{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fs5dRV3L6w+gNcdvo9OQlC7j+k6UAOIEr+KCgJkZQfSwHUQGgq+3whXlbFJE\\\\\\\\\\\\\\\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\\\\\\\\\\\\\\\/JDigVHmj1R4ByA\\\\\\\\\\\\\\\/wLRGDjXqql0D4EiIdMt2saKCgfCkDegWuwKhzzvTc57ljXgbmjtbLxoi2eTvn1S36IavApt3iBdliP+M\\\\\\\\\\\\\\\/20Nij4sKdni\\\\\\\\\\\\\\\/X3b7mhe2Kt0q0DxToEpVRjWv6fCsEVE5\\\\\\\\\\\\\\\/lYHpl+5rpZkqdx9zY9oNWrfkRZw0RvZ07Q3Kt14kyq37RikpYNLYMqNaryJoLHArALCzym3uQ1hUvNosD2+b79W7ph8gMkaJ172q5MOYQ6\\\\\\\\\\\\\\\/3gI+cQNyeUPXOR94y\\\\\\\\\\\\\\\/TcO\\\\\\\\\\\\\\\/6MHJSnP3xsVEgFlGQU5Gcg8FGZPmb+RRdOG1M+pVcXwWgXMBeVgN\\\\\\\\\\\\\\\/zWLKmhxgjvUozWJE+zLTieh\\\\\\\\\\\\\\\/+GYEXu+6Fc6e\\\\\\\\\\\\\\\/qyee1ENL2FAKgkDqQmyiamx242i3DcBTmdMheCmzTP\\\\\\\\\\\\\\\/IIA9lNK1OIQk2qPmrOO1batJKEl6saE4zK+InnI5LpakVpO0smE1NsvaSqvfOBFCl0lg0zIUhhA\\\\\\\\\\\\\\\/KWMfX9W1SHH7cXxeXfPwjqhMaqy0Nz2zMUxFt5Ht6DXSaA5Dx5NERPN+dBXvB8knyRBsJLDJCbFp+EG1S53YTMI+JH54C9nen\\\\\\\\\\\\\\\/fp+Eyowvri34bzC0NDzeg\\\\\\\\\\\\\\\/aOZ2QNJfj+Gu0ljkdZzcSKGndGN7lRmhDmJop2cnepbdDqVKacZ5\\\\\\\\\\\\\\\/M8QSyB6z7a757N8iSYdNX9pwEMCGJSPYq287Wo6JSNEmMYq\\\\\\\\\\\\\\\/jBEMsG96q1JrUuQbsXWsLdGRktBqvhj5XMln5s6CaJzcDcZuHRQi8DohcRo6Nzgx6dPWqtIK5wwheUqVFTd44QgfqA3QYh4ljVPbNaCl8Oqo9EZYjJ8O+1HEh9pQU5uBF1dSjwnF4kKm+vgCbK39S1eqCYl8N9SkNa39EPhlvs2I\\\\\\\\\\\\\\\/vpup5cXkH7apW8\\\\\\\\\\\\\\\/jEPBpgo9tnjvQ1QfuFs0ZZz\\\\\\\\\\\\\\\/NqHb1SXJGowu\\\\\\\\\\\\\\\/g50yLEsr\\\\\\\\\\\\\\\/Tk\\\\\\\\\\\\\\\/BqNKm+HN0PSOj2BopV5nZUkIMv8f2KN7QXYYGtZOMnvyvsIa8dxY8UP+4jr7KMu3AnmQc\\\\\\\\\\\\\\\/nlg39FGFUY79r+Ms+0d\\\\\\\\\\\\\\\/i9O3Em8PvM6Bfo0qd0RW6P88ATVtGRAmU\\\\\\\\\\\\\\\/F3NB5qz6B467I1ivVDdD9JruVj\\\\\\\\\\\\\\\/4KP3hmaSm3otH26+MwDX51BArd6Ff6XNRo+Hmhz7fcvJuVGXkb5+Z2JuyjIB+64Chhu\\\\\\\\\\\\\\\/9P\\\\\\\\\\\\\\\/n2CGtNyrYwd0a77YPJp6bE\\\\\\\\\\\\\\\/3IMhNLeeZ2QnEK5pNt2MkGdyBd4FtrRAx3YINno4eHFNiPZNBE9BSeHJCPsKIcKBSoxXmNN60GAYWDogbjeoygbCCV9AGRhXqKBAe7xXUYMD8H6IjE7Pn7qSR1iOBEnblHmTOuNeDXRH247QcGUb1vR+A82mlk36akyrbr7Mt54QZnwNDZRVpMLizD4FRW5nEamTYEWGEcuZpEfmDBAh6j+3XxDXcq8XwB\\\\\\\\\\\\\\\/0Y8ttxyWxbW2lQf4xKboh569+f1b2qHSt+ZyEE5uPh+PcqsVJ1IK6S5qUjhJzd+ibo9iRfrLYa6s6esQPYX8ulVe6KVQtQ8eLHRd0PpSQn2A9MeZDU6PxJY4+0laZkv6x0tFcq72Kx9lXQh\\\\\\\\\\\\\\\/02uykx8ZhOXhASDIJ9Oak6E72wFYX3SSl5APENgWzscxXhwj+7XSXGCLkicEFM7G4+7e5jmKLd6MUL\\\\\\\\\\\\\\\/Cq5+fheqrVRpyVtasbp9U46pIgNcrRgt46YCBGGrqQLtPjT5gVJBC57ySHv3L0xMqvf4qh\\\\\\\\\\\\\\\/YI7QObcBZByndM8izHVVsBi0LKbfcF9cfyUs3Wnq3rJbYRud\\\\\\\\\\\\\\\/yE7+3HPxZto7scn7pjsClzVhfvgySqhXtcn43trcehG90FRsQOskKVJZb7DpZFYh9vVS0vYJCZLm6nKn8IpcIDP0pdL7g60rgeKVo3N9oA3BBp1hC45EQeWGQnX2Xo\\\\\\\\\\\\\\\/ht6NGaoZc5PrLhHd1EUulbqkMBLTVVDfvxKXyZnRkrZKJOPzYPyke7ZutHtiYFnEnoiiQzkCsjYnMu+UKVfIOjBCabelb3kyhxfAm5x1YVLBEjeiN4BnTMCxq45pZ6xFHRd3uq6olwrc8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022nkLC1j99astK3PPoVg0WDg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224793189da44ee0c31d7cd8c913b0786998e29f1485655592533e7f94a538bc29\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/10\\\/e007535.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/10\\\/e007535.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-007535\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-007535\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-007535\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}