{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jUOTp9IEQMqDFrTG1+My9Ujuz7iS1juWcP7r+5i1Qh82Moo0C3T2EqOINEU47AE4D1j8jFF6RvQ9zh4CcqsTGQafu1iA3sM0Fk23UHCSvWBy5A2LFr209yhdm4hOKcRUGqoqFqhY\\\\\\\\\\\\\\\/zH8mk1xeQ5elw7AlWDG3PWqaccWVVNoN1HOcTdK4fWLAV7UltA7lqfl0AdYvhHxomQIX2lVp0WufRH3Nq5OLtHc8F4HenRncXVvA+XSJvrguqy4fBOcQBwhReJ26loWdFDqob206uwprZyuo4iB4knGCTY+u\\\\\\\\\\\\\\\/JhevXcIDxjyg1T6l8WVkxhedmVUBmL39HZeVRp7\\\\\\\\\\\\\\\/StNtdjWwduXAcBB7JvQVm0s8Kv0zG0pfw\\\\\\\\\\\\\\\/i8WGdVh+oe5EdzM\\\\\\\\\\\\\\\/o2oZ5weyLUlnF5I9XnMNa7BRanFfVjprl0spl+V0xofoUVXGmWjA55AsyNpYp9aU3LNfTBkljiTWAZnI54fd0Qujj8WOS8OWUP8F8HsfL1SjU6GZJAlqzElEIJaR6fAMOGms\\\\\\\\\\\\\\\/QXZJnfTfTTfHabccb0d0bx8rOU9skyGTT0QNK8GR+i7ijmfNei1tLdzQpqweRdzIjX8oHkOyausu9Nsx16nQ4qwpElRARi\\\\\\\\\\\\\\\/pjiLXz2Xknu3L\\\\\\\\\\\\\\\/tVyF1MkwExbGKnFPIe4gpfbNG3O8VmXjwfYf9A0THYsnuSwMDEkDozGPs1KZg41wr75f\\\\\\\\\\\\\\\/VR\\\\\\\\\\\\\\\/tZ3M0YXakS9jRlOb6sI6kup3vPUXaRflijUkno9jm\\\\\\\\\\\\\\\/p0ER+kcHrbfUyL5ExQ951LOcFcDLq6YimIRTtaQVBqhMY+LaUF0ueg1q\\\\\\\\\\\\\\\/BNJt44Zxa2Wk7hpgBMR38iigS\\\\\\\\\\\\\\\/vgbRLLbiqrXUTepLOEN1N\\\\\\\\\\\\\\\/htpbjNafmDNw6TtlrrX325uwyYIHxt1mSFsfSdPHyI0bVWqR5rLM2hY0ie2mMmDS8FIoNBT0IilsPB8Cc139MAG9mk6aifwTxE+JlQ7oAjx\\\\\\\\\\\\\\\/hAyBMp+P\\\\\\\\\\\\\\\/ZvyHsuV9+7qi21onNTm3e7+myIMVk1B41VblVUZMGbAdZcX+rkHG0EoHmET32M1nZckr3QAEfymUqVUssFJsk5jRqqzEQ7WucV0UsZcrq1gdD6ttZ7yLr5esTpL9dHQm727A37lie0fKMRwH8pAdYQRK\\\\\\\\\\\\\\\/lK1N6UmdwgSeo6K2WpTW5ArDugBF+ziiOda6XdsCH5qoLCPwTDjtIOlG\\\\\\\\\\\\\\\/JCg6vYHFhaPsOyTCEkyQExj02yBRTBvwUgG+gKstSr9DV1PzVK\\\\\\\\\\\\\\\/jiYsEwHOcd8s\\\\\\\\\\\\\\\/Cd+0qZB2ZKMhNjEMWOb6rhRpRfSVhRAdTWF6F9gJMmkocvU8DU8\\\\\\\\\\\\\\\/ZBOiNjlz+T5E3anZwdT5DPitrU6jKZt4VKeQxYqvoAwk1OeGrY0NPcPGAQo6mG1PcE44rSWidu2bYJtzaEnqIytpO1y8V\\\\\\\\\\\\\\\/+p2jdat8zYBVad3U77PNEHc3TBPbognb6rpwdZodAF1gzrr6DiKwN7WrtgClHwRT9FzlNcFkJJ76VhfsfXpQ5JXwoHORTmP1gOL+nLdso1Yx