{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bbLCpQurgeoK8i54SBRGTOjPrhstzZNbF99DgFsbNUP3oAGmMNLXPc37BBNWfWg6irzVULrySA3\\\\\\\\\\\\\\\/V71TU80qQt2NKtBgasoZGpflpzBt6rzi9iSk8UVq7EHCgBQwkWEZqZX7+HgUh+BPgpfJzuAzdbfmti1v3ExAz0UYPMgoG4\\\\\\\\\\\\\\\/6lNU2\\\\\\\\\\\\\\\/oIv9PhIdVKJ7OYbtQZ5hmwBe2eD26fN8opHQBE2F8Hxv5ZrxoRGwpfwTpZ0rZqihEYDjpoUcfAZSVYeuQyWShN1dXh0oD15UpOej5pmXxnVhPP8PJKTFY+07Ck7s4vmaGYAvW7dMoAH4I4OVKn1IobXslCF0Y4qMuQgDGgPt1OC5G\\\\\\\\\\\\\\\/4NRclqt9ChbWSxICu8AEWLOlab7vkbuGDRqSVWaGf0x15UiQv6VnjNvTzuat8wo+GIf8t9YytpsPflN1aZ+c\\\\\\\\\\\\\\\/WGUvbtUIG8z26QYdP2ZsHAH7eEoHG9cNvITwZBAIEGlgqVhfrICw0oM+EciGMG9adZiIWT7H7YODC7ZMaNRttIZ8mQqrXDTi9YMQNw4x5bbzfLtteiFbK1WB4\\\\\\\\\\\\\\\/5mSRyhZCjLGBWji2e9fgwKJ3TbQtwaV\\\\\\\\\\\\\\\/wL2X0UssyQx4iwb4b2M2KTO6F6YegBJhMIl+RdHD1VlpjzYNqemeRqsjWCvMSBlwxDqpqkbwpoiHW0blDutDkSUKHJNU0E1W5o\\\\\\\\\\\\\\\/D78xCG3K\\\\\\\\\\\\\\\/W2iTZnpxz30Lx66FGOIR3RZRwJdpWfGEYdnzg\\\\\\\\\\\\\\\/JnkwvCnx8ccO5hQ3+UA5nip0tbQdbAjnVmbX5t3C9dsXnGvsa7LD+7AS\\\\\\\\\\\\\\\/gghHYH6WSy2PgZLj8qUiHgwfqEV2ZF8ki77ntqkwHx5nluwb0qf7XOmImNFa9VxL+cAt6dS4xY+UszBJnghOIbhL1KJhSIqKuBb7asXVQDDu6eYvVCObsftKvdRQ5gYw99qdXulv6H3Kr22ZNyHmRSmkXc1pKSK9TjPjbnDQZRf0PGjTuljaaZSp5TcTdwTkEMmMQBcYZyStqlakDkhhwuTY5zoLxV0ji9D\\\\\\\\\\\\\\\/rDyy3LOvPU8G1zGRvlZfH4fWeSfeM8o8zYZjUcTfeQK2fmvwVEadXS7nH4S+5RJfFa+zAuNt2psSXbl0ZiHsp25dD8hbeFn5DF8vBaTHhxg4dWuonsNfU98xv9gXcs9zX7Ss\\\\\\\\\\\\\\\/8k0w4j\\\\\\\\\\\\\\\/cpXJWwgOHD3IscjBh3hJ13LGcNIaJMMB9xgEEs8lUsYUqQQMREATqb2+Xy9gH4ZEUOYFRCYSl\\\\\\\\\\\\\\\/94AQ1+LR8JGyVOQ8lrHdv\\\\\\\\\\\\\\\/LZbSKBD6Cd03pR1TGq9DgaBwXz02s8vGgrxGRU0inyGecOetzB5YrGDfet7eYN5Q8Nh5nbJF5Wxd6nCM7wZu4M+4RTf41yPQYFDdi80sx6yDOXM1bGWAJb5B5js1EA1Q7U8XSUNIwQiSCbHdBPu7+qbRc\\\\\\\\\\\\\\\/l9Fm+hFY+raxVh7Yv6uT3uc6vSeRoZ56QjK3pCRQC2uGZLCbcimutsBPcAD\\\\\\\\\\\\\\\/Juv6x\\\\\\\\\\\\\\\/f4KlrNxRRCKizAm\\\\\\\\\\\\\\\/5dzUO9f3WvY5tOpDM\\\\\\\\\\\\\\\/XfacbXmgwhfNYqouWH149eKcBNxj7NvpdmQzOR+hreYZQMIm5BQGNtY\\\\\\\\\\\\\\\/yyed3\\\\\\\\\\\\\\\/qhVNt3XdRvOpUpERYuRNV2bDEsfKpfBVrY6hXAIVfgHHB2xhObUy\\\\\\\\\\\\\\\/enp\\\\\\\\\\\\\\\/r79MRtQThoBwpIK+PQ9OiRLEyr+kciMpY3n8lROhoAgU1DmWZHXflm8uYy+TaU8eQJmnzr91ZLv19wuaq0RNZzUiELHpDiavHwjZDJo2+RVhfSGVlzbnSn4OCI+xkWUbcSL+VtwLo1YErpz8eafc9nr4PmAVW3Lwp\\\\\\\\\\\\\\\/9b5g6zAoHh8bdNfpKUu0nZmPfQQh6jh7Vm5Y6ISBqxpTHl44w2\\\\\\\\\\\\\\\/yahpXBxqqh1JaNW5k30JfrohUFNFY\\\\\\\\\\\\\\\/f8+34ZYGb4xpyzKI1J7SmMxHT9m8mmnttIGa4QF4GRFIuhBMrDdBbBbK+yyFc7qJDhnoB2l7sUdqu3ePKx0xPxjt2f18JR3pBV\\\\\\\\\\\\\\\/eRyYA1hliaJ3cG8W+rf36M9KBgbSAbV7LtZJAnMWiyVLEPS+AEMCfYYLQc\\\\\\\\\\\\\\\/p3w1GfUXSiSFiS21Ayx\\\\\\\\\\\\\\\/HTW0Ih6G5A+UXK+RipAcaHzsdaATjB0emHGnvBb45PuHtC3Lm4chTZ4qreB77Q1yDYvoXyGxLI11jFQjrVtl8Znker7Z+5Tj7+FkMhRx4SYMklAOPMePrwAQ\\\\\\\\\\\\\\\/U17XoILzq0KDLLpMtWJznX50Xk489a1C1XZpC7F2mWQAsWKZZEmh1hvxexp2ifI6+YEfaCjG0kpIiThkHJe5VYlTSJo1OqXGfcbuLEjaEIjdmFpA83oBuuNh23s8ZLy0NhDAUZKnHW2nqtX\\\\\\\\\\\\\\\/JECR1uyGpw3T2j5I\\\\\\\\\\\\\\\/NzpjcIqcwxmCanQMfkvVBSLr8CK\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/8i8JV3oW4I194Mi53acKadJWQk4iySYhZiD6jv1Pizc1upHOslm1nk+4r7\\\\\\\\\\\\\\\/xkkJj5xGs562G8yRCdXsN1Ntd96ukPNpYaGxJ+svSaZ52nZgA7i7IIg4AFp+4tLaulxIng2VBWgKvcTIaYUYT3l72ooN0txtdPnb\\\\\\\\\\\\\\\/j93D+kwzfJcCQ8ncwkj1jOgH3cQ1XCVIt2zihxM1jHkG8aOoBtItGVq4ouKNeQ8NCqbrJ2rq2DT8W\\\\\\\\\\\\\\\/GE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022f7KlqeEZtrOZ4xzmri72gw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002267ff72661ce33383a6d817a3823aede81dc2104b6053bb3d67aace516c24a5eb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e006923.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e006923.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006923\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006923\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006923\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}