{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223HnJ2oO9pii2Nk9PeUnKnNNRkIfccAMLf8wO5hXRIOfWDTn7hmCzV6mX1IBCz\\\\\\\\\\\\\\\/ObSDBUwfwDohasmrNLsLHSWXzimx37fLIJftEzgkAj\\\\\\\\\\\\\\\/Y4BS\\\\\\\\\\\\\\\/2adajX4g0wrmEdUERcdpWhhXZ0L9\\\\\\\\\\\\\\\/GwQN0s\\\\\\\\\\\\\\\/8BwW2kh4DBSycNI8\\\\\\\\\\\\\\\/34aTpIe8a7+9iY\\\\\\\\\\\\\\\/IBsz5nplWslNvZAVcX4peDUkraVVtJx6uJ9LHeaf5Ig1rYlC29rcswjR8yssPqwV+I0aBAd8ACsoDSxGyCN\\\\\\\\\\\\\\\/Pr3qKgA8ieLJAI5GMFzP+kE5jRKr51aYbV66jypLKMJpLgtzt29kzevVI50D0VZ4qSrX8rBn4g5gHhbWxq3mj9J+cKy6ACaT+TgDR4sgmrbb8X07iCj+yOHZIa6HClcA0uLh+RFEzTyz\\\\\\\\\\\\\\\/4nJZriucVFs7wY0lZfwPtnGOJE6ebayGLiRN15Mw1Xt0RIYTkW37wL8PwrA++htDry3yfb86DqfuziEotoF7glRXSiqo267DKj0qVmrNSY3gEFUJhOPhxLlLOgUOHO0qelf47ou3tL1JVFfeGZnN398UMnLurX0l291XeGHBxSXhuqphTFGwsRqJf+XqpVrmia39pLLiUgrW3Il6fPe6wJIp\\\\\\\\\\\\\\\/aGUA7mr2XrlaOmVMSvurlSlRb4GxxE2lMI9Dka4JBkoXIhyMMlSRkf7lbAgPhW0BlQGtBM+ic4OSTutyaQAboDJibtlSHHBWjMMEt3JK3gfIL8T+15zU4soelE2NflpTldzqFeaB8LTtwiKOYHTVFgD\\\\\\\\\\\\\\\/zLqG7jiGchXwXRlngZckkjt5S2kMcJY63scg+LDgxXdlpBZLfSi2XemhH7+TNb2dv4i0j5qokTxowjQZfiyDfrW9eIQIReDYlFhoI62cOhYc9JjaO4nscTJyeRQ+AqWEbmDv9yK+1UE1oLTYDlp58vcosYaqOBFHtwitBxMfrLC\\\\\\\\\\\\\\\/Og9my2gR8mPeM90iWN3fj1JhpZqB4rS\\\\\\\\\\\\\\\/Y6Xvyg1JuSjXkTagQ+hrEBI++VU+WEtjAa1tfbIM9PdgJaIaKg0HdFDXf8VYk0TDi3T3BMI874wW0XE4wEwivYO4VfS0MrgIn10QUpQhBPC3u\\\\\\\\\\\\\\\/ZS8Wo3dQQDiJDbma2tnh6KApr7lpil+shzYz5y9XBgXZ7znFQ7agRW\\\\\\\\\\\\\\\/08kuoRy7BdYg8Kuo7eTX6BYKgVt6Er2qe2Se\\\\\\\\\\\\\\\/kjFNA6mJCn9yJA+cLCJqM4otP9lGqh+2vL9oIwP31mLpK0QJpdC9GxZiLDkN896qKbq9t7BC2REnDNDfiTTNWv\\\\\\\\\\\\\\\/npc0mBLNX9Xkhv1nMysE\\\\\\\\\\\\\\\/UfsGt2dJOdA5ODz8bUrgoldPi+QTUAHAeSimJTJLxTJZvf9JL6iDyIUeAffRqEju+blUOeana7QJP\\\\\\\\\\\\\\\/GRVhptsJNHulkmWLm1veb0t\\\\\\\\\\\\\\\/Tqvb7Oz92JvjWZgk+tDrDDzHNYjKhx+JUjuSmANKc8yHdSPa0aa7M4QbmP1bI\\\\\\\\\\\\\\\/z8NjwKuAza2aJFD+WAoA9pF5n4br5SFPJu8WUMX5yJ5EUKQayNXs6YEBM1rTXf2C4I4Tb6K4b3H7OvNSNIVfWH9RTNuYRqhZRPlHSs6b7DGcvSOAZC0u\\\\\\\\\\\\\\\/nPSZxyjIvpKogaCUTtg2Wf0x3cZt8NJRzDN6N2IChW20YAYrrYUJSk7Vs4\\\\\\\\\\\\\\\/6ddgSgj04daIGNMaBclBxZk\\\\\\\\\\\\\\\/6McGOoyC6a0PoIXI7LyY8TbiW99SYMywvB9+CzgdTPhyXiluuQsRa+QsjAEZcWlS1phvYPIIgDC5MW6jgWJ4MQVNzFRFcE+piHTVpL4d8CZ\\\\\\\\\\\\\\\/T2RTXefMDq7mWfOiGwr3FnKnPU7Jqwz0C35hgn0JlXNQQPrqDj94AXXlAK05pacPMt0qdQvXXXseZ7cWLT8OJo0Di10\\\\\\\\\\\\\\\/UBz8zjxqWPxeqPHUjwVO8lvNRqOmJdAjcKftemkSzthQfzpSI1tL\\\\\\\\\\\\\\\/RWszf\\\\\\\\\\\\\\\/WVeof4szt4on+BU3dbQ9UFGMpmW8b99BrNVNiCwKt60b2DdORR62dZ5b2RJaWBPfnCOjLOXF5gpuvHAGYay39ifo97Dz\\\\\\\\\\\\\\\/tsUfNb7qETSuDbMXwAXbtupnWDdmyQYdSd6dzL+jnhdcUpS69fPPO7tH6t3faezk\\\\\\\\\\\\\\\/7bjEay9r4efwMzX8JlETIfoSGx4kRtCKzmlRMZfSlcSIDkBPKevCnTTDqPXGYcnyNQ3HGC1fa0x6IERP2sGNhJFhotzpVH\\\\\\\\\\\\\\\/tbCw82IJrLDQNrF4PW5nQAMRMFvzPP9+zAmCmkUeLuIR6dEtW237QPIMS77Oc7C5cpN4SSOT8RDo6oZLTXx3juKGJYKOFwYUtWF35XS2MDjJ1IYbuZXi9DNeAUUEC0VGczCGmX+pbm8ztJDdm4PJaukhcfOBwhzXKqnisC\\\\\\\\\\\\\\\/A17r9llgUYxjesGczkKervsmWz4AEU\\\\\\\\\\\\\\\/REpQZWhBJyfzclYQymEBekD5zy8tR\\\\\\\\\\\\\\\/a8jatVvATvDW1iOvxH2L2sK87cx+SxSDCPIFDRHL3FmxUSTL2qAFSkFuaXfF\\\\\\\\\\\\\\\/cjmDwggG14WGt70h2TA0E6OIkcfli0OPPWJFq\\\\\\\\\\\\\\\/1ZHkh2P1Est2y6t8xiJKU+3icyNCzYalRi2Ias5ueanFUa\\\\\\\\\\\\\\\/VNbCJM62tpusBsh9fkgOI+Fc7jkG86+Uzl80SQXdCFBf5HtMp\\\\\\\\\\\\\\\/pJz0IRbm5upPqaPpU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022C5+nxfFZLDwTqjKN3BuifA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022049329815c139dbf8287390880ee41d672769c7a20acd6b9f365db06addad816\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P313.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P313.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P313\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P313\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P313\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P313\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}