{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022u+Q5McVeYd768MBgncMfnX4gb\\\\\\\\\\\\\\\/Kf4Eae1Rbw+qmGZw1Fbp4WlSi5ajcl0heIMsJRHPHjozj\\\\\\\\\\\\\\\/JzPeqTT+YD\\\\\\\\\\\\\\\/0PtNCg\\\\\\\\\\\\\\\/5bIDmThx8phr2u6XOpVecTNlnA7o8A9ir\\\\\\\\\\\\\\\/wIb4nwFfPiiCm4e63Ba0UCbGwwwkP1JdPgBNhvxed4SjEN1Bs1ndt1Ivp8\\\\\\\\\\\\\\\/8SHkYEsN4CZsfj0g9MUCfiDHD952LJArFpfBmDoAb265jJuFoKDcflxAz5913VFcPgY7dpc+MvSaSSML6edItqi1oDfYMy0zlHIAkfY4cf56qaa3cxWZD2AOQaQhjizo41yf4t8iUa4YVb56D9Y9Msl9GThTUgB1vaXVxTmxf9ehRXgJHisYBUYFa9Fjewhoo7\\\\\\\\\\\\\\\/stDgx95jWRib9ZVWece0AaUNdjzNTBmbORjK3qoyvSTmt\\\\\\\\\\\\\\\/7FM0L8JbQ8PySKFq5vs04grwQpHZcmmpUo3FU0Sx4fUVwpc532GShaL9UrMSX7ccc1yAyrXsyuVap9gnAObAapjOvvhdCIPmTlnf2bgL2q0wMm+DNszxl1MTC6O7H0qd0gblCLnRMnKXn4D\\\\\\\\\\\\\\\/vxs4nJ3ngcnk0fOSY7YXC3bBTVGqKMfm72TAu\\\\\\\\\\\\\\\/D+8gJE7VISNQbSROKUvfohGzRoYbUMx0YD2N3o+ZqLm7+XOmuRx0OUU0zzp\\\\\\\\\\\\\\\/DaX4CAoQMJ9z3tmDLqJaP\\\\\\\\\\\\\\\/JwQNILZPcPacDN+nwHJxJXOUVyZpXM4LtIwGUHI3STpk49MhDOZWpfHWbMIaMxE1UOIC7Sk5\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/GzptGm0mKDZtPBP5AF3x+xBHshvcQHdhZuzzu1XHOSuGwmBhXbKrCugbrNaOs2qGdYwnIbWMCFI71KTimgNVC5l5rzUbDNvFMGtS8\\\\\\\\\\\\\\\/lro5frT\\\\\\\\\\\\\\\/NcnigyiisvVy9WqicTjcozGDUZExRjnIglUMh\\\\\\\\\\\\\\\/sBw1ImdZGdt\\\\\\\\\\\\\\\/GiZNapkoJFHW75vLpQTS8KPTfLc0IRl1fMFH5EmTvOiqTXSjYT+xEcuNFIPKH+ssD0yDafm4m5754wy\\\\\\\\\\\\\\\/BYMLxkN4GppJ8Juyip+ylAAKDbfXl21rukpWsBqiADU4mDyq2qIdqNzeu2baO5kq6ipgmT7kmHw0Jhfa14FMYQ9PdpjylbUS3rf2T2xSbtbsR5lO+T4CTbqIBn0CSlU\\\\\\\\\\\\\\\/cJ8E1B6hcWjLbVQGrvD08Z7aimoEyRhj+kgqNYM8C\\\\\\\\\\\\\\\/LGJzoBZatQJ5fFEgwJ\\\\\\\\\\\\\\\/+CxhF0LQll4Es\\\\\\\\\\\\\\\/JuyPWcvfsFi5AuHguQIscLK72hiV2EOIhVXs+LfCwIDl+edAcrj7vpueLFcJmtqFDWKePZXCLw5iCzxBbKkHmbEQQ3e5e1gta+nBUA4MNtLFmgPB5A2px7USyS8o+0YNu+RRJ9HUUjhosfAIvCtkSfUnPwcfDxQ0Ap8BBC2TX6y4ngj5tcTNjcK1ZBWWKYCM13M+YCE0xJ7MFBYQXRxQJFwzhyEOrPhw24bvO8oucIqrblVWhcROuKV\\\\\\\\\\\\\\\/XNUGLSjj4pAQpvBFkwk+YzHSR6cq4wPmO7j26qR8klA7bokjNCwvrbXGWfR+vRtkk6MINAJmq8SYUMDRO\\\\\\\\\\\\