{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022YYRbvIbj0gxc4kJdTw2uEnAv\\\\\\\\\\\\\\\/og27XbymaTinajL0WyHL+zjGc5933Qt0rXcqpPcYgbKDei\\\\\\\\\\\\\\\/uTq3KKznp9QiVakzXCsH7O2T4koMhyv0DUCUfhlSVAdoAIY5LiWeMmi\\\\\\\\\\\\\\\/+Cr46c5Iqp0bdYvnWhTLI0FjAnGJKyMoyWawKk22H3cWG36NW6w8carBEK8VmTgQZzC5eZLh21lvhAF+gub0wIeY9Wefw53+6T8mS0kR\\\\\\\\\\\\\\\/Ayag9ALB8WenBVrSqRSYWhUCPuyhzyfn3z4IQ+nqlUywnMpzQ6mLmdYWjQKcnFlEQWeebi8\\\\\\\\\\\\\\\/gHfEYlEws7NJZvhgPwaEJqwP5Rf9NHyW\\\\\\\\\\\\\\\/IMpuqlttbikUO3FD7Geudjeo1jrt+1NDKhsDRvKaRMkZTgmmi8CK7fUZADFquj4l18yxslsMMhWzPf2kdyXXZPwSX2idODWjXJInotncRZeOp\\\\\\\\\\\\\\\/FfIPLkpmlai5Cy1htF1i9lJezxIUi0jmLrIR9+i9PQIKRCoohxKESGhFESMxgs47tZ2MYlbBzSRUe0pqjH7xA9vYJWilWh\\\\\\\\\\\\\\\/ADmgdv+nQhQyqcGIPYIUEUw4RBUJ\\\\\\\\\\\\\\\/TOfACJp05j0Xfqwreifwgqdv096b7bgRZjaUJNO026vj5gCD+eCVX\\\\\\\\\\\\\\\/pkOj6C\\\\\\\\\\\\\\\/+TZDjn9c4soiEQWSh4\\\\\\\\\\\\\\\/uqE0JBFbT4gSxDI19FqGATIYbkqKwU8lIohJgm19qqJWRDa3N+wZ3nIJ0XK2K3FgAjH8y80oPm634cN0hjJaU+\\\\\\\\\\\\\\\/QiejoWWv4TXmVZ5K8LfT9wU93tZh4Nt1h59JXJXdbq7puwKS4MHxIp0MqIpGiQhgbnbPgFjf4KWnPy\\\\\\\\\\\\\\\/SWmI5JmgtcNO6rQ45DtlTwAnjsFYyWaXdPtzhU9I2eYKEhNxfsRMp3R0JdMb5w9Ezav3R1s4O7gVVBey3zT\\\\\\\\\\\\\\\/J+u4elR6ifDxf18xVKiWu3SBLqx59Fp873PtOjt4XUEZn2yMUKbZoSOWFDVL3zxzR3oRZM9rT6MLZ7jFlPbLuCxsH7mZHFxh4+NK0DkFEyQA\\\\\\\\\\\\\\\/oBCnsdKlKN9j2DoyBCsJFwbVZL0FMqfUmcVS4ghOkcdv7z9RLEzoaXNi\\\\\\\\\\\\\\\/ZgKn3VBIie92KlEtfaSaFgLJfpuhdIHuWy4BBOB1yzejBviShDMghqBjaf1LRsRKaXSGPT5kPdtkonAfcIxH8oah4VUFLr8JfRDfPjvjbt8ozpWyAt6eEhjEidhnBYMiSASozGWc6onTl0PFlg3i4LLfizAuCiS8t0tikrDtgObqCCCE9L8PctO3U1y9otBtz36c3UitRBaONHjXdsg\\\\\\\\\\\\\\\/1JoUBZVs\\\\\\\\\\\\\\\/WYCjmqzJvpSOENSxkeiV1hOW3iARLVLUgehD2GwD+BcuY\\\\\\\\\\\\\\\/hCzd5NSlmYVIk9GPWjaEmSHJvxhjzP6c07RlCWVKl1ZMoSLRlMim1cKOc+DZXhtc\\\\\\\\\\\\\\\/liRigyVjyIydsVYcvuNLCWsDKqdODftjULH9XVSVPTQFsYpHH3h9\\\\\\\\\\\\\\\/GbasVhKHPeib6ASwItviUHC56ZlOf41i9ddYIhAMsHiTHik5hNO0s5Mxuaq0VWjapp\\\\\\\\\\\\\\\/oXSgSVvbchcbsMlHzV8X\\\\\\\\\\\\\\\/iWkb8hG0U7AX6Dw7i8qHZYS\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