{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LJwxfcqBhj2ZJ1QnC0V0xtSsOI0axUC2LpazhpuXJLYd2IH3yHAB+WiqeJ4z16SevpURGY0ahYdNTqVsCbj2vpJsme2aLtIOO9faxdXiZgCAB\\\\\\\\\\\\\\\/4dpGp6d3Hr7POs9W2LxS3gi1t+LuiHWlhxcdo2+q38k6Z5EKb9EGOCYQN9AyLRuRO3s30jSuUqws9DSzCwrjTdVeZg7XJ5lhUwNbCpzlrJXdc8FuQ8HUI4Ly0apTVtdB1n7B95P5863AkV1aGsYsBUQbughNpzEMNe7hMiOfOhsgWBi996kGSSRwGQ\\\\\\\\\\\\\\\/FL8Ep3J0JNvoZXGeXCk65H8W\\\\\\\\\\\\\\\/hNB\\\\\\\\\\\\\\\/k0MOhWRr9QsL5MEaKlsNCMmI1VVqkjtBeDRNUrpw9zDohnxKcdOQdIa2CdpgDe\\\\\\\\\\\\\\\/TmXSiFceW7c1V3cFZg1G\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/t2j7MIdlat0IbhMjwmjxhxuzpwj54wbPgJGURnkwqs6Mklnrq60Dur2al1+SzRBFtk\\\\\\\\\\\\\\\/B8Bzdv3Fpl19S9AuyIX1wK9dHuMBTtyC0D7akHzV0OU3YPB9+sB3O7Wn4h7baOVieZPGfoP+vBOIkN\\\\\\\\\\\\\\\/72Tybm4rU08HZys8m+sLROb7FOXXv506VmfsKebzbaaIlfYvbnMu8CEnFfSwxsLZVg0FBNIDRhexidh9a532lyxfIAve2VV9ICOJV4p+0O9pyBSr8kHjN19jUL2e+6U7hMlMreyiTUveBJqHK+fnRgrJxstzSQWPSoLmQ97auINWs77DvzlPcHQ6leZWWK7Pj54\\\\\\\\\\\\\\\/N7CzC5XYjuhHvc1zMktqv0b8Tbb3FqMPJT7P8Sl3iXViCOUU7zKNL5Rg1\\\\\\\\\\\\\\\/CFMDX9enN4YSwGEWSA1p4dGiTUamZBW46cN2cJ8oAvWVIOmFpqnB1UK+no44uaDPdkiy4iD5spxuavP6gj\\\\\\\\\\\\\\\/18vFkO9mbGfze2+44O06Rwg0JfrQeSw7PhEhKHKeK6Tyj51cOExQdxeyd6SJa0046ZT2pONh7WDuMU+f\\\\\\\\\\\\\\\/60oAHk1oJyaYcX1EEBy+CLIZr9LJHyGu7ba2zsawa8rp9h6xDijJ4x5oDesKD637arbt35eI+CgSnZJcn9avALygsjwyUJhJpJzbMbH80jbh6DsHj8AcJiVXjvnxmUKFWxN8BFB+rqEzbD4d20I5QGoDfIjwlOhbY8r+QmY12rG54rORj7dPcYTbM69WR8s1Dcff58eGm6Pdb2QDKkOmBxaiv2G6UocOf3tT5BPkl4N+2K2u3+OcMh0DmsoC8KBkUNTS9joGzUMf1iJqjrCafCQhnSPCZxzH3OeecZMgjfjDgEMYH5+T61Pjp6PsRTqGrh\\\\\\\\\\\\\\\/WH8CYcbT7wMu+IV1B79TfeQdO9sBafWKktojYO4GW+IaqkMFO8kJn\\\\\\\\\\\\\\\/O5WEGx9iMqlGFI664JJQ2rjltygXsbCkvheRACiSYQWTAQ2KguC4YaV+JDdP0f6P3QxDegjCpk8ohxYgHaCgIGRMWSLFDbgYgp6KrHGpqO2V6Ipt3TrPqg5CUGPVFU8K5SEcLyG2dHU8lHE1Akpc8G7DxKCkrSYv0GIAGGkf8S+t0QG0WriJHu5v5pOG1uI5aRTYoyoQWHsoTu8r7go6A8+89kowBy\\\\\\\\\\\\\\\/fxr1RsgtfFhpLCmLUuqbGxFppzE3zB5Oy8vq1ttCmCGnGSNqFPuPCgXVkYFK1wYJFsQEK1B5G8pv\\\\\\\\\\\\\\\/vQ0l9iuszy4mx+xduY+DpiNEPgiDAPJGQtD9NYA\\\\\\\\\\\\\\\/B9+2CS9bSdmsIh\\\\\\\\\\\\\\\/Uj15v\\\\\\\\\\\\\\\/82KmnfZM63hXQiYyKrT1DETyLChKwfsZu3adR4MH9bW7b8xCKKHMOiRDXYMf4QftccJcR7N35\\\\\\\\\\\\\\\/HAfK8iBH7OD\\\\\\\\\\\\\\\/UUiK4jwfI+hKAfLlt4a1Vbqf8k9XQusvIeJIooD+F0PWr1rdQ2UjI7+VG8zIGW\\\\\\\\\\\\\\\/QzyvYiWXZ+SHgPHhtccg7v1sAepPiApU489AX0qe5TPL0SQn+EwvXCL2Jr6Tho1gUT7boHWe8cLAyCxxhQyburQtE5nLu\\\\\\\\\\\\\\\/xtFKXTpw9cMvRFh8et8QRmlVcNs3rhitwMd1gOG6vGdJB7NxCNQLZU8tiXQgXVON+5+Hk1sojS0OiaT5\\\\\\\\\\\\\\\/mkKXioTNO14CnsNQ4CuFy7+iCpmM0oPj1eci3CpxiB3QNzDs5wCbWKwA8uAgbrDbeRlLtMYatXu\\\\\\\\\\\\\\\/tvnjejMcJeeYGMSw8Ej3nLJU62MwK6+dGcVP\\\\\\\\\\\\\\\/Su+bUIUAJ7f46+1blxOF6gugsZjX03zxJr9P49ALT7u\\\\\\\\\\\\\\\/MCB+JwIqA3KvW7BUbF8OFv9RLRdUHmwW3nKOKHV1F3HoAjppsuCA1QqMvK6bxzBnKKXfWyIVMKZrBD4V\\\\\\\\\\\\\\\/6HAdszajDypXzCyIq0lN2EwvVE\\\\\\\\\\\\\\\/QvI2vKhkNr4tzKWhEu6hH1YeFZSg87qYk\\\\\\\\\\\\\\\/+PAGISRZcrbANF2qObjQ2TWD0sSOeaUYZvzQpa\\\\\\\\\\\\\\\/VWEui\\\\\\\\\\\\\\\/xsTCR0dGz3rc4PEaf7RtZRBOKCAtM67wTqmGT+nhyNHHgUadCjMR41d7IwuRjAOKjMw13pa8HcIyO+rROSd+vtumSFCXjneWorFA+0XEAxcZF92\\\\\\\\\\\\\\\/e\\\\\\\\\\\\\\\/yHXlg\\\\\\\\\\\\\\\/0pk2+2vaaz3dWyKr2Xfnp61iFQPwkh3yv8YtRPQOw\\\\\\\\\\\\\\\/Y5pvonidSsQDA+V3sxy6mP3Y1XUHfbJVh3ODFJCU1hVGZjcYtODJP5XFj0AM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GnRvECqBztxtn3Or2PvsMA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002220ef5e129648a4664abce4cad4f8ef04cdc807a88eeccc6443776b6faca2077e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P92.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P92.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P92\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P92\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P92\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P92\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}