{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tO5JTePaJlTXXBQBkKVZHmngI+AWglQ13Wav3Na0xJ\\\\\\\\\\\\\\\/ikFeid40qMuGSySXJ9bKFIuvEYZI1HJPAXAUN3V6bErqvzfj2X8BgflGEvLKjnAaQhOnmIPjUtrVoF\\\\\\\\\\\\\\\/2XS9nmDsxB1vVtTGZMg1yXBjRLioOhKtWTXGkDWA0H\\\\\\\\\\\\\\\/KX48be2tU17EUopH97e0mGM\\\\\\\\\\\\\\\/tZaNUzku+xI\\\\\\\\\\\\\\\/qPu7CDugUaWQZB5YYVKZC2EYyGx1lLbDzcVY3E9tF294\\\\\\\\\\\\\\\/scPX8xFZMkZKcXkGF0nTAjgLQsEqLsSBPDSQwhZ52hdSOxW4ewxNBwVLm275mQ0Vw8joisiffO\\\\\\\\\\\\\\\/5k8xuVYFzELLdEROhJTiWLqLzj4tiRxMeLf5M37SlbilVSUwRQTAB\\\\\\\\\\\\\\\/XfdRJZztn0Kqu7Xx1mRXWEjravSyr+enYiHRAitfIGjZ5iX72xhhCB8JG3o4LqrkDxqPa5Qe0kelDsoug+FoWwY4LSwxD5PlWf3Tg9nF9tjrsG0T+uJQ\\\\\\\\\\\\\\\/Pv0i\\\\\\\\\\\\\\\/dRydZgzBPDTX4fKB3XAdJd20+i8N3bYtUvT3OH0Oz8TA1CXUv7E\\\\\\\\\\\\\\\/k7nEt9m05XIfkPPE95eK2YVrkZhEqsyVkWEzgzCZrYPjrdqrKXMkM3xJzXWYa5S21X47P4nud1CVEjloxK71FHlKtiDym6d+LWAup\\\\\\\\\\\\\\\/AkLT8k3Hx25pv4Jv9M1YcOVrC82BzjPZGfbJav+uoo584fQ5uw9Q9TcrcQKtt4gNXM2OoJs\\\\\\\\\\\\\\\/iEoIm3KqfwaYF63hwfGG5JiO6IBiOnojGa4jAqh89\\\\\\\\\\\\\\\/moglOkrGkzhmxd\\\\\\\\\\\\\\\/8QhyDqFjYb8Psl4Q7mXEL6dwzAzKYND36q1L7G6lSN9H7lhmoqAPcKtu81yosEUVkO+CJrBLLobDX\\\\\\\\\\\\\\\/fxyFlGN4py0c6T348Gw86cnMKPQZEFoNYllkliHmDIO2OhIEqZSnBqkIFylEuebI\\\\\\\\\\\\\\\/YNKU3KX9W2Mj9V+H+MXxuYq7rA\\\\\\\\\\\\\\\/TdP1aa3CZUKsaDjlsr\\\\\\\\\\\\\\\/+mcAq8OHyxgPpdAjugvNfUG9F07BiGBQ0wAc7F12wSa\\\\\\\\\\\\\\\/nj2J8IzT5HVvbgErHvJD6wnBDEOtw+7JzewVUPlsBT8nxSTxl55fUBtahEHhE59gZD64qov6CVf\\\\\\\\\\\\\\\/Jo9Sp16tHp51CL+V1xOF63C7qXrxf3oE58TK82+YEC88ZIuMZcR769bUDK1sO0jURJjverqXmxBxWjCAveYI1ZayxRLKBkAQ0RpmxxsXzs96q3JuHuAXLbA77YS3WhbmMLGDvHohGuZoWyiIOeXNE\\\\\\\\\\\\\\\/aB9cktrmvth4EfavTT\\\\\\\\\\\\\\\/kazvhZvMYhynCF63xRYszbTl6Ytf1TLK1H4vizbpcLkZAf8i0GGziI3MBqKurO+uzacW7NDVTy02DpKcUVAdxMKi56UBUnUYajWj25PsgfVVljoE+Un9PqMPFEa3tI50FSTlILiQWyjLS1bmI1vWM5UENok+iOVhsXCFS3pVVwp6h\\\\\\\\\\\\\\\/etji23kIgEjS4d\\\\\\\\\\\\\\\/ZpT6+wVzNY75Iuc2A\\\\\\\\\\\\\\\/xVwga5kyKRX\\\\\\\\\\\\\\\/m7