{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sN3aAiGGT9SvZnpm9imYI3gfOZoxThMxVnHybtDVQcDMQvKEIa7FriCSbjB659S1pxWXeYlAcY4zbsycbyjBQH9NZmWv3y6jWW\\\\\\\\\\\\\\\/Xlb008Qo81KbLcFnR0\\\\\\\\\\\\\\\/rNKcjo8Q+x\\\\\\\\\\\\\\\/Hzb58vKNTHmV8lwCTobXn55pWV9YMpMvacFmIXiPTHXrL93pHjadIb\\\\\\\\\\\\\\\/4fXrB+jWvVt6dpMzA6EQ51LwvoHxn+JPsOd6UEM3GbYABFrzx2L6itMA5iwN1wSw+H2aT2nYcCEriffyNpDYI+ster\\\\\\\\\\\\\\\/efrlR\\\\\\\\\\\\\\\/VeBUznjWGwwq9MtXl5\\\\\\\\\\\\\\\/COy0DwpP+l1y83r2eiVhHQN9OkrcLurEUiX9CzRpSm9RN+uHl7CKBdq2DRuW5qsbJrz7X9TfRpuSK\\\\\\\\\\\\\\\/8yBsfFqwfoBoh+BZjbvJzcfnED3eO2QGIaG8d\\\\\\\\\\\\\\\/ly0UtavTIDbyOnMC1xpA79RdcMb90NIywc4GctAMHVl1O+xJVXAQHMpSQnOXxpclkdFSRPJhthO6Sj+rQT8C4b0C2N3KTWI8EOk82eLYQeCtROBJ9vskedj4AX6cD9wBD0+3v56hfi5fHebLeomRUMONM23masHA8ZL3eZk\\\\\\\\\\\\\\\/2BaHC9B3syYYrR6etF8guesLSP1Mr5oEVSImYt9Zn8W72xTf3smnaoLUz9umclkA90sfxCeOLnDEo5tJWD9Zr4Fj7m5PbTIi9bg3c0j9BsSOMc+VC6Ao8vxCS8L0SQIWqKdc7rAVyQmXwQBAhik1pewvY9x8CvDEUTdCLS5dpIGjyRoTf9zHF3zHhH+da22pWsMBd5f\\\\\\\\\\\\\\\/F9gUq2E\\\\\\\\\\\\\\\/4iHnb6ALGMgqFuZHMrUW4yBss5fSjXrx3YNnyy7BPPNP1cT9dqMiM7ysV5cW+7+GYWir8gzJrGamdMpW89RRlIQrQMPYbEPTX3RsFpovFf+NpbRIF4qDCEiUx48\\\\\\\\\\\\\\\/ihlCivPggLd9Mq8FCAkDW+Kf3v0Zu+MjNJS4HYiBvsnEKQPTHn2dDZTDPg2q3GYBQ6WD1zQ61TwNKav+Qko9ZmgiayBr2jyJAtNNbJQG44TpPEtOZWzET0LIL0H0gErWBJc9R5abeVBe0Z8pSNqWW3UjLOT2dezpr7UdYyn9fsFKQFBbaC+fo1CQbMzvrmYfCGqSpZcQ32iMwFZG+1E2V+MVSQe5De35fh4\\\\\\\\\\\\\\\/0aXTC2zWVTAnvDmUbus31UvpBT6T7CHimdf1v40omuUuDg4Nqb3Q\\\\\\\\\\\\\\\/OiABBLKTaGLVt4NxVRctP0i87mNg+zitwU\\\\\\\\\\\\\\\/koUxts4ozWddPfahMagxktOcGGOrf77FWX+prK4JmwoK9Vm2WjFjVyoZjzJKS+JL1GxxIoeBXBtEIYGT2el\\\\\\\\\\\\\\\/0RhHfo2AxgziS2V\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/z+tgd4Lj7mLzSiOKabrDQ+XkZQgD1QmCVt0xvHe7hCUFdsNyU7RRjCfToqTfxEDhiyh1aRtViqfZETvso\\\\\\\\\\\\\\\/aqtLdD1rFqfUvxEkdT41gA9CCw\\\\\\\\\\\\\\\/pX+VTxzccOhIkwaOy8TtbceAhkYkt5p8gLwc8sJTsZBWFx9ek1qKCkvDGq83UC4nXqoKLvDlgtmenUT6zX8dI1uYXr3zUVZDcUw1LdQdL4pC+zSelnOxhUAJY5