{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223SyG8kBCPfRazsnuTNE77RLe8UnomYwTVTaYlTr8Wyjmagtr3Au4neTm45SwZR6zEjFbHaEdPSq38ag\\\\\\\\\\\\\\\/1TnFza+61mbuPVPJFEdoHAlaTniPsg1281LGYCUW3RC0zfjKjDSuuL76esUYf2kx0EjXdOvZo8L9yRBMX92NGEyVEyKjG6r+ej9jtXv7OvxLkQ7ypRQqVRfaa3dGSovzintnp6nBRpFvEavNxN9vdidNa2H3PrMpWVcW4JIB8nDncVGKb3RCZ47L7M\\\\\\\\\\\\\\\/Bf9ZkizmqzR7F9HQE7TpbCzvGlmZlGUtQCIRq\\\\\\\\\\\\\\\/dVSwKpzVnRsLYS0oNdqIrp63KFiE6CDsz4N0cUGeh\\\\\\\\\\\\\\\/xHvnX+LUN2DfkPRwxPq4+FCQlChfXx26tJRapYamXx+DaRnW\\\\\\\\\\\\\\\/0hMXpS8imK0qTt5eBuOJnFHoECXf22PB1xaLBa3WYPs61mk6MYOdazKB7frTdWawMj27GxMdLEYvrRQbm8SweG5os7d6xYvsVqar89LUvd5dqIs3pkZ\\\\\\\\\\\\\\\/6YqgXL3y4+xx1iMlT925swztRFOu5fWN4dnTfYLNHVFRRcE4Nt7OP7\\\\\\\\\\\\\\\/P\\\\\\\\\\\\\\\/fc3k4NtYNuNxCBqM6ZgyoeF9ID0za6ybRtpamsy4kZBrOQtTbeFC4e5vHsvRtJV\\\\\\\\\\\\\\\/Do+XcsygToLCnNwcIJkJaCQ865aKBk78hnZCrEKYlweWaDPRQgtJ064x9fLsXts+89h6TnOcwlZH6Q5EpmJc5OlCTpSck4ssKBzhPBRj07BHiK9j7Bjcar1uDp+XJ3Ba4MS+xPOO+53UsIKrBjyqCNFrB7ErLe4hSAZcW8s4NhKF73qHh7sb+a+clJ0QLJLs13flxaVXDKC3y9egbH4i+7ueh9wvum094J8426BMc+jJmi63fPsRnltt0eQD+gyEXJgCwa7cd\\\\\\\\\\\\\\\/XmwxwyGb\\\\\\\\\\\\\\\/eS5jxDSy\\\\\\\\\\\\\\\/hRyGMsppBSS5dyIKswoEJOnmIIAyG2SQnteZ+Zldne1tnTLAirQvn8TYyqVsITo+SrkwYNLJRLEza5bZhUCg+lEb1aMxwPKX8yDRL0+fvEajEF07\\\\\\\\\\\\\\\/1j9q52KiNg6y33mj6\\\\\\\\\\\\\\\/29nbqSFjEQE5AcnhEDoICFd8XZUfo5l7vmAxtWeD+bFkCA3xHbO1K9pEFoIHoNTm1MHioU60DYwYd00Ewwd+k1tAcX7HtlcaY2NJV5IlZYwCU94N41MZS5TIcmMs0fOn4ZzRSCEbnCIGTRhEC09t2WAtUlBnbJPaDlZN0Q+s2rhHKUE+mmiJOGeplvTG2Tv58SVFTJku5m+fKdPeU55wFb1qQnYWFSMJdGnnutPib1pUpEVSqoCv1q+RxCH6dsroFhjbVc6l6MYv57vu780l2TFBtwGrZgKzT6HxiKLk9kbOSXyPf5Z82x0FfDaCWNijjaDyk0Wgm7LVkpnI8\\\\\\\\\\\\\\\/iXlKUNloyxb7KIsZh4DMvcRNabjsdD3HlRdm\\\\\\\\\\\\\\\/rlb0ECFvb+Kb8hYIhvF23K5\\\\\\\\\\\\\\\/bAApEHrJ+rsg8c\\\\\\\\\\\\\\\/0+I+fPHrVRzie57+y4JeFaQINXKW1vywGEB1N+Xz\\\\\\\\\\\\\\\/xm52Me\\\\\\\\\\\\\\\/8enXcAj+XscJCA\\\\\\\\\\\\\\\/lHhGeMUxd+wJWvFrBUNv1a3c6YGQd1a1a9ADNmyEvBi0G+Xkuw2HyFLC91BB2jQxiA96sfcItRtMVw14pixlh08iT9WnyUMpoE9UcVXvcyo8m\\\\\\\\\\\\\\\/Hkkbynr+y2eM0IsflSeTha3uGp+RJjCI0NU+92eJ2K92htC0Za6mKE7LNNjxVHcZ1uGSmaJe2SsQ4RYCJKV95KdkOsPInl+BwgjrU8jgvGAi\\\\\\\\\\\\\\\/2vjfCY+jCOf2N+npyL27UdiiLaZucx54B1mgVn7iA0jQI3kBf7AnBCx92VV9xpLUjJjCtJZc+rz1+xekz99MWTlFgQImcyQh5oESovvK8NkaAeBlLIVjsuS8dtKWna\\\\\\\\\\\\\\\/ZbWc1KXSNDvMBskuWHIZQUw7XKumeef9lcuzXVhsubk62efUaIdw5I90mXS7+buGdgQ8PcknecLH2Ufu0PU20nf7AeGtlt0qwnqwSbdhlyONg5vryryStUXD7d3O4Dl88fNv16SGFIoDap8IcRPmTGGPsh+XET7PdM2\\\\\\\\\\\\\\\/e0WclXS\\\\\\\\\\\\\\\/KLqH4kAtgz2yAQO9DB450NZatZDpzj6Mthbt88UkmEArn+mGtH5nBt341I7NJbDi25plGZPch+g8yoVy3n3D1hrlGGxV65fpixTmQFIsopF52W9avCwqoJ7F7xvE6YiI1VyTlLpgAuYtFgw5YaLPfTTLPGd8COn6fC18ndP66rpUHdF8sdzrp2zyy5ZGDPnNiQnJ++MlxFzNxTHxqKxJ38Htwt45z9Sk\\\\\\\\\\\\\\\/CuJtCqwWFVQPo+orCsjb0wAIJFVuw8sZ9HtLzZhS0C9VftBg3KJuvPtb2i8xnXYqFqmogO3a3WNj+AJHkzpAdqWUOehr24hBQsXqjqnfenWYavq7lBLGE3VLrlxv0Uwpv6ZaO+fgRvjRrjFAlbg5yspYiwZEknDc9ics4z\\\\\\\\\\\\\\\/ORgg2IW2BKalGiZ2cENlo+n\\\\\\\\\\\\\\\/feA\\\\\\\\\\\\\\\/PtIynvZchXJeIp9\\\\\\\\\\\\\\\/pBmZrU1HbsI7FNVOOvJ96bYL96Kir5YVkJu7q+OHZRHQzuLRiQCATX\\\\\\\\\\\\\\\/qtxIKKyPvaGdVOs4\\\\\\\\\\\\\\\/dmfUmgP5o4clI9vpbgqE87y9lY8oRuxc63kIS6z1X+8gkDLexId8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225Ct6zQaqYCD5ggEFw+bj3w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e588ed3e97f07aea91df4bc36e525f94f4210410573f1010c75c6d5846933812\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/O13.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/O13.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_3\\\/O13\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S3-O13\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S3-O13\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S3-O13\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}