jE894wclpW3gUM7Gsw06m5rAyqZupNFdJqpMGXEuVxQ5h4JbBaTj9FtjO+ymeCHh1N9M0KfT3O5u1WJXGoza4DCdNrsxe\\\\\\\\\\\\\\\/+0LXs7b39msZoIvcpTwZbj4Pc0auJ07lWZ0GbCKYkavJwi+u\\\\\\\\\\\\\\\/lD+\\\\\\\\\\\\\\\/GDIYJnNsuQUUOBgR29bxt+fYMTgVzbph5kyOiB9a+VPgm5a3nWKJeykwBeimut1r+WHv4b9yNHwyrYCdAPUur716BNQf39bFC2DLdsK8NmomLljObD0Th3dw0aEDu\\\\\\\\\\\\\\\/t8S7ix39jz4BOLQ+g5qhBw\\\\\\\\\\\\\\\/WTiK89fd\\\\\\\\\\\\\\\/7nbwR+HsZpQsdCpGBm3JRTEUmIlnNryrnN07ug1WDusbgeBGL9pVYS+ZItGMsp4LsHDnzdlVsNtjm67JS+I1+1KIcf7MUdbeG6m+q6lccOBi5Tyj6\\\\\\\\\\\\\\\/k4TrxC8cl1IGBj431l+ecfHbEvfHK5Aje8Qoizyqi4FOc2ZZRgZfePlP0fI5\\\\\\\\\\\\\\\/9IfGDn85LnyzJCIC6f\\\\\\\\\\\\\\\/+hrjc\\\\\\\\\\\\\\\/qmlQv8mkK4V+Hw3xyFUAQ2waJUDeuzsAHY9WmcmCu7ieMymclpzXuXDcYtheRxo1pynlft\\\\\\\\\\\\\\\/gK94nqL1VOm1TbC9D2f6uaNNJ40FzCiNs7\\\\\\\\\\\\\\\/dO7z1fZU\\\\\\\\\\\\\\\/69LYXCUZ5EJ0fqKIcKjfbm6fw7TvTJ\\\\\\\\\\\\\\\/wt3229Kx5an7qvCROKXZy\\\\\\\\\\\\\\\/vjhmJCBbvR4eq9nf81ggHKa5AgMq5e0fkf6Z1O6mMV\\\\\\\\\\\\\\\/Byxv5fURs4cAUUwo1RaAAYMD0HK3KjJTETor3EqbwjJ2gYkcdJb+Oy68WMqmZFB10YslGCMXVU\\\\\\\\\\\\\\\/9RFv6\\\\\\\\\\\\\\\/l2H9YR3Xh4gzIEyV7N2ShKCPGBsgdyWaZ1MIYxcXxhy\\\\\\\\\\\\\\\/5GnH3cftKACUxhjr5hjaHU7keqwcGKMV9uuB\\\\\\\\\\\\\\\/BddzhLpm3c+Ksu8JQpwkIaFiEDcyBhZUemr79k8EVbAa5Bv9FSrEEiPgkKGs0nVfsQBxnqaolP3RFBZ1dhksTvuJ2YfxD6AEqAahi6Ljs2GFaItgHVEFNNKVmnYe3wwBlOAiXYPNgbOTp\\\\\\\\\\\\\\\/rhP8qfeeibgxUn3ox8Y9j0yeVsUwIvY1j2NKr3tYCk0bFnZafgRnmpcN72ejGQF70EeFrqTHaEV9tG5jBtd8TImWfCp1GyTD31Yf0I3NwJ63bN6Ptt1\\\\\\\\\\\\\\\/G7d7IFQdtCsho8Ie9aypzkknj0apGA9nf8jCgYZ2AenYn5R8x5VdGGErj0BJXSv+S648XJ3yA0JNF4sWortpvods5XjSHXsHUTKF4GNfO\\\\\\\\\\\\\\\/UEzr6uJ8doTDKWzJ\\\\\\\\\\\\\\\/3RFQ8mXYoc\\\\\\\\\\\\\\\/m9GJF24ypEubhp6Ggk4wuH6V7FZLL54VWGQwKEX4\\\\\\\\\\\\\\\/2lkYM3xw0v+v8Sj1Xhc4xxnQGee8U41LxAJI+zxwNB3da6u8iVvAlhipcBawrP3JYmvlsNF6T6WDYBeIKTYzin2PbE0lihi9BdL3w4W6uzVsoebvzTmpGU8M\\\\\\\\\\\\\\\/ZYnYOxYXhLL9zFiycgJ5VBsMYDaQ0FyUk7XqA2sjhR2DGt1dlc\\\\\\\\\\\\\\\/xroBTPWTHCpKEtq19OcMMSnQj30uNz8GHsKsCIJSrhnb0t00uCt86Bq\\\\\\\\\\\\\\\/RYq2veA0Rx1I5LqnddZg0i9HIpubcsB1SdWxJdwyt+1kZ7ciVxN+UTTHBRxFR9NQwZPLSPTkrIjGEpUr\\\\\\\\\\\\\\\/3vaLzIMRPt82G8oe4jfg5KyahKmSU\\\\\\\\\\\\\\\/qaFIJKI2tq\\\\\\\\\\\\\\\/y002csBOJDTr\\\\\\\\\\\\\\\/fb7r8YsO0oM39Wgy6fWigecK7ZkO47SAOrf\\\\\\\\\\\\\\\/zvjxGjAYxSfqYYy15zrdBWNTZZukjFW7PelNLdbnGk6cjcfuTq+\\\\\\\\\\\\\\\/np\\\\\\\\\\\\\\\/3UMBAaNKqHt3eRYqhJCiOCXXPkAkZzhR0GnaoGU9QKPaEa7\\\\\\\\\\\\\\\/PeL2vFZyEAisYi7Lk4n6E9J6Ps2anNPnofmcJ+4XZLTtdtjBm\\\\\\\\\\\\\\\/BxWSfdWHzDvTBQYiginQZarE8C1C\\\\\\\\\\\\\\\/MfYlkhESDeoRWJfVMvNRglIq2V88WTk2bSqhz6kOwp8h\\\\\\\\\\\\\\\/IvTt1NHPqA7DxBNhcB0cRX4TpxXa5aLoehs0Llodewi8pZudhA3n+CxmYcDN7W+0XIra\\\\\\\\\\\\\\\/+B5vwr2DZAgJIHvK4JjNrL53qDsq8jHhy+v3Fh9Jc+AY28VG8iY3pNFmjZu1XPkJKGMB7P1Bk8sJPp+zpNo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SAAJCQ7JYUOIQUlMkCF3KA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c120582fd9c47829598368cf5e590d96cb14b32a1d35c7abad79c09db41298ad\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e007047.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e007047.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007047\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007047\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007047\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}