{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dxQ4xoDm1VobJEaxOTyiJbGoSN7LbgBvDFHs9N0zLcUo0YOoVikGwF+rlRabINt2JzRX85IjbyV5xs2zZ+XLziL8xN2pusg3\\\\\\\\\\\\\\\/EA8+O24sAg7z1qBuXM1k6sp7qsyh7IcZ2C8V8H6Zoon6zkyfjMXnPA5YwcpCIwtPvhAKftgJssYV89pbIqSTy8bfI09ZxPuTKNvR\\\\\\\\\\\\\\\/DBPP3s6WxOwz\\\\\\\\\\\\\\\/kEoqZBM\\\\\\\\\\\\\\\/zRsSjeugmdfbtlLrB76ajklfuSaLnfpnBJl9uBxJ6gU8PmcitPYGQtY7U6t9p7v1G\\\\\\\\\\\\\\\/P+9OwK699G3JmmTLPFzsvgyZrVWM9uBuMX9pxDb6mDmZzskRf6MflFkS7PFurGTFYnWM2ivOf7hnzppXMzII\\\\\\\\\\\\\\\/UpAEt5eyD\\\\\\\\\\\\\\\/fry8ivIedyL\\\\\\\\\\\\\\\/39GHO+HuKFbp4cqWD5ibcG0xpIIU2ivhJF8jjW7z\\\\\\\\\\\\\\\/GlSo+CbbWnGhmNvrPkCmB+bw0MSyOqKdurUexUV1zlUh0PHtR9wV0rGwriVDdFbu3O84\\\\\\\\\\\\\\\/L8rNzWXaO7wJUfY92JXsY9zkSeqSAXrA\\\\\\\\\\\\\\\/QchckeAyTizDoDBOO2ZHhfswr04xKZ9t0UwK6IyeZo9yOogr\\\\\\\\\\\\\\\/pyibSUyEhPLZzYOop4mQuxdMxLyCbYuQvS+6g2qSkQKFnk8vsxoYmInpy4o45OfMZlGZajQR5IclDh3ztnTas6TBOFWvoCRUHWvSIwv+7o8RP95C4mYQ9ludKlT\\\\\\\\\\\\\\\/JH68qh2uaR494uNUb1ljENTP6cZIKs\\\\\\\\\\\\\\\/6vH7cxsMZgoEu+oYI6WZgAqG1JKN\\\\\\\\\\\\\\\/CeQRg3CjrkHkWquCJyEwbH5pIB8cURxq\\\\\\\\\\\\\\\/d54uUKDc8hhGvqPLoganSKm56tyMgqpiYXLcNbctlH2XLMHzUXn\\\\\\\\\\\\\\\/LPkVkhCk2WGhPboUnmSGG4vMXfERPzKhgekprKRNyUWWmIBH8p8sR+16ZiLD4gG9J80CkL8Sb2l4CXZ+1R9irFU\\\\\\\\\\\\\\\/Ges+Lt0ZnHJsMnwWU6PJIRh2LSd9RgGExIgLSMC13YZZUZceqYGgX5dmy+J+W9wJWgZsPCn4yQM9DyO9MhcH5CX13semThGTb0lZMHjmpwZmYR38Hk1jRivAJK+xM1sWm9WQgCgbi5es4lQxdKjaUtyaiHmOY3o3x0X+2FGSehJyqVhvIA4CPuU9YCig+qwnJ\\\\\\\\\\\\\\\/cLGtFbZ8qgn2d\\\\\\\\\\\\\\\/XszWxh0q3DhHC2TGUyN6ZvIRAnrNsEy\\\\\\\\\\\\\\\/xJbBy3kbIbrgDT5loOJN7MH6ABRNuw9uGhXgvJ8LR2NEXR6qIqswwpOih337n4XwWcWqpu7NmTeYJDjP8cA\\\\\\\\\\\\\\\/9+aPhw2i1liAP\\\\\\\\\\\\\\\/hL22S8BZUATqh9ihm5kkWhGFS8G8nyLNapn707NfkBpOSBQm9JM1p26RTL9zzvD8rDfMQMvqReNe\\\\\\\\\\\\\\\/tRgDyxSJ7XmNMN9evOIcLODF1KyZvqW2O8wuMiLIC2t9q21XmGLQp9prEkQdTvx3FeE3HoOYBr7tW1oJiMSU8AClNGiPbx9k\\\\\\\\\\\\\\\/yaKLCoVLuKPbHzfcS9y98qqeW9RJIT0bG\\\\\\\\\\\\\\\