{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221p8MuGTvsfwIrNU2+rbZ3cC7GiZhH0AFeo\\\\\\\\\\\\\\\/i5UjgAog6SuqHZE52ghqkTyF51ce+m64Wu9iAGEgKMTN5Ptimix0ieNk319Grec2G8kXpN65FQM8Bgtim0H\\\\\\\\\\\\\\\/CoAzmJk+FXp1Y6LUs4szB64R4wifgvfSP11GXFNe0TF4sBxwMDUu8eYDdJBDisTandEa62HXskg27\\\\\\\\\\\\\\\/4+1oC+t2RILF7SJm2JYLQgKbx4CYSLROM\\\\\\\\\\\\\\\/GdRgE+3jrzxhGNxUYyVd83YGmUjj1dAXedqy\\\\\\\\\\\\\\\/Q655ED6YHekSbnzg0nC6p5t15f3JSt5TFcsTvqlB5PR5tOhBDSRo8uI+dsCXbTEbr7KsMiN8vj+UB\\\\\\\\\\\\\\\/RgvVCAiqo7lLnoZiMGS1wilFtqqeL2DIpH8vtd9lZDTTHklidPfxBQCBjp8mPHOsrhWCZjmbZeXYMU4r9ddA4KzKR4A9NJ2qkHegv7U1\\\\\\\\\\\\\\\/Qy9Xyxb+kPRAxcIUap9IozLZLYQyEBbVa\\\\\\\\\\\\\\\/PCjwQCi4doNsjzM322oH5IrbcxN4T067Pfa8JtHcBMEKJ\\\\\\\\\\\\\\\/FAS8\\\\\\\\\\\\\\\/TLqr1rC2SP9xmaH3oUMHG2oOr8vYQfTCVGd6zSXnCep802m5w4Lep2X6JM4YHaMh1ZUvjoEDxh3\\\\\\\\\\\\\\\/y2e94AepW4enCfXgC0FeDxBpXXGxqfbB2cS4KNopc5HB2T+qgNT\\\\\\\\\\\\\\\/ygAzcDhrpmom069Li3CFx20YdbQV2pQIBNEjHKb7sJbyay1EJvsr0y5mrCWmp0n8WbEybRbBaV8CpU6cc4wUz8aNLWwaYl8tpzF3zGFVhmyKeiAw+k+4xtsWAyAbsHWOkXcD9MO5no+0HNWJsoPdeKAE005k0t4pnz1qZWy3lXRBhP7pnv+FEh0jdawWU+22XBQcbHzlWajCGGTTQpSVEDAXt0WCCQVVANF5b8Df25dyr9T0dqGZGzgmdYEXBQiIecfNMNX0gljqFT\\\\\\\\\\\\\\\/O8Ef6mgJdHxl2mToPJtDZrBxUX4lTlJoL8dRUFEf1vGAAoiwVNVnJKsW2nEX3iIRMXmbeHZotWfel3Zl7tTui\\\\\\\\\\\\\\\/eEsJgBUq+dXxdTUju0rMzuNeMLFkezuXaqJemuq5DnPITPKi0T8JFA23LcOjc3cKpx3fm6xKqG7MqPTG3lkz8aNd4ZAFzCqMsWhYQEWnCS4kl\\\\\\\\\\\\\\\/eGQBpY2W+aPvuA9ITOrusK1r0\\\\\\\\\\\\\\\/cHFvUesIeUXQy9E96yAC6jZp9KqtcuVCbw2dfST0s1Sn+\\\\\\\\\\\\\\\/IDYVdyXhZr4n4F0mPay+ALh8jCZLmrsO6spoHL69hzyFyaSncWSATFS8h5mwhC7MGZQWBBlPG3E\\\\\\\\\\\\\\\/vIbXJtk1Idh1hCJB4uyB+cVZ2lRpubERhPdkiRkFuyXuiEfil\\\\\\\\\\\\\\\/RVDz3oCUb\\\\\\\\\\\\\\\/7M10VWc\\\\\\\\\\\\\\\/YLoL7d5gXrT4mdaeqBMqS1zsYVFKDD+FjhI1KN0FewLPO+JHDLcpEtQHl3\\\\\\\\\\\\\\\/+dk47aM3v9JpZzT21jf9P2VgF8DLQwGsfiJrzgXDK3hCnQ3TZBd\\\\\\\\\\\\\\\/TteXBhgwtja4AY+Un\\\\\\\\\\\\\\\/gLLwqCUtRCsxVMaep78uzy88e2XE3\\\\\\\\\\\\\\\/XqFgrlb2otoVYNsddKLznXCl5D0pPwzULg4wRCmeYoJbek