QN8d9OMv+yOnKk1VU1bAfBdTfuCy1J2Qr4eLRbkZ+SCt72tOLoQBKKwYxePQoyuiho0P0PorSNfX21gZsSPk1ak9GIjItUCNW5prY4t4tMEvTCAfpplbJ0UuVQLzwg5iH5c1Zeeh0eJMdMI\\\\\\\\\\\\\\\/Z7YVJoF0\\\\\\\\\\\\\\\/ry2wUZRMlQXKwv9BPCq+J6le\\\\\\\\\\\\\\\/oPKdh5diKJllp+NtBRkpeLu40LY\\\\\\\\\\\\\\\/Ifds1ntuthAAqFrDi8L1Lm+4nZtr40h2Oaa9P3fAiQ9C6ZAB2yge+Ok\\\\\\\\\\\\\\\/wZsxZt1L4jS023s9fZrLuR\\\\\\\\\\\\\\\/66dftTUOW1NbI2Xw4LpWPIYKYsOickZrCiuJWn4RUqzy8T6mGUE9lbEK11j\\\\\\\\\\\\\\\/4NFs5bJAz24cn7Dnyrh8CLsT+lh+7BcAi7TQEes3CbOMKomokDBLmTGf+LCqJTYhcJV4LwA00euzmdfkGjI9np1nHDTc0tyh\\\\\\\\\\\\\\\/3NTRGeKPkmzl\\\\\\\\\\\\\\\/WYmbglX8BOuyV3DQ+C6Pw+kFupLIDLqjCvq\\\\\\\\\\\\\\\/PuURiPyisZgOPzcqhCkCZ6Ul243\\\\\\\\\\\\\\\/UNx7JbVy9HQ+qkyg6xL+YTL7VDsWsyj\\\\\\\\\\\\\\\/u4e\\\\\\\\\\\\\\\/VHM958aiteICM3phACC5QLKyu5Vsx81g3UMONd4Id+n\\\\\\\\\\\\\\\/iSIbcuXPeCfbiOGxOzM1q6lGNOgPhJZ1Zev7BNJFyEeYQ3Mfz6qJ2kuUQnrlk35RQ10auXyeD5U23jOosO7SFDeNSgASPDD8coDzUaUahDxgKyyx\\\\\\\\\\\\\\\/DsKw78LDLcCDeDbGrQvJbM60ogIKS3qnN6oce9IbM\\\\\\\\\\\\\\\/+dAD6dSlslyBdbEY4qbkBXTwaDkDovKcQlek7kpMUrvpDmIt7YJ7EMACFeijRxgMm+FIrE1A3LyflivMSiPD4\\\\\\\\\\\\\\\/B4GEDzu83BVHpNhqiSMF1P\\\\\\\\\\\\\\\/JIBTafyGwZtiUj3HPSd0iVHh4L3cPjkZICN40bFdw\\\\\\\\\\\\\\\/RQfZNr6lEzchPHnxsH4y6fZuEaHktBYyuM+wDWKViqH+u68jYHdiIshkm1D8EEugNOXbwy6tcoXpxPnbG\\\\\\\\\\\\\\\/5X7SCdt4PMQ8YK7zZqW5Igy5gAi0+jLzAPdyR4N4jnDet9yOpGo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kF\\\\\\\\\\\\\\\/1RZvo\\\\\\\\\\\\\\\/RW5VnBso6IUTQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f7b701672cdedade042d1cf41036ea83a2158feef684e51adaa777829491fccd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P89.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P89.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P89\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P89\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P89\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P89\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}