\\\/PvZ\\\\\\\\\\\\\\\/5pWF2+psSwWqoC4anySjmjffNJaZYh8dM3x\\\\\\\\\\\\\\\/bFfKYtxwoE51TJYFvAI3aSl4EbMdXp4Kf+ERemYxq1ZkBxszwDHeYZVQDsaw5ScSH4kdJXJAutSoeOl7fw\\\\\\\\\\\\\\\/fbkF1g8bYLbqAmu0dJWcEAamJn2ROTwj4gwGwQcZ+TM6eHD5VAHoWtjT9ggQcO1aMyW2cnBJO2Rq46PrPmFs4qzufrvA11yO17oic\\\\\\\\\\\\\\\/7T+7xNklK8xm1r+u2swLUlcfsYMiCwz+bwUEVxlMCuk1oTSDgcU3RuXpE1EUEqZdAXhFWD6tqTgtp+mPaygVHZf3L0MgRh98zuonAxZHRMTa60J+z7dV49Ok3kSpDtVz1ql2QWQOYbGpVOd28TwweSi01DAhIdy3pOdqxf9A0I+pUVIszAKNwtf8tsT6nBRjCnCmM\\\\\\\\\\\\\\\/CLgTkqLptaB1gTtQ2EGZwbx\\\\\\\\\\\\\\\/Wx77PetGeoo+BDqIkUn48d4tTnhCEwvtLK4Dl+QgI\\\\\\\\\\\\\\\/OqCitlR6D0f+LEdQcqNx2u\\\\\\\\\\\\\\\/mE8xGtF++\\\\\\\\\\\\\\\/RY8y4IWE6Nr3kyD0piSCDkcRcKVZDHYmp5xiiiy4gJaIYtT5X8j5O4qI+QKs38NhEhCOf0lZOgGqW2idzYlw+NYyHVg6FVQsZBshMfWlDWj1G3eT+5zpHNHu5y6\\\\\\\\\\\\\\\/cVwjqX1wSvz2iLpE5dLhXOgIoHQNGWd64mIDhtDyj23u7rPVLBpFWGfGSYGtrJc1YFSi1ZezYLJLVGS+KDenxx\\\\\\\\\\\\\\\/NCWUWarlOEEG5GZHdpJMP9eb2tMmahRON5QJvRoNyN4\\\\\\\\\\\\\\\/0wy63DP02eCoZFWK9Y6PW0hCR1PQcIinmCpiG4XzCJp3KyVdrPSwSu0Nu4dJiD6M26W8OdJH0Ar\\\\\\\\\\\\\\\/V3lyIWkqk\\\\\\\\\\\\\\\/sUhzOUMGtZDrKMJtGyHtWOcUfYrE7L7Wr3wyA1UffQZ5o0rC8JJZptJ0JybpOhvhZj0Ouv4DrW8i6c43a20Pg7SCRUa4+mg+f43eCDn79rist3rTwLQVkkZJe8D9nm33D4AvWtuTH4YlnefQmxGNVV9OfiSli3QNyjewmnGfI38CdcOOpYVnlOYCA7DMp3t+ox8lmu5+i\\\\\\\\\\\\\\\/PU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022eo\\\\\\\\\\\\\\\/MLwRAVETOoiIAmD40Qw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fbf965c8b002341bde810a0c80a95b338c9fbdb213cc6f4f456a6ed433731fbd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P109.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/Suppl_2\\\/P109.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;3\\\/Suppl_2\\\/P109\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/2051-1426-3-S2-P109\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/2051-1426-3-S2-P109\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/2051-1426-3-S2-P109\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}