{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022C4wsfsJxj37RTX4s5+15mfoXXa6zD86+egijwSL0syH+UJv3dOUaz1j1l7guYjvzKDVq6V9Gt0wviNqboc0OHIVfKevimJhCZhRtXWoxAXaP+IwFSLLjcOJDmNNAn3JMqwRUbJIjnn2KDWeshGk0NMdFcGyQ3VNYSlC8dXESIa5N+9KOi5Z0rc\\\\\\\\\\\\\\\/6sj0FBZ1FKdQJkrL7Eig\\\\\\\\\\\\\\\/bFJkIDD8AFyaNe1UtnFwJTPKvlNjDSy2mvg6kUwhMnL8mteIsAirvDvttnzX5EK00TfIuLlDP5v+bKvDJ3giZzm5h44KFVzyMiaSfx7JmwVpyYWu8LPWzP\\\\\\\\\\\\\\\/4MuLKPYL3Q1D4JhwmNu0ra2kTUS1yjehS6cFS150BAhZji+JQkcpSbc5kFg+HAFtcddYfurm0nyZV\\\\\\\\\\\\\\\/jXLyIJXUZsu0r\\\\\\\\\\\\\\\/MMloyYnjTxtxnSi89i8kayRH9JpKdYfmU4Lw62SQda2cJfZNKctvPSNHmEB4yQXx\\\\\\\\\\\\\\\/ONTMXvkId+F+lDI4tbB2mqlE013eu4uOggL074sC7S8MOcZg3EU+EgTpVAtbLAGttgVojpsNng2aJD\\\\\\\\\\\\\\\/MBZQbGJJO2F3Fpc4JD7RfXAT+omJMP8MHC2dwdB3n5jB6iXGRvhoj\\\\\\\\\\\\\\\/TkUYRN2GXSfKi310DsEIltlDEOnV6LPT\\\\\\\\\\\\\\\/cg\\\\\\\\\\\\\\\/6G1LNTjrQkZxES40\\\\\\\\\\\\\\\/YDEUka1S6TXX+N6M6hssr0ecL+BDasdNgb3lKBhMJO614H72K29ReGaZXdGfTEDBNRYfznVNGUY70SbvtHGDGxIDTyKxmkxBiKrLJDu1cbiRmPdDs3cQ\\\\\\\\\\\\\\\/sWYwXs1iugYm53Cn2V0bP8fzlZ\\\\\\\\\\\\\\\/u4ixuPVDi4uJ7vAMS4Js57mXN0vRGHfayCwXiYel2LbMhMY7nadfrWNHbwKno5puu8mDphRkMMH6+KuN4myKBk2WF5vTwALkG\\\\\\\\\\\\\\\/Hl15+mkga41w9qDcdtSh+Qh92oKrP6q5zHzGON3CG7hePYRwaTgykr6TbdGUnxhbYng90cogFclU2awghzrY8NgNG8Y0p48rNwTw4LSnYPW7bQzujFD\\\\\\\\\\\\\\\/pJN5b5uBkIXtaRQqsicfjutboIRjbNzy42tWMDh0C\\\\\\\\\\\\\\\/dZ7usUOMxVeI+zlFSOwoSz9aCLXAS3lrr77TDLj1OgpA63JGEC1fYOzjUvA7VI0zGKfLhrSuAf9SDunEu9In2SN4p3xFmSWMOlmip2Xa9AWYD6Xx+7gLBREoXOwNM5JgSyFaIlXdsIGf9Las8GyM4C1Sx1nrSdCMZQbekEU3Z4ZE5g0Pdn4hDajg1jju62iPzyDVvIEloED6FOSb4qzqbZ7Q7yzFkg36J6cCyYhk89\\\\\\\\\\\\\\\/2yNEzEhGQW8dgqOSXyfqrOTJI+eiAd8WumSUNXGDB9RXPLnh\\\\\\\\\\\\\\\/7vSOmlFa7l2GCr+N7mlwFlUAvssN\\\\\\\\\\\\\\\/CrL8JTJFEXj1wz8DqketSkXz5BEUNAD+ys9HYJQuCGjoC235B3ji0h+jsAvXItRIoxmhAgsFK5JtCMPnq84ZP3HODBEaq+zVMbLNkE33iTjB24KWXl1invBBM5Yl8dOW+pa4uaeFbkzOd95h12hr05m4+E0eZ7lhUG7rO\\\\\\\\\\\\\\\/oX4i8RQOZxWnvfflmxHkU6ao+1JTMMjZ\\\\\\\\\\\\\\\/a+idUl5tTn1WZnmZF4DhuLIq6rMFowCkxMq4pi6ByEpVJ6X\\\\\\\\\\\\\\\/kueTP\\\\\\\\\\\\\\\/yKxFol+i2UW+IXkSh03419ZNNCqyefx36MofHRuJQhkC3U2nJcYJ0jTepmqdTdfKFl8z9SApWUllCei9eDXQn\\\\\\\\\\\\\\\/reLdGT2LOUJbZeU9ze3TVsBqZ5xn7bmW\\\\\\\\\\\\\\\/amfC9car3jYJjmKzTDnDq6G+ptI3zqrgdF3TuXhgeDJc8Cd0TNmM2PSJOTDZJNIIxkTSLlm5eEjHL1oDpTzI0JRkVNnqhTWEV8+WU9uF38ILYZkLMRcaF+lLOfkboIDpBCLtoWJIESbN4l3SvNQY7nio8mwXXWAVMBaq4YsQIoXbxemgBFK5clS6NpVVHwDWk1gFfPPJy5uyBURmzVX1fibXE1SGwnEz4NZJ+CLYxheDDcNiDlNRlDIe26gug8Ii3RV9I1+80Zxfw\\\\\\\\\\\\\\\/dz0DK+I3iV3kA77HXrLGYpdeErK8s2btuqUQ++yxC8yP+jZ3Vi+sjKGBD7q8xXcXTGEqHaW42HkLixa1MsfF9W2d\\\\\\\\\\\\\\\/W0mAkRxxt9YN\\\\\\\\\\\\\\\/+MkGv2b9hvkFTOnomUNrD65KuiKS3JIr\\\\\\\\\\\\\\\/JyVNPyfDgPDMOKTkcFaVCIApRVjHgo21JwipE3dMZYtOwAogHcaj8rX5QmiXMHi5tivLREoFoQxS35EIrXGkgTiWXYBVp+5xAmPf6vQLWOptm+FriZHTQa5eR7gGA7E3H8r15o0n+s6aZeDxSU+1JTMrIwd+LVvtxhc8eU9TTOMKUoobUlX\\\\\\\\\\\\\\\/G+\\\\\\\\\\\\\\\/ebgABb191sen0ky6XCNOBaVjf0s6Eas2\\\\\\\\\\\\\\\/Lq9kgNsvGNfp1wYRY7MBqA8fRriR8nMbpQejZn7Qg+Darg3XoB6oeP3NclP1hnBqYFSZ0LC\\\\\\\\\\\\\\\/Oy4KteRD9GylGkUAM0hSnRY3lTovtBq59GT5fuI1eQ5iTuhBe2uzByotM8YTUJdiutaM2GUoURAdkixeOcLriMhO+OucPc7N20xNaOY9Rk5yUlNtjtUAXej80JEWTsPRoiIfejCIvNWSMDUWqc4KeBHhBehdIFc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002230UlCrsq42HtOgbP42qWnw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b453756eef15845dfd00d5c6238ce5b8b95549326b6a66ee0e58b94d40db8c89\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/541.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/Suppl_1\\\/541.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0482\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-SITC2023.0482\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-SITC2023.0482\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}