/QwZ3X7iQ3ZjFr8KGXn5pAle0ZCAym0WLoHLlFtU2oE1Y64k\\\\\\\\\\\\\\\/SgVtHYa75zqtVBWyzyJVXPSY1PIwSl\\\\\\\\\\\\\\\/7kcfZIoulicCZLKXJcy3DgOIvg7hEbM6k6Wu2ufVa42MMspzGSs9rlb0DOteX8WXnotfInoaENQjcXW4WgGcGuHwqDDd7uDeUYqC66nZ3nbH9J84zr85kPfdBZzqUORyGB9mMYN5zEom44K5xpk5FDU+SwI59PNXHYXkLIqw9YzE6ypwqAQupTIK\\\\\\\\\\\\\\\/V1XWUX5GMu7BIt\\\\\\\\\\\\\\\/0lr1O9OYvupwtxAvhAUsFkhar2XAmVDW0k\\\\\\\\\\\\\\\/xylP1mtvA+\\\\\\\\\\\\\\\/ijFXuCF5+2yBenPkvlPmy\\\\\\\\\\\\\\\/eDM\\\\\\\\\\\\\\\/8wQksBCyN1w37ph5N0Qhzphc2aRThc68OkkTkzlCf\\\\\\\\\\\\\\\/7ffb+\\\\\\\\\\\\\\\/H5CvJnzbPVMabbtVs6RvTx5K8\\\\\\\\\\\\\\\/DiOUcYsuEXAiLB1kIlaMXpJRmUPCMFYrixC+lqSl1JyX4Qzpq4bA+UsHxGKyw8PtkMa\\\\\\\\\\\\\\\/AYVwAaycKZHqGtWjZpAUr4Sw+dmZLRFaxPdMXrubEMFDQryzAktKp+CteIdvIn+K1a6NFiDp21\\\\\\\\\\\\\\\/LX7JYCD2kVMku\\\\\\\\\\\\\\\/v5IyFCOaA5VyF8d6G1S3bfIqkg8yu6sr1ZqoGk9u4YUkMvDK41JQVJhfa82YPrPeJCIkXt1pss\\\\\\\\\\\\\\\/Rg7RFz\\\\\\\\\\\\\\\/3Ja3c3wgkvS2\\\\\\\\\\\\\\\/YjvDNSBKspn0B6bXQwbaFJnwVyboAkZOQxYk8lKmmbZLxzqo9tzr43V1A7uXRsTRKsobWdzbRhjL0\\\\\\\\\\\\\\\/BskLYzVz6Bp637lK6yFwR4PdkFSELJefXlKcaKEZhWaNz0T+4\\\\\\\\\\\\\\\/XkoOw+rOQCrYnoAWcmGRSvnYJr17drhy\\\\\\\\\\\\\\\/EN2oWYZXYRvkz6\\\\\\\\\\\\\\\/0aoA7GRPIG+Ggze4D91QrH4k65HW5lFICUKOWJoUQYXNvtNw8JA62x1W\\\\\\\\\\\\\\\/StoMf4N1eanZD04jV7xjD3jaiwCAbdM2dkgzDCoqNIQ3+rVn11JlipIROwcAqO2CbeP+fP3D+AlSFSJtXMfVpwD\\\\\\\\\\\\\\\/onJ\\\\\\\\\\\\\\\/bs0fYeO0qwowGNNgMS7W3QLnojRiSxQ2zQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Urhcze8c7IitG2hy9YBtTw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222c0182dea9a4040d286585b9d81722a4640471d696b1f3ad43ebc5a793a2c2a3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/O6.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/2\\\/Suppl_3\\\/O6.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;2\\\/Suppl_3\\\/O6\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-2-S3-O6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-2-S3-O6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-2-S3-O6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}