{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022F3+I7GaE0z8B4wwk4CRkL7yeOveq2aSPz9qwagLytPmXpqCrgWKCF6TLQ+dzhGqFvWKDIEDd1ISRdi7GIUvMHf8OBJ6xdN8hgiOI5Py7kwKXy+OQ1QOoz0LOivClqu4omTntiu57DNC5zHnW+A0fepTFPnnNwjCSwiYqPDNY55tIDpUjpyeuSWM+AERYwVXWuPt5ndM9waIcbA6cXclnPcH\\\\\\\\\\\\\\\/dt3dMBDBqThUclQgLxBr9zZdkL3zIrhxtIPVvQ5\\\\\\\\\\\\\\\/EJd4RCFl4GNsJdAmnPhR816hMgR1LR2bh2eElZXsnq36kvBjeaO3rgrSQFqE0WAZD6zGAIjonGwu3dBKAZGiTyYu5jx38Hr5eS55bsQbG9cGTZV42pJu\\\\\\\\\\\\\\\/YmhNqZMIkWL7SRnrwvLOfnXMFxe\\\\\\\\\\\\\\\/IHTxchfzOy5Gdqce1pmBOBNG6pEcigb5yoCYk\\\\\\\\\\\\\\\/Q7w5uvSjoffWFg7wWvsYCDyF52YPBPGN6MhBfthbtQi55JEQ6rw3yOBgpHTWiildrOYMfFbUS3fYC4XUk4D43vz44rA5aaQRxczI2FaBL5LPlYux8OHketE9udCuH+OCaPLT3zDEpcyL+Ah5RIL22PAZBSMQ2Oa\\\\\\\\\\\\\\\/vLP5wzR27VnPPbwGmUvtUetj6JUPqAP1n3gF2Wo4SBEZRxi5xpFtnvWxQ8vpcOUE4rK3i+GpwynXZScGDiWsbdyJGatSd2\\\\\\\\\\\\\\\/Jzy2K4sr1zyPNdtTvjytMXtScKkPLe6zI\\\\\\\\\\\\\\\/tp\\\\\\\\\\\\\\\/zILDjflKHrTWI6cxGG1WjWQW9brfvW6BnTrGq+hLtdjtyFHV3uTzKyMwEpgaqpZwWNe7ZyMrr0mk5\\\\\\\\\\\\\\\/3FVjtp1PXpLmFcow0kF82hw8q9fGtpCBveEmwCjzONCJdEhivUTKPPDml9RaUarar01cjOHgM32M7PrPDyDuwPueanq8ncrrt\\\\\\\\\\\\\\\/eWzjPcfs4mOif4vynPo+TGoovplUhGLLR9GzHu0nDfuZO6Ez3c\\\\\\\\\\\\\\\/BpB+zmIEN666Qjy\\\\\\\\\\\\\\\/ke1nNRZoe6FltzMHcWYUgt18U0L\\\\\\\\\\\\\\\/Ki1bAnN+VflLYWDSG2v3makq4tP0\\\\\\\\\\\\\\\/X3oY86W0WpsqIV00GsmcqP33SX\\\\\\\\\\\\\\\/hsKjEj66ZGFg2rAvQF7Xz2Ke36TzmZ31aPjCiA3dusog884qN12NNOrGVWiheSbcXWEKeULUVw8jHYkEo5FNdVpbyycvHYuuuxKjCa7SNigrYDTC8ZyjIGyal8c8w4zUDvfHQKQoDbt0LNo82dSZd0iZ9n3Lwbc66o2gQE+Q3nSKQzVTncpu04kqrPlckhMZsxSu\\\\\\\\\\\\\\\/DCECL9QJgm6hmHLbFAenxyUXNBp3WC7OTZYO2I6SkzpVDpvjP4mokB8E\\\\\\\\\\\\\\\/tmpt43hkh5DKYe2SWheP+AwRL2F6RuweQKWWp0wwEd07xTACWmMYg4rDfkXJO5L4RRnSjtZUhbiHD24dAX3JDtb2fVnAaU36MRy7LI88WwM+A2abjk9HtkNjWPc6\\\\\\\\\\\\\\\/oQfM\\\\\\\\\\\\\\\/ugmeuvqbfZWpE1lI1Rf90SKkES6d9gI6k5cydcZQwzpo\\\\\\\\\\\\\\\/xRUykQo54pH7Swy0NrWE2UJTHrdT5U50DY4KkWDTbaiSI\\\\\\\\\\\\\\\/RGZIv4IGbkzyV+d5HKrbN1D8Q19Lc26itkF3VPk448QlQqounjyRxw1Lo\\\\\\\\\\\\\\\/+s7tdU402GUcpeqFeO2EYDpZ2tmMZUV8pSogbptG5HSubn2Nf0mSRjuhFyY4aqr8+5bjvZ8W0UuW42F+rLIrhoTnhakMyXGmAfb4vBmSty33S+p+mkCBwNyRyzm0C4LtDnY9L9dYasbcUXwb792tandu2TESbFFUvIwz8OLYx4kUGuqzg7oRt\\\\\\\\\\\\\\\/iDCFVXrxKuoSzKqq4hckvJelxaSJHltVCX3WleORFoamsfqVhuU0YD90+PAchhRMPe3kHXItCx5Gv1hfpfoMPqN+dPYu7R3LxJp49D9FROXCiIgl2PxpBrNvq2UmGGVC9vpKMNNK9CnevFJLg8sMBY+D6gbg2upaXLUhNf3qQX2kJ\\\\\\\\\\\\\\\/sXbEMSogbu8zMiyY4dpcJ1DpFhEPPNKmih0An84cx605JVlaOd6qgBbceX74LxXoEizGVU+Qhp1wBBV2XJ0u4PtDmGP7TLp1swJ9\\\\\\\\\\\\\\\/Kp\\\\\\\\\\\\\\\/Y4ppNy6iFrmWOUztAxZxdTeoUCBJzqIkWqSWzh0Ruufy8Vqi9BSQdGkKNMDKNBB+g7lIO3qABSa0EWbnt8R2SzjkwxPXKsmYE6s1LU9i7Gru101jc6Z5GyaBNm5PIeyCMOTch5xzQkYzjyMECgQHkNzRQJRbpLoKKFKuDG6BCaO\\\\\\\\\\\\\\\/Xxp\\\\\\\\\\\\\\\/uVE7Cm1Dx24nEQ5aJirJC65hkGr88CJH39R3tw\\\\\\\\\\\\\\\/ViyELtqSwyHR4YEWPmAxO6DSpGKTjEZVfO4BhmmsD13PkZ2K\\\\\\\\\\\\\\\/qv0EuZk9Ks9eyF\\\\\\\\\\\\\\\/mKgnwrxav\\\\\\\\\\\\\\\/o4sgC4LYp8\\\\\\\\\\\\\\\/1yf6LcWQuHAt4SDQwxhLCPEYY62jngUGJGn5NMqa33wn+kUn+qEa3W9A6N\\\\\\\\\\\\\\\/BptLBuLvZGZJpMfz+0AzQg3bybWDAwk6z0TK0Jt0fQHbX4lvOmPolBbJ2rkklaSXPOH5ttWotePPMUknnEy6aZ7tX\\\\\\\\\\\\\\\/h4nf+d9m2lr1IRKrJcNexc\\\\\\\\\\\\\\\/AnyHqXud4eXxZb0lU2fyXOa0RyBe3sIbKR5yMt2pSIGd+JEnU3kuYuMEJ98xajnxUbXVt+KMMtxIGNVQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UEDRZXWi3OcJYUBZo1hW5A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002234955a383f90835b00137c4d12a4f967cf280e15493e4c21445131b387a14162\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/9\\\/e006802corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/9\\\/e006802corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/9\\\/e006802corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006802corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006802corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006802corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}