5hH9SzlgyWaQBBjKpVvs\\\\\\\\\\\\\\\/zSUWD5hPTuXujrfLRke8px5+Azn5U0ruonPQd7gikcXZsO2Jz0eKFP99bzSi5DCE6DZN6YzUESe7oTy7tV\\\\\\\\\\\\\\\/l1DRp8QF932NZwTHKAXueb18RsnM7CcXDEFTopIy5ipWeN6VsbyJKRR0cvIeLkJ\\\\\\\\\\\\\\\/yBki53kyFt1EYSS3LW4HFtlvMW0tT8AYYBsvJRDqshm8GppVLm1z9KQErotZdzJ5HGMnWAjDJ12esUpq8R9FiAJQJw4CU6Xlge3z6P32YCMtxpms421hJNG7bYK7FM88bE3AhD\\\\\\\\\\\\\\\/u1TRl6PVHuTL0xhTGtKDGV4xWOP34FhiBoUN86MSp7YRTL4aFKODdp4kbtvIHcS5cwgklUwYYUaG1Lnv6EYjNQbYQ\\\\\\\\\\\\\\\/Cpo\\\\\\\\\\\\\\\/23ixVjeeooGyYswrBKxbu9LSfn95Pv4L4eyRMnepFNXk1Y7u0YQ1eGDBfxDL74h\\\\\\\\\\\\\\\/wl3OMgna8IYA2XlYVHAClTcvGnU42chxecEMQbfm9LJKTeAKE3AjbNK9+5ZVZiWEN+s0sHm6mq\\\\\\\\\\\\\\\/z5cIgyUlGI5Bay2VcK9P+pbN2qpyrg5L5ktatiYQsIFRge6Ft7rjmej\\\\\\\\\\\\\\\/AGxicfeE871IO8vhbe7n9V05NVVtHhJvNOU\\\\\\\\\\\\\\\/uAaYYvUrxy8D+8dzT9Fxq6g7xvJn0NzWGGFo5Q9wnSlsqHDhLAh+uThNfh1e+JyyuPAcAk4oxEtqwpy64B5kSxCPBn\\\\\\\\\\\\\\\/OVYgNwW4bujMQPTBqhYGSAZdqwMjuuYRd6StrCmEAXaa+VPOuWRQYAk\\\\\\\\\\\\\\\/kpUBYEie8K4sXcS66e9\\\\\\\\\\\\\\\/XvN0TtN+ZF\\\\\\\\\\\\\\\/BS08bW5cQqzZOq5Q31pwnrFf9lGwOppYjjQgEzeIzdgtwOWPgPn6Ycpgf4eugcQCo+F5K5\\\\\\\\\\\\\\\/JyBb3UD\\\\\\\\\\\\\\\/rkIPUkL0k2QcSaWQrgkkENB3ySl7bw3wJWN45WEf0yMVkeRu\\\\\\\\\\\\\\\/E29boAe2ySxS5qvG5Bb94YrLVwLroqJ6BqcvpsZu+HcwsdEUw3hHrQTwZ9kdkTEW00COYoj0YKBUwgFQndpvh81dr6\\\\\\\\\\\\\\\/0ujlbC+kOfr5vnyJr+TvTZAMTA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022zWERGIC83Pn98WEAklv5RQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022dba2e903fed10b8f09a39cb61bffadfd34ac709c51586fa8b67c55a9ea9a66f3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/9\\\/e006802corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/9\\\/e006802corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/9\\\/e006802corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2023-006802corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2023-006802corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2023-006802corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}