/Uot7qMtwom2SX\\\\\\\\\\\\\\\/1oQuSVKvQtbBDfy3w+FbTdgkCTjfAAl5b6\\\\\\\\\\\\\\\/nSYncvmj2ggNFNj6gV7OSaUQaIKCpzCAKu536VI8pwGW1ssS8BmFYtn4jK4Kk1JUMuwCKbaJHH4cvpp7WDWHnOaHCg7DhzkEmOofMFV79UIkSp5uel2oNBEnPYh72H57b0efoV9rp6W9LE8J8e5KPgw9kJP6BVJy46zdC0JpGihUnkZqS\\\\\\\\\\\\\\\/paj69pTRq+\\\\\\\\\\\\\\\/wPrd3tcYyNp8Ew0cc2zPhvnvNKSGRH8zyEV2ZgtwcSV1e\\\\\\\\\\\\\\\/VZak2rWEniZvaYfeQklCydd+fyrnu5de6AeRa8UdX91PpV5nGOuxgeRax0MIFJmUv+m52XQJFNr\\\\\\\\\\\\\\\/Dv6DViHJC1B1HrfPAR3Q\\\\\\\\\\\\\\\/brVodQeSeVPyiuaLZgh8GoTBstywpNXcf8PYmo9ObIe8LI5tKf7y2t0AsjB6RlI4bYQvsKcY664boWWGp\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/xHYErXeptPawjyzyLbIBwsvXl5aKb1bhb\\\\\\\\\\\\\\\/Xy3jBFYUAdYGSuN7m8Jwb8twaZD2yqK4RCouNEmEl4DZtghNjRqhZoiP9MvK2xPFbXMHBScEwmU82BFdaVOuszvViFNCH5EKclo+fXaSuzidGiqcXkMNLEqhWUV\\\\\\\\\\\\\\\/AQFxqQSbzn11OeDi9zBhqdaiIoMrqq1BiASYB6ioGjeB0D9txXnwBPWintaGyXyqVAFoMB4DSrwi4ApxIYa4oiOq0eMuEq23+L204o+gZsLhn\\\\\\\\\\\\\\\/cXntbVaebQYjGo1fTHwY4qd47OuImiP8MtMutf2zk46mN2hWteJbyGz36s3hezMS\\\\\\\\\\\\\\\/hUs44dxHom5LvgxAue5vGlTvDnAiJzQX\\\\\\\\\\\\\\\/HwUZjl\\\\\\\\\\\\\\\/8e6Qn4E4YgyMww+VLvK7z7HGTaVHSm791pKyk06s8e3jyRriL8s5mn\\\\\\\\\\\\\\\/vpF6zG7jXPWapoZWqro1KcTf1q1owSK3NxXG0mSmvIj5Ul0ovI9CvG4b9Ks8sFWqmqkdoyQSnUSaJvoRnGm073Iofl5407SBIMjYDogil5HskXwOH0nPH543QOaYxLr8v8Va349LZCHuglsezcv4HacIuVAxT3PaTH9oj2MH7vaTMVlAqhvwXj+cC6g4YtgRm4aPaD4qZIGX0cxtm2gyaGgY4SLsWGw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022e7zznMYJPKioTzg7Ou+NQA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e40d29642841d9f354e40d12dd2efedc55dfb84c87b202f562625dd3c034faf1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e007327.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e007327.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007327\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007327\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007327\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}