vtmABbCQNOqUTf59057gkL3UxJkdaKuWAVfRWt6thCNvARv+u1IwTLLTn9neui5xvnCWMPRv50U8Va6mx4RNOFqqtPU36i\\\\\\\\\\\\\\\/pf7yDZV2iqC\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/RYIgP7wBQow4YFAS5+4sxsx2YZay\\\\\\\\\\\\\\\/kBx9GDSMq19b63ca\\\\\\\\\\\\\\\/moTJNZTH236RPepRXhchvCbArfzWxQB6t0c0A8ls7sGMhm2Vx+8NW9AisBIe8nAlVaWZ96DDAIOCtF7csEXfGlEmTc0MyYEJpv0w0KKf7VR6DXhlyk0OaJFT+hDV1bRVXpmeftcm331wQjHr48gMzVfGQkVvotzuCJhTlOxG0A8UBYtEJnK7axsRXAb02xUK+ubNSftuWzvkAvleDfUswsu6K9B9tP1ocU2TTnFsSm\\\\\\\\\\\\\\\/ROkQpwFsSXD2eYhQMoeIB9a1OESRLU6Suskf5400Qograuijrxn1g\\\\\\\\\\\\\\\/qSkbhcpJz1cbBEg5Yw9VbaA0Cp8rge4R2d2FAMTtmkykoIpjr2QpkoqamFiNYYjjp61cSfiTUqi1JOYyY4vZ188sSVF1js9SxiyDMi7pqJ7KTNunOruon6qQDhqJ4zYjGN95WYvNzkZzBmt0GzvFsVvuUufxov9L5Tozkf0H8cD5+vJi5QKRJFORZfZYDdKuM7KewhB1FtqpJzVCMaUprnmD1s47NEoOq5\\\\\\\\\\\\\\\/ackdQHr5xW4rF2wOhj0rdHSaz1jLwO+ov+7HdElydia7WK3TR3Lbm1mZzqtJRCafPp0DFTBg9CZC18oBgrWzuEuLVcMUcaTMQ3rBNvM2hAJ9y6naylutBNlvV97k8llslbj8NAw7JnIEjxiwVD1TKNufX0PrmVxb8kqSsiLDXjjitbPgPrdUAuwivN+5+pUKZUQsdRR6yMgNdSu2dgSozZXl733s0FKFanl3V9\\\\\\\\\\\\\\\/7AYSzKjiY\\\\\\\\\\\\\\\/otZUhE37hES0oc5XbD35kXLemudvI+cuXeFvPkmocvPgfnd9tglNQxSG7W1IusvizSJ4eQt9eiZb5zFXBoNfciov6M0Hjm6Wb9re7pVN1WjfQDjPW0HATlZLVYUSOrUB+Ajof9i2O\\\\\\\\\\\\\\\/slqJ+A9O\\\\\\\\\\\\\\\/vTd5r4l7\\\\\\\\\\\\\\\/FtIYb2Dq1Of8GJb7qdjSafEoTq59BRNIdClmeuhjQeMNJdto7k4i0Rm4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022A1mzYhJ7AUegyEjzhkajQA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a66a5f74d1af71f34edbdcadbaaa72fae3712e8014953a3581ffd3611fdf472b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P408.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P408.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P408\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P408\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P408\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P408\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}