4qgdcbY2zaOO0p8j2XDq1zfVDilfPMChwCHd2gVWO6Gpk6uPqX\\\\\\\\\\\\\\\/L4nF471JAQrScRlBeIaIKXmhXyGqNLNUwy3\\\\\\\\\\\\\\\/3wdhpIA\\\\\\\\\\\\\\\/yu+LgbiOQN4UxXatt0tWMj3JRSelUtLwN\\\\\\\\\\\\\\\/7Gn2ikpfWrbhR9iFRhNDUYucO7Dz9NYkFdsu5SFHc7ee2nHvbJeIdBcHgue1SgBCut3VgIdzQ+lUzEmBwAJNb7y0qfee2iL3FpY9pWk3vqndDPldc\\\\\\\\\\\\\\\/xZ6+WpTFUNVpN8xA91Pn4H5X7HauQkrhLv4ci5FNBwUldUaAc0Sx\\\\\\\\\\\\\\\/I3JjmZPfbbpYb7VcX5y1pwgluE6NrpoUO5LJdmlkavSZiUZgGe\\\\\\\\\\\\\\\/cvIdjxQE05QOnUa5604nBrPsula7bJDlOWarP+cu7VOg3tbBcCGerLqkESEahVqIFMD90HWbK0SSbJU8jx0F0uKdewcVVjCbbuYOrq3GvdgeKAlqewI8p7QNCsbyh+1y3HJoF9SGRsBbW7ALVyu63nP5DFpnB0kZYpacyDCg0xWbWg37N2tSa7615pzyrcc+rUfDX0zXvIwMJHbML9VPhYauGV0YBlBctim6eW8Sgutxwm1jPuR46ZQCY7tcnLmw4kVHRDFni8cvjHCu23g9YxNvWywoNN9daAvthBRxerz27fX13DxM2QMU\\\\\\\\\\\\\\\/T4\\\\\\\\\\\\\\\/6axeaLxw9gVeOYlAnfvrY9V1XlUgEp4y0ElHW2ZMThW\\\\\\\\\\\\\\\/UinsspFSUtCSG+UDq5wb8XJwjSee+WPARHi5RolFHWhKBDtWAJAK9V9hfD0Snue1UmCBbixUFjXfDsYUA2ZEXj5vMCCwFGPovgIlHl0\\\\\\\\\\\\\\\/4pVeeZTagOaNIctvnDjOCvqF8CsDKQ38\\\\\\\\\\\\\\\/owLA0Xzrs6O4kJHWN1lViTVwiWWVgnghQzXUyvrJUmL5p6dtoaXPKs4wRnfY6Dy17FtOmE+oG0UPhlFmOq4Xw72hnjH1bOaPOmGeOLvObnDyr2pbwyF82+P4K54w+wlyOYFSJvMgXm6Sag5cD2biMdQH+4IxaOxUbaKj01AqU0mX3ZJQLXpnaxmdaCWypAfywWVgFVi\\\\\\\\\\\\\\\/pAPG5hs4AG\\\\\\\\\\\\\\\/68UiQrVjtsgesAmeHKb9rVMmSXchR4gWcLumWANYVCToTXXjQqSdXLmx08=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002256k9OHJJ+ZAsWGFuWWk+8Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f0ce5ac162e5a8d63fd6d5808fe73867fbb5efcb7d8a4bad8b14cc3810237d1e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e007528.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e007528.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007528\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007528\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007528\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}