{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022+NwzYm0Pybaw8RB1mroHiMoaUDXVWzOtfdAb\\\\\\\\\\\\\\\/fIZEUAWn0HrroKqfVxmt50BGPo88BK7FhAjASoDOJiAwoqPBjna8yrmsSyVax2mgXSKXVmmCUQ4tKtlabOCwrQbkOzNBE77o21p\\\\\\\\\\\\\\\/leme1VhLpEjSVaGlkEa81nziiu5o3E7gWgbuG+\\\\\\\\\\\\\\\/yE5YdO8tSu2Oznmrez6hSJU9QeEJPCJAnQngK0tZDjrfMCXl+A3BNwW02r7gSYCibPJT5eKWFN2evkN22IVERrcaLH0cKAN4e\\\\\\\\\\\\\\\/C5ma83ZpAQ6wLWjLkw5U4G\\\\\\\\\\\\\\\/Td0hpSsYkwP0lysRiYeHvPSPVt6HA6yFU4XHDv8J99RxzRzsMgAyqx3X4Clno\\\\\\\\\\\\\\\/u27UIutQfhYQLuhEbWWoD4LnjH7D4BPmt53he6UPJAcSbZ0QS\\\\\\\\\\\\\\\/3XRcruag7QBx8eiqjNNzeiJ+oXPbKhw0gM3HF0UQpeLnQXhcni2pOU8O5M\\\\\\\\\\\\\\\/J5TC9sqVEpM1OR7CKGxbTvrJUnoNBQh+xGqFvpoPkgwNSDgxl7FHuZsgYq6fJSYWKV3oaxWQMR9I3paKc9a1l0dcygcmzL2nlmkCDI9YdVUUxwSQlxKaz\\\\\\\\\\\\\\\/hmPWArmk\\\\\\\\\\\\\\\/oB7adt9zCvvo3gESBQBPLZ0aeZDD8JKhc\\\\\\\\\\\\\\\/HpmZCLKAd4XrSVREod6wykrj767dgvbGP8WW9kFMDs5KUy3EBfQn4KmWsEWkyaUQDKgrsBrhBrFNSSNokGiJmxdR5lsnfnHosfM7TnWKbKae1sYdALHb2G1o0XiycIFA5hxQV\\\\\\\\\\\\\\\/mrsujP0EgkPzkobi40PzEru7OrT98umu4hIPZ4zQxPVP5\\\\\\\\\\\\\\\/bQ3m0u0E\\\\\\\\\\\\\\\/iUhX7CEWH64XbMfTLsO61Hmb+ufcECzpPd8JmzgxPKjteBq\\\\\\\\\\\\\\\/np7GTxYWWB5ILCOdHDby1oZMr9fPx3mJTkA5iYTQOSQgKwJndf7YqPYYrKE0u3vEPEYAeRf13WaEMihuRau90BfWKCX28dt17XIeaJS5d1Bo1djpUCdV9Rc6D4XpfaSQX9UZ\\\\\\\\\\\\\\\/XGezCrIztfgS8tg46CWKGkIXgJsNW6n9Hps1MBrXkpUsK5m0yx8KvOZxJmYW\\\\\\\\\\\\\\\/b1JEkfCdV7QSMHkls436q9a9cEQk08jAFA4ZUjznnsmDG\\\\\\\\\\\\\\\/yk3O+Aej6emXcylNbfpQVYdwLljcXBs34OpsPon\\\\\\\\\\\\\\\/2FuH4ftZYSN+Hbm3ZIEhsq\\\\\\\\\\\\\\\/i4ASUzpMl45S2Y78fWKmRT+IPaugInZjP2mfgXag7452oeZl1HfoSoDJ2eL98QTwwyXJ5i4mDXPVibk8L32fCoQwFZqxgQS4cnOMvGhB3T2rfhuIVRk6Vg6cQ0uPNFnnV5FF3UNGvWUAAXQinTldhSiLrvEz++jLd\\\\\\\\\\\\\\\/wmhmusarTz6QRIvYP7HHn4RJ85sysL93ODsZ0Zz\\\\\\\\\\\\\\\/EW5LN+MDQFQhcacGIbb7qRvtGtCOZQh\\\\\\\\\\\\\\\/c\\\\\\\\\\\\\\\/YQdgSirm0WkLCxJsdxa5iMhYRGXvjGVBj7UqCJrHWOVN8ezWDoRezmexltooBoKxSxhAtLvXd6eVJhzBubfQTs3SrSN4R6839uJDkjFCgXfYrszD0zi+SXEaTYseZm8136+LYA7h7ldzq754Ve001s0S+zjJdaL1j2ACYMPnfEcrO9PVCx2gWyIUFSsL+otDQbX\\\\\\\\\\\\\\\/DbuHJLXvRfWL4vtX4iBRy63OvGBiDv0orzeadCsI0rtNWWz9DEIOEeibHz48Idu1LwJQXl1tXIreKvdz7azMDNl9uONmw6+fls5X5XFqhofHP8J6LIsa397ND+D8AiUwwqqP6+UhYeW4zVXv5oeLtErGhVMkTf0jU9LyDe+IIk553HDxIQ3aoly0TqDW5E3VIX4uWq\\\\\\\\\\\\\\\/k0s818OztQO+J3Ronc5YCruthi2Cmf0RD4lQV14uiSOa9MTFNwqpr3BXHcT1gYR0QPBAiFL38YxgX8Ke6VFIGtEX7rF19LziEIhrDcwrvi6I5MRMw1Fl3T4j7SbIHNxctvA7nYDB\\\\\\\\\\\\\\\/HpRL3vH9zgKkHZw3egAqRxqF8AOwHcAJVhIsJok3SFAg7GXeVP3htI\\\\\\\\\\\\\\\/SJv1vnqh9muqzepyLSNzWbeyWZMOdutQNDNYv69v+gPbfeQt+5j+q8eCV2O\\\\\\\\\\\\\\\/oDlJUyjnsXesbkM6j2uxmDV3hhjD\\\\\\\\\\\\\\\/PwcPx9UOsKgRxrf8aS7puNY90Onui8XqhCNYLlV63Be0jdBtJMov+uizV36uTdTo2aBK86jSPac9ab80fmDuIAimdBGGcE3PiMHU7+zi1A\\\\\\\\\\\\\\\/VwVME1r\\\\\\\\\\\\\\\/alMN1hClP+irx5hfiu0SCTFmy4S\\\\\\\\\\\\\\\/maWDKtr6Ik4oIV12OWDADtvsMh77YaltduViiq0dxuf5llcQd27dZIY26BXTyinUY\\\\\\\\\\\\\\\/vJtuQnA8w3laWtRgTG7TBTosZrg\\\\\\\\\\\\\\\/dFiPjw+1SM1KjtVeVbeCVHtBBkGAJKdozE\\\\\\\\\\\\\\\/kVdk6B53LgSHUNGvcbmuE4+Oa7CNdN7p3aQl91RTap+PCuX6BsqL6CxK9h2mRS3ZjFI8f\\\\\\\\\\\\\\\/+iaOAr1JSLVFSbPWoA67b4eOzf+NzmKkc5+oyMuHY0QD36oZdyt9GVS0vGjikPWiLy3b0CO1a7E9T1KE+ab10eIbjIfb4+oqTG\\\\\\\\\\\\\\\/lu7VKj9LnBi81mYs+ai9CYs1vElqKI\\\\\\\\\\\\\\\/Krg7njgbPervwq9GIA0ZUSWtRAqDJGcGnDo9OLgYllndzzESbI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022nsmYZanafaBgla8T4PXg+g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c8a900d4874bf436115f33a0ffa04e3356f40ad85ca9df3a0e583aa563ec990a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e007699.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e007699.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007699\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007699